tricuspid valve disease: A disease involving the tricuspid valve.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
923 |
4. Check minimum number of eventsNone |
923 |
5. Include endpointsNone |
923 |
6. Filter based on genotype QC (FinnGen only) |
923 |
Control definitions (FinnGen only)
- Control exclude
- I9_RHEUFEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic valve diseases
based on the number of shared cases.
Similar with more cases:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16608 | 8594 | 7551 |
| Only index persons | 6507 | 3468 | 3039 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.25 | 0.21 |
| Only index persons | 0.12 | 0.13 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 64.36 | 67.55 | 60.72 |
| Only index persons | 57.15 | 61.05 | 52.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 923 | 398 | 525 |
| Unadjusted period prevalence (%) | 0.19 | 0.14 | 0.23 |
| Median age at first event (years) | 56.39 | 51.98 | 59.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 848
- Matched controls
- 8481
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
2624.9
205.9
191
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
23.6
134.1
197
107
B01AA03
ATC
warfarin; systemic
5.5
115.1
498
1737
I35.0
ICD-10 Finland
Aortic (valve) stenosis
6.8
80.7
227
430
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.3
77.0
231
474
5273
FHL
Repair with flap prosthesis or graft
173.9
76.4
79
5
C01AA05
ATC
digoxin; systemic
4.9
75.2
302
867
I05.0
ICD-10 Finland
Mitral stenosis
+∞
74.1
70
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.5
70.8
306
936
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
70.8
67
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
11.4
68.0
133
136
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
8.1
65.2
157
231
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
62.3
59
*
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
62.3
59
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.3
55.3
414
1914
C03CA01
ATC
furosemide; systemic
3.0
51.9
500
2715
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
11.8
50.0
95
90
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
49.5
47
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
20.9
48.8
73
38
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
48.4
46
*
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
47.3
45
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.2
47.3
121
191
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
49.8
46.6
56
12
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
46.3
44
*
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
46.3
44
*
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
45.2
43
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.2
45.0
311
1309
5253
FHL
Cardiac lung machine
14.8
44.2
75
55
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.7
40.2
123
244
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
59.3
38.7
45
8
I50.0
ICD-10 Finland
Congestive heart failure
3.6
37.9
201
681
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
36.7
35
*
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
36.7
35
*
XF640
NOMESCO Finland
NA
7.4
35.8
89
133
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
35.7
34
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
6.2
35.5
100
178
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
24.1
35.2
50
22
K83
ICPC
Heart valve disease NOS
18.8
34.5
53
30
C03DA01
ATC
spironolactone; oral
3.4
34.3
192
674
I34.1
ICD-10 Finland
Mitral (valve) prolapse
8.8
31.9
70
86
C07AA07
ATC
sotalol; systemic
4.5
30.4
114
280
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
30.4
29
*
81
HP
Angiography of the heart and coronary arteries
3.6
29.7
147
464
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
50.5
28.6
34
7
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
28.3
27
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
5.2
27.6
89
186
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
27.2
235
1077
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
26.9
263
1288
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
26.2
25
*
207
Kela drug reimbursment
Chronic arrhythmias
2.7
26.0
218
978
62
HP
Catheterization and pressure measurement of the right side of the heart
31.1
25.2
33
11
C07AB07
ATC
bisoprolol; oral
2.1
25.0
493
3337
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
257.3
24.8
25
*
I50.1
ICD-10 Finland
Left ventricular failure
3.6
24.1
119
372
TFP20
NOMESCO Finland
Cardiodefibrillation
3.7
23.6
112
339
21
HP
Aortic Valve Replacement (AVR)
34.5
23.5
30
9
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
46.4
22.5
27
6
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
22.0
21
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
32.1
21.6
28
9
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
11.0
21.6
41
39
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.7
21.3
99
294
AN1
HP
Coronary angiography
2.6
20.2
166
726
B01AB05
ATC
enoxaparin; parenteral
2.1
20.2
280
1587
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
24.1
20.1
28
12
5284
FHL
Mitral defect correction with flap prosthesis or graft
+∞
19.9
19
*
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
19.9
19
*
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
19.9
19
*
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.2
19.5
110
379
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
6.6
19.2
50
80
61
HP
Catheterization and pressure measurement of the left side of the heart
5.3
18.5
57
113
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
17.8
17
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
9.8
17.0
34
36
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
16.9
380
2552
C07AB02
ATC
metoprolol; systemic
2.0
16.9
278
1665
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
7.0
16.7
41
61
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
20.5
16.5
24
12
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
5.5
16.3
48
91
AP2
HP
Catheterization of the right side of the heart
30.7
16.2
21
7
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
7.3
16.0
38
54
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
15.7
15
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
6.6
15.7
40
63
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
4.9
15.4
51
110
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
32.3
14.8
19
6
AC2
HP
MVR bio
57.7
14.8
17
*
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.7
240
1419
K78
ICPC
Atrial fibrillation/flutter
2.7
14.6
109
446
J01DA01
ATC
[U] cefalexin; systemic
1.8
14.5
519
3983
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.4
14.5
72
226
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.2
14.2
76
252
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.7
14.2
104
421
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.2
14.1
77
259
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.5
14.1
118
514
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
54.3
13.8
16
*
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
13.6
13
*
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
13.6
13
*
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
5.7
13.4
38
69
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
21.6
13.4
19
9
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
8.7
13.3
28
33
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
13.2
191
1070
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
50.8
12.9
15
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.1
12.7
71
240
22
HP
Mitral valve Replacement (MVR)
70.9
12.6
14
*
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
12.5
12
*
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
12.5
12
*
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
AB2
HP
AVR bio, stent
7.8
12.5
28
37
M04AA01
ATC
allopurinol; systemic
2.0
12.5
168
915
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
12.2
164
890
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
14.9
11.8
19
13
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
11.5
11
*
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
11.5
11
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
5.6
11.3
32
59
C01BD01
ATC
amiodarone; systemic
3.7
11.2
49
140
A12BA01
ATC
potassium chloride; oral
2.4
11.1
95
419
K84
ICPC
Heart disease other
4.1
10.9
42
107
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
10.9
431
5329
25
HP
Valve and coronary artery bypass surgery
21.8
10.7
15
7
I50
ICD-10 Finland
Heart failure
3.0
10.6
60
207
WX872
NOMESCO Finland
Intensive care
3.1
10.5
59
202
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
10.4
10
*
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
+∞
10.4
10
*
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
16.3
10.4
16
10
J01CA04
ATC
amoxicillin; systemic
1.7
10.4
583
4844
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.3
10.3
98
456
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
10.1
274
1873
C08DA01
ATC
verapamil; systemic
2.8
10.0
63
235
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
9.8
225
1465
C02EA02
ATC
NA
2.4
9.8
81
352
J01FF01
ATC
clindamycin; systemic
1.8
9.8
204
1287
4289X
ICD-9 Finland
Heart failure, unspecified
5.3
9.6
28
54
XFE00
NOMESCO Finland
Epicardial ultrasonography
3.6
9.6
42
121
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
9.5
35
86
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
C09AA02
ATC
enalapril; systemic
1.7
9.3
216
1407
AP3
HP
Catheterization of the right and left side of the heart
18.8
8.9
13
7
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
8.9
242
1645
R50.9
ICD-10 Finland
Fever, unspecified
2.0
8.9
125
685
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
6.4
8.8
22
35
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
14.2
8.7
14
10
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
8.7
274
1935
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
8.3
8.6
18
22
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
8.6
231
1564
XF404
NOMESCO Finland
Ambulatory ECG
2.2
8.5
90
439
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
8.5
286
2051
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.5
148
876
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
90.9
8.4
9
*
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
+∞
8.3
8
*
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
8.3
8
*
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
14.6
8.2
13
9
AB1
HP
AVR mechanical
17.4
8.1
12
7
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
8.1
117
649
J01FA06
ATC
roxithromycin; oral
1.6
8.0
300
2202
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
22.3
8.0
11
5
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
5.6
8.0
22
40
R04.0
ICD-10 Finland
Epistaxis
2.2
7.9
81
390
J01FA10
ATC
azithromycin; systemic
1.5
7.8
346
2637
24
HP
Multi-valve repair or other valve surgery
45.4
7.7
9
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.6
7.6
238
1669
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.7
7.5
48
181
R05FB02
ATC
cough suppressants and expectorants
1.5
7.5
306
2286
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
7.4
72
340
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
80.8
7.4
8
*
23
HP
Mitral valve plasty
80.8
7.4
8
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
13.5
7.4
12
9
C01DA14
ATC
isosorbide mononitrate; oral
1.6
7.4
223
1546
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.5
7.4
55
228
I44.2
ICD-10 Finland
Atrioventricular block, complete
2.8
7.3
44
161
C01BA03
ATC
disopyramide; systemic
5.2
7.3
21
41
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
4.9
7.2
22
46
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
30.3
7.2
9
*
Z94.1
ICD-10 Finland
Heart transplant status
30.3
7.2
9
*
42799
ICD-8 Finland
Symptomatic heart disease, Other and unspecified disorders or heart rhythm
30.3
7.2
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
7.1
118
686
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
7.1
87
455
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
6.9
44
164
73
HP
Initial pacemaker installation
5.5
6.9
19
35
R07.3
ICD-10 Finland
Other chest pain
2.1
6.9
79
399
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
6.9
55
236
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
7.6
6.9
15
20
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
4.0
6.9
26
67
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
4.4
6.9
23
53
L04AA01
ATC
[U] ciclosporin; systemic
5.7
6.8
18
32
AD1
HP
TVP
40.4
6.8
8
*
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
40.4
6.8
8
*
5311
FHL
Bypass surgery in one vein
16.8
6.8
10
6
ZXD05
NOMESCO Finland
Urgent procedure
1.5
6.7
255
1861
I42.0
ICD-10 Finland
Dilated cardiomyopathy
3.2
6.7
33
106
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.8
6.7
40
146
N18.8
ICD-10 Finland
Other chronic renal failure
3.3
6.7
32
101
L04AX01
ATC
azathioprine; systemic
3.1
6.6
34
113
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.3
6.6
31
97
Z2221
NOMESCO Finland
Medical doctor
1.6
6.5
202
1406
K92.1
ICD-10 Finland
Melaena
2.3
6.5
57
257
116
Kela drug reimbursment
Prostate cancer
0.3
6.4
13
426
J01MA12
ATC
levofloxacin; systemic
1.6
6.4
158
1037
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
6.4
67
328
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.4
6.4
49
208
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.3
6.4
30
94
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
6.6
6.4
15
23
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.8
6.3
39
146
L04AA06
ATC
mycophenolic acid; systemic
5.2
6.3
18
35
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
6.3
239
1738
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
4.0
6.3
23
58
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
11.1
6.3
11
10
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
6.3
6
*
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
6.3
6
*
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.3
252
1860
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
6.2
128
800
H02AB06
ATC
prednisolone; systemic
1.4
6.1
348
2758
AC4
HP
MVP
8.7
6.1
12
14
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
8.7
6.1
12
14
N19
ICD-10 Finland
Unspecified kidney failure
2.6
6.0
41
163
TFN04
NOMESCO Finland
NA
6.8
6.0
14
21
N05CF01
ATC
zopiclone; oral
1.5
6.0
287
2193
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUVALV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUVALV | 2.207 [1.98, 2.46] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.169 |
During the follow-up period (1.1.1998 — 31.12.2019), 1537 out of 2635 females with I9_RHEUVALV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUVALV | 2.004 [1.75, 2.29] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 2107 males with I9_RHEUVALV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUVALV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | 0.411% |
| 5 | 1.219% | 2.429% |
| 10 | 2.95% | 6.713% |
| 15 | 5.653% | 11.989% |
| 20 | 10.282% | 19.825% |
Relationships between endpoints
↥Index endpoint: I9_RHEUVALV – Rheumatic valve diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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