cocaine dependence: A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
- Control exclude
- F5_SUBSNOALCO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F10-F19
- Name in latin
- Perturbationes mentis et modi se gerendi ex usu cocaini
Similar endpoints
↥List of similar endpoints to
Mental and behavioural disorders due to cocaine
based on the number of shared cases.
Similar with more cases:
- Substance use, excluding alcohol
- Substance abuse, excluding more controls
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 540 | 155 | 381 |
| Only index persons | 457 | 137 | 320 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 30.18 | 29.30 | 30.44 |
| Only index persons | 29.08 | 27.60 | 29.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 19 | 40 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 31.79 | 27.05 | 34.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 50
- Matched controls
- 497
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B18.2
ICD-10 Finland
Chronic viral hepatitis C
+∞
16.6
15
*
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
+∞
13.1
12
*
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
+∞
11.9
11
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
22.7
11.3
16
10
P19
ICPC
Drug abuse
137.7
10.9
11
*
N05AH03
ATC
olanzapine; systemic
18.9
10.6
16
12
N03AG01
ATC
valproic acid; systemic, rectal
18.9
10.6
16
12
N05BA01
ATC
diazepam; systemic, rectal
11.2
10.5
21
30
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
20.7
10.3
15
10
T36
ICD-10 Finland
Poisoning by systemic antibiotics
17.4
10.3
16
13
N05AA02
ATC
levomepromazine; systemic
28.5
10.0
13
6
N05BA04
ATC
oxazepam; oral
7.8
9.9
28
70
F39
ICD-10 Finland
Unspecified mood [affective] disorder
122.2
9.8
10
*
N05AH04
ATC
quetiapine; oral
7.7
9.6
26
61
F60.9
ICD-10 Finland
Personality disorder, unspecified
45.9
9.5
11
*
N05CF01
ATC
zopiclone; oral
7.2
9.3
28
75
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
11.1
9.2
18
24
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
61.1
9.0
10
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
34.4
8.9
11
*
F14.1
ICD-10 Finland
Mental and behavioural disorders due to use of cocaine, harmful use
+∞
8.6
8
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
14.4
8.4
14
13
N07BB01
ATC
disulfiram; oral
27.5
8.4
11
5
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
40.7
8.4
10
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
19.2
8.2
12
8
N03AE01
ATC
clonazepam; systemic
15.4
8.1
13
11
N05CD07
ATC
temazepam; oral
10.8
7.8
15
19
N06AB06
ATC
sertraline; oral
8.3
7.5
17
29
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
+∞
7.5
7
*
F13.20
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent
+∞
7.5
7
*
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
+∞
7.5
7
*
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
+∞
7.5
7
*
3042A
ICD-9 Finland
Drug dependence, Cocaine dependence
+∞
7.5
7
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
7.5
7
*
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
+∞
7.5
7
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
20.3
7.1
10
6
N05AA01
ATC
chlorpromazine; systemic, rectal
46.5
7.0
8
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
46.5
7.0
8
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
46.5
7.0
8
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
26.8
6.9
9
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
26.8
6.9
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.6
6.7
16
29
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
79.6
6.6
7
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
31.0
6.4
8
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
9.3
6.4
13
18
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
+∞
6.4
6
*
F11.21
ICD-10 Finland
Addiction-indiced dependence caused by opiates currently independent but staying in controlling environment
+∞
6.4
6
*
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
+∞
6.4
6
*
F13.29
ICD-10 Finland
Addiction caused by sedative and hypnotic UNS
+∞
6.4
6
*
X57
ICD-10 Finland
Unspecified privation
+∞
6.4
6
*
N06AX16
ATC
venlafaxine; oral
6.1
6.3
18
42
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
5
26.46
8.36
2.1
1.2
—
—
—
0
0
14
27
6.49
7.38
1.6
1.3
—
—
—
0
0
10
6
19.64
7.02
3.3
1.2
—
—
—
0
0
10
14
8.40
6.92
3.4
3.8
23.6
24.4
mmol/l
—
10
14
12
24
6.02
6.04
3.0
4.9
5.8
6.0
kpa
0.48
12
24
35
165
3.76
5.86
5.3
10.3
1.2
1.2
mmol/l
0.48
30
145
8
5
18.16
5.58
15.7
12.4
861.5
601.0
nmol/l
—
8
5
8
5
18.16
5.58
19.0
18.2
1308.7
938.8
nmol/l
—
8
5
8
6
15.12
5.24
4.5
4.2
416.3
277.2
umol/l
—
8
6
46
272
4.14
5.23
14.7
8.5
4.1
3.9
e9/l
0.16
34
236
20
73
3.63
4.78
1.3
1.4
20.4
20.6
nmol/l
0.03
20
68
27
123
3.20
4.51
2.0
1.5
96.3
100.9
pmol/l
0.22
17
59
48
313
3.86
4.26
3.8
3.8
14.2
14.8
pmol/l
1.00
43
298
22
97
3.02
3.79
2.8
2.3
—
—
—
0
0
19
86
2.78
3.05
2.5
2.1
—
—
—
0
0
8
20
4.45
2.67
2.9
4.7
25.3
25.1
mmol/l
—
8
20
8
21
4.23
2.57
1.8
1.2
—
—
—
0
0
16
75
2.56
2.35
1.8
3.6
156.8
46.4
ng/l
—
10
49
10
37
3.05
2.23
3.9
2.3
—
—
—
0
0
54
453
3.26
2.12
19.1
12.2
3.9
4.0
mmol/l
0.91
54
438
5
10
5.34
2.11
1.4
1.1
—
—
—
0
0
20
109
2.26
2.11
3.6
2.7
0.0
0.3
e6/l
1.41
13
81
6
15
4.32
2.09
1.7
1.7
—
—
—
0
0
51
437
2.23
1.41
18.0
8.7
101.0
93.8
ml/min/173m2
1.33
41
351
9
43
2.29
1.37
3.7
2.0
—
—
—
0
0
5
20
2.63
1.17
8.4
11.7
0.8
1.9
%
—
5
20
20
134
1.75
1.11
3.7
2.6
—
—
—
0
0
7
33
2.27
1.10
4.1
2.0
—
—
—
0
0
9
47
2.08
1.08
1.7
1.5
—
—
—
0
0
9
48
2.03
1.06
1.8
1.5
—
—
—
0
0
17
110
1.77
1.05
1.0
1.3
0.7
1.2
u/ml
—
5
28
11
63
1.92
0.98
2.5
1.7
—
—
—
0
0
43
370
1.60
0.80
4.8
2.9
49.6
39.8
u/l
0.53
43
358
10
61
1.77
0.74
2.2
2.2
31.5
30.6
s
—
10
61
0
21
0.00
0.61
0.0
1.2
—
—
—
0
0
17
133
1.39
0.45
4.4
2.8
11.6
25.1
ng/l
—
9
77
12
89
1.44
0.42
3.3
2.4
—
—
—
0
0
0
15
0.00
0.42
0.0
2.9
—
24.7
—
0
15
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.42
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
14
111
1.34
0.34
1.7
1.7
—
—
—
0
0
48
453
1.32
0.28
3.7
3.2
1.7
1.3
mmol/l
1.40
42
429
14
168
0.78
0.27
4.9
2.7
—
—
—
0
0
5
39
1.31
0.23
9.6
22.4
-1.0
1.7
mmol/l
—
5
33
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
21
191
1.15
0.14
4.8
4.6
—
—
—
0
0
5
62
0.79
0.08
2.2
1.5
—
—
—
0
0
39
395
0.96
0.00
4.1
3.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
2.8
—
106.3
—
0
6
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
121.3
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
13.1
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
851.0
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
12.6
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint F5_COCAINE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_COCAINE | 5.817 [3.31, 10.22] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 271 males with F5_COCAINE died.
Mortality risk
Mortality risk for people of age
years, who have F5_COCAINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.888% |
| 5 | No data | 6.195% |
| 10 | No data | 14.98% |
| 15 | No data | 26.713% |
| 20 | No data | 42.334% |
Relationships between endpoints
↥Index endpoint: F5_COCAINE – Mental and behavioural disorders due to cocaine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data