No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
179 |
4. Check minimum number of eventsNone |
179 |
5. Include endpointsNone |
179 |
6. Filter based on genotype QC (FinnGen only) |
176 |
Control definitions (FinnGen only)
- Control exclude
- I9_RHEUFEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever with heart involvement
based on the number of shared cases.
Similar with more cases:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1875 | 843 | 1004 |
| Only index persons | 1312 | 610 | 702 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 45.88 | 50.55 | 41.60 |
| Only index persons | 36.70 | 41.53 | 32.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 176 | 87 | 89 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 44.68 | 45.90 | 43.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 179
- Matched controls
- 1790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I01.0
ICD-10 Finland
Acute rheumatic pericarditis
+∞
76.7
68
*
39197
ICD-8 Finland
Rheumatic fever with heart involvement, Suspecta
+∞
23.4
22
*
39199
ICD-8 Finland
Rheumatic fever with heart involvement, Other active rheumatic heart disease
+∞
23.4
22
*
I01.9
ICD-10 Finland
Acute rheumatic heart disease, unspecified
+∞
14.8
14
*
I01.1
ICD-10 Finland
Acute rheumatic endocarditis
+∞
10.5
10
*
I01.8
ICD-10 Finland
Other acute rheumatic heart disease
+∞
9.5
9
*
J46
ICD-10 Finland
Status asthmaticus
9.8
8.8
17
19
TDM10
NOMESCO Finland
Puncture of maxillary antrum
8.6
8.6
18
23
3910A
ICD-9 Finland
Rheumatic fever with heart involvement, Acute rheumatic pericarditis
+∞
8.4
8
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.5
8.0
20
34
R50.9
ICD-10 Finland
Fever, unspecified
3.0
7.8
40
157
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.6
7.4
54
255
UJF32
NOMESCO Finland
Coloscopy
2.5
7.1
59
295
H02AB06
ATC
prednisolone; systemic
2.3
6.9
98
617
L01BA01
ATC
methotrexate; systemic
7.7
6.9
15
21
I02.0
ICD-10 Finland
Rheumatic chorea with heart involvement
+∞
6.3
6
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.5
6.2
22
68
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
6.2
43
196
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.9
6.2
31
119
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.7
6.1
20
59
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
114
3.20
7.31
2.2
1.6
—
—
—
0
0
18
52
3.74
5.62
1.7
1.3
—
—
—
0
0
41
204
2.31
4.82
3.0
1.8
30.14
29.34
s
0.42
41
196
15
37
4.33
4.53
1.4
1.3
357.11
299.36
ug/g
—
9
23
33
166
2.21
3.75
7.5
4.2
232.85
228.67
u/l
0.11
33
155
88
623
1.81
3.72
14.3
5.4
1.20
1.21
mmol/l
0.64
82
569
11
25
4.62
3.69
1.3
1.1
—
—
—
0
0
33
170
2.15
3.53
10.2
6.1
104.94
104.40
mmol/l
0.26
33
170
6
6
10.29
3.52
1.2
1.3
44.00
51.33
u/l
—
6
6
92
679
1.73
3.23
14.6
6.5
1.20
1.21
mmol/l
0.83
82
577
35
191
2.03
3.22
16.0
5.1
1.09
1.04
mmol/l
0.54
35
176
38
215
1.97
3.17
3.3
1.8
—
—
—
0
0
7
12
6.02
3.05
1.1
1.6
—
—
—
0
0
5
5
10.23
2.99
1.2
1.2
65.60
74.40
u/l
—
5
5
5
5
10.23
2.99
1.2
1.2
23.60
21.40
u/l
—
5
5
9
22
4.25
2.92
4.2
2.9
57.11
58.64
%
—
9
22
63
438
1.68
2.64
2.8
2.3
55.36
53.71
u/l
0.19
58
406
13
50
2.73
2.59
1.5
1.2
—
—
—
0
0
13
50
2.73
2.59
1.5
1.2
—
—
—
0
0
28
155
1.96
2.47
3.1
1.8
—
—
—
0
0
100
790
1.60
2.47
16.9
9.3
4.39
4.13
e9/l
0.42
92
679
51
342
1.69
2.42
5.7
2.6
365.26
6968.46
umol/l
1.47
46
286
6
12
5.13
2.42
1.0
1.0
—
—
—
0
0
90
697
1.59
2.39
4.5
3.8
0.00
0.01
estimate
0.50
16
147
22
116
2.02
2.22
18.6
6.1
10.51
9.88
mmol/l
0.18
22
108
36
224
1.76
2.22
5.4
3.3
0.84
0.82
mmol/l
0.63
36
209
87
678
1.55
2.19
24.5
13.9
1.35
1.25
inr
0.45
30
205
76
576
1.56
2.16
5.1
4.2
41.87
41.06
ng/l
0.03
59
431
27
155
1.87
2.15
2.5
1.8
—
—
—
0
0
6
15
4.10
2.05
1.0
1.3
—
—
—
0
0
71
540
1.52
1.95
3.2
2.4
76.10
76.90
nmol/l
0.09
65
480
6
17
3.61
1.85
1.5
1.4
—
—
—
0
0
87
696
1.49
1.85
5.4
5.1
0.00
0.00
estimate
-0.00
16
139
14
67
2.18
1.81
2.4
1.6
—
—
—
0
0
123
1060
1.51
1.78
12.8
7.1
78.32
78.63
u/l
0.04
117
991
5
13
3.92
1.72
1.6
1.6
—
—
—
0
0
5
13
3.92
1.72
3.0
2.3
633.20
415.62
e6/l
—
5
13
5
13
3.92
1.72
1.4
1.0
486.80
269.62
pmol/l
—
5
13
43
303
1.55
1.64
3.6
2.3
—
—
—
0
0
78
622
1.45
1.63
3.5
2.6
—
—
—
0
0
5
14
3.64
1.62
3.2
3.7
—
—
—
0
0
5
14
3.64
1.62
1.0
1.1
—
—
—
0
0
8
32
2.57
1.62
1.5
1.3
—
—
—
0
0
11
50
2.28
1.60
7.5
3.1
—
—
—
0
0
86
704
1.43
1.54
4.4
3.8
0.00
0.00
estimate
-0.00
15
131
5
15
3.40
1.53
1.0
1.1
—
—
—
0
0
6
21
2.92
1.52
1.8
1.3
14900.83
2985.18
e6/l
—
6
11
20
119
1.77
1.45
1.8
2.1
332.75
350.18
nmol/l
0.21
20
106
18
104
1.81
1.43
1.9
3.0
75.22
60.37
ml/min/173m2
—
9
46
6
23
2.66
1.38
3.2
1.4
—
—
—
0
0
114
997
1.39
1.32
6.9
4.1
14.89
12.24
mm/h
0.96
109
905
5
18
2.83
1.29
7.0
2.0
—
—
—
0
0
31
216
1.53
1.24
1.3
1.2
14.87
29.75
iu/ml
—
6
69
6
26
2.35
1.19
3.2
1.4
—
—
—
0
0
39
289
1.45
1.17
1.7
1.7
1529.82
1267.66
nmol/l
0.74
33
212
51
398
1.39
1.15
5.2
3.9
0.00
0.00
estimate
-0.00
15
128
56
445
1.38
1.14
3.8
3.7
20.39
8.71
mg/mmol
0.43
36
283
64
520
1.36
1.13
4.0
3.1
—
—
—
0
0
5
21
2.42
1.10
3.4
1.2
—
—
—
0
0
5
21
2.42
1.10
7.0
1.9
—
—
—
0
0
11
60
1.89
1.05
8.1
2.6
0.61
0.66
%
0.20
11
60
35
260
1.43
1.04
8.3
3.7
818.38
94.26
ng/l
0.51
29
199
7
35
2.04
1.01
16.0
4.2
51.80
30.88
mg/l
—
7
27
7
35
2.04
1.01
16.1
4.2
25.49
54.33
mg/l
—
7
27
7
35
2.04
1.01
1.1
1.6
—
—
—
0
0
11
61
1.86
1.01
8.1
2.6
0.98
1.21
%
0.70
11
61
15
93
1.67
0.97
1.4
1.4
—
—
—
0
0
7
37
1.93
0.95
1.9
1.6
—
—
—
0
0
7
37
1.93
0.95
5.3
1.6
—
—
—
0
0
7
37
1.93
0.95
5.3
1.6
—
—
—
0
0
5
103
0.47
0.92
1.4
1.7
—
—
—
0
0
6
29
2.10
0.90
3.3
1.4
—
—
—
0
0
8
42
1.95
0.90
2.0
1.5
—
—
—
0
0
8
44
1.86
0.87
1.1
1.4
0.24
0.24
g/l
—
8
44
24
172
1.46
0.86
14.5
6.2
1.57
1.44
mmol/l
0.05
19
132
8
45
1.81
0.85
4.4
1.8
—
—
—
0
0
43
343
1.33
0.84
1.6
1.7
1.29
1.34
mmol/l
0.17
34
282
49
399
1.31
0.84
3.7
3.0
0.65
0.37
e6/l
0.51
40
301
112
1018
1.27
0.78
4.7
3.7
14.96
14.85
pmol/l
0.19
105
911
13
83
1.61
0.77
1.5
1.3
—
—
—
0
0
5
24
2.11
0.75
7.0
1.8
—
—
—
0
0
5
24
2.11
0.75
3.8
1.4
—
—
—
0
0
5
24
2.11
0.75
7.0
1.8
—
—
—
0
0
7
38
1.88
0.74
2.3
1.8
—
—
—
0
0
23
169
1.41
0.74
15.0
6.1
11.57
11.51
kpa
0.04
23
161
23
169
1.41
0.74
15.0
6.1
5.19
5.12
kpa
0.17
23
158
5
25
2.03
0.73
1.8
1.9
—
—
—
0
0
36
289
1.31
0.68
1.8
1.8
0.99
1.31
mg/l
0.41
24
228
144
1360
1.30
0.68
32.0
15.0
23.46
22.99
mg/l
0.07
121
1085
5
28
1.81
0.66
6.2
1.5
—
—
—
0
0
7
44
1.61
0.66
1.1
1.5
1.19
1.09
g/l
—
7
44
63
549
1.23
0.61
2.5
2.0
93.36
95.46
pmol/l
0.14
31
269
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
8
53
1.53
0.59
5.0
1.9
117.00
448.52
ug/l
—
8
48
26
204
1.32
0.58
1.3
1.2
1.75
7.40
u/ml
1.40
12
80
6
35
1.74
0.58
1.5
1.3
—
—
—
0
0
63
553
1.21
0.57
4.8
3.9
—
—
—
0
0
87
791
1.19
0.53
3.2
3.0
—
—
—
0
0
82
894
0.85
0.48
3.6
3.0
52.38
49.13
u/l
0.15
74
835
20
157
1.31
0.46
4.4
3.5
—
—
—
0
0
5
33
1.53
0.41
1.0
1.4
—
—
—
0
0
5
33
1.53
0.41
1.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
24.06
—
0
5
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
6
45
1.34
0.34
3.8
1.9
—
—
—
0
0
27
230
1.20
0.33
3.3
2.7
2.62
0.99
e6/l
0.84
13
138
34
299
1.17
0.30
1.2
1.3
0.65
1.05
u/ml
—
6
79
14
113
1.26
0.27
11.9
3.3
64.22
66.56
g/l
0.44
14
103
9
72
1.26
0.26
1.0
1.0
—
—
—
0
0
128
1237
1.12
0.25
5.7
4.6
1.86
1.97
mu/l
0.44
121
1117
5
37
1.36
0.23
2.0
1.9
—
—
—
0
0
12
97
1.25
0.23
4.0
2.9
0.63
2.03
mmol/l
—
7
70
5
40
1.26
0.22
3.0
1.4
14.40
21.15
iu/l
—
5
31
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
8.61
—
0
13
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
12
100
1.21
0.18
17.8
6.4
25.46
24.73
mmol/l
0.27
12
95
50
469
1.09
0.17
5.2
4.9
1.99
2.20
ug/l
0.22
45
419
128
1308
0.92
0.14
5.3
4.7
6.13
6.03
mmol/l
0.39
119
1187
134
1318
1.07
0.10
4.4
4.4
1.44
1.45
mmol/l
0.17
122
1203
5
45
1.11
0.10
1.8
1.9
—
—
—
0
0
5
48
1.04
0.09
1.4
2.7
6.14
10.16
g/l
—
5
43
127
1290
0.95
0.09
7.3
5.9
41.65
40.44
mmol/mol
0.63
118
1201
24
226
1.07
0.07
1.5
1.6
—
—
—
0
0
129
1273
1.05
0.07
27.7
14.1
75.72
79.32
ml/min/173m2
0.77
108
1039
38
368
1.04
0.04
4.6
4.6
18.88
22.02
%
0.58
21
185
146
1449
1.04
0.04
17.4
10.2
24.31
25.62
u/l
0.54
141
1389
145
1441
1.03
0.02
35.5
17.3
94.09
79.13
umol/l
1.30
145
1441
137
1361
1.03
0.02
5.2
5.0
2.51
2.70
mmol/l
1.55
125
1246
151
1502
1.03
0.02
43.8
21.6
38.89
40.11
%
1.32
142
1411
18
173
1.04
0.01
1.2
1.4
—
—
—
0
0
19
183
1.04
0.01
14.4
8.9
—
—
—
0
0
133
1326
1.01
0.00
4.6
4.5
4.44
4.58
mmol/l
0.77
121
1220
12
117
1.03
0.00
2.1
1.8
—
—
—
0
0
22
217
1.02
0.00
3.5
3.0
4.01
2.68
e6/l
—
8
126
127
1265
1.01
0.00
4.1
4.0
1.28
1.29
mmol/l
0.04
118
1148
13
128
1.02
0.00
2.0
2.1
—
—
—
0
0
5
56
0.89
0.00
1.8
2.1
—
—
—
0
0
5
53
0.94
0.00
1.4
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
-0.00
2.9
2.3
11.20
13.39
nmol/l
—
10
94
0
5
0.00
-0.00
0.0
1.0
—
0.35
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
8.61
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEVHRT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVHRT | 1.944 [1.55, 2.44] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.117 |
During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 399 females with I9_RHEUFEVHRT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVHRT | 1.889 [1.43, 2.5] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 376 males with I9_RHEUFEVHRT died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEVHRT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.435% |
| 5 | 1.056% | 2.189% |
| 10 | 2.706% | 5.49% |
| 15 | 5.191% | 10.508% |
| 20 | 8.884% | 17.473% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEVHRT – Rheumatic fever with heart involvement
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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