Risteys · G6_DISMULTIP

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G52.7 Hospital discharge: ICD-9 — 3526 Cause of death: ICD-10 — G52.7 Cause of death: ICD-9 — 3526 2 out of 7 registries used, show all original rules.	32
4. Check minimum number of events None	32
5. Include endpoints None	32
6. Filter based on genotype QC (FinnGen only)	32

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	255	133	119
Only index persons	207	113	94
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	52.61	49.79	55.66
Only index persons	50.65	48.32	53.45

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	16	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	51.04	47.98	54.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

17.30

4.81

1.3

1.2

469.9

592.2

mg/l

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

11.49

3.08

1.4

5.4

3.2

e6/l

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

11.49

3.08

1.4

4.0

e6/l

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

4.95

2.52

3.0

1.6

11.7

12.6

nmol/l

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.48

2.36

1.7

2.0

27.5

28.3

—

(3019060) Gas panel - Arterial blood

3.44

1.67

7.8

29.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.51

1.40

4.3

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.09

1.34

1.0

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.29

1.17

2.5

6.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

141

2.12

1.15

5.5

8.9

6.6

mmol/l

0.03

133

(3018010) Neutrophils/100 leukocytes in Blood

114

2.05

1.11

5.6

5.8

61.7

56.2

0.99

105

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

177

0.48

1.09

1.9

3.0

—

(40758558) Short blood count panel - Blood

2.14

1.07

8.3

6.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

116

1.99

1.04

6.3

11.2

1.2

mmol/l

0.48

101

(3013650) Neutrophils [#/volume] in Blood by Automated count

145

2.01

1.02

11.2

10.1

4.7

3.9

e9/l

1.19

122

(3033658) Prothrombin time (PT) actual/Normal

2.14

1.02

3.8

4.4

89.1

94.7

—

(3015736) pH of Urine

1.99

1.00

2.9

3.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

118

1.94

0.97

7.2

5.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

1.92

0.90

2.8

2.3

120.8

370.3

u/l

0.60

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.07

0.87

2.3

2.6

0.2

0.9

e6/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.18

0.76

1.2

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.80

0.76

2.7

3.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

116

1.76

0.74

5.9

6.2

26.2

28.2

0.32

107

(3010813) Leukocytes [#/volume] in Blood

293

0.50

0.72

34.7

22.1

7.1

6.4

e9/l

1.26

288

(3007461) Platelets [#/volume] in Blood

293

0.50

0.72

34.8

22.1

264.7

244.0

e9/l

0.75

288

(3000494) Fungus identified in Specimen by Culture

2.00

0.72

5.8

2.0

—

(40761511) CBC panel - Blood by Automated count

269

0.57

0.67

25.1

14.6

—

(3044889) 12 lead EKG panel

179

1.73

0.64

4.5

3.6

—

(3009508) Creatinine [Moles/volume] in Urine

1.74

0.64

2.5

2.9

7.5

7.3

mmol/l

0.05

(3017181) Myelocytes/100 leukocytes in Blood

0.00

0.63

0.0

4.9

—

0.6

—

(3019069) Monocytes/100 leukocytes in Blood

113

1.62

0.57

6.1

6.4

7.0

8.9

2.38

103

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.66

0.56

1.2

1.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.57

0.50

3.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

165

1.57

0.50

4.7

4.4

—

78.2

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

265

0.62

0.48

26.2

19.3

139.7

139.8

mmol/l

0.08

258

(3000850) Epithelial cells [#/volume] in Urine

1.60

0.48

2.5

3.0

0.9

2.7

e6/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

264

0.64

0.48

26.2

19.4

4.0

mmol/l

0.30

257

(3002256) Pathology report gross observation

1.72

0.45

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.61

0.43

2.4

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

6.9

—

24.0

—

(3000991) Gas panel - Venous blood

0.00

0.42

0.0

13.6

—

(3025159) Blasts/100 leukocytes in Blood

0.00

0.42

0.0

5.4

—

0.0

—

(3021440) Promyelocytes/100 leukocytes in Blood

0.00

0.41

0.0

5.2

—

0.1

—

(42870588) Differential panel, method unspecified - Blood

1.54

0.41

7.8

6.0

—

(3006504) Eosinophils/100 leukocytes in Blood

111

1.46

0.39

6.5

5.9

2.8

2.7

0.06

100

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.53

0.38

1.0

1.4

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.45

0.37

2.8

5.4

0.8

mmol/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.46

0.33

1.6

1.8

1.3

mmol/l

—

(36304419) Bacteria [Presence] in Urine

1.37

0.30

3.0

2.6

—

(3013512) EKG study

1.28

0.28

4.4

4.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

208

1.37

0.25

10.9

8.2

70.1

80.4

u/l

1.21

198

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.41

0.25

1.2

1.5

—

(3042936) Bacteria identified in Isolate by Culture

1.41

0.25

9.4

2.9

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

282

0.73

0.24

15.7

11.0

28.3

24.6

u/l

0.46

273

(3022096) Basophils/100 leukocytes in Blood

109

1.32

0.23

6.9

6.1

0.7

0.6

0.19

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

109

1.32

0.23

5.5

3.7

9.7

26.0

ng/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

100

1.32

0.22

2.3

1.9

105.1

95.8

pmol/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.1

—

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.22

0.0

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.1

—

0.7

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

6.4

—

616.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

1.32

0.20

1.9

2.7

—

(40768804) Tissue Pathology biopsy report

111

1.29

0.20

2.1

1.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.28

0.19

3.4

3.0

262.5

14872.6

umol/l

—

(3030467) Casts [#/volume] in Urine by Automated count

1.26

0.19

3.3

2.8

0.0

0.4

e6/l

—

(3002582) Erythrocytes [#/volume] in Urine

1.26

0.18

2.9

3.3

24.1

884.8

e6/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.15

0.17

2.8

3.4

49.4

52.8

u/l

—

(1761868) Lipid panel - Serum or Plasma

104

0.81

0.16

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

176

1.20

0.11

7.0

4.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

188

0.90

0.03

5.6

3.3

48.7

49.9

u/l

0.04

177

(3003338) MCHC [Mass/volume]

223

0.96

0.00

38.2

19.3

333.7

331.7

g/l

0.58

223

(3023368) Bacteria identified in Blood by Culture

0.98

0.00

4.6

5.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

17.4

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.2

—

239.6

—

(3010421) pH of Blood

0.00

0.0

5.5

—

7.4

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.5

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

8.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.94

0.00

2.2

2.6

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.9

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

3.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

5.4

—

9.1

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

3.9

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

5.4

—

5.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.91

0.00

2.3

3.4

—

(3026008) Bacteria identified in Urine by Culture

1.02

0.00

3.3

2.8

—

(1616796) Gas panel - Central venous blood

0.00

0.0

6.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.00

0.00

1.5

27.8

26.0

nmol/l

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

587.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.2

—

13.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DISMULTIP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_DISMULTIP.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_DISMULTIP – Disorders of multiple cranial nerves

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_DISMULTIP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G527
HD_ICD_9	3526
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G527
COD_ICD_9	3526
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Disorders of multiple cranial nerves

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints