Complicated migraine, drug-induced

COMPLICATED_MIGRAINE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — G43.3# 1 out of 7 registries used, show all original rules.	40
4. Check minimum number of events None	40
5. Include endpoints None	40
6. Filter based on genotype QC (FinnGen only)	40

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	COMPLICATED_MIGRAINE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	G433
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complicated migraine, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	40	29	11
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	38.52	33.70	51.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

348

+∞

2.07

17.0

12.4

20.22

19.36

mg/l

0.05

262

(36660697) Celiac disease serology panel - Serum

3.46

1.90

1.1

1.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.25

1.60

2.9

2.2

105.41

106.57

u/l

0.02

(3003694) ABO and Rh group [Type] in Blood

119

0.34

1.59

1.0

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.12

1.25

2.1

1.8

1.01

1.24

mg/l

0.13

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

1.21

0.0

5.2

—

34.90

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.43

1.15

1.9

1.1

—

(3025941) Bacteria identified in Stool by Culture

2.45

1.06

1.0

1.3

—

(3019225) pH of Specimen

0.00

1.02

0.0

3.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.00

1.02

0.0

3.6

—

26.76

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.02

0.0

1.5

—

(3023368) Bacteria identified in Blood by Culture

1.95

0.94

5.8

4.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.87

0.87

2.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

104

0.50

0.75

2.3

3.2

—

(3021589) Normoblasts [#/volume] in Blood

147

0.57

0.72

19.1

8.7

0.00

e9/l

—

122

(3044889) 12 lead EKG panel

223

1.65

0.68

3.7

3.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.89

0.68

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

194

1.59

0.65

5.6

3.8

6.25

6.43

mmol/l

0.15

180

(3001122) Ferritin [Mass/volume] in Serum or Plasma

155

1.58

0.65

2.7

96.94

69.91

ug/l

0.74

148

(1002224) Polysomnography panel

0.00

0.62

0.0

1.1

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.62

0.0

2.3

—

2846.41

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.62

0.0

1.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.62

0.0

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

128

1.57

0.62

4.0

3.2

19.33

36.04

ng/l

—

(3002032) Base excess in Venous blood by calculation

0.00

0.61

0.0

3.1

—

2.29

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.84

0.61

3.2

4.6

223.17

222.83

u/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.63

0.56

3.2

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.63

0.56

4.2

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.56

0.52

1.2

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.59

0.52

2.2

3.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

116

1.47

0.46

1.6

3.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

107

1.47

0.45

5.3

3.2

21.79

31.00

u/l

0.97

101

(40768793) Breast Pathology biopsy report

0.00

0.42

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.42

0.0

1.4

—

(40768804) Tissue Pathology biopsy report

143

0.68

0.41

2.5

1.8

—

(3000991) Gas panel - Venous blood

0.00

0.41

0.0

3.1

—

(3026361) Erythrocytes [#/volume] in Blood

382

+∞

0.41

23.3

18.3

4.55

4.46

e12/l

0.59

372

(3007461) Platelets [#/volume] in Blood

382

+∞

0.41

23.3

18.4

242.07

256.87

e9/l

0.85

374

(3035941) MCH [Entitic mass]

382

+∞

0.41

23.1

18.2

30.27

30.35

0.13

375

(3000963) Hemoglobin [Mass/volume] in Blood

382

+∞

0.41

23.3

18.4

137.30

134.94

g/l

0.49

375

(3010813) Leukocytes [#/volume] in Blood

382

+∞

0.41

23.3

18.3

6.40

6.75

e9/l

0.56

373

(3024731) MCV [Entitic volume]

382

+∞

0.41

23.2

18.3

90.53

90.90

0.25

375

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

100

1.44

0.40

2.8

2.3

42.92

54.83

u/l

1.38

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.39

0.31

2.3

1.9

—

(3021960) Folate [Moles/volume] in Serum or Plasma

0.63

0.29

1.8

1.5

17.20

20.39

nmol/l

—

(3032080) INR in Blood by Coagulation assay

116

1.32

0.27

7.6

6.2

1.06

1.16

inr

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.40

0.25

4.0

8.3

—

(1761868) Lipid panel - Serum or Plasma

127

1.29

0.24

3.1

2.6

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

110

0.77

0.24

3.6

3.1

2.33

2.34

mmol/l

—

(21494755) Public health laboratory ask at order entry panel

1.25

0.23

1.4

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.25

0.23

4.6

14.4

—

1.07

—

(3018095) Leukocytes [#/volume] in Urine

109

1.29

0.22

4.0

3.8

105.81

42.08

e6/l

—

(40768443) Skin Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.1

—

16.70

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.21

0.0

3.8

—

23.68

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.4

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.21

0.0

3.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.4

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.21

0.0

1.6

—

7.42

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.21

0.20

4.2

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.28

0.20

1.7

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

140

0.80

0.19

2.4

3.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

334

1.38

0.18

4.4

4.1

4.85

4.77

mmol/l

0.20

309

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.71

0.18

1.2

2.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

332

1.43

0.18

4.2

4.1

1.56

1.51

mmol/l

0.22

305

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

170

0.81

0.18

3.7

4.2

—

(3015736) pH of Urine

139

0.80

0.18

2.4

3.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.16

0.17

1.3

2.0

3.49

3.14

mg/l

—

(3009508) Creatinine [Moles/volume] in Urine

1.27

0.17

2.8

3.3

8.01

7.37

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

0.77

0.16

1.5

2.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

172

1.20

0.15

5.4

6.2

11.11

10.40

umol/l

0.18

163

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

123

1.21

0.15

10.3

4.9

1.18

1.22

mmol/l

1.33

118

(3002030) Lymphocytes/100 leukocytes in Blood

156

0.84

0.13

11.4

6.0

27.22

28.59

0.21

148

(3026008) Bacteria identified in Urine by Culture

1.20

0.11

2.5

2.7

—

(3042936) Bacteria identified in Isolate by Culture

1.19

0.10

2.0

2.7

—

(3002582) Erythrocytes [#/volume] in Urine

1.18

0.10

3.7

3.1

10.68

23.81

e6/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

327

0.89

0.08

3.8

4.2

5.88

5.78

mmol/l

0.11

301

(40758558) Short blood count panel - Blood

0.85

0.08

4.6

7.7

—

(3013512) EKG study

1.11

0.08

1.9

3.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.11

0.08

2.6

1.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

310

1.16

0.07

4.5

5.0

38.41

38.89

mmol/mol

0.08

292

(40760892) CBC W Ordered Manual Differential panel - Blood

1.04

0.07

6.0

3.9

—

(42870588) Differential panel, method unspecified - Blood

103

0.84

0.07

15.9

5.8

—

(3018010) Neutrophils/100 leukocytes in Blood

151

0.89

0.06

10.5

5.9

60.06

56.41

0.58

146

(3019069) Monocytes/100 leukocytes in Blood

151

0.89

0.06

11.4

6.3

7.89

8.48

0.48

146

(3013115) Eosinophils [#/volume] in Blood

170

0.90

0.05

10.9

5.9

0.19

0.18

e9/l

0.10

155

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

309

0.88

0.05

12.6

11.3

82.32

86.44

ml/min/173m2

0.46

256

(3006504) Eosinophils/100 leukocytes in Blood

149

0.91

0.04

11.2

6.0

2.90

2.59

0.24

144

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

252

1.09

0.03

2.5

3.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

227

0.93

0.02

4.1

4.5

—

(3022096) Basophils/100 leukocytes in Blood

146

0.94

0.01

11.2

5.9

0.79

0.68

0.32

140

(3019198) Lymphocytes [#/volume] in Blood

166

0.94

0.01

10.2

5.8

1.96

2.17

e9/l

0.22

153

(3006315) Basophils [#/volume] in Blood

163

0.97

0.00

9.9

5.8

0.04

e9/l

0.20

148

(3001604) Monocytes [#/volume] in Blood

162

0.98

0.00

8.9

5.7

0.52

0.59

e9/l

0.82

147

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.2

—

(4027681)

0.00

0.0

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

4.72

—

(3022313) Gas panel - Capillary blood

0.00

0.0

2.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

3.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

83.48

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

2.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

2.2

—

24.42

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

2.62

—

(4062490)

0.00

0.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.98

0.00

1.9

1.7

—

(36304419) Bacteria [Presence] in Urine

0.91

0.00

2.0

2.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

4.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

318

1.03

0.00

3.7

1.42

1.21

mmol/l

0.36

293

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

4.5

—

105.50

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

35.00

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

4.7

—

7.13

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.04

0.00

2.1

1.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

4.5

—

4.00

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

4.7

—

1.06

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: COMPLICATED_MIGRAINE – Complicated migraine, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Complicated migraine, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Complicated migraine, drug-induced (COMPLICATED_MIGRAINE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints