rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1282 |
6. Filter based on genotype QC (FinnGen only) |
1228 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever incl heart disease
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20505 | 10490 | 9486 |
| Only index persons | 9214 | 4842 | 4372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.30 | 0.27 |
| Only index persons | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.81 | 65.18 | 57.95 |
| Only index persons | 51.22 | 55.20 | 46.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1228 | 560 | 668 |
| Unadjusted period prevalence (%) | 0.26 | 0.20 | 0.31 |
| Median age at first event (years) | 51.57 | 47.17 | 55.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1281
- Matched controls
- 12810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
20.7
288.4
231
135
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
2307.1
220.3
207
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.8
140.0
302
643
B01AA03
ATC
warfarin; systemic
4.1
134.7
628
2438
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
50.1
122.2
71
15
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.2
107.7
260
603
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
15.6
100.7
89
61
C01AA05
ATC
digoxin; systemic
4.0
100.4
367
1168
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
7.5
98.1
150
223
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
10.2
97.0
113
120
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
5.7
90.2
186
373
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
87.2
428
1636
5253
FHL
Cardiac lung machine
12.7
86.5
86
72
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
6.3
83.5
152
270
I05.0
ICD-10 Finland
Mitral stenosis
+∞
80.0
76
*
5273
FHL
Repair with flap prosthesis or graft
145.9
77.9
82
6
K83
ICPC
Heart valve disease NOS
15.8
75.5
66
44
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
21.3
75.3
57
28
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
74.7
71
*
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
72.6
69
*
I01.0
ICD-10 Finland
Acute rheumatic pericarditis
+∞
71.5
68
*
XF640, ,
NOMESCO Finland
7.1
71.0
111
168
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.8
69.6
170
392
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.8
68.0
550
2719
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
6.4
67.6
117
197
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
63.0
60
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.8
61.7
422
1895
62
HP
Catheterization and pressure measurement of the right side of the heart
22.2
58.0
43
20
I50.0
ICD-10 Finland
Congestive heart failure
3.3
57.8
260
918
C03CA01
ATC
furosemide; systemic
2.5
56.4
689
4058
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
55.6
53
*
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
55.6
53
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
6.7
55.2
90
142
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
53.5
51
*
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
12.7
49.8
49
40
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
49.3
47
*
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
48.2
46
*
C07AA07
ATC
sotalol; systemic
4.2
48.1
137
354
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
47.2
45
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
12.7
43.7
43
35
C03DA01
ATC
spironolactone; oral
2.8
43.1
269
1127
81
HP
Angiography of the heart and coronary arteries
3.2
42.1
187
648
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
41.9
40
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.4
41.4
108
260
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
40.8
39
*
39097
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Suspecta
+∞
40.8
39
*
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
39.8
38
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
8.0
39.3
54
70
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
52.9
38.8
46
9
I50.1
ICD-10 Finland
Left ventricular failure
3.2
36.3
154
518
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
6.4
35.9
61
100
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
35.7
390
2092
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
33.5
32
*
207
Kela drug reimbursment
Chronic arrhythmias
2.3
33.2
310
1551
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
92.6
32.9
36
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
6.4
32.8
55
89
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
32.4
31
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
12.7
31.6
31
25
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
59.9
30.2
35
6
61
HP
Catheterization and pressure measurement of the left side of the heart
4.8
29.9
69
150
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
28.2
27
*
21
HP
Aortic Valve Replacement (AVR)
43.6
27.8
34
8
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
27.7
288
1494
AB2
HP
AVR bio, stent
8.9
27.3
34
39
TFP20
NOMESCO Finland
Cardiodefibrillation
2.8
27.2
146
558
AN1
HP
Coronary angiography
2.4
26.8
220
1033
C07AB07
ATC
bisoprolol; oral
1.9
26.8
729
5267
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
5.6
26.6
51
94
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.0
26.3
128
464
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.9
26.2
136
511
I00
ICD-10 Finland
Rheumatic fever without mention of heart involvement
+∞
26.1
25
*
39099
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Unspecified
+∞
26.1
25
*
C07AB02
ATC
metoprolol; systemic
2.0
25.7
381
2248
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
25.2
336
1908
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
25.1
24
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
32.8
24.7
32
10
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
132.6
24.7
26
*
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
24.0
23
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
23.4
262
1391
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.6
23.3
148
615
B01AB05
ATC
enoxaparin; parenteral
1.9
23.0
420
2639
39199
ICD-8 Finland
Rheumatic fever with heart involvement, Other active rheumatic heart disease
+∞
23.0
22
*
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
23.0
22
*
39197
ICD-8 Finland
Rheumatic fever with heart involvement, Suspecta
+∞
23.0
22
*
5284
FHL
Mitral defect correction with flap prosthesis or graft
234.0
22.7
23
*
C01BD01
ATC
amiodarone; systemic
3.9
21.4
65
175
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
20.9
20
*
L04AA01
ATC
[U] ciclosporin
7.5
20.8
30
41
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
20.8
106
393
R50.9
ICD-10 Finland
Fever, unspecified
2.1
20.2
216
1122
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
6.7
20.1
32
49
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
3.9
19.6
58
153
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
19.3
52
128
K84
ICPC
Heart disease other
3.9
19.0
57
152
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.8
18.9
97
361
XFE00
NOMESCO Finland
Epicardial ultrasonography
4.0
18.9
54
139
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.7
18.8
44
97
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
18.4
588
4278
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
3.8
18.3
57
156
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
25.5
18.3
25
10
M04AA01
ATC
allopurinol; systemic
2.0
18.1
238
1329
L04AA06
ATC
mycophenolic acid; systemic
5.9
18.0
32
55
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
67.6
17.8
20
*
J01DA01
ATC
[U] cefalexin
1.7
17.5
781
6172
WX872
NOMESCO Finland
Intensive care
2.9
17.4
84
302
K78
ICPC
Atrial fibrillation/flutter
2.2
17.0
148
706
XF404
NOMESCO Finland
Ambulatory ECG
2.3
16.7
138
644
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
16.7
16
*
AC2
HP
MVR bio
91.3
16.6
18
*
127
Kela drug reimbursment
Transplant complication
6.0
16.6
29
49
C02EA02, ,
ATC
2.5
16.5
105
436
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
16.3
401
2700
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
2.7
16.1
92
362
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.1
15.8
154
769
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.9
15.7
76
274
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
15.7
15
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
15.4
62
201
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
29.0
15.2
20
7
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
15.2
359
2385
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
5.8
15.0
27
47
R06.0
ICD-10 Finland
Dyspnoea
1.7
14.9
367
2462
J01FF01
ATC
clindamycin; systemic
1.7
14.9
322
2086
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
14.8
372
2509
AP2
HP
Catheterization of the right side of the heart
18.6
14.7
22
12
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
3.8
14.7
45
122
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
14.6
14
*
I01.9
ICD-10 Finland
Acute rheumatic heart disease, unspecified
+∞
14.6
14
*
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
14.6
14
*
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
14.6
14
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.1
14.6
143
715
L01BA01
ATC
methotrexate; systemic
3.2
14.2
56
179
R04.0
ICD-10 Finland
Epistaxis
2.2
14.2
124
591
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.7
14.2
45
125
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
14.1
91
380
A12BA01
ATC
potassium chloride; oral
2.2
14.0
118
555
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
30.4
13.9
18
6
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
24.1
13.8
19
8
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
20.3
13.8
20
10
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.5
13.6
90
380
22
HP
Mitral valve Replacement (MVR)
76.0
13.6
15
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
13.6
248
1526
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
13.6
13
*
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
13.6
13
*
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
+∞
13.6
13
*
C08DA01
ATC
verapamil; systemic
2.5
13.5
88
370
H02AB06
ATC
prednisolone; systemic
1.6
13.4
576
4398
4289X
ICD-9 Finland
Heart failure, unspecified
4.6
13.1
31
69
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
12.8
420
3005
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
9.8
12.7
25
26
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
12.2
138
726
J01MA12
ATC
levofloxacin; systemic
1.7
12.2
251
1595
ZXD05
NOMESCO Finland
Urgent procedure
1.6
12.1
385
2727
C09AA02
ATC
enalapril; systemic
1.7
12.0
297
1978
J01CA04
ATC
amoxicillin; systemic
1.6
12.0
908
7772
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
4.4
12.0
30
70
C01DA14
ATC
isosorbide mononitrate; oral
1.6
11.8
317
2157
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
11.7
395
2833
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
11.5
11
*
I09.0
ICD-10 Finland
Rheumatic myocarditis
+∞
11.5
11
*
I50
ICD-10 Finland
Heart failure
2.5
11.4
73
304
N05BA01
ATC
diazepam; systemic, rectal
1.8
11.3
174
1013
25
HP
Valve and coronary artery bypass surgery
17.2
11.2
17
10
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
11.2
215
1338
J01FA10
ATC
azithromycin; systemic
1.5
11.0
560
4373
L04AD01
ATC
ciclosporin; systemic
4.4
11.0
27
62
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
11.0
740
8610
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
10.8
115
592
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.6
10.8
63
251
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.6
10.8
35
99
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
18.0
10.7
16
9
AD1
HP
TVP
28.3
10.7
14
5
L04AX01
ATC
azathioprine; systemic
2.8
10.7
54
200
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
13.0
10.7
18
14
J01FA06
ATC
roxithromycin; oral
1.5
10.6
464
3509
24
HP
Multi-valve repair or other valve surgery
110.9
10.4
11
*
I01.1
ICD-10 Finland
Acute rheumatic endocarditis
+∞
10.4
10
*
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
10.4
10
*
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
+∞
10.4
10
*
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
16.2
10.4
16
10
H02AB07
ATC
prednisone; oral
1.7
10.3
188
1151
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
10.3
389
2848
C01BA03
ATC
disopyramide; systemic
4.6
10.3
24
53
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
7.5
10.2
23
31
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.3
10.2
74
327
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
9.9
328
2329
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.9
9.9
46
163
A41.9
ICD-10 Finland
Sepsis, unspecified
2.5
9.8
62
257
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
4.0
9.8
27
68
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
55.4
9.7
11
*
Z3231
NOMESCO Finland
Registered nurse
1.5
9.6
329
2351
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
9.5
224
1467
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.2
9.5
36
113
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
9.5
286
1987
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
9.5
274
1886
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
100.8
9.4
10
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
9.4
175
1077
I01.8
ICD-10 Finland
Other acute rheumatic heart disease
+∞
9.4
9
*
I09.9
ICD-10 Finland
Rheumatic heart disease, unspecified
+∞
9.4
9
*
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
C01BA01
ATC
quinidine; oral
4.6
9.3
22
49
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
2.6
9.3
54
215
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.1
9.3
38
125
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.9
9.2
42
147
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
9.2
167
1019
J46
ICD-10 Finland
Status asthmaticus
3.0
9.1
40
137
Z2221
NOMESCO Finland
Medical doctor
1.5
9.0
311
2224
N05CF01
ATC
zopiclone; oral
1.5
9.0
424
3230
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.5
8.9
56
232
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.9
138
805
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
6.9
8.9
21
31
P01BA02
ATC
hydroxychloroquine; oral
2.1
8.8
88
443
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.0
8.8
93
478
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
8.7
257
1773
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
3.0
8.7
37
125
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.6
380
2852
TK800
NOMESCO Finland
Hemodialysis
3.2
8.5
33
105
K99
ICPC
Cardiovascular disease other
2.7
8.4
44
167
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
8.3
8
*
L54.0*I00
ICD-10 Finland
Erythema marginatum in acute rheumatic fever
+∞
8.3
8
*
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
3910A
ICD-9 Finland
Rheumatic fever with heart involvement, Acute rheumatic pericarditis
+∞
8.3
8
*
H02AB04
ATC
methylprednisolone; systemic
1.7
8.3
169
1063
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
4.1
8.3
22
54
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
8.2
88
454
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.7
8.2
42
157
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.2
422
3257
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
8.2
152
934
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
4.4
8.2
20
46
A46
ICD-10 Finland
Erysipelas
1.6
8.0
185
1202
5311
FHL
Bypass surgery in one vein
22.2
8.0
11
5
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
7.8
7.9
17
22
AC4
HP
MVP
9.5
7.8
15
16
ZX120
NOMESCO Finland
Intravenous
1.8
7.8
115
661
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
7.8
70
339
Z94.0
ICD-10 Finland
Kidney transplant status
6.4
7.7
19
30
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
7.7
82
423
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
7.7
72
354
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.7
494
3956
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
7.7
102
567
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
7.7
93
502
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.0
7.6
85
446
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
11.9
7.6
13
11
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
7.6
194
1293
R02
ICPC
Shortness of breath/dyspnoea
1.7
7.5
148
924
C02EA01, ,
ATC
3.2
7.4
29
93
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
7.4
158
1006
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
80.5
7.4
8
*
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.5
7.4
46
190
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
7.4
155
983
4140X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,MÄÄRITTELEMÄT]
3.8
7.4
22
59
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
7.4
199
1343
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.2
7.3
57
260
I49.5
ICD-10 Finland
Sick sinus syndrome
2.1
7.3
71
354
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
3.1
7.3
29
94
Q21.10
ICD-10 Finland
Persistent ostium secundum
10.9
7.3
13
12
I07.9
ICD-10 Finland
Tricuspid valve disease, unspecified
+∞
7.3
7
*
3900A
ICD-9 Finland
Rheumatic fever without mention of heart involvement[FEBRIS RHEUMATICA, MORBO CORDIS NON INDICATO]
+∞
7.3
7
*
39899
ICD-8 Finland
Other heart disease, specified as rheumatic
+∞
7.3
7
*
I02.9
ICD-10 Finland
Rheumatic chorea without heart involvement
+∞
7.3
7
*
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.3
7
*
K92.1
ICD-10 Finland
Melaena
1.9
7.3
87
467
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
4.2
7.3
19
46
M45
ICD-10 Finland
Ankylosing spondylitis
3.3
7.3
27
84
K80
ICPC
Cardiac arrhythmia NOS
1.9
7.2
89
483
C09AA01
ATC
captopril; oral
2.5
7.2
43
174
B03XA01
ATC
erythropoietin; parenteral
3.7
7.2
22
60
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
30.2
7.2
9
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
7.1
93
514
J01AA02
ATC
doxycycline; systemic
1.4
7.1
883
7844
PD5AD
NOMESCO Finland
CT of aorta
2.8
7.0
33
118
A02BC01
ATC
omeprazole; systemic
1.4
7.0
338
2564
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
3.2
7.0
27
86
A10AC01
ATC
insulin (human); parenteral
1.7
7.0
119
713
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.0
468
3760
FL1AC
NOMESCO Finland
Left cardioangiography
3.0
6.9
30
103
I47.2
ICD-10 Finland
Ventricular tachycardia
2.9
6.9
32
114
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
2.0
6.9
69
349
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
6.9
25
77
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.8
233
1652
Z94.1
ICD-10 Finland
Heart transplant status
11.0
6.8
12
11
AP3
HP
Catheterization of the right and left side of the heart
9.4
6.8
13
14
5312
FHL
Bypass surgery for two vessels
9.4
6.8
13
14
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
6.8
105
613
A11CC03
ATC
alfacalcidol; systemic
2.7
6.8
36
138
R03BA05
ATC
fluticasone; inhalant
1.5
6.7
192
1310
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
2.5
6.7
39
156
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
7.2
6.7
15
21
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.7
239
1711
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.1
6.7
65
325
A02BC03
ATC
lansoprazole; oral
1.4
6.7
343
2631
N18.8
ICD-10 Finland
Other chronic renal failure
2.5
6.6
41
169
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
4.0
6.6
18
45
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.9
6.6
76
403
N05CD07
ATC
temazepam; oral
1.5
6.6
189
1291
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.6
196
1350
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
3.0
6.6
28
95
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.9
6.5
15
22
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.8
6.5
31
112
M01CB01
ATC
sodium aurothiomalate; parenteral
3.7
6.5
20
55
L04AD02
ATC
tacrolimus; systemic
6.2
6.5
16
26
J01DA09
ATC
[U] cefadroxil
1.4
6.5
283
2107
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.0
6.4
28
96
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
3.2
6.4
24
75
A03FA02
ATC
cisapride; oral, rectal
1.7
6.4
106
630
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
70.2
6.4
7
*
C08CA05
ATC
nifedipine; systemic
1.8
6.4
99
577
UJF32
NOMESCO Finland
Coloscopy
1.4
6.4
292
2189
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.7
6.4
104
616
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
6.4
94
541
I97.0
ICD-10 Finland
Postcardiotomy syndrome
8.2
6.3
13
16
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
3.6
6.3
20
56
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.5
6.3
21
61
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.3
134
853
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
3.3
6.3
23
71
40299
ICD-8 Finland
Hypertensive heart disease
3.4
6.3
22
66
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
I02.0
ICD-10 Finland
Rheumatic chorea with heart involvement
+∞
6.3
6
*
42401
ICD-8 Finland
Chronic disease of endocardium, Mitralis, operata
+∞
6.3
6
*
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
2.9
6.2
28
98
WX892
NOMESCO Finland
Monitored bed care
1.8
6.2
92
530
C09AA04
ATC
perindopril; oral
1.9
6.2
70
370
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.4
6.2
40
169
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
6.3
6.2
15
24
TFN04, ,
NOMESCO Finland
5.4
6.2
17
32
A12AA04
ATC
calcium carbonate; oral
3.1
6.1
25
83
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.7
6.1
32
122
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
6.1
67
351
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.1
6.0
53
255
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.1
6.0
58
289
42799
ICD-8 Finland
Symptomatic heart disease, Other and unspecified disorders or heart rhythm
10.1
6.0
11
11
I38
ICD-10 Finland
Endocarditis, valve unspecified
10.1
6.0
11
11
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
6.0
39
165
L01AA01
ATC
cyclophosphamide; systemic
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
468
3191
1.74
18.70
4.9
3.2
2532.80
1966.30
ng/l
1.36
428
2741
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
92
360
2.68
16.29
4.9
2.5
0.32
0.36
u/ml
0.81
62
204
254
1543
1.81
14.62
4.0
2.4
11.51
12.31
umol/l
1.23
233
1423
620
4764
1.58
14.36
58.5
18.3
1.81
1.36
inr
10.35
165
1359
159
860
1.97
13.04
12.1
6.7
12.63
11.30
mmol/l
1.19
147
815
230
1407
1.77
12.80
4.2
2.4
2.33
2.28
g/l
0.68
214
1295
43
125
3.52
12.71
5.7
5.8
10.94
12.36
mg/l
1.29
38
113
218
1334
1.76
12.07
4.4
2.4
20.70
21.90
%
0.65
193
1136
101
482
2.19
11.56
2.4
1.9
1.35
1.53
g/l
0.86
70
418
186
1108
1.79
11.24
4.5
3.9
289.20
255.14
u/l
1.37
178
1041
164
944
1.85
11.08
3.4
3.1
294.89
249.21
ng/l
0.56
150
857
157
941
1.76
9.24
2.4
2.5
11.73
6.45
ug/l
1.03
138
797
194
1272
1.62
8.13
10.0
5.2
1.07
1.04
mmol/l
1.09
176
1156
179
1163
1.63
7.77
9.4
6.8
1.15
1.28
mmol/l
0.16
136
896
63
300
2.16
7.31
2.3
3.2
0.90
0.86
nmol/l
0.17
46
239
517
4207
1.38
7.18
8.8
5.6
24.77
26.40
%
2.48
482
3922
176
1168
1.59
6.98
9.4
6.7
5.20
5.08
kpa
0.77
163
1101
176
1169
1.59
6.96
9.3
6.7
11.76
11.76
kpa
0.00
163
1105
138
868
1.66
6.80
10.4
6.7
1.33
1.44
mmol/l
0.64
132
844
506
4139
1.37
6.67
8.5
5.5
60.17
58.36
%
2.70
472
3862
52
240
2.22
6.55
2.4
2.7
3.81
3.64
g/l
0.33
52
227
37
150
2.51
6.23
7.2
6.2
264.00
346.91
iu/ml
—
9
23
157
1045
1.57
6.14
9.8
7.0
95.23
95.25
%
0.01
151
1001
18
48
3.79
6.10
2.9
1.9
374.46
623.76
e6/l
0.69
13
41
117
734
1.65
5.83
1.9
1.6
—
—
—
0
0
91
533
1.76
5.82
12.7
9.3
24.47
24.48
mmol/l
0.01
82
509
173
1195
1.52
5.72
3.5
2.4
1.84
1.80
%
0.16
156
1054
16
41
3.94
5.72
1.6
1.9
—
—
—
0
0
235
1731
1.44
5.62
2.0
1.9
—
—
—
0
0
31
122
2.58
5.57
3.0
2.6
—
657.45
—
0
11
54
272
2.03
5.48
2.1
1.6
—
—
—
0
0
51
252
2.07
5.45
1.6
1.4
—
—
—
0
0
9
8
11.32
5.29
2.0
4.9
—
—
—
0
0
173
1218
1.49
5.22
1.7
1.8
—
—
—
0
0
49
244
2.05
5.15
1.2
1.3
—
—
—
0
0
49
244
2.05
5.15
1.2
1.3
—
—
—
0
0
36
159
2.30
5.08
2.1
1.7
—
—
—
0
0
98
610
1.66
5.06
4.0
4.0
1.78
1.98
mmol/l
0.25
69
446
462
3855
1.31
4.94
5.9
4.0
58.43
59.53
ng/l
0.03
358
2850
172
1226
1.47
4.87
1.8
1.8
—
—
—
0
0
68
386
1.80
4.87
4.3
4.6
25.25
24.99
mmol/l
0.40
59
359
328
2611
1.34
4.87
3.0
2.2
3.53
3.15
mg/l
1.96
294
2192
81
485
1.72
4.84
5.5
3.5
23.94
24.03
mmol/l
0.10
76
471
891
9621
0.76
4.80
39.7
23.5
38.94
39.41
%
1.35
831
8857
90
556
1.67
4.79
11.3
7.8
24.91
24.92
mmol/l
0.01
90
551
892
9629
0.76
4.79
39.3
23.5
130.26
133.07
g/l
5.71
873
9411
892
9626
0.76
4.75
39.0
23.4
4.36
4.41
e12/l
1.77
863
9281
892
9624
0.76
4.72
39.0
23.4
231.44
242.38
e9/l
4.81
864
9313
97
614
1.63
4.70
12.3
8.6
0.63
0.68
%
0.72
97
608
101
648
1.61
4.64
4.1
4.0
5.18
5.18
kpa
0.01
93
620
506
4305
1.29
4.59
9.7
5.8
1.20
1.21
mmol/l
2.48
463
3873
200
1495
1.40
4.37
4.8
3.1
0.83
0.82
mmol/l
0.87
189
1384
294
2337
1.33
4.36
4.0
2.7
3717.62
8735.09
umol/l
1.50
247
1982
96
621
1.59
4.28
12.3
8.4
1.32
1.38
%
0.27
96
615
582
5075
1.27
4.23
11.4
8.3
4.39
4.26
e9/l
0.56
507
4409
103
686
1.55
4.06
3.1
2.9
62.07
61.28
ml/min/173m2
0.07
55
293
30
137
2.22
3.98
1.3
1.3
—
—
—
0
0
278
2227
1.32
3.87
3.2
2.4
—
—
—
0
0
43
228
1.92
3.86
1.3
1.4
—
—
—
0
0
92
607
1.56
3.79
1.5
1.5
—
—
—
0
0
134
957
1.45
3.77
6.4
3.4
1.49
2.05
mmol/l
1.18
115
762
109
748
1.50
3.75
5.6
3.6
135.43
91.54
ng/l
1.72
96
643
445
3806
1.26
3.68
4.3
2.7
167.62
140.62
ug/l
0.59
416
3435
46
255
1.83
3.63
2.2
1.6
—
—
—
0
0
40
213
1.91
3.57
2.1
1.7
—
—
—
0
0
36
185
1.97
3.55
2.0
1.6
—
—
—
0
0
539
4725
1.24
3.55
10.3
6.5
1.20
1.21
mmol/l
1.59
463
3966
133
962
1.43
3.51
6.5
3.4
5.91
5.83
kpa
0.37
127
929
41
223
1.87
3.44
2.1
1.6
—
—
—
0
0
113
802
1.45
3.31
6.1
2.8
4.43
4.48
kpa
0.09
107
773
546
4827
1.23
3.24
7.1
6.0
13.37
12.10
umol/l
1.18
514
4555
339
2853
1.26
3.14
2.7
2.5
59.06
88.12
u/l
0.51
312
2621
54
330
1.66
3.09
5.6
3.5
63.17
73.66
mg/l
0.21
42
269
613
5507
1.22
3.04
7.4
4.7
6.83
6.82
mmol/l
0.04
575
5163
54
332
1.65
3.02
5.6
3.5
41.40
48.34
mg/l
0.27
42
273
7
12
5.86
3.02
1.1
1.1
93.14
89.75
%
—
7
12
40
226
1.79
3.01
1.7
1.7
21537.29
16145.27
e6/l
0.35
34
161
196
1547
1.32
3.01
1.7
1.4
2.87
2.61
g/l
0.65
110
912
24
114
2.13
2.95
1.8
1.5
—
—
—
0
0
25
123
2.05
2.82
1.6
1.8
89.14
89.84
%
0.23
25
123
12
39
3.10
2.77
3.2
1.8
—
—
—
0
0
12
39
3.10
2.77
1.7
3.8
95.75
98.44
%
0.11
12
39
12
39
3.10
2.77
3.2
1.8
—
—
—
0
0
139
1059
1.35
2.73
2.5
2.8
9.10
9.46
umol/l
0.07
114
915
25
125
2.02
2.72
1.7
1.6
—
—
—
0
0
237
1945
1.27
2.70
5.4
4.0
536.53
340.03
ng/l
0.32
208
1620
12
40
3.02
2.69
3.2
1.8
—
—
—
0
0
279
2335
1.25
2.68
5.2
3.9
72.93
85.81
%
8.49
272
2279
868
9202
0.82
2.64
14.4
10.3
24.75
25.33
u/l
0.45
831
8783
53
337
1.60
2.63
1.4
1.2
—
—
—
0
0
202
1633
1.28
2.60
3.6
2.9
1.31
1.14
e6/l
0.19
113
955
780
8346
0.83
2.59
5.1
4.7
6.08
6.03
mmol/l
0.43
707
7415
22
107
2.07
2.58
3.8
3.9
—
—
—
0
0
17
75
2.28
2.51
1.3
1.7
—
—
—
0
0
114
854
1.37
2.50
3.6
2.7
65.38
66.09
g/l
0.42
106
761
36
210
1.73
2.48
1.3
1.3
—
—
—
0
0
65
440
1.50
2.47
3.3
3.1
4.29
4.55
pmol/l
1.29
60
383
25
130
1.94
2.46
1.6
1.2
221.47
292.82
u/ml
0.72
19
74
403
3534
1.20
2.44
4.6
3.3
—
—
—
0
0
26
138
1.90
2.42
1.5
1.2
—
—
—
0
0
11
38
2.91
2.41
1.9
2.2
606.36
835.24
u/ml
0.60
11
38
18
83
2.19
2.41
3.3
1.9
—
—
—
0
0
120
912
1.35
2.41
2.4
2.1
129.67
135.63
ug/g
0.09
98
724
318
2729
1.22
2.40
4.3
3.3
0.73
0.52
e6/l
0.82
257
2129
255
2140
1.24
2.39
3.3
2.6
6.17
5.33
e6/l
0.44
230
1930
800
8514
0.84
2.38
5.3
5.0
2.51
2.64
mmol/l
3.60
735
7658
90
656
1.40
2.34
1.7
1.6
—
—
—
0
0
227
2703
0.81
2.30
4.6
4.5
21.82
21.72
%
0.03
116
1378
6
13
4.63
2.27
2.0
1.0
—
—
—
0
0
65
449
1.47
2.26
1.3
1.2
104.77
222.45
u/ml
1.27
56
406
155
1925
0.78
2.26
3.0
3.2
0.79
0.82
ug/l
0.20
110
1328
39
241
1.64
2.21
1.6
1.5
0.01
22.94
iu/ml
—
9
53
10
35
2.87
2.21
1.0
1.0
—
—
—
0
0
13
54
2.42
2.20
2.2
2.2
—
—
—
0
0
25
136
1.85
2.18
1.5
1.3
13008.25
88021.66
e6/l
0.94
16
77
866
9129
0.84
2.18
32.1
19.3
4.02
4.00
mmol/l
1.44
842
8819
290
3350
0.83
2.17
4.5
5.2
2.71
4.69
ug/l
0.84
259
2951
30
174
1.74
2.14
1.5
1.5
29.60
30.75
g/l
0.25
23
157
11
42
2.63
2.14
2.2
1.2
—
—
—
0
0
11
42
2.63
2.14
2.2
1.2
—
—
—
0
0
13
55
2.38
2.12
1.9
1.7
—
—
—
0
0
865
9109
0.84
2.10
31.8
19.2
139.35
139.57
mmol/l
1.52
842
8812
23
124
1.87
2.08
2.0
1.4
104.40
115.21
u/ml
—
5
24
20
103
1.96
2.06
1.3
1.7
—
—
—
0
0
775
8224
0.85
2.03
4.7
4.4
1.38
1.44
mmol/l
3.32
709
7386
17
83
2.06
2.01
3.2
1.6
—
—
—
0
0
17
83
2.06
2.01
3.2
1.6
—
—
—
0
0
17
83
2.06
2.01
3.2
1.6
—
—
—
0
0
110
850
1.32
2.01
2.4
2.3
36.91
34.21
u/l
0.23
90
717
783
8299
0.85
2.00
4.7
4.4
4.33
4.51
mmol/l
4.46
720
7510
10
38
2.64
2.00
1.1
1.3
—
—
—
0
0
24
133
1.82
2.00
1.8
1.5
—
—
—
0
0
755
8024
0.86
2.00
6.6
6.1
41.06
40.68
mmol/mol
0.43
698
7298
746
7935
0.86
1.99
4.3
3.9
1.31
1.27
mmol/l
0.60
684
7063
22
119
1.86
1.98
2.0
1.5
—
—
—
0
0
325
2845
1.19
1.97
3.9
3.8
18.16
9.22
mg/mmol
1.55
218
1828
7
21
3.35
1.96
1.9
1.3
—
—
—
0
0
9
33
2.74
1.93
4.6
3.1
—
—
—
0
0
9
33
2.74
1.93
4.6
3.1
—
—
—
0
0
18
92
1.97
1.90
3.3
1.9
—
—
—
0
0
12
52
2.32
1.88
3.2
1.7
—
—
—
0
0
12
52
2.32
1.88
3.2
1.7
—
—
—
0
0
6
17
3.54
1.84
1.0
1.0
—
—
—
0
0
40
262
1.54
1.83
1.5
1.5
287.85
276.31
ug/g
0.15
26
153
325
2862
1.18
1.83
2.8
2.1
170.27
249.52
u/l
1.61
313
2668
5
12
4.18
1.82
21.0
11.1
3.86
6.59
mmol/l
—
5
12
51
353
1.46
1.81
3.3
2.9
—
—
—
0
0
18
96
1.89
1.71
1.9
1.6
60.23
64.06
%
0.16
13
70
185
1560
1.22
1.67
3.8
3.1
2.56
2.18
e6/l
0.28
95
890
338
3009
1.17
1.65
4.4
3.4
136.31
96.69
e6/l
0.19
267
2369
203
1730
1.21
1.65
1.3
1.3
1.01
1.54
u/ml
0.61
45
440
15
76
1.99
1.64
1.4
1.6
—
—
—
0
0
26
158
1.66
1.63
2.0
2.2
417.11
3048.05
u/l
—
8
58
25
151
1.67
1.60
1.9
1.5
—
—
—
0
0
380
3424
1.16
1.58
5.1
3.9
156.58
137.33
e6/l
0.12
286
2521
314
2790
1.17
1.57
3.6
3.1
7.03
7.38
mmol/l
0.79
258
2294
25
152
1.66
1.57
1.6
1.4
1453.00
1320.27
e6/l
0.09
16
104
40
273
1.48
1.55
1.3
1.2
0.32
1.36
u/ml
—
5
23
242
2114
1.18
1.50
1.8
1.8
1328.34
1191.78
nmol/l
1.20
187
1550
44
310
1.43
1.47
3.5
3.2
3.84
3.96
mmol/l
1.04
44
304
148
1241
1.22
1.43
1.3
1.3
9.50
11.36
u/ml
0.17
43
452
10
46
2.18
1.40
1.6
1.7
—
—
—
0
0
31
206
1.52
1.38
2.5
2.4
15.98
15.28
%
0.32
14
103
13
67
1.95
1.38
1.7
1.3
—
—
—
0
0
24
150
1.61
1.38
2.7
1.6
—
—
—
0
0
24
150
1.61
1.38
2.7
1.6
—
—
—
0
0
9
41
2.20
1.37
1.1
1.1
—
—
—
0
0
26
167
1.57
1.35
4.9
3.4
56.00
59.93
%
0.91
26
167
20
121
1.66
1.31
1.5
1.4
—
—
—
0
0
107
877
1.24
1.30
2.5
2.1
0.20
0.20
g/l
0.01
98
801
25
161
1.56
1.29
3.0
3.1
3.77
4.44
e9/l
1.14
25
161
5
18
2.78
1.28
1.4
1.5
—
—
—
0
0
20
122
1.65
1.27
1.5
1.4
—
—
—
0
0
20
123
1.64
1.24
1.5
1.4
—
—
—
0
0
20
123
1.64
1.24
1.5
1.4
—
—
—
0
0
20
123
1.64
1.24
1.6
1.4
—
—
—
0
0
61
469
1.32
1.24
8.4
3.7
51.23
47.30
%
0.62
61
463
67
851
0.78
1.24
1.9
1.7
1.59
1.48
%
0.57
60
726
13
227
0.57
1.22
1.3
1.3
—
—
—
0
0
5
19
2.64
1.21
1.0
1.4
—
—
—
0
0
8
37
2.17
1.21
2.6
1.2
—
—
—
0
0
152
1301
1.19
1.21
1.3
1.3
38.53
35.50
iu/ml
0.12
42
407
20
124
1.62
1.21
1.5
1.4
—
—
—
0
0
30
205
1.47
1.20
1.5
1.4
—
—
—
0
0
17
101
1.69
1.20
1.2
1.3
—
—
—
0
0
18
109
1.66
1.19
1.3
1.2
—
0.70
nmol/l
—
0
6
11
57
1.94
1.17
1.6
1.5
—
—
—
0
0
11
58
1.90
1.12
2.2
1.3
—
—
—
0
0
11
58
1.90
1.12
2.2
1.3
—
—
—
0
0
13
73
1.79
1.11
1.2
1.1
—
—
—
0
0
295
2679
1.13
1.08
3.5
3.2
303.46
293.90
mg/l
0.01
203
1747
7
32
2.19
1.08
1.7
1.4
—
—
—
0
0
16
97
1.66
1.07
1.1
1.1
0.63
1.77
u/ml
—
8
47
450
4194
1.11
1.05
3.3
2.6
—
—
—
0
0
52
402
1.31
1.05
1.5
2.4
—
—
—
0
0
9
46
1.96
1.03
1.7
1.7
—
—
—
0
0
125
1071
1.19
1.01
4.8
4.6
31.26
32.57
%
0.71
98
681
9
49
1.84
0.98
1.3
1.2
—
—
—
0
0
851
8799
0.90
0.98
27.4
16.2
23.54
26.55
mg/l
2.16
746
7138
37
275
1.36
0.98
1.3
1.2
—
—
—
0
0
63
505
1.26
0.98
6.9
3.2
24.53
25.14
mmol/l
0.79
63
489
53
416
1.29
0.97
2.4
1.9
—
—
—
0
0
763
7928
0.91
0.96
5.1
4.6
2.03
2.14
mu/l
0.29
692
7097
0
31
0.00
0.96
0.0
1.5
—
7.36
—
0
31
37
277
1.35
0.94
1.3
1.2
—
—
—
0
0
49
618
0.78
0.91
2.0
2.2
13.63
12.69
nmol/l
0.32
44
542
16
102
1.58
0.90
1.7
2.2
3.86
2.11
u/field
—
7
28
8
43
1.87
0.87
1.3
1.2
141.28
176.58
pmol/l
—
8
43
620
6486
0.91
0.87
4.2
3.8
15.04
14.94
pmol/l
0.48
561
5763
302
2783
1.11
0.87
3.6
3.1
34.51
35.12
u/l
0.06
284
2637
445
4183
1.10
0.86
6.2
4.6
34.29
34.79
g/l
1.07
401
3842
8
44
1.82
0.86
2.1
2.6
271.25
215.82
u/l
—
8
44
12
191
0.62
0.84
1.1
1.5
—
—
—
0
0
13
203
0.64
0.84
1.8
1.6
379.31
298.32
mu/l
0.33
13
185
725
6971
1.09
0.84
9.7
7.2
83.15
80.34
u/l
0.67
680
6464
42
534
0.78
0.84
1.4
1.7
—
—
—
0
0
133
1167
1.16
0.83
1.7
1.4
—
—
—
0
0
781
8075
0.92
0.82
23.7
15.3
72.90
75.47
ml/min/173m2
2.01
663
6676
13
81
1.61
0.81
1.1
1.2
—
—
—
0
0
264
2432
1.11
0.77
5.3
4.2
0.00
0.01
estimate
0.69
81
786
717
7429
0.92
0.77
31.5
19.0
15.92
15.11
%
2.67
701
7270
31
235
1.33
0.76
1.6
1.9
—
—
—
0
0
47
378
1.25
0.75
1.8
1.7
—
—
—
0
0
5
25
2.00
0.72
6.4
1.9
—
—
—
0
0
7
40
1.75
0.71
2.0
1.3
—
—
—
0
0
9
57
1.58
0.71
1.3
1.1
—
—
—
0
0
9
57
1.58
0.71
1.3
1.1
—
—
—
0
0
5
26
1.93
0.70
1.0
2.2
—
—
—
0
0
9
58
1.56
0.70
2.0
1.3
—
—
—
0
0
9
58
1.56
0.70
1.3
1.1
—
—
—
0
0
9
58
1.56
0.70
2.0
1.3
—
—
—
0
0
9
58
1.56
0.70
1.3
1.1
—
—
—
0
0
9
58
1.56
0.70
1.3
1.1
—
—
—
0
0
176
1933
0.90
0.68
2.6
3.1
2.46
2.46
mmol/l
0.10
135
1668
7
119
0.59
0.68
1.4
1.5
—
—
—
0
0
45
367
1.23
0.66
1.1
1.0
—
—
—
0
0
37
296
1.26
0.64
1.4
1.6
—
198.82
—
0
17
29
225
1.30
0.63
6.3
4.3
5.07
5.06
kpa
0.02
29
220
674
6511
1.07
0.63
5.7
3.9
15.43
13.94
mm/h
1.42
620
5906
11
71
1.55
0.62
1.0
1.2
—
—
—
0
0
28
217
1.30
0.62
2.2
2.2
124.75
125.36
g/l
0.04
20
160
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
23
173
1.34
0.62
1.7
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
70
809
0.86
0.59
9.2
3.7
1.22
1.23
mmol/l
0.61
63
690
6
35
1.72
0.57
4.3
2.7
44016.67
36125.86
ug/l
—
6
35
8
54
1.48
0.57
1.8
1.2
—
—
—
0
0
5
87
0.57
0.56
1.2
1.3
—
—
—
0
0
8
55
1.46
0.56
1.8
1.2
—
—
—
0
0
10
65
1.54
0.55
1.1
1.1
—
—
—
0
0
29
233
1.25
0.51
2.8
2.2
184.78
91.48
ug/min
0.56
18
140
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
459
4407
1.06
0.49
4.9
4.0
0.00
0.00
estimate
0.50
92
912
40
475
0.84
0.49
1.2
1.2
46.85
142.64
iu/ml
2.07
15
188
7
45
1.56
0.49
1.3
1.3
2.01
1.94
mmol/l
—
7
45
457
4390
1.06
0.48
6.5
5.4
0.00
0.00
estimate
-0.00
88
829
7
110
0.63
0.48
1.1
1.1
—
—
—
0
0
36
299
1.21
0.48
1.6
1.9
—
—
—
0
0
46
392
1.18
0.47
1.3
1.3
—
—
—
0
0
12
165
0.72
0.46
1.3
1.2
4.35
3.81
mmol/l
0.55
12
153
523
5405
0.95
0.44
3.5
3.1
64.32
52.08
u/l
1.49
477
4949
460
4770
0.94
0.44
2.9
2.8
—
—
—
0
0
13
172
0.75
0.41
2.3
1.3
461.85
801.62
e6/l
0.21
13
141
13
172
0.75
0.41
2.2
1.2
4.62
27.08
e6/l
0.66
13
137
30
250
1.20
0.40
7.9
3.3
1.52
1.63
mmol/l
0.43
30
245
87
788
1.11
0.40
1.7
1.9
345.43
373.41
nmol/l
0.84
79
716
91
1000
0.90
0.40
3.3
4.1
7.38
27.79
ug/l
1.49
76
846
8
61
1.31
0.39
1.1
1.1
—
70.43
—
0
7
27
224
1.21
0.38
4.1
4.0
20.28
28.16
mg/l
0.95
20
160
28
234
1.20
0.37
1.7
1.6
—
—
—
0
0
8
112
0.71
0.37
1.3
1.4
—
—
—
0
0
8
112
0.71
0.37
1.3
1.4
—
—
—
0
0
8
112
0.71
0.37
1.3
1.4
—
—
—
0
0
8
112
0.71
0.37
1.3
1.4
—
—
—
0
0
5
37
1.35
0.37
1.2
1.1
—
—
—
0
0
5
37
1.35
0.37
1.4
1.2
—
—
—
0
0
637
6218
1.05
0.36
6.2
5.0
187.82
2690.28
e6/l
1.96
11
107
62
555
1.12
0.36
1.9
1.9
—
—
—
0
0
459
4447
1.05
0.35
4.9
4.0
0.00
0.00
estimate
0.50
86
816
13
99
1.32
0.35
2.0
1.5
—
—
—
0
0
13
99
1.32
0.35
2.0
1.5
—
—
—
0
0
20
163
1.23
0.34
5.3
3.1
0.90
1.35
%
0.54
20
142
17
136
1.25
0.33
1.6
1.6
—
—
—
0
0
15
118
1.27
0.33
3.0
1.7
—
—
—
0
0
6
46
1.31
0.33
3.3
4.5
—
—
—
0
0
13
165
0.79
0.32
1.5
1.4
—
—
—
0
0
68
618
1.11
0.31
1.9
2.0
—
—
—
0
0
201
1911
1.06
0.31
2.0
1.7
1.03
1.34
mg/l
1.43
148
1492
7
53
1.32
0.31
2.1
3.1
—
—
—
0
0
7
99
0.71
0.30
1.3
1.2
105.43
115.76
%
—
7
92
33
378
0.87
0.30
1.9
3.2
31.40
10626.01
u/ml
0.84
25
325
17
205
0.83
0.28
1.6
1.8
45.71
39.68
nmol/l
0.30
17
193
16
194
0.82
0.27
4.9
3.9
41.13
1515.75
u/ml
0.62
16
183
9
120
0.75
0.27
1.4
1.1
—
—
—
0
0
22
187
1.18
0.26
1.5
1.3
—
—
—
0
0
5
73
0.68
0.26
1.4
1.4
—
—
—
0
0
227
2181
1.05
0.26
1.6
1.6
1.31
1.35
mmol/l
0.30
197
1814
206
1977
1.05
0.25
5.5
4.4
1.01
1.02
kg/l
0.61
31
286
22
255
0.86
0.24
1.6
1.7
5.89
3.33
mg/l
0.41
16
197
12
148
0.81
0.24
1.7
2.1
285.00
218.81
pmol/l
0.66
12
139
352
3423
1.04
0.24
5.2
4.3
—
—
—
0
0
5
38
1.32
0.23
4.0
6.1
—
87.56
—
0
9
14
116
1.21
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
18.06
—
0
7
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
37
335
1.11
0.20
1.8
2.0
39.26
39.30
u/l
0.00
31
292
120
1143
1.06
0.20
12.3
8.6
—
—
—
0
0
16
186
0.86
0.19
1.3
1.2
376.06
475.92
mg/l
0.68
16
175
15
174
0.86
0.18
1.3
1.3
222.83
238.49
miu/ml
—
7
80
7
63
1.11
0.17
1.0
1.0
—
—
—
0
0
5
66
0.76
0.17
1.0
1.2
—
—
—
0
0
11
130
0.84
0.16
1.5
1.4
—
—
—
0
0
6
76
0.79
0.15
1.7
1.7
—
—
—
0
0
20
178
1.13
0.15
1.9
1.5
11.94
10.46
u/l
0.20
15
137
23
207
1.11
0.15
1.3
1.2
—
32.96
—
0
10
98
940
1.05
0.14
1.5
1.4
—
—
—
0
0
12
103
1.17
0.13
1.0
1.0
—
—
—
0
0
17
151
1.13
0.13
1.3
1.2
—
29.06
—
0
12
109
1051
1.04
0.13
4.7
3.6
—
—
—
0
0
366
3601
1.02
0.12
2.8
2.2
80.14
77.80
nmol/l
0.86
332
3132
10
114
0.88
0.09
1.6
1.2
9.00
5.73
u/ml
—
5
52
5
60
0.83
0.08
1.0
1.9
114.20
93.03
umol/l
—
5
60
6
70
0.86
0.07
1.2
1.3
—
56.25
—
0
8
6
74
0.81
0.07
1.2
1.4
—
322.00
—
0
10
7
83
0.84
0.07
1.9
1.6
—
—
—
0
0
26
245
1.06
0.07
2.3
1.9
—
—
—
0
0
24
253
0.95
0.05
2.6
1.7
—
—
—
0
0
20
189
1.06
0.04
1.2
1.1
—
—
—
0
0
11
101
1.09
0.04
2.9
2.5
—
—
—
0
0
10
107
0.93
0.02
1.6
1.2
3.40
4.31
u/ml
—
5
35
214
2130
1.01
0.01
1.8
1.7
50270714.28
9181719.83
pmol/l
0.38
185
1710
400
3994
1.00
0.00
2.3
2.1
93.62
92.89
pmol/l
0.11
212
2037
13
129
1.01
0.00
1.1
1.1
—
—
—
0
0
237
2374
1.00
0.00
1.8
1.6
21.10
20.43
nmol/l
0.25
207
1989
51
512
1.00
0.00
2.3
2.4
19.80
19.19
au/ml
—
5
31
324
3242
1.00
0.00
3.0
3.2
2.34
2.35
mmol/l
0.21
272
2788
8
82
0.98
0.00
1.3
1.5
—
22.20
—
0
15
5
52
0.96
0.00
1.0
2.3
24.80
18.37
nmol/l
—
5
47
7
71
0.99
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
465.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
2.4
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
—
—
0
0
7
74
0.95
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
2.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 2.108 [1.91, 2.33] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 3349 females with I9_RHEUFEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 1.918 [1.69, 2.18] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1381 out of 2720 males with I9_RHEUFEV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.234% |
| 5 | 0.939% | 1.818% |
| 10 | 2.767% | 4.92% |
| 15 | 5.439% | 8.981% |
| 20 | 9.551% | 15.703% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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