No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
179 |
4. Check minimum number of eventsNone |
179 |
5. Include endpointsNone |
179 |
6. Filter based on genotype QC (FinnGen only) |
179 |
Control definitions (FinnGen only)
- Control exclude
- I9_RHEUFEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever with heart involvement
based on the number of shared cases.
Similar with more cases:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1875 | 843 | 1004 |
| Only index persons | 1312 | 610 | 702 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 45.88 | 50.55 | 41.60 |
| Only index persons | 36.70 | 41.53 | 32.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 179 | 87 | 92 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 44.87 | 45.90 | 43.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 163
- Matched controls
- 1630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I01.0
ICD-10 Finland
Acute rheumatic pericarditis
+∞
68.7
61
*
39199
ICD-8 Finland
Rheumatic fever with heart involvement, Other active rheumatic heart disease
+∞
21.3
20
*
39197
ICD-8 Finland
Rheumatic fever with heart involvement, Suspecta
+∞
21.3
20
*
I01.9
ICD-10 Finland
Acute rheumatic heart disease, unspecified
+∞
11.6
11
*
I01.1
ICD-10 Finland
Acute rheumatic endocarditis
+∞
10.5
10
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
12.5
9.8
17
15
I01.8
ICD-10 Finland
Other acute rheumatic heart disease
+∞
8.4
8
*
3910A
ICD-9 Finland
Rheumatic fever with heart involvement, Acute rheumatic pericarditis
+∞
8.4
8
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.9
8.2
18
25
H02AB06
ATC
prednisolone; systemic
2.6
7.9
87
501
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.4
7.5
22
46
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.4
36
123
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.1
7.2
43
168
J46
ICD-10 Finland
Status asthmaticus
9.4
7.2
14
16
UJF32
NOMESCO Finland
Coloscopy
2.6
6.3
54
263
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.8
6.3
20
46
35399
ICD-8 Finland
Sciatica
27.8
6.3
8
*
I02.0
ICD-10 Finland
Rheumatic chorea with heart involvement
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEVHRT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVHRT | 1.944 [1.55, 2.44] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.117 |
During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 399 females with I9_RHEUFEVHRT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVHRT | 1.889 [1.43, 2.5] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 376 males with I9_RHEUFEVHRT died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEVHRT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.435% |
| 5 | 1.056% | 2.189% |
| 10 | 2.706% | 5.49% |
| 15 | 5.191% | 10.508% |
| 20 | 8.884% | 17.473% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEVHRT – Rheumatic fever with heart involvement
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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