Noninfective disorders of pinna

H8_PINNADIS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H61.1
  • Hospital discharge: ICD-9 3803
  • Cause of death: ICD-10 H61.1
  • Cause of death: ICD-9 3803

2 out of 7 registries used, show all original rules.

80

4. Check minimum number of events

None

80

5. Include endpoints

None

80

6. Filter based on genotype QC (FinnGen only)

80

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H61
Name in latin
Morbositates non infectiosae auriculae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 684 319 359
Only index persons 610 287 323
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 32.55 34.65 30.36
Only index persons 32.98 37.05 29.37

-FinnGen-

Key figures

All Female Male
Number of individuals 80 45 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 50.23 46.07 55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
70
Matched controls
698
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.1
ICD-10 Finland
Noninfective disorders of pinna
+∞
80.5
61
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
14.2
7.4
12
10
3803B
ICD-9 Finland
Disorders of external ear, Non-infectious disorders of pinna[DEFORMATIO AURICULARIS AQCUISITA]
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
66
3.96
6.12
1.7
1.4
—
—
—
0
0
19
71
3.20
4.19
1.2
1.4
173.3
461.2
titre
—
6
17
6
12
5.31
2.45
1.2
1.0
—
—
—
0
0
25
142
2.11
2.27
2.5
1.3
2.0
2.3
g/l
0.74
19
82
26
155
2.00
2.06
1.3
1.2
8.4
0.9
u/ml
—
8
44
5
12
4.37
1.85
1.0
1.3
—
—
—
0
0
6
19
3.33
1.69
1.2
1.2
5.6
5.9
u/l
—
6
14
7
25
2.97
1.69
1.0
1.2
—
—
—
0
0
42
314
1.71
1.54
5.2
5.5
1.8
1.8
e9/l
0.09
37
284
28
189
1.74
1.46
5.4
5.1
—
—
—
0
0
40
299
1.68
1.44
5.3
5.6
0.5
0.6
e9/l
0.11
33
264
40
299
1.68
1.44
5.3
5.7
0.0
0.0
e9/l
0.22
33
267
41
310
1.66
1.40
5.2
5.9
0.2
0.2
e9/l
0.13
35
280
45
349
1.66
1.39
6.7
10.3
4.5
3.9
e9/l
0.69
38
316
59
496
1.72
1.30
3.8
4.0
14.5
14.9
pmol/l
0.58
50
456
6
26
2.41
1.21
3.3
1.1
—
—
—
0
0
38
295
1.55
1.09
9.3
8.4
0.0
0.0
e9/l
0.50
27
244
6
28
2.23
0.94
4.7
6.4
23.8
24.0
mmol/l
—
6
28
54
464
1.50
0.90
3.9
4.0
15.6
11.1
mm/h
0.83
49
439
6
30
2.08
0.89
1.3
1.2
—
—
—
0
0
66
595
1.62
0.85
15.6
13.4
40.6
40.5
%
0.06
50
475
0
25
0.00
0.80
0.0
1.3
—
—
—
0
0
29
226
1.44
0.77
12.5
6.7
1.2
1.2
inr
—
9
77
21
154
1.49
0.75
5.2
3.8
—
—
—
0
0
5
26
1.98
0.72
3.0
1.8
24.8
41.1
nmol/l
—
5
26
5
29
1.77
0.65
6.2
10.9
93.3
94.3
%
—
5
29
13
182
0.66
0.63
2.2
2.9
—
—
—
0
0
11
72
1.61
0.63
1.2
1.2
—
—
—
0
0
8
52
1.60
0.62
1.4
2.0
—
—
—
0
0
0
20
0.00
0.61
0.0
2.4
—
3.4
—
0
12
0
23
0.00
0.59
0.0
4.7
—
34.9
—
0
14
71
665
1.60
0.58
15.2
12.7
28.3
20.2
mg/l
0.80
55
521
48
423
1.34
0.57
3.8
3.5
—
—
—
0
0
12
83
1.52
0.55
1.8
1.9
—
—
—
0
0
6
39
1.58
0.54
1.0
1.6
—
—
—
0
0
29
239
1.33
0.53
2.4
2.1
—
—
—
0
0
14
187
0.70
0.53
2.7
2.7
—
—
—
0
0
10
67
1.56
0.52
1.6
1.4
—
—
—
0
0
19
239
0.73
0.51
3.6
3.7
24.5
32.6
ng/l
0.30
13
158
30
250
1.32
0.51
3.2
3.1
16.6
53.8
e6/l
1.05
20
179
19
148
1.37
0.49
2.3
3.3
—
—
—
0
0
8
57
1.45
0.44
2.5
2.8
—
—
—
0
0
0
17
0.00
0.41
0.0
3.5
—
55.8
—
0
17
28
240
1.26
0.37
2.5
1.8
100.9
98.3
pmol/l
0.11
13
124
48
439
1.23
0.35
4.2
4.0
—
62.8
—
0
10
6
45
1.36
0.34
4.3
7.5
—
—
—
0
0
6
46
1.33
0.34
1.0
1.3
—
—
—
0
0
16
130
1.29
0.32
1.9
1.7
1.3
1.3
mg/l
—
10
108
58
613
0.80
0.31
4.4
3.6
1.3
1.3
mmol/l
0.15
52
568
20
169
1.24
0.29
6.8
6.3
—
—
—
0
0
9
71
1.30
0.27
1.0
1.5
—
—
—
0
0
9
76
1.21
0.26
1.3
1.2
—
—
—
0
0
14
115
1.26
0.25
1.7
1.7
926.3
1233.8
nmol/l
—
9
91
6
84
0.69
0.25
1.2
1.3
—
—
—
0
0
15
178
0.81
0.25
8.0
3.4
5.1
10.6
mg/mmol
—
9
100
5
37
1.37
0.24
6.0
3.8
—
—
—
0
0
10
79
1.30
0.23
2.0
1.9
—
—
—
0
0
24
213
1.18
0.22
3.3
2.6
17.5
30.8
e6/l
0.49
18
165
0
11
0.00
0.21
0.0
3.5
—
3.2
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
21
237
0.85
0.21
3.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
5.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
1.6
—
0
12
0
12
0.00
0.21
0.0
3.1
—
7.2
—
0
12
18
156
1.20
0.21
2.1
2.0
—
—
—
0
0
22
195
1.18
0.20
3.0
2.3
—
—
—
0
0
7
57
1.25
0.19
1.1
1.6
—
—
—
0
0
16
139
1.19
0.18
3.8
4.6
—
—
—
0
0
14
120
1.20
0.18
1.8
1.8
—
—
—
0
0
64
618
1.18
0.17
4.8
4.2
6.0
5.8
mmol/l
0.37
59
576
17
189
0.87
0.13
1.4
1.5
—
—
—
0
0
17
153
1.14
0.12
3.6
3.6
—
—
—
0
0
70
685
1.18
0.11
13.8
11.8
—
—
—
0
0
21
193
1.12
0.11
2.6
2.2
—
—
—
0
0
21
194
1.11
0.10
3.1
2.4
0.6
0.3
e6/l
0.26
15
147
6
57
1.06
0.09
5.3
6.6
0.2
0.4
mmol/l
—
6
40
6
58
1.04
0.08
1.5
1.3
—
—
—
0
0
7
68
1.03
0.08
2.4
1.7
—
—
—
0
0
46
450
1.05
0.03
4.7
4.2
—
—
—
0
0
33
321
1.05
0.03
2.4
3.3
0.0
0.0
estimate
—
7
74
15
142
1.07
0.02
1.4
1.6
455.1
437.7
pmol/l
—
10
124
33
323
1.04
0.01
2.9
4.4
0.0
0.0
estimate
—
7
74
14
134
1.05
0.00
2.4
3.5
—
1.0
—
0
19
63
636
0.96
0.00
4.8
4.1
4.5
4.7
mmol/l
0.87
56
592
33
327
1.02
0.00
2.4
3.3
0.0
0.0
estimate
—
7
69
17
175
0.96
0.00
3.1
3.6
0.0
0.0
estimate
—
6
72
65
646
1.03
0.00
4.9
4.5
2.6
2.8
mmol/l
0.70
60
602
63
634
0.97
0.00
4.7
4.0
1.4
1.5
mmol/l
0.64
57
589
0
8
0.00
0.00
0.0
3.3
—
106.6
—
0
8
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
239.3
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
10.8
—
0
7
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
75.5
—
0
6
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
4.0
—
0
8
0
5
0.00
0.00
0.0
2.2
—
6.6
—
0
5
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
5
50
1.00
0.00
2.8
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
67.0
—
0
9
9
89
1.01
0.00
1.7
1.8
—
—
—
0
0
6
59
1.02
0.00
1.2
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_PINNADIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_PINNADIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_PINNADIS – Noninfective disorders of pinna

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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