Rheumatic fever with heart involvement

I9_RHEUFEVHRT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I01, I02.0 Hospital discharge: ICD-9 — 391 Hospital discharge: ICD-8 — 391 Cause of death: ICD-10 — I01, I02.0 Cause of death: ICD-9 — 391 Cause of death: ICD-8 — 391 2 out of 7 registries used, show all original rules.	179
4. Check minimum number of events None	179
5. Include endpoints None	179
6. Filter based on genotype QC (FinnGen only)	179

Control definitions (FinnGen only)

Control exclude: I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	I9_RHEUFEVHRT
CONTROL_EXCLUDE	I9_RHEUFEV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I01\|I020
HD_ICD_9	391
HD_ICD_8	391
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I01\|I020
COD_ICD_9	391
COD_ICD_8	391
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rheumatic fever with heart involvement based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1875	843	1004
Only index persons	1312	610	702
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.02	0.02	0.03
Median age at first event (years)
Whole population	45.88	50.55	41.60
Only index persons	36.70	41.53	32.50

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	179	87	92
Unadjusted period prevalence (%)	0.04	0.03	0.04
Median age at first event (years)	44.87	45.90	43.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
163: Matched controls
1630

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I01.0

ICD-10 Finland

Acute rheumatic pericarditis

+∞

68.7

39199

ICD-8 Finland

Rheumatic fever with heart involvement, Other active rheumatic heart disease

+∞

21.3

39197

ICD-8 Finland

Rheumatic fever with heart involvement, Suspecta

+∞

21.3

I01.9

ICD-10 Finland

Acute rheumatic heart disease, unspecified

+∞

11.6

I01.1

ICD-10 Finland

Acute rheumatic endocarditis

+∞

10.5

TDM10

NOMESCO Finland

Puncture of maxillary antrum

12.5

9.8

3910A

ICD-9 Finland

Rheumatic fever with heart involvement, Acute rheumatic pericarditis

+∞

8.4

I01.8

ICD-10 Finland

Other acute rheumatic heart disease

+∞

8.4

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

7.9

8.2

H02AB06

ATC

prednisolone; systemic

2.6

7.9

501

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

5.4

7.5

R50.9

ICD-10 Finland

Fever, unspecified

3.5

7.4

123

J01.0

ICD-10 Finland

Acute maxillary sinusitis

3.1

7.2

168

J46

ICD-10 Finland

Status asthmaticus

9.4

7.2

UJF32

NOMESCO Finland

Coloscopy

2.6

6.3

263

201

Kela drug reimbursment

Chronic cardiac insufficiency

4.8

6.3

35399

ICD-8 Finland

Sciatica

27.8

6.3

I02.0

ICD-10 Finland

Rheumatic chorea with heart involvement

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

114

3.20

7.31

2.2

1.6

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

4.33

5.75

1.4

1.3

357.1

299.4

ug/g

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.74

5.62

1.7

1.3

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

204

2.31

4.82

3.0

1.8

30.1

29.3

0.42

196

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.62

4.63

1.3

1.1

—

(3000991) Gas panel - Venous blood

110

2.60

4.31

12.9

7.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

151

2.36

4.22

4.4

1.8

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

166

2.21

3.75

7.5

4.2

232.8

228.7

u/l

0.11

155

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

623

1.81

3.72

14.3

5.4

1.2

mmol/l

0.61

566

(3023368) Bacteria identified in Blood by Culture

394

1.88

3.71

7.7

4.1

—

(3048689) Calprotectin [Mass/mass] in Stool

166

2.13

3.36

2.9

2.2

190.8

125.6

ug/g

0.41

134

(3013115) Eosinophils [#/volume] in Blood

695

1.74

3.30

12.7

5.7

0.2

e9/l

0.13

603

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

679

1.73

3.23

14.6

6.5

1.2

mmol/l

0.73

572

(3021788) Differential panel - Synovial fluid

5.53

3.23

1.5

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

191

2.03

3.22

16.0

5.1

1.1

1.0

mmol/l

0.54

176

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

215

1.97

3.17

3.3

1.8

—

(3025941) Bacteria identified in Stool by Culture

2.59

3.16

1.6

1.3

—

(3006315) Basophils [#/volume] in Blood

675

1.71

3.10

12.3

5.4

0.0

e9/l

0.05

573

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

6.02

3.05

1.1

1.6

—

(3035400) Alkaline phosphatase.liver [Enzymatic activity/volume] in Serum or Plasma

10.23

2.99

1.2

65.6

74.4

u/l

—

(3045684) Alkaline phosphatase.other fractions [Enzymatic activity/volume] in Serum or Plasma

10.23

2.99

1.2

23.6

21.4

u/l

—

(40758558) Short blood count panel - Blood

350

1.78

2.95

14.3

6.6

—

(3001604) Monocytes [#/volume] in Blood

672

1.68

2.95

12.4

5.4

0.6

e9/l

0.11

569

(3019198) Lymphocytes [#/volume] in Blood

692

1.68

2.92

12.3

5.4

1.7

2.0

e9/l

1.42

607

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.25

2.92

4.2

2.9

57.1

58.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.25

2.92

4.2

2.1

3.7

4.5

e9/l

—

(3018418) pH of Serum or Plasma

424

1.71

2.79

11.2

4.0

7.4

—

(3044941) Cell count panel - Synovial fluid

6.16

2.72

1.5

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

438

1.68

2.64

2.8

2.3

55.4

53.7

u/l

0.19

406

(42529406) Shigella sp [Presence] in Stool by Culture

2.73

2.59

1.5

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.73

2.59

1.5

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.73

2.59

1.5

1.2

—

(42870588) Differential panel, method unspecified - Blood

442

1.66

2.54

10.6

5.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

155

1.96

2.47

3.1

1.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

100

790

1.60

2.47

16.9

9.3

4.4

4.1

e9/l

0.42

679

(3026493) Urate [Moles/volume] in Serum or Plasma

342

1.69

2.42

5.7

2.6

364.5

7014.9

umol/l

1.47

284

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

5.13

2.42

1.0

—

(3035350) Ketones [Presence] in Urine by Test strip

696

1.59

2.41

4.5

3.8

0.0

estimate

0.00

140

(3023419) Bacteria identified in Sputum by Culture

3.76

2.39

5.9

2.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

633

1.58

2.34

11.3

5.7

24.0

28.1

2.29

586

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

4.00

2.27

1.4

1.7

—

(3032080) INR in Blood by Coagulation assay

573

1.57

2.23

19.3

8.0

1.4

1.2

inr

0.51

181

(3020779) Urea [Moles/volume] in Serum or Plasma

116

2.02

2.22

18.6

6.1

10.5

9.9

mmol/l

0.18

108

(3012095) Magnesium [Moles/volume] in Serum or Plasma

224

1.76

2.22

5.4

3.3

0.8

mmol/l

0.77

208

(3011397) Hemoglobin [Presence] in Urine by Test strip

325

1.65

2.18

4.6

3.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

308

1.66

2.18

8.2

4.6

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

457

1.58

2.17

4.6

3.1

2.4

mmol/l

0.33

396

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

576

1.56

2.16

5.1

4.2

41.8

41.2

ng/l

0.02

428

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

155

1.87

2.15

2.5

1.8

—

(3026389) Candida sp identified in Specimen by Organism specific culture

4.10

2.05

1.0

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.84

1.95

1.5

1.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

540

1.52

1.95

3.2

2.4

76.1

76.9

nmol/l

0.09

480

(3012544) pH of Venous blood

131

1.87

1.88

9.6

3.7

—

(3017181) Myelocytes/100 leukocytes in Blood

116

1.92

1.88

7.4

4.3

0.8

0.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

696

1.49

1.85

5.4

5.1

0.0

estimate

0.00

139

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.18

1.81

2.4

1.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

123

1060

1.51

1.78

12.8

7.1

78.3

78.7

u/l

0.04

117

990

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.41

1.76

2.8

1.4

—

(3018095) Leukocytes [#/volume] in Urine

513

1.49

1.75

4.4

3.8

128.6

84.6

e6/l

0.32

374

(3026008) Bacteria identified in Urine by Culture

432

1.51

1.73

3.9

3.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

3.92

1.72

1.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.92

1.72

1.0

1.1

—

(3044889) 12 lead EKG panel

113

962

1.47

1.70

4.7

4.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.23

1.67

2.8

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

303

1.55

1.64

3.6

2.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

153

1.74

1.64

2.2

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

622

1.45

1.63

5.4

4.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.64

1.62

1.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

3.64

1.62

3.6

4.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.57

1.62

1.5

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.28

1.60

7.5

3.1

—

(3009261) Glucose [Presence] in Urine by Test strip

704

1.43

1.54

4.4

3.8

0.0

estimate

0.00

131

(4062490)

3.40

1.53

2.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

3.40

1.53

1.0

1.1

—

(3000475) Leukocytes [#/volume] in Synovial fluid

2.92

1.52

1.8

1.3

14900.8

2985.2

e6/l

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

119

1.77

1.45

1.8

2.1

332.8

350.2

nmol/l

0.21

106

(3000494) Fungus identified in Specimen by Culture

159

1.67

1.44

2.6

1.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

104

1.81

1.43

1.9

3.1

75.2

60.4

ml/min/173m2

—

(3042936) Bacteria identified in Isolate by Culture

209

1.58

1.43

3.8

2.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.66

1.38

3.2

1.4

—

(3002256) Pathology report gross observation

153

1.66

1.37

1.3

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.99

1.37

13.2

2.2

56.2

60.8

—

(3044640) Blood type and Crossmatch panel - Blood

423

1.43

1.36

3.6

2.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

114

997

1.39

1.32

6.9

4.1

14.9

12.2

mm/h

0.96

109

905

(3020891) Body temperature

2.07

1.30

4.8

3.5

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

2.83

1.29

7.0

2.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

216

1.53

1.24

1.3

1.2

14.9

30.1

iu/ml

—

(3049717) Cytology report of Urine Cyto stain

2.10

1.24

1.2

2.8

—

(1761868) Lipid panel - Serum or Plasma

471

0.68

1.22

3.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.35

1.19

3.2

1.4

—

(3024928) Oxygen saturation in Venous blood

2.35

1.19

14.7

2.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

103

1.72

1.17

1.5

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

289

1.45

1.17

1.7

1529.8

1267.7

nmol/l

0.74

212

(3029937) Albumin [Presence] in Urine by Test strip

398

1.39

1.15

5.2

3.9

0.0

estimate

0.00

128

(40761535) Cells panel - Urine sediment

128

1.63

1.14

5.5

3.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

445

1.38

1.14

3.9

20.4

8.7

mg/mmol

0.43

283

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.39

1.13

1.4

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

520

1.36

1.13

4.1

3.2

—

(3016502) Oxygen saturation in Arterial blood

153

1.58

1.13

14.2

6.5

97.0

95.6

2.05

146

(3009508) Creatinine [Moles/volume] in Urine

447

1.37

1.10

3.2

3.0

6.9

7.5

mmol/l

0.52

371

(21494755) Public health laboratory ask at order entry panel

123

0.47

1.10

1.2

1.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.42

1.10

3.4

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.42

1.10

7.0

1.9

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.89

1.05

8.1

2.6

0.6

0.7

0.20

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

260

1.43

1.04

8.3

3.7

818.4

94.3

ng/l

0.51

199

(3037467) Urinalysis macro (dipstick) panel - Urine

107

947

1.32

1.03

5.5

4.3

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.04

1.01

16.1

4.2

25.5

54.3

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.04

1.01

16.0

4.2

51.8

30.9

mg/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.04

1.01

1.1

1.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.86

1.01

8.1

2.6

1.0

1.2

0.70

(40768804) Tissue Pathology biopsy report

510

1.33

1.00

2.3

2.0

—

(3042631) Mycobacterium sp identified in Specimen

2.21

0.98

2.6

3.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.67

0.97

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.77

0.95

17.6

6.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.77

0.95

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.93

0.95

5.3

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.93

0.95

1.9

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.93

0.95

5.3

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

103

0.47

0.92

1.4

1.7

—

(3023520) Reticulocytes [#/volume] in Blood

128

1.54

0.90

3.0

2.8

90.8

71.6

e9/l

1.01

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.10

0.90

3.3

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.95

0.90

2.0

1.5

—

(3012516) Albumin [Mass/volume] in Urine

414

1.32

0.89

3.4

3.1

103.6

211.8

mg/l

0.30

270

(3021589) Normoblasts [#/volume] in Blood

623

1.29

0.89

18.0

10.0

0.0

e9/l

0.62

498

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.86

0.87

1.1

1.4

0.2

g/l

—

(3003396) Base excess in Arterial blood by calculation

172

1.46

0.86

14.5

6.2

1.5

mmol/l

0.01

132

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.81

0.85

4.4

1.8

—

(3019150) Specific gravity of Urine by Refractometry

315

1.35

0.85

6.2

4.1

1.0

kg/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

343

1.33

0.84

1.6

1.7

1.3

mmol/l

0.17

282

(3030467) Casts [#/volume] in Urine by Automated count

399

1.31

0.84

3.7

3.0

0.7

0.4

e6/l

0.53

300

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.79

0.0

1.0

—

14.2

—

(3002582) Erythrocytes [#/volume] in Urine

449

1.29

0.79

3.8

3.2

19.8

223.2

e6/l

0.81

353

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

112

1018

1.27

0.78

4.7

3.7

15.0

14.9

pmol/l

0.19

105

911

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.61

0.77

1.5

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.11

0.75

3.8

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.88

0.74

2.3

1.8

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

169

1.41

0.74

15.0

6.1

5.2

5.1

kpa

0.17

158

(3027801) Oxygen [Partial pressure] in Arterial blood

169

1.41

0.74

15.0

6.1

11.6

11.5

kpa

0.04

161

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.03

0.73

1.8

1.9

—

(4010399)

101

1.53

0.73

1.3

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.88

0.69

3.0

1.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

289

1.31

0.68

1.8

1.0

1.3

mg/l

0.41

228

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

144

1360

1.30

0.68

32.0

15.0

23.4

23.0

mg/l

0.06

121

1085

(3052851) Hemolysis interference index of Serum or Plasma

1.65

0.67

11.6

3.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.81

0.66

6.2

1.5

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.61

0.66

1.1

1.5

1.2

1.1

g/l

—

(36304419) Bacteria [Presence] in Urine

384

1.27

0.65

4.0

2.9

—

(3037756) Immunofixation for Serum or Plasma

1.69

0.62

2.2

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

549

1.23

0.61

2.5

2.0

93.4

95.5

pmol/l

0.14

269

(3022145) Colonoscopy Study observation

149

1.39

0.61

1.4

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.60

0.0

1.6

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.53

0.59

5.0

1.9

117.0

448.5

ug/l

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.58

0.0

1.0

—

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

204

1.32

0.58

1.3

1.2

1.8

7.4

u/ml

1.40

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.74

0.58

1.5

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

553

1.21

0.57

4.8

3.9

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.64

0.56

4.0

2.6

1.9

1.6

mg/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

791

1.19

0.53

3.2

3.0

—

(3047181) Lactate [Moles/volume] in Blood

1.52

0.52

23.3

5.5

1.3

mmol/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

894

0.85

0.48

3.6

3.0

52.4

49.1

u/l

0.15

835

(4034850)

1.51

0.48

9.3

13.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

192

1.29

0.48

2.3

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

157

1.31

0.46

4.4

3.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.53

0.41

1.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.53

0.41

1.0

1.4

—

(40768443) Skin Pathology biopsy report

1.37

0.41

1.6

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.37

0.41

1.0

1.1

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.41

0.0

1.7

—

(3019060) Gas panel - Arterial blood

106

1.35

0.40

12.4

3.5

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.40

0.0

2.0

—

24.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.39

0.0

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

265

1.21

0.37

1.7

1.4

2.0

2.3

g/l

0.37

150

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.64

0.36

4.8

2.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.34

0.34

3.8

1.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

230

1.20

0.33

3.3

2.7

2.6

1.0

e6/l

0.84

138

(3022621) pH of Urine by Test strip

1.35

0.31

4.6

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.31

0.31

10.6

2.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

299

1.17

0.30

1.2

1.3

0.7

1.1

u/ml

—

(3020630) Protein [Mass/volume] in Serum or Plasma

113

1.26

0.27

11.9

3.3

64.2

66.6

g/l

0.44

103

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.26

0.26

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

227

1.17

0.25

2.6

1.9

—

(40761536) Microorganisms panel - Urine sediment

124

1.23

0.25

3.1

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

116

1203

0.90

0.24

33.9

15.4

38.0

40.2

1.49

836

(3021901) Oxygen saturation in Capillary blood

1.36

0.23

2.2

2.6

—

(3008898) HLA-B27 [Presence]

1.36

0.23

1.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.36

0.23

2.2

1.9

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.25

0.23

4.0

2.9

0.6

2.0

mmol/l

—

(1616796) Gas panel - Central venous blood

1.32

0.23

4.4

2.8

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.26

0.22

3.0

1.4

14.4

21.1

iu/l

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.20

0.21

1.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3035880) pH of Pleural fluid

0.00

0.21

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

117

1.21

0.21

2.0

1.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

8.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

6.7

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

112

0.79

0.20

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.20

0.0

1.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

1.16

0.19

1.3

1.7

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

127

1235

1.10

0.19

5.8

4.6

1.8

2.0

mu/l

0.50

120

1114

(4035726)

128

1.19

0.19

1.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

100

1.21

0.18

17.8

6.4

25.3

24.7

mmol/l

0.22

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

469

1.09

0.17

5.2

4.9

2.0

2.2

ug/l

0.22

419

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

128

1308

0.92

0.14

5.3

4.7

6.1

6.0

mmol/l

0.39

119

1187

(3003694) ABO and Rh group [Type] in Blood

345

1.09

0.14

1.4

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

134

1318

1.07

0.10

4.4

1.4

1.5

mmol/l

0.18

122

1203

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.11

0.10

1.8

1.9

—

(3019225) pH of Specimen

116

1.13

0.09

8.1

4.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

129

1269

1.06

0.09

27.7

14.1

75.7

79.3

ml/min/173m2

0.77

108

1034

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

127

1290

0.95

0.09

7.3

6.0

41.6

40.4

mmol/mol

0.63

118

1201

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.09

0.09

22.3

5.2

1.8

1.6

—

(1002224) Polysomnography panel

0.80

0.08

1.0

1.1

—

(3022313) Gas panel - Capillary blood

1.06

0.08

5.1

2.8

—

(3000492) Spirometry study

118

1.11

0.07

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

226

1.07

0.07

1.5

1.6

—

(40761511) CBC panel - Blood by Automated count

140

1415

0.95

0.06

25.3

14.2

—

(3013512) EKG study

415

0.95

0.06

3.6

4.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

130

1.08

0.04

1.4

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

368

1.04

0.04

4.6

18.9

22.0

0.58

185

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

146

1449

1.04

0.04

17.4

10.2

24.3

25.6

u/l

0.54

141

1389

(3041096) Erythrocytes [Presence] in Urine by Automated

390

0.97

0.03

3.6

3.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

145

1441

1.03

0.02

35.5

17.3

94.1

79.1

umol/l

1.30

145

1441

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

137

1361

1.03

0.02

5.2

5.0

2.5

2.7

mmol/l

1.54

125

1246

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

173

1.04

0.01

1.2

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

183

1.04

0.01

14.4

8.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

101

0.99

0.00

1.7

1.4

—

(40768797) Stomach Pathology biopsy report

179

1.01

0.00

1.4

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

133

1326

1.01

0.00

4.6

4.5

4.4

4.6

mmol/l

0.76

121

1220

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

117

1.03

0.00

2.1

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

217

1.02

0.00

3.5

3.0

4.0

2.7

e6/l

—

126

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

127

1265

1.01

0.00

4.1

4.0

1.3

mmol/l

0.04

118

1148

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

128

1.02

0.00

2.0

2.1

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.94

0.00

1.4

2.7

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.8

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(44813793)

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3017732) Neutrophils [#/volume] in Blood

0.98

0.00

1.9

2.6

3.6

3.4

e9/l

—

(3022689) Creatine [Moles/volume] in Urine

0.00

0.0

1.6

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.4

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

1.8

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.6

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

18.6

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

100

1.00

0.00

2.9

2.3

11.2

13.5

nmol/l

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.89

0.00

1.8

2.1

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.8

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUFEVHRT and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_RHEUFEVHRT	1.944 [1.55, 2.44]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.117

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 399 females with I9_RHEUFEVHRT died.

Males

Parameter	HR [95% CI]	p-value
I9_RHEUFEVHRT	1.889 [1.43, 2.5]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 376 males with I9_RHEUFEVHRT died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUFEVHRT.

N-year risk	Females	Males
1	0.185%	0.435%
5	1.056%	2.189%
10	2.706%	5.49%
15	5.191%	10.508%
20	8.884%	17.473%

Relationships between endpoints

↥

Index endpoint: I9_RHEUFEVHRT – Rheumatic fever with heart involvement

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rheumatic fever with heart involvement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints