Rheumatic heart disease, other

I9_RHEUOTHHRT

rheumatic heart disease: Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I09 Hospital discharge: ICD-9 — 3920A\|393\|39[7-8] Hospital discharge: ICD-8 — 3920\|393\|3979\|398 Cause of death: ICD-10 — I09 Cause of death: ICD-9 — 3920A\|393\|39[7-8] Cause of death: ICD-8 — 3920\|393\|3979\|398 2 out of 7 registries used, show all original rules.	69
4. Check minimum number of events None	69
5. Include endpoints None	69
6. Filter based on genotype QC (FinnGen only)	69

Control definitions (FinnGen only)

Control exclude: I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: I05-I09
Name in latin: Alii morbi cordis rheumatici

NAME	I9_RHEUOTHHRT
CONTROL_EXCLUDE	I9_RHEUFEV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I09
HD_ICD_9	3920A\|393\|39[7-8]
HD_ICD_8	3920\|393\|3979\|398
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I09
COD_ICD_9	3920A\|393\|39[7-8]
COD_ICD_8	3920\|393\|3979\|398
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rheumatic heart disease, other based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1169	566	564
Only index persons	564	283	281
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.10	56.37	51.36
Only index persons	39.07	41.36	36.76

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	69	40	29
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	36.59	34.92	38.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
59: Matched controls
590

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I09.9

ICD-10 Finland

Rheumatic heart disease, unspecified

+∞

7.4

I09.0

ICD-10 Finland

Rheumatic myocarditis

+∞

6.4

39899

ICD-8 Finland

Other heart disease, specified as rheumatic

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032080) INR in Blood by Coagulation assay

216

2.39

3.13

7.2

6.3

1.3

inr

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.86

2.85

2.7

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.36

2.45

1.0

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

3.08

2.31

5.0

4.5

68.6

68.9

e9/l

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

5.89

2.25

2.0

3.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.29

2.10

1.8

2.5

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

4.27

2.08

1.0

2.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.80

1.97

1.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.80

1.97

1.0

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.80

1.97

1.4

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

122

2.04

1.81

1.9

2.9

384.8

7152.3

umol/l

0.79

(3017181) Myelocytes/100 leukocytes in Blood

2.62

1.77

8.9

5.1

1.3

0.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.16

1.50

1.3

1.6

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.89

1.47

1.8

3.8

1.3

1.0

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.43

1.47

1.6

2.2

267.7

247.4

ng/l

—

(3044640) Blood type and Crossmatch panel - Blood

165

1.81

1.45

3.0

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

123

1.88

1.45

2.0

2.1

—

(3023368) Bacteria identified in Blood by Culture

151

1.78

1.35

4.9

3.7

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

2.91

1.31

1.2

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.75

1.24

1.0

1.4

—

(40761535) Cells panel - Urine sediment

2.19

1.20

2.8

3.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.99

1.18

1.3

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.82

1.16

1.4

1.9

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.37

1.05

2.0

3.7

2.8

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.00

1.03

1.6

1.4

—

(3012516) Albumin [Mass/volume] in Urine

123

1.63

0.89

3.3

2.7

42.1

29.2

mg/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

242

1.51

0.87

5.7

6.1

1.2

mmol/l

0.04

201

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.02

0.86

1.7

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.85

0.85

8.3

11.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

116

1.62

0.84

4.2

4.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

371

1.51

0.84

5.1

4.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.96

0.84

1.2

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

225

1.50

0.83

4.1

4.2

33.4

35.3

g/l

1.17

215

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

244

1.49

0.83

6.4

3.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.79

0.72

1.7

—

(3019060) Gas panel - Arterial blood

1.74

0.71

1.9

3.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

131

1.51

0.68

3.6

3.4

4.4

5.2

mg/mmol

0.12

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

178

1.44

0.65

3.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.58

0.62

1.7

2.6

1.0

0.8

e6/l

—

(40768797) Stomach Pathology biopsy report

1.63

0.59

1.4

1.3

—

(3003694) ABO and Rh group [Type] in Blood

135

0.62

0.59

1.2

1.4

—

(3042936) Bacteria identified in Isolate by Culture

1.57

0.57

4.6

1.5

—

(4035726)

1.63

0.56

1.5

1.2

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.59

0.54

2.5

5.2

23.2

23.6

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

184

1.38

0.53

2.9

3.5

20.3

65.5

e6/l

1.30

130

(3026008) Bacteria identified in Urine by Culture

175

1.38

0.52

2.7

3.5

—

(3002032) Base excess in Venous blood by calculation

1.54

0.49

3.9

2.9

2.0

2.2

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

104

1.43

0.48

9.6

5.7

—

(3012544) pH of Venous blood

1.48

0.47

3.9

2.9

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.44

0.46

3.9

2.8

5.9

5.6

kpa

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.44

0.45

1.8

1.4

2.6

2.2

g/l

—

(3015736) pH of Urine

217

1.32

0.45

4.2

3.8

—

(3030467) Casts [#/volume] in Urine by Automated count

142

1.36

0.44

2.5

3.0

0.4

0.3

e6/l

0.07

103

(36304419) Bacteria [Presence] in Urine

142

1.36

0.44

2.5

2.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.61

0.43

1.2

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.0

—

(42870588) Differential panel, method unspecified - Blood

182

1.31

0.40

9.5

5.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

379

1.28

0.38

4.2

4.5

16.4

13.1

mm/h

0.52

339

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.43

0.37

1.9

1.5

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.47

0.37

3.8

2.3

4.4

3.9

kpa

—

(3019150) Specific gravity of Urine by Refractometry

128

1.33

0.36

4.9

4.4

—

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

526

1.34

0.36

21.5

14.6

33.4

23.4

mg/l

0.73

416

(36660697) Celiac disease serology panel - Serum

1.40

0.35

1.5

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

204

1.27

0.35

1.7

1.9

79.8

93.8

pmol/l

0.99

(3000991) Gas panel - Venous blood

1.36

0.35

5.8

6.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.36

0.32

1.0

1.3

—

(3007461) Platelets [#/volume] in Blood

584

1.38

0.32

29.1

21.5

249.8

246.6

e9/l

0.09

570

(3010813) Leukocytes [#/volume] in Blood

584

1.38

0.32

29.2

21.5

7.2

6.7

e9/l

0.91

562

(3026361) Erythrocytes [#/volume] in Blood

584

1.38

0.32

29.1

21.6

4.5

e12/l

0.01

564

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.28

0.30

4.6

6.3

124.4

121.2

g/l

—

(40761511) CBC panel - Blood by Automated count

553

1.31

0.27

21.8

13.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.65

0.27

2.0

1.4

—

(3044889) 12 lead EKG panel

348

1.20

0.27

4.6

3.8

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.34

0.24

5.6

7.0

0.6

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.34

0.24

2.0

7.0

0.9

1.2

—

(4010399)

1.27

0.23

1.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.27

0.23

1.2

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.21

0.22

1.8

2.0

—

(4094501)

0.00

0.21

0.0

1.1

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

4.7

—

4.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

4.7

—

8.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

156

1.21

0.21

2.7

3.1

11.5

27.0

e6/l

0.97

118

(3019225) pH of Specimen

1.30

0.21

3.8

4.6

—

(3000492) Spirometry study

1.27

0.21

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(40758558) Short blood count panel - Blood

128

1.22

0.20

1.9

8.0

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.20

0.0

4.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

494

0.85

0.19

15.4

13.0

80.2

79.7

ml/min/173m2

0.05

389

(3000850) Epithelial cells [#/volume] in Urine

110

1.22

0.19

2.9

2.7

3.4

5.6

e6/l

1.28

100

(3013512) EKG study

149

1.19

0.18

5.8

4.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

511

1.16

0.14

4.4

4.1

4.5

4.6

mmol/l

0.24

466

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

525

1.13

0.10

5.2

4.5

2.5

2.7

mmol/l

0.64

476

(3009542) Hematocrit [Volume Fraction] of Blood

475

1.11

0.09

19.0

16.2

39.4

40.1

0.18

347

(3000494) Fungus identified in Specimen by Culture

1.06

0.09

1.8

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.04

0.07

1.9

2.7

0.9

0.8

mmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

100

0.89

0.07

2.1

1.6

—

(3002385) Erythrocyte distribution width [Ratio]

431

0.93

0.05

21.3

18.0

14.1

13.7

0.77

421

(3020564) Creatinine [Moles/volume] in Serum or Plasma

551

1.09

0.04

21.9

16.7

75.5

77.1

umol/l

0.18

551

(40768804) Tissue Pathology biopsy report

211

1.06

0.03

1.8

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.07

0.01

2.1

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

386

0.97

0.00

3.6

3.9

15.4

14.9

pmol/l

0.44

343

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

324

1.04

0.00

2.7

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

153

0.97

0.00

3.7

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

483

0.98

0.00

3.9

3.7

1.5

1.2

mmol/l

0.82

438

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

213

0.98

0.00

5.4

4.2

—

(1761868) Lipid panel - Serum or Plasma

174

0.97

0.00

2.3

2.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

508

1.02

0.00

4.5

4.0

1.3

1.5

mmol/l

2.68

460

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

466

1.03

0.00

4.3

4.8

1.7

1.9

mu/l

0.55

414

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

2.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

3.0

—

88.2

—

(4306422)

0.00

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

1.2

—

60.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.7

—

0.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

7.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.4

—

29.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

1.6

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

280.8

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3002256) Pathology report gross observation

0.96

0.00

1.0

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

500

1.00

0.00

4.2

4.5

5.9

5.8

mmol/l

0.08

451

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

45.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.4

—

(3024928) Oxygen saturation in Venous blood

0.00

-0.00

0.0

2.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

-0.00

0.0

5.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

-0.00

0.0

2.8

—

1.9

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

93.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUOTHHRT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUOTHHRT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: I9_RHEUOTHHRT – Rheumatic heart disease, other

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rheumatic heart disease, other

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints