cocaine dependence: A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
63 |
4. Check minimum number of eventsNone |
63 |
5. Include endpointsNone |
63 |
6. Filter based on genotype QC (FinnGen only) |
58 |
Control definitions (FinnGen only)
- Control exclude
- F5_SUBSNOALCO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F10-F19
- Name in latin
- Perturbationes mentis et modi se gerendi ex usu cocaini
Similar endpoints
↥List of similar endpoints to
Mental and behavioural disorders due to cocaine
based on the number of shared cases.
Similar with more cases:
- Substance use, excluding alcohol
- Substance abuse, excluding more controls
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 540 | 155 | 381 |
| Only index persons | 457 | 137 | 320 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 30.18 | 29.30 | 30.44 |
| Only index persons | 29.08 | 27.60 | 29.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 58 | 21 | 37 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 31.91 | 28.04 | 34.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 63
- Matched controls
- 630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
10.7
20.7
36
70
N05BA04
ATC
oxazepam; oral
9.0
17.7
37
86
P19
ICPC
Drug abuse
227.9
17.4
17
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
227.9
17.4
17
*
N05BA01
ATC
diazepam; systemic, rectal
10.2
17.2
25
38
T36
ICD-10 Finland
Poisoning by systemic antibiotics
29.8
16.6
22
11
F14.1
ICD-10 Finland
Mental and behavioural disorders due to use of cocaine, harmful use
+∞
16.3
15
*
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
+∞
16.3
15
*
N05CF01
ATC
zopiclone; oral
8.2
16.0
34
79
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
29.4
14.4
19
9
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
20.3
14.0
21
15
N05AH03
ATC
olanzapine; systemic
17.1
13.7
22
19
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
+∞
12.9
12
*
N05AA02
ATC
levomepromazine; systemic
34.9
12.8
16
6
N03AG01
ATC
valproic acid; systemic, rectal
18.8
12.5
19
14
F29
ICD-10 Finland
Unspecified nonorganic psychosis
25.2
12.4
17
9
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.8
12.1
21
38
N07BB01
ATC
disulfiram; oral
22.7
12.0
17
10
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
7.3
11.8
22
43
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
12.8
11.1
20
22
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
10.7
10
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
48.4
10.4
12
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
6.3
10.4
23
53
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
25.1
10.3
14
7
Z3231
NOMESCO Finland
Registered nurse
5.5
10.3
31
94
X59
ICD-10 Finland
Exposure to unspecified factor
5.6
10.3
29
83
Z2221
NOMESCO Finland
Medical doctor
5.4
10.0
31
96
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
22.0
9.9
14
8
N05CD07
ATC
temazepam; oral
11.5
9.6
18
21
Z2446
NOMESCO Finland
Social worker
11.5
9.6
18
21
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
+∞
9.6
9
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
19.5
9.6
14
9
P29
ICPC
Psychological sympt/compl other
9.6
9.5
20
29
N06AB06
ATC
sertraline; oral
6.1
9.5
21
48
N03AE01
ATC
clonazepam; systemic
14.7
9.2
15
13
N06AB04
ATC
citalopram; systemic
5.6
9.1
23
59
F10.20
ICD-10 Finland
Alcohol dependence currently independent
20.0
9.0
13
8
F39
ICD-10 Finland
Unspecified mood [affective] disorder
20.0
9.0
13
8
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
58.4
9.0
10
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
13.6
8.9
15
14
N05AX08
ATC
risperidone; systemic
10.6
8.8
17
21
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
+∞
8.5
8
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
11.9
8.3
15
16
ZY010
NOMESCO Finland
Hospital outpatient
10.3
8.2
16
20
IGY02
NOMESCO Finland
Psychiatric monitoring contact
14.5
8.0
13
11
N05AD01
ATC
haloperidol; systemic
51.6
7.9
9
*
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
51.6
7.9
9
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
21.8
7.9
11
6
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
11.6
7.8
14
15
N06AX11
ATC
mirtazapine; oral
4.4
7.7
31
114
N06AX16
ATC
venlafaxine; oral
5.0
7.7
21
57
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
90.3
7.6
8
*
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
+∞
7.4
7
*
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
+∞
7.4
7
*
3042A
ICD-9 Finland
Drug dependence, Cocaine dependence
+∞
7.4
7
*
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
+∞
7.4
7
*
F13.20
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent
+∞
7.4
7
*
P18
ICPC
Medication abuse
+∞
7.4
7
*
F13.29
ICD-10 Finland
Addiction caused by sedative and hypnotic UNS
+∞
7.4
7
*
F12.1
ICD-10 Finland
Mental and behavioural disorders due to use of cannabinoids, harmful use
+∞
7.4
7
*
F61.0
ICD-10 Finland
Mixed personality disorders
34.4
7.4
9
*
N05AA01
ATC
chlorpromazine; systemic, rectal
34.4
7.4
9
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
10.2
7.3
14
17
C07AA05
ATC
propranolol; systemic
4.4
7.1
24
77
AA1AD
NOMESCO Finland
CT of head and brain
4.4
7.1
24
77
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
10.6
7.0
13
15
N06AA06
ATC
trimipramine; systemic
25.8
6.9
9
*
N05BE01
ATC
buspirone; oral
16.6
6.6
10
7
N05AH02
ATC
clozapine; systemic
16.6
6.6
10
7
N03AX09
ATC
lamotrigine; oral
11.1
6.6
12
13
N05BA02
ATC
chlordiazepoxide; systemic
77.4
6.6
7
*
F99
ICD-10 Finland
Mental disorder, not otherwise specified
77.4
6.6
7
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
77.4
6.6
7
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
77.4
6.6
7
*
N05BA12
ATC
alprazolam; oral
8.2
6.5
14
21
F10.25
ICD-10 Finland
Alcohol dependence continuous use
20.6
6.5
9
5
R07.4
ICD-10 Finland
Chest pain, unspecified
4.2
6.5
23
76
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
30.0
6.4
8
*
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
30.0
6.4
8
*
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
F11.21
ICD-10 Finland
Addiction-indiced dependence caused by opiates currently independent but staying in controlling environment
+∞
6.3
6
*
F14.30
ICD-10 Finland
Withdrawal symptoms caused by cocaine uncomplicated
+∞
6.3
6
*
F14.00
ICD-10 Finland
Intoxication caused by cocaine uncomplicated
+∞
6.3
6
*
F19.9
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, unspecified mental and behavioural disorder
+∞
6.3
6
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
+∞
6.3
6
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.8
6.3
29
115
Z01.7
ICD-10 Finland
Laboratory examination
4.4
6.2
19
56
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
6.9
6.2
15
27
F20.9
ICD-10 Finland
Schizophrenia, unspecified
17.2
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
7
22.88
9.39
3.1
1.1
—
—
—
0
0
11
5
26.12
8.34
2.1
1.2
—
—
—
0
0
39
174
4.26
7.37
5.6
10.1
1.21
1.22
mmol/l
0.30
34
151
10
6
19.42
7.00
3.8
4.2
422.10
277.17
umol/l
—
10
6
31
130
3.73
6.16
1.9
1.5
96.24
99.62
pmol/l
0.17
19
60
50
290
4.51
6.05
14.7
8.5
4.37
3.92
e9/l
0.48
38
250
15
29
6.44
5.86
1.6
1.2
—
—
—
0
0
11
15
8.62
5.41
3.9
3.6
23.64
24.27
mmol/l
0.35
11
15
8
6
14.99
5.23
15.8
15.0
861.50
643.83
nmol/l
—
8
6
8
6
14.99
5.23
19.0
19.8
1308.75
958.67
nmol/l
—
8
6
13
25
6.26
5.11
3.5
4.8
5.76
6.03
kpa
0.56
13
25
12
22
6.47
4.89
2.1
2.5
5.75
4.55
kpa
0.61
12
22
52
336
4.14
4.81
4.3
3.7
14.21
14.72
pmol/l
0.91
47
317
25
110
3.11
4.35
3.0
2.3
—
—
—
0
0
14
42
4.00
4.34
12.1
10.0
105.14
104.33
mmol/l
0.24
14
42
10
21
5.45
3.74
5.0
4.5
25.65
25.17
mmol/l
—
10
21
19
77
3.10
3.73
3.2
3.6
143.00
45.59
ng/l
0.42
11
50
13
37
4.15
3.67
7.3
6.2
2.18
1.08
mmol/l
0.87
13
37
16
59
3.29
3.65
3.3
3.0
3.20
1.51
e6/l
—
5
28
22
99
2.88
3.59
2.5
2.1
—
—
—
0
0
24
114
2.79
3.54
4.4
2.8
0.02
0.32
e6/l
1.52
16
85
10
24
4.75
3.36
1.6
1.3
—
—
—
0
0
7
13
5.90
2.96
10.7
13.7
24.71
24.37
mmol/l
—
7
13
7
15
5.10
2.68
1.9
1.7
—
—
—
0
0
58
478
3.68
2.62
21.1
12.0
3.89
3.96
mmol/l
1.14
58
463
6
13
4.98
2.33
3.5
2.8
203.00
293.95
ug/l
—
6
13
24
139
2.17
2.17
4.5
2.8
—
—
—
0
0
7
20
3.80
2.12
9.9
11.7
1.26
1.86
%
—
7
20
7
20
3.80
2.12
9.9
11.7
0.39
0.73
%
—
7
20
10
39
2.85
2.05
3.9
2.3
—
—
—
0
0
5
11
4.83
1.98
1.4
1.1
—
—
—
0
0
54
445
2.49
1.93
31.7
13.6
14.18
13.79
%
0.30
54
438
5
13
4.08
1.75
1.0
1.5
4.88
3.64
mmol/l
—
5
13
18
101
2.10
1.72
2.3
1.7
1.38
0.78
mg/l
0.70
12
77
55
465
2.44
1.68
19.7
8.6
101.75
94.14
ml/min/173m2
1.62
45
376
6
20
3.20
1.62
2.8
1.7
—
—
—
0
0
5
15
3.52
1.55
1.4
1.5
678.60
622.80
mg/l
—
5
15
5
15
3.52
1.55
2.0
2.1
65.80
89.73
%
—
5
15
5
17
3.10
1.38
1.4
1.2
—
488.86
miu/ml
—
0
7
10
48
2.29
1.36
2.0
1.5
—
—
—
0
0
12
63
2.12
1.33
2.2
2.2
31.58
30.53
s
0.28
12
63
10
49
2.24
1.30
2.1
1.5
—
—
—
0
0
12
65
2.05
1.23
2.8
1.6
—
—
—
0
0
24
165
1.73
1.22
13.5
9.5
1.08
1.16
inr
—
5
51
18
115
1.79
1.16
1.0
1.3
0.72
1.13
u/ml
—
5
30
8
41
2.09
1.13
3.7
2.1
—
—
—
0
0
47
395
1.75
1.08
5.1
2.9
47.81
39.63
u/l
0.46
47
383
10
54
2.01
1.03
3.5
2.1
—
—
—
0
0
15
95
1.76
0.98
2.9
2.4
—
—
—
0
0
0
27
0.00
0.79
0.0
1.5
—
—
—
0
0
7
39
1.89
0.75
10.7
22.4
0.10
1.67
mmol/l
—
7
33
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
0
22
0.00
0.60
0.0
1.6
—
—
—
0
0
18
135
1.47
0.60
4.3
2.8
11.59
25.57
ng/l
—
9
79
0
16
0.00
0.41
0.0
2.7
—
24.69
—
0
16
16
126
1.36
0.40
1.8
1.6
—
—
—
0
0
51
477
1.36
0.36
3.6
3.2
1.64
1.25
mmol/l
1.27
45
453
24
205
1.28
0.35
3.3
2.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
16
180
0.85
0.16
4.6
2.8
—
—
—
0
0
42
428
0.94
0.02
4.3
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
6.82
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
121.33
—
0
6
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
2.8
—
106.33
—
0
6
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
7
70
1.00
-0.00
1.9
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
13.06
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
12.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
46.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_COCAINE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_COCAINE | 5.817 [3.31, 10.22] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 271 males with F5_COCAINE died.
Mortality risk
Mortality risk for people of age
years, who have F5_COCAINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.888% |
| 5 | No data | 6.195% |
| 10 | No data | 14.98% |
| 15 | No data | 26.713% |
| 20 | No data | 42.334% |
Relationships between endpoints
↥Index endpoint: F5_COCAINE – Mental and behavioural disorders due to cocaine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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