Acquired coagulation factor deficiency

D3_ACQCOAFACDEF

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D68.4 Hospital discharge: ICD-9 — 2867 Cause of death: ICD-10 — D68.4 Cause of death: ICD-9 — 2867 2 out of 7 registries used, show all original rules.	58
4. Check minimum number of events None	58
5. Include endpoints None	58
6. Filter based on genotype QC (FinnGen only)	58

Control definitions (FinnGen only)

Control exclude: D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D68
Name in latin: Deficientia factoris coagulationis acquisita

NAME	D3_ACQCOAFACDEF
CONTROL_EXCLUDE	D3_COAGDEF_PURPUR_HAEMORRHAGIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D684
HD_ICD_9	2867
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D684
COD_ICD_9	2867
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acquired coagulation factor deficiency based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	397	225	170
Only index persons	317	190	127
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	59.15	53.57	66.31
Only index persons	55.43	47.69	67.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	58	40	18
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	59.96	54.59	71.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
522

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D68.4

ICD-10 Finland

Acquired coagulation factor deficiency

+∞

61.0

D68.8

ICD-10 Finland

Other specified coagulation defects

+∞

10.8

D68.2

ICD-10 Finland

Hereditary deficiency of other clotting factors

+∞

10.8

B02AA02

ATC

tranexamic acid; systemic

6.9

7.5

2867X

ICD-9 Finland

Coagulation defects, Acquired coagulation factor deficiency[DEFECTIO COAGULATIONIS, E DEFICIENTIA NON DEFINITA]

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3006109) Coagulation factor IX activity actual/normal in Platelet poor plasma by Coagulation assay

+∞

12.98

2.0

0.0

109.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

26.87

11.93

11.0

1.0

96.1

96.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

7.46

10.19

5.2

1.2

—

(42870588) Differential panel, method unspecified - Blood

139

5.19

8.83

7.0

3.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

5.02

8.43

8.0

1.7

1.2

mg/l

0.00

(3032080) INR in Blood by Coagulation assay

197

4.69

7.11

22.7

8.8

1.4

1.2

inr

0.85

(3049242) von Willebrand panel - Platelet poor plasma

+∞

6.35

2.5

0.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

4.31

6.32

6.1

2.0

11.3

12.9

umol/l

0.44

(3027945) Reticulocytes/100 erythrocytes in Blood

4.56

6.23

3.2

1.9

2.9

1.8

2.10

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

4.20

5.96

6.7

2.0

19.3

21.5

0.30

(3037522) Nuclear Ab [Titer] in Serum

4.38

5.93

1.2

1.3

784.0

426.7

titre

—

(3037756) Immunofixation for Serum or Plasma

13.01

5.50

2.9

1.3

—

(40761593) Coagulation factor VIII Ab [Presence] in Platelet poor plasma by Immunoassay

+∞

5.28

1.4

0.0

—

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

+∞

5.28

3.0

0.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

11.55

5.23

8.7

1.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

333

4.03

4.47

5.7

4.8

—

362.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

226

3.22

4.25

7.5

5.1

1.2

mmol/l

0.19

183

(3017181) Myelocytes/100 leukocytes in Blood

3.97

4.23

7.7

3.5

1.3

0.7

—

(3021589) Normoblasts [#/volume] in Blood

204

3.02

4.00

18.3

9.9

0.0

e9/l

0.37

168

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.61

3.71

5.6

4.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

8.65

3.67

3.9

1.6

—

(3028271) Lactate [Moles/volume] in Capillary blood

7.77

3.47

2.1

2.8

1.9

1.6

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

102

2.86

3.43

7.2

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

9.38

3.34

1.2

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

9.38

3.34

1.2

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

327

3.31

3.32

5.1

4.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

8.19

3.13

2.3

3.0

86.7

90.2

—

(40761536) Microorganisms panel - Urine sediment

3.28

3.05

6.2

4.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.96

2.96

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

7.28

2.94

1.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

4.97

2.91

3.1

3.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

8.96

2.80

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

169

2.43

2.75

3.0

3.1

—

(3018418) pH of Serum or Plasma

145

2.44

2.71

5.6

3.9

7.4

0.57

(36304419) Bacteria [Presence] in Urine

138

2.43

2.65

2.8

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

5.94

2.61

2.7

1.3

0.1

0.2

g/l

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

7.67

2.60

1.2

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

7.67

2.60

1.2

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

7.67

2.60

1.2

1.1

—

(40758558) Short blood count panel - Blood

117

2.42

2.51

10.5

6.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.44

2.47

4.7

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

6.70

2.42

1.4

1.3

—

(3023368) Bacteria identified in Blood by Culture

111

2.40

2.41

6.4

4.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.63

2.36

1.9

1.8

—

(3013512) EKG study

145

2.27

2.32

4.3

4.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.95

2.26

2.6

1.9

58.0

63.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

5.95

2.26

1.6

1.9

4.2

5.6

e9/l

—

(3013290) Carbon dioxide [Partial pressure] in Blood

4.65

2.21

10.0

4.7

5.1

4.9

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

4.65

2.21

10.0

4.7

8.2

kpa

—

(3044640) Blood type and Crossmatch panel - Blood

149

2.19

2.14

8.6

2.0

—

(1616796) Gas panel - Central venous blood

5.35

2.11

7.6

4.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.40

2.10

9.3

4.0

25.8

24.8

mmol/l

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

102

2.28

2.07

6.7

2.7

2.4

2.5

mmol/l

0.76

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.64

2.03

2.6

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.86

1.98

1.0

1.4

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

3.81

1.89

2.7

1.0

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.81

1.89

2.7

1.0

0.0

g/l

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

3.81

1.89

2.7

1.0

1.2

0.1

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

3.81

1.89

2.7

1.0

0.0

g/l

—

(3042936) Bacteria identified in Isolate by Culture

2.46

1.88

3.4

2.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

210

2.02

1.83

2.0

97.0

96.1

pmol/l

0.04

(40768443) Skin Pathology biopsy report

3.17

1.78

1.3

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

221

2.00

1.78

8.3

3.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

186

1.98

1.72

4.9

4.2

35.0

35.2

ng/l

0.01

130

(40768804) Tissue Pathology biopsy report

196

1.96

1.69

2.8

2.0

—

(3018095) Leukocytes [#/volume] in Urine

179

1.95

1.66

3.4

3.9

279.0

79.4

e6/l

0.54

126

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.54

1.55

8.0

1.7

26.9

25.1

mmol/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.06

1.55

2.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

139

1.94

1.53

5.5

3.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

116

1.95

1.45

1.9

1.7

1185.2

1247.2

nmol/l

0.12

(3000492) Spirometry study

2.60

1.44

1.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.60

1.44

1.3

—

(3003338) MCHC [Mass/volume]

375

0.55

1.41

45.9

18.7

327.5

330.6

g/l

1.14

375

(3003694) ABO and Rh group [Type] in Blood

109

1.94

1.40

1.6

1.5

—

(3019225) pH of Specimen

2.31

1.37

7.1

2.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.31

1.37

2.2

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.94

1.31

2.0

2.2

—

(3022313) Gas panel - Capillary blood

2.78

1.24

7.8

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

107

1.83

1.16

10.4

4.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.12

1.14

5.8

3.6

1.0

mmol/l

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.51

1.11

3.6

1.9

—

(40768797) Stomach Pathology biopsy report

1.96

1.02

1.2

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

104

0.43

1.01

4.2

3.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

1.00

0.0

1.3

—

(4035726)

1.90

1.00

1.6

1.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.95

0.95

8.6

5.1

3.8

11.8

ug/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.86

0.87

1.8

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.86

0.87

1.8

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.79

0.0

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

139

1.55

0.73

6.0

4.5

0.0

estimate

0.00

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.80

0.73

1.7

1.4

—

(40761511) CBC panel - Blood by Automated count

478

1.85

0.70

36.7

13.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

103

0.53

0.70

1.3

1.2

—

0.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

187

1.48

0.69

5.7

4.3

—

(3019060) Gas panel - Arterial blood

1.86

0.68

2.2

4.2

—

(3002256) Pathology report gross observation

1.69

0.65

1.1

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.61

0.0

3.1

—

24.0

—

(3022145) Colonoscopy Study observation

1.56

0.57

1.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.53

0.56

1.7

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.58

0.55

1.3

1.9

—

(40761535) Cells panel - Urine sediment

1.56

0.53

2.5

3.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

407

1.47

0.52

30.4

14.5

36.8

39.2

0.80

278

(3035350) Ketones [Presence] in Urine by Test strip

244

1.38

0.52

5.2

4.0

0.0

estimate

0.00

(3019832) Treponema pallidum Ab [Presence] in Serum

1.63

0.51

1.1

1.8

—

(3009261) Glucose [Presence] in Urine by Test strip

246

1.36

0.48

5.3

4.1

0.0

estimate

0.00

(1761868) Lipid panel - Serum or Plasma

158

0.70

0.45

4.0

2.9

—

(21494755) Public health laboratory ask at order entry panel

1.61

0.43

1.0

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.5

—

(40768793) Breast Pathology biopsy report

0.00

0.42

0.0

1.5

—

(4034850)

0.00

0.42

0.0

12.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.41

0.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.00

0.41

0.0

1.1

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.41

0.0

3.4

—

41.4

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.41

0.0

2.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

137

1.34

0.38

2.4

2.5

57.1

57.3

u/l

0.01

128

(3021601) Nitrite [Presence] in Urine by Test strip

243

1.29

0.37

6.5

5.3

0.0

estimate

0.00

(3012516) Albumin [Mass/volume] in Urine

123

1.30

0.29

3.1

29.9

63.5

mg/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

134

1.27

0.26

4.7

3.8

3.3

7.6

mg/mmol

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.38

0.24

3.8

3.6

1.5

1.4

mmol/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.31

0.23

2.0

2.4

22.0

36.7

u/l

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

45.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.3

—

23.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.3

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.21

0.0

6.4

—

1.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

147

1.22

0.21

2.6

2.5

24.9

30.0

u/l

0.95

140

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.25

0.21

1.8

2.1

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.20

0.0

4.2

—

1.0

—

(4094501)

0.00

0.20

0.0

1.2

—

(3000494) Fungus identified in Specimen by Culture

1.17

0.20

2.3

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.72

0.18

1.8

2.7

0.4

0.8

ug/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

280

1.15

0.14

3.3

3.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.05

0.09

2.0

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.06

0.08

1.9

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.87

0.07

1.4

—

(3015736) pH of Urine

188

1.10

0.06

3.8

3.9

—

(3026008) Bacteria identified in Urine by Culture

169

1.01

0.00

5.2

2.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

4.7

—

1.5

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.7

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

4.7

—

7.8

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3039000) Anion gap in Blood

0.00

0.0

6.6

—

9.9

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3044889) 12 lead EKG panel

330

1.00

0.00

4.8

3.9

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

6.6

—

104.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.7

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(4146454)

0.00

0.0

3.4

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.2

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

0.9

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.6

—

223.9

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.5

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_ACQCOAFACDEF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_ACQCOAFACDEF.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_ACQCOAFACDEF – Acquired coagulation factor deficiency

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acquired coagulation factor deficiency

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints