tricuspid valve disease: A disease involving the tricuspid valve.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
925 |
4. Check minimum number of eventsNone |
925 |
5. Include endpointsNone |
925 |
6. Filter based on genotype QC (FinnGen only) |
877 |
Control definitions (FinnGen only)
- Control exclude
- I9_RHEUFEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic valve diseases
based on the number of shared cases.
Similar with more cases:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16608 | 8594 | 7551 |
| Only index persons | 6507 | 3468 | 3039 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.25 | 0.21 |
| Only index persons | 0.12 | 0.13 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 64.36 | 67.55 | 60.72 |
| Only index persons | 57.15 | 61.05 | 52.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 877 | 374 | 503 |
| Unadjusted period prevalence (%) | 0.19 | 0.13 | 0.23 |
| Median age at first event (years) | 56.60 | 52.18 | 59.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 925
- Matched controls
- 9250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
28.4
316.2
226
104
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
+∞
225.5
207
*
B01AA03
ATC
warfarin; systemic
5.7
152.1
552
1915
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.9
141.0
268
517
I35.0
ICD-10 Finland
Aortic (valve) stenosis
6.7
128.3
243
464
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
63.0
125.8
70
12
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
10.0
118.1
145
168
C01AA05
ATC
digoxin; systemic
4.9
110.0
333
954
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
13.3
109.1
108
91
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
21.1
108.0
83
43
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
7.3
105.4
173
282
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.8
93.7
141
208
5253
FHL
Cardiac lung machine
15.0
92.3
84
61
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.2
91.4
356
1211
K83
ICPC
Heart valve disease NOS
22.8
83.9
62
29
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
30.7
83.0
55
19
I05.0
ICD-10 Finland
Mitral stenosis
+∞
80.4
76
*
XF640, ,
NOMESCO Finland
9.0
80.1
104
128
5273
FHL
Repair with flap prosthesis or graft
149.7
78.3
82
6
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
6.1
76.6
148
281
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
7.8
75.2
111
159
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
75.0
71
*
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
72.9
69
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.4
72.7
466
2133
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
63.3
60
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.2
60.9
360
1537
I34.1
ICD-10 Finland
Mitral (valve) prolapse
8.5
60.9
82
105
I50.0
ICD-10 Finland
Congestive heart failure
3.7
57.5
230
768
C03CA01
ATC
furosemide; systemic
3.0
56.8
567
3202
62
HP
Catheterization and pressure measurement of the right side of the heart
24.5
55.9
40
17
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
55.8
53
*
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
55.8
53
*
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
53.7
51
*
C07AA07
ATC
sotalol; systemic
4.9
50.3
121
276
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
49.4
47
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
5.6
49.0
99
194
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
13.8
48.8
46
35
C03DA01
ATC
spironolactone; oral
3.3
48.7
231
851
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
48.4
46
*
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
47.3
45
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
14.7
45.3
41
29
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
42.0
40
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
9.6
41.6
50
55
81
HP
Angiography of the heart and coronary arteries
3.5
41.5
162
525
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
40.9
39
*
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
39.9
38
*
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
59.0
38.7
45
8
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
7.6
37.2
54
75
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
7.2
36.4
55
80
I50.1
ICD-10 Finland
Left ventricular failure
3.6
36.3
135
422
61
HP
Catheterization and pressure measurement of the left side of the heart
5.8
34.1
65
120
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
34.0
302
1514
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
33.5
32
*
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
32.5
31
*
207
Kela drug reimbursment
Chronic arrhythmias
2.5
32.0
251
1183
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
90.9
31.9
35
*
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
90.9
31.9
35
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.4
29.6
114
363
21
HP
Aortic Valve Replacement (AVR)
58.7
29.3
34
6
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
6.8
28.8
46
71
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
28.3
27
*
TFP20
NOMESCO Finland
Cardiodefibrillation
3.2
27.9
124
431
AN1
HP
Coronary angiography
2.6
26.5
178
772
C01BD01
ATC
amiodarone; systemic
5.0
26.3
58
122
AB2
HP
AVR bio, stent
10.0
26.0
30
31
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
26.0
263
1372
C07AB07
ATC
bisoprolol; oral
2.1
25.6
560
3913
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
5.1
25.1
54
111
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
25.1
24
*
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
133.6
24.7
26
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
44.2
24.7
30
7
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
8.9
24.6
31
36
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
24.6
222
1100
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
6.7
24.4
39
60
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.0
24.3
118
430
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
24.1
23
*
C07AB02
ATC
metoprolol; systemic
2.1
23.9
303
1721
B01AB05
ATC
enoxaparin; parenteral
2.1
23.6
322
1877
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
23.1
124
477
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
23.0
22
*
5284
FHL
Mitral defect correction with flap prosthesis or graft
235.6
22.7
23
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.4
22.3
84
263
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
20.9
20
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.2
20.7
86
286
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
16.8
19.7
31
19
K84
ICPC
Heart disease other
4.5
19.7
49
114
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
19.4
202
1051
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
18.8
81
275
K78
ICPC
Atrial fibrillation/flutter
2.5
18.7
126
542
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
25.6
18.3
25
10
WX872
NOMESCO Finland
Intensive care
3.3
17.9
71
229
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
4.0
17.6
51
133
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
96.9
17.6
19
*
AC2
HP
MVR bio
183.4
17.6
18
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
4.2
17.2
46
113
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
16.7
16
*
M04AA01
ATC
allopurinol; systemic
2.1
16.6
192
1035
AP2
HP
Catheterization of the right side of the heart
25.0
16.1
22
9
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.9
16.0
81
301
L04AA06
ATC
mycophenolic acid; systemic
7.3
15.7
23
32
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
15.7
15
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
15.5
62
201
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
4.1
15.4
42
105
C02EA02, ,
ATC
2.7
15.4
88
349
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
15.2
126
593
XF404
NOMESCO Finland
Ambulatory ECG
2.5
15.1
105
457
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
32.3
14.8
19
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
14.8
39
95
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.4
14.7
113
515
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
14.6
14
*
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
14.6
14
*
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
14.6
14
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
36.7
14.5
18
5
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
14.3
471
5921
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
6.3
14.3
24
39
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
14.1
429
3104
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
30.5
13.9
18
6
A12BA01
ATC
potassium chloride; oral
2.4
13.8
104
469
C09AA02
ATC
enalapril; systemic
1.8
13.8
242
1494
R04.0
ICD-10 Finland
Epistaxis
2.4
13.7
101
452
4289X
ICD-9 Finland
Heart failure, unspecified
4.9
13.6
30
63
22
HP
Mitral valve Replacement (MVR)
76.3
13.6
15
*
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
13.6
13
*
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
+∞
13.6
13
*
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
13.6
13
*
C08DA01
ATC
verapamil; systemic
2.7
13.6
75
292
J01DA01
ATC
[U] cefalexin
1.7
13.2
566
4458
I50
ICD-10 Finland
Heart failure
2.8
13.0
66
246
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
19.4
12.9
19
10
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
11.8
12.9
23
20
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
12.4
270
1769
R50.9
ICD-10 Finland
Fever, unspecified
2.0
12.3
148
804
25
HP
Valve and coronary artery bypass surgery
21.6
12.0
17
8
J01FF01
ATC
clindamycin; systemic
1.8
12.0
229
1441
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
16.7
11.7
18
11
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
11.5
11
*
24
HP
Multi-valve repair or other valve surgery
+∞
11.5
11
*
AD1
HP
TVP
35.5
11.3
14
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
11.2
306
2120
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
11.0
254
1682
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
4.9
11.0
24
50
J01CA04
ATC
amoxicillin; systemic
1.7
11.0
653
5462
C01BA03
ATC
disopyramide; systemic
5.2
10.8
22
43
ZXD05
NOMESCO Finland
Urgent procedure
1.7
10.8
285
1953
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
4.6
10.8
25
55
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
21.7
10.7
15
7
C02EA01, ,
ATC
4.2
10.7
28
68
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.9
10.6
51
184
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
11.4
10.6
19
17
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.6
10.6
62
249
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
10.4
10
*
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
+∞
10.4
10
*
C01BA01
ATC
quinidine; oral
5.4
10.1
20
38
127
Kela drug reimbursment
Transplant complication
8.6
10.1
21
25
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
10.0
65
274
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.6
10.0
33
95
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
16.9
9.9
15
9
I42.0
ICD-10 Finland
Dilated cardiomyopathy
3.2
9.8
38
121
TK800
NOMESCO Finland
Hemodialysis
4.1
9.8
27
68
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
55.6
9.7
11
*
PD5AD
NOMESCO Finland
CT of aorta
3.8
9.5
29
79
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
9.5
134
766
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
2.8
9.4
48
179
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
101.0
9.4
10
*
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
9.2
260
1802
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.2
8.8
34
108
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.8
8.8
26
69
J01MA12
ATC
levofloxacin; systemic
1.7
8.8
183
1170
GD1LA
NOMESCO Finland
GD
4.2
8.8
23
56
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.7
8.7
48
187
L04AA01
ATC
[U] ciclosporin
7.7
8.7
19
25
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
3.8
8.7
26
70
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
8.6
296
2141
J01FA10
ATC
azithromycin; systemic
1.5
8.6
383
2934
K99
ICPC
Cardiovascular disease other
3.1
8.5
36
121
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
8.5
311
2280
I44.2
ICD-10 Finland
Atrioventricular block, complete
2.5
8.5
51
207
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
8.4
316
2331
Z2221
NOMESCO Finland
Medical doctor
1.6
8.4
229
1570
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
8.3
8
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
8.3
89
463
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.9
8.2
38
135
Z94.1
ICD-10 Finland
Heart transplant status
22.2
8.0
11
5
I49.5
ICD-10 Finland
Sick sinus syndrome
2.3
8.0
61
277
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
7.9
56
246
C01DA14
ATC
isosorbide mononitrate; oral
1.6
7.9
245
1728
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.8
173
1122
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
15.2
7.7
12
8
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
7.7
258
1848
I38
ICD-10 Finland
Endocarditis, valve unspecified
18.5
7.6
11
6
AP3
HP
Catheterization of the right and left side of the heart
12.0
7.6
13
11
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
7.5
129
781
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
4.5
7.5
18
41
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.2
7.4
28
88
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
80.7
7.4
8
*
H02AB06
ATC
prednisolone; systemic
1.5
7.4
398
3141
N05CF01
ATC
zopiclone; oral
1.5
7.4
323
2447
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
8.5
7.3
15
18
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.3
203
1391
TFN04, ,
NOMESCO Finland
6.9
7.3
17
25
AC4
HP
MVP
11.0
7.3
13
12
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.3
7
*
I07.9
ICD-10 Finland
Tricuspid valve disease, unspecified
+∞
7.3
7
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.2
271
1985
J01FA06
ATC
roxithromycin; oral
1.5
7.2
334
2554
L04AX01
ATC
azathioprine; systemic
2.7
7.2
37
139
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
3.7
7.2
22
60
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.2
7.2
57
263
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.2
243
1741
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
30.3
7.2
9
*
5311
FHL
Bypass surgery in one vein
20.2
7.1
10
5
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
7.1
73
373
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
8.0
7.1
15
19
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.6
7.1
41
164
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
7.1
179
1199
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.9
7.0
20
52
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
7.0
83
447
H02AB07
ATC
prednisone; oral
1.7
7.0
135
845
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
3.7
6.9
21
57
A41.9
ICD-10 Finland
Sepsis, unspecified
2.4
6.9
47
203
N05BA01
ATC
diazepam; systemic, rectal
1.7
6.9
122
744
Z3231
NOMESCO Finland
Registered nurse
1.5
6.9
235
1686
73
HP
Initial pacemaker installation
3.8
6.8
20
53
AB1
HP
AVR mechanical
11.0
6.8
12
11
I97.0
ICD-10 Finland
Postcardiotomy syndrome
11.0
6.8
12
11
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
5.7
6.8
18
32
C09AA01
ATC
captopril; oral
2.6
6.8
37
144
I34
ICD-10 Finland
Nonrheumatic mitral valve disorders
22.7
6.7
9
*
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.1
6.7
27
89
L04AD01
ATC
ciclosporin; systemic
5.5
6.6
18
33
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.6
147
953
I47.2
ICD-10 Finland
Ventricular tachycardia
3.2
6.6
25
79
42799
ICD-8 Finland
Symptomatic heart disease, Other and unspecified disorders or heart rhythm
12.4
6.6
11
9
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.6
95
546
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
70.3
6.4
7
*
XFP02, ,
NOMESCO Finland
14.4
6.4
10
7
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.0
6.4
65
332
Z94.0
ICD-10 Finland
Kidney transplant status
8.2
6.3
13
16
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.5
6.3
21
61
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
6.3
318
2460
N05CD07
ATC
temazepam; oral
1.6
6.3
150
989
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
42401
ICD-8 Finland
Chronic disease of endocardium, Mitralis, operata
+∞
6.3
6
*
AC1
HP
MVR mechanical
26.9
6.2
8
*
ZX120
NOMESCO Finland
Intravenous
1.9
6.2
83
466
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
6.3
6.2
15
24
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
6.1
79
438
X57
ICD-10 Finland
Unspecified privation
3.1
6.1
25
83
Q21.10
ICD-10 Finland
Persistent ostium secundum
12.6
6.1
10
8
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
8.7
6.1
12
14
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.7
6.0
31
117
250, ,
Kela drug reimbursment
5.2
6.0
17
33
R02
ICPC
Shortness of breath/dyspnoea
1.7
6.0
108
661
K80
ICPC
Cardiac arrhythmia NOS
2.0
6.0
63
325
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
81
251
3.44
21.81
5.0
2.3
0.32
0.37
u/ml
0.65
54
142
359
2341
1.87
17.98
5.2
3.1
2671.87
2125.59
ng/l
1.01
328
1997
122
607
2.16
12.82
11.5
6.4
13.29
11.58
mmol/l
1.43
110
575
79
346
2.40
11.20
2.5
1.8
1.21
1.58
g/l
2.15
53
302
120
660
1.94
9.52
3.6
3.1
327.63
268.08
ng/l
0.55
110
599
439
3429
1.53
9.17
74.9
18.8
2.03
1.38
inr
12.65
111
966
137
801
1.83
8.99
3.6
3.6
298.88
249.41
u/l
2.24
131
747
53
223
2.46
8.23
2.3
3.2
0.92
0.89
nmol/l
0.11
38
177
161
1019
1.70
8.00
4.2
2.3
2.29
2.27
g/l
0.12
147
935
173
1120
1.67
7.90
4.1
2.3
10.88
12.01
umol/l
1.76
155
1034
114
668
1.81
7.40
2.3
2.6
14.60
6.28
ug/l
1.22
97
560
151
964
1.68
7.24
4.5
2.4
19.48
21.56
%
1.20
133
830
56
276
2.10
6.05
3.6
5.1
25.23
25.14
mmol/l
0.10
48
259
41
178
2.36
6.00
2.3
1.5
—
—
—
0
0
586
6565
0.71
5.80
41.2
24.5
129.17
132.20
g/l
4.26
571
6408
586
6562
0.71
5.75
40.9
24.3
4.34
4.38
e12/l
0.90
569
6323
586
6561
0.71
5.73
40.9
24.3
224.27
239.71
e9/l
6.19
569
6349
586
6558
0.71
5.69
41.8
24.4
38.89
39.15
%
0.52
547
6021
37
158
2.40
5.63
2.5
2.5
3.74
3.67
g/l
0.11
37
149
126
828
1.60
5.35
9.1
6.0
1.08
1.22
mmol/l
0.14
94
634
136
911
1.58
5.32
8.9
5.0
1.07
1.03
mmol/l
0.74
119
819
25
93
2.74
5.04
8.6
6.3
240.60
399.93
iu/ml
—
5
14
130
880
1.56
4.86
3.3
2.4
1.73
1.80
%
0.38
115
771
124
831
1.57
4.84
9.0
5.9
5.21
5.05
kpa
0.95
112
781
124
832
1.57
4.82
9.0
5.9
11.86
11.52
kpa
0.22
112
785
65
369
1.82
4.72
13.3
7.6
24.21
24.46
mmol/l
0.22
57
348
45
227
2.03
4.63
4.2
3.2
71.46
84.38
mg/l
0.18
34
180
45
228
2.02
4.57
4.2
3.2
40.16
49.40
mg/l
0.29
34
182
74
442
1.73
4.53
3.6
4.3
1.93
2.17
mmol/l
0.24
53
327
22
82
2.72
4.44
1.3
1.3
—
—
—
0
0
94
604
1.62
4.38
10.9
5.6
1.28
1.51
mmol/l
1.49
89
582
36
171
2.15
4.34
1.7
1.4
—
—
—
0
0
346
2860
1.34
4.22
8.7
5.6
23.73
25.96
%
3.05
318
2647
36
173
2.12
4.22
1.2
1.4
—
—
—
0
0
36
173
2.12
4.22
1.2
1.4
—
—
—
0
0
338
2804
1.32
3.97
8.5
5.3
61.00
58.77
%
2.71
311
2602
569
6267
0.76
3.87
14.0
10.4
24.26
24.90
u/l
0.47
544
5974
75
471
1.64
3.85
3.7
4.2
5.25
5.16
kpa
0.32
67
452
20
77
2.63
3.82
3.1
2.7
—
834.63
—
0
8
519
5762
0.77
3.59
5.4
5.0
2.46
2.59
mmol/l
2.77
477
5155
11
27
4.11
3.40
1.8
1.9
—
—
—
0
0
573
6265
0.78
3.39
33.8
20.1
4.03
4.01
mmol/l
1.30
555
6046
31
155
2.03
3.33
2.9
2.3
84.35
89.33
%
0.61
31
150
233
1875
1.32
3.29
2.9
2.2
3.66
3.23
mg/l
1.74
206
1586
513
5676
0.78
3.29
5.1
4.7
6.09
6.08
mmol/l
0.07
464
5011
573
6255
0.78
3.28
33.5
20.0
139.19
139.53
mmol/l
2.13
556
6041
500
5546
0.79
3.25
4.7
4.4
1.36
1.43
mmol/l
3.32
456
4958
69
444
1.60
3.24
1.5
1.4
—
—
—
0
0
27
130
2.11
3.20
2.1
1.5
—
—
—
0
0
493
5469
0.79
3.16
6.4
6.2
41.19
41.04
mmol/mol
0.11
453
4951
507
5603
0.79
3.13
4.7
4.4
4.24
4.46
mmol/l
4.23
466
5048
10
25
4.03
3.09
1.7
4.1
97.60
97.36
%
—
10
25
55
339
1.66
3.08
4.5
3.6
23.70
23.76
mmol/l
0.05
50
326
88
611
1.49
2.96
2.7
2.5
65.69
65.93
g/l
0.10
81
539
153
1957
0.74
2.95
4.2
4.5
21.66
21.89
%
0.07
73
998
24
116
2.10
2.85
1.4
1.6
—
—
—
0
0
485
5357
0.80
2.83
4.4
3.9
1.29
1.26
mmol/l
0.35
443
4743
159
1238
1.34
2.80
1.7
1.8
—
—
—
0
0
138
1052
1.37
2.78
5.1
3.0
0.83
0.82
mmol/l
0.63
127
977
200
2444
0.77
2.76
4.2
5.2
2.92
3.77
ug/l
0.55
174
2142
323
2786
1.24
2.55
6.2
4.1
67.64
57.40
ng/l
0.25
248
2112
116
876
1.37
2.49
1.5
1.8
—
—
—
0
0
76
532
1.47
2.49
5.6
3.6
142.04
92.73
ng/l
1.37
65
455
305
2620
1.24
2.48
4.2
2.7
168.70
143.27
ug/l
0.55
284
2349
189
1538
1.29
2.42
3.4
2.4
—
—
—
0
0
20
97
2.09
2.38
1.4
1.3
13577.67
103154.66
e6/l
0.83
12
59
5
8
6.28
2.37
1.2
1.1
95.60
96.75
%
—
5
8
116
884
1.36
2.36
1.6
1.8
—
—
—
0
0
81
581
1.43
2.35
6.2
2.9
4.21
4.39
kpa
0.40
76
553
146
1153
1.32
2.34
3.8
2.9
1.21
1.18
e6/l
0.03
84
672
9
28
3.24
2.31
1.4
1.3
—
—
—
0
0
9
28
3.24
2.31
1.4
1.3
—
—
—
0
0
9
28
3.24
2.31
1.9
1.9
—
—
—
0
0
9
28
3.24
2.31
1.9
1.9
—
—
—
0
0
99
742
1.37
2.24
2.5
2.8
11.36
9.66
umol/l
0.28
80
640
24
128
1.90
2.23
1.5
1.4
27.79
30.22
g/l
0.67
18
112
9
29
3.12
2.23
1.9
1.9
—
—
—
0
0
565
6065
0.82
2.15
28.4
16.8
23.50
27.01
mg/l
2.21
508
4966
7
19
3.70
2.15
1.0
1.1
—
—
—
0
0
92
688
1.37
2.12
6.6
3.5
1.55
2.02
mmol/l
0.69
78
532
68
482
1.44
2.12
3.5
2.9
58.34
59.32
ml/min/173m2
0.09
38
216
139
1107
1.30
2.10
3.9
3.2
1.86
2.16
e6/l
0.22
76
631
191
1585
1.26
2.08
5.4
3.9
64.85
84.41
%
11.96
186
1551
92
692
1.37
2.05
6.6
3.5
5.96
5.80
kpa
0.74
87
663
388
3473
1.20
2.02
10.2
8.2
4.53
4.34
e9/l
0.66
330
3011
29
170
1.73
2.02
1.3
1.4
—
—
—
0
0
167
1369
1.27
2.01
5.1
4.0
223.52
236.47
ng/l
0.05
149
1168
11
44
2.52
2.01
2.1
1.6
—
—
—
0
0
399
4405
0.83
1.99
4.3
3.8
15.19
15.01
pmol/l
0.71
355
3874
24
134
1.81
1.97
1.2
1.2
—
—
—
0
0
26
149
1.77
1.96
1.4
1.6
—
—
—
0
0
193
1616
1.25
1.94
3.9
2.7
4058.81
8009.58
umol/l
0.73
161
1361
27
157
1.74
1.94
1.4
1.6
—
—
—
0
0
6
16
3.77
1.93
2.0
1.3
—
—
—
0
0
344
3060
1.20
1.89
9.1
5.4
1.20
1.21
mmol/l
1.63
311
2742
502
5414
0.84
1.87
5.1
4.6
2.14
1.99
mu/l
1.57
452
4810
140
1134
1.28
1.87
1.4
1.3
1.12
1.30
u/ml
0.15
34
290
78
582
1.37
1.85
2.3
2.3
37.24
32.85
u/l
0.40
63
489
74
549
1.38
1.82
1.8
1.6
—
—
—
0
0
7
23
3.06
1.80
1.4
1.5
558.29
906.96
u/ml
—
7
23
42
280
1.52
1.80
1.5
1.9
—
—
—
0
0
30
186
1.63
1.74
2.3
1.5
—
—
—
0
0
112
1389
0.78
1.70
2.8
3.2
0.81
0.83
ug/l
0.11
77
955
20
112
1.80
1.65
1.6
1.3
1200.83
1384.53
e6/l
0.10
12
78
5
131
0.38
1.63
1.6
1.5
572.60
299.74
mu/l
—
5
121
114
1395
0.79
1.56
2.5
3.1
2.45
2.46
mmol/l
0.23
82
1195
17
93
1.84
1.52
1.3
1.8
88.21
89.85
%
0.44
17
93
472
5065
0.86
1.49
32.7
19.7
16.24
15.17
%
2.82
461
4961
9
38
2.38
1.46
2.0
2.4
—
—
—
0
0
9
38
2.38
1.46
1.9
1.8
—
—
—
0
0
9
38
2.38
1.46
1.9
1.8
—
—
—
0
0
15
80
1.89
1.45
3.9
3.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
16
3.14
1.44
1.0
1.3
103.40
108.94
%
—
5
16
280
2498
1.17
1.43
4.7
3.4
—
—
—
0
0
7
29
2.42
1.39
1.1
1.1
—
—
—
0
0
92
737
1.28
1.38
4.7
4.6
31.81
32.48
%
0.23
74
465
9
41
2.21
1.37
1.4
1.3
—
—
—
0
0
9
41
2.21
1.37
1.4
1.3
—
—
—
0
0
367
3360
1.15
1.32
7.0
5.8
14.34
12.23
umol/l
2.00
343
3156
62
474
1.33
1.31
1.6
1.7
—
—
—
0
0
419
3877
1.15
1.29
7.2
4.5
6.87
6.87
mmol/l
0.01
393
3638
16
91
1.77
1.29
1.5
1.2
—
—
—
0
0
11
55
2.01
1.27
1.1
1.1
—
—
—
0
0
8
35
2.30
1.27
2.0
1.3
—
—
—
0
0
16
92
1.75
1.25
3.4
1.9
31.94
32.88
pg
0.37
16
92
5
117
0.42
1.25
1.4
1.2
3.76
3.85
mmol/l
—
5
110
285
3143
0.87
1.25
2.8
2.7
—
—
—
0
0
6
25
2.41
1.24
6.3
3.3
—
—
—
0
0
6
25
2.41
1.24
6.3
3.3
—
—
—
0
0
47
348
1.37
1.23
9.5
3.7
48.10
47.13
%
0.10
47
342
11
56
1.98
1.22
1.1
1.7
—
—
—
0
0
7
143
0.49
1.21
1.0
1.1
—
9.54
—
0
15
12
64
1.89
1.18
1.8
1.9
—
—
—
0
0
215
1907
1.17
1.17
3.5
3.1
36.55
34.94
u/l
0.13
201
1808
365
3364
1.14
1.17
9.8
6.2
1.21
1.21
mmol/l
0.84
307
2817
8
41
1.96
1.09
1.0
1.2
—
—
—
0
0
520
5478
0.88
1.08
24.3
15.9
70.58
73.63
ml/min/173m2
1.88
442
4518
15
89
1.70
1.08
1.1
1.6
—
—
—
0
0
35
253
1.40
1.08
2.2
2.9
—
—
—
0
0
11
59
1.87
1.07
2.0
1.9
—
—
—
0
0
13
74
1.77
1.07
1.1
1.6
—
—
—
0
0
218
1953
1.15
1.05
4.6
3.3
0.77
0.54
e6/l
0.67
175
1515
7
34
2.07
1.03
1.9
1.3
—
—
—
0
0
7
35
2.01
1.00
1.9
1.3
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
16
101
1.59
0.94
1.6
1.5
—
—
—
0
0
16
101
1.59
0.94
1.6
1.5
—
—
—
0
0
22
315
0.69
0.93
1.4
1.7
—
—
—
0
0
6
28
2.15
0.91
3.2
1.3
—
—
—
0
0
172
1532
1.15
0.90
3.4
2.7
6.45
5.01
e6/l
0.68
151
1370
11
63
1.76
0.90
1.7
1.7
—
—
—
0
0
11
63
1.76
0.90
1.7
1.7
—
—
—
0
0
11
63
1.76
0.90
1.7
1.7
—
—
—
0
0
14
87
1.62
0.88
1.2
1.5
—
—
—
0
0
6
30
2.01
0.87
1.7
2.8
308.83
227.10
u/l
—
6
30
28
204
1.38
0.86
1.4
1.7
—
188.89
—
0
9
8
45
1.78
0.84
1.3
1.1
—
—
—
0
0
73
609
1.22
0.83
2.7
2.1
0.19
0.20
g/l
0.51
67
552
219
1994
1.13
0.83
2.7
2.4
60.21
99.90
u/l
0.49
200
1838
11
65
1.70
0.82
2.1
1.8
—
—
—
0
0
16
105
1.53
0.82
1.9
1.3
—
—
—
0
0
6
32
1.88
0.82
1.5
1.3
—
—
—
0
0
38
295
1.30
0.79
2.1
1.9
—
—
—
0
0
128
1440
0.87
0.75
1.6
1.6
1.28
1.31
mmol/l
0.20
113
1184
6
106
0.56
0.73
1.0
2.1
220.67
232.39
pmol/l
—
6
100
5
25
2.01
0.72
1.2
1.3
—
—
—
0
0
213
1953
1.12
0.72
3.9
3.8
20.91
9.23
mg/mmol
1.70
149
1258
340
3609
0.91
0.72
3.7
3.1
74.68
53.44
u/l
1.98
312
3292
5
26
1.93
0.70
2.2
1.3
—
—
—
0
0
9
143
0.63
0.70
1.2
1.9
42.89
40.93
nmol/l
—
9
135
232
2143
1.11
0.69
4.7
3.5
194.00
112.24
e6/l
0.28
180
1679
25
187
1.35
0.68
8.5
3.4
1.60
1.61
mmol/l
0.04
25
182
7
42
1.67
0.68
2.1
1.4
—
—
—
0
0
7
42
1.67
0.68
2.1
1.4
—
—
—
0
0
23
170
1.36
0.68
1.6
2.0
—
—
—
0
0
11
168
0.65
0.68
1.6
1.7
—
—
—
0
0
62
731
0.84
0.66
3.6
4.0
9.14
28.90
ug/l
0.97
54
628
20
146
1.38
0.64
1.5
2.5
15.00
15.40
%
—
6
71
157
1724
0.89
0.64
1.8
1.6
19.88
20.36
nmol/l
0.13
133
1436
12
79
1.53
0.62
1.8
1.5
—
—
—
0
0
21
279
0.75
0.62
2.2
3.2
44.81
14371.66
u/ml
0.82
16
237
19
139
1.37
0.60
1.7
1.4
—
—
—
0
0
9
140
0.64
0.60
1.4
1.3
—
—
—
0
0
14
97
1.45
0.59
1.2
1.5
—
—
—
0
0
45
373
1.22
0.59
8.4
3.3
24.60
25.11
mmol/l
0.46
45
362
19
140
1.36
0.58
1.5
1.9
—
—
—
0
0
7
113
0.62
0.58
1.0
1.5
—
—
—
0
0
31
247
1.26
0.57
1.1
1.0
—
—
—
0
0
12
81
1.49
0.57
1.8
1.5
—
—
—
0
0
12
81
1.49
0.57
1.8
1.5
—
—
—
0
0
12
81
1.49
0.57
1.8
1.5
—
—
—
0
0
12
81
1.49
0.57
1.8
1.5
—
—
—
0
0
6
37
1.63
0.55
1.0
1.3
—
—
—
0
0
8
123
0.65
0.55
2.9
1.3
6.38
10.95
e6/l
—
8
99
8
123
0.65
0.55
2.9
1.3
598.75
1098.81
e6/l
—
8
102
12
82
1.47
0.54
1.8
1.5
—
—
—
0
0
22
169
1.31
0.53
1.6
1.4
244.53
285.77
ug/g
0.46
15
90
170
1569
1.10
0.53
1.9
1.8
1237.59
1180.49
nmol/l
0.32
129
1147
91
811
1.14
0.52
1.3
1.3
14.95
10.57
u/ml
0.25
23
287
81
717
1.14
0.51
1.8
1.4
—
—
—
0
0
13
92
1.42
0.50
1.2
1.5
—
—
—
0
0
214
2282
0.92
0.49
2.6
3.2
2.34
2.35
mmol/l
0.31
170
1951
19
146
1.31
0.47
1.6
1.6
—
—
—
0
0
15
112
1.34
0.45
1.3
1.5
—
—
—
0
0
15
112
1.34
0.45
2.3
3.2
4.08
4.54
e9/l
0.53
15
112
30
248
1.22
0.43
1.3
1.2
—
—
—
0
0
9
131
0.68
0.43
1.3
1.3
316.56
464.48
mg/l
—
9
126
95
862
1.11
0.43
1.3
1.3
49.18
34.15
iu/ml
0.54
29
279
32
267
1.21
0.42
1.8
1.7
—
—
—
0
0
236
2490
0.93
0.42
2.8
2.2
80.70
78.07
nmol/l
0.70
214
2150
202
1903
1.08
0.41
3.6
3.1
7.07
7.20
mmol/l
0.16
166
1555
5
33
1.52
0.41
1.4
1.3
99.84
165.79
pmol/l
—
5
33
0
15
0.00
0.41
0.0
1.5
—
8.01
—
0
15
9
66
1.37
0.38
1.0
1.0
—
—
—
0
0
5
36
1.39
0.38
1.2
1.6
—
—
—
0
0
5
36
1.39
0.38
1.6
1.6
32.08
31.04
u/l
—
5
29
216
2048
1.07
0.37
2.8
2.1
168.17
263.76
u/l
1.40
206
1902
15
116
1.30
0.37
2.7
3.6
59.27
59.98
%
0.09
15
116
10
72
1.39
0.37
1.7
2.2
3.80
2.28
u/field
—
5
18
253
2418
1.06
0.35
5.5
3.9
191.46
164.47
e6/l
0.12
190
1784
273
2846
0.94
0.34
2.4
2.1
94.89
92.49
pmol/l
0.39
149
1470
6
45
1.34
0.33
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
1.3
1.5
—
—
—
0
0
142
1510
0.93
0.33
1.7
1.8
76859946.43
9726121.95
pmol/l
0.41
121
1203
6
90
0.66
0.33
1.3
1.1
—
—
—
0
0
7
52
1.35
0.31
1.3
1.1
1.15
1.61
nmol/l
—
7
43
7
52
1.35
0.31
1.0
1.5
—
—
—
0
0
180
1710
1.07
0.30
5.2
4.4
0.00
0.00
estimate
0.50
53
547
299
2884
1.05
0.30
3.5
2.6
—
—
—
0
0
14
111
1.27
0.30
1.2
1.2
—
—
—
0
0
8
63
1.27
0.28
1.0
1.3
—
—
—
0
0
8
63
1.27
0.28
1.0
1.3
—
—
—
0
0
14
113
1.24
0.26
2.0
3.2
0.86
1.44
%
0.53
14
98
9
76
1.19
0.24
1.3
1.3
—
—
—
0
0
134
1410
0.94
0.24
5.3
4.5
1.01
1.02
kg/l
0.54
23
207
7
93
0.75
0.22
1.6
1.4
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
7
95
0.73
0.22
1.1
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
10
124
0.80
0.21
6.1
3.5
59.89
2242.08
u/ml
—
10
118
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
21.13
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
81.83
—
0
6
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
14
166
0.84
0.20
2.4
2.1
—
—
—
0
0
427
4351
0.97
0.20
6.4
5.1
322.17
3514.17
e6/l
—
6
81
20
174
1.15
0.19
3.0
2.3
113.53
84.66
ug/min
0.21
15
105
6
52
1.15
0.19
1.0
1.1
—
—
—
0
0
299
3061
0.97
0.18
5.1
4.2
0.00
0.00
estimate
0.50
63
637
5
66
0.76
0.17
1.4
1.5
—
—
—
0
0
5
66
0.76
0.17
1.4
1.5
—
—
—
0
0
5
66
0.76
0.17
1.4
1.5
—
—
—
0
0
26
288
0.90
0.17
1.2
1.2
53.08
138.50
iu/ml
1.29
12
108
5
70
0.71
0.16
1.0
1.1
—
—
—
0
0
444
4509
0.97
0.16
5.8
4.0
16.08
14.34
mm/h
1.23
404
4065
8
70
1.14
0.16
1.0
1.1
—
—
—
0
0
303
3091
0.97
0.15
5.1
4.2
0.00
0.01
estimate
0.50
59
566
40
372
1.08
0.14
2.1
2.0
—
—
—
0
0
14
123
1.14
0.12
1.5
1.3
—
—
—
0
0
21
192
1.10
0.11
1.2
1.2
—
—
—
0
0
188
1843
1.03
0.09
3.6
3.2
418.66
298.61
mg/l
0.14
137
1218
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
21
194
1.08
0.09
1.2
1.2
—
—
—
0
0
237
2407
0.98
0.09
5.4
4.4
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
5
61
0.82
0.08
1.0
1.4
—
17.00
—
0
11
135
1321
1.03
0.08
2.0
1.7
1.01
1.42
mg/l
2.20
100
1034
301
3047
0.98
0.08
7.0
5.6
0.00
0.00
estimate
-0.00
60
570
7
68
1.03
0.08
2.9
2.5
—
—
—
0
0
74
721
1.03
0.06
4.7
3.9
—
—
—
0
0
12
131
0.91
0.05
1.2
1.1
—
—
—
0
0
11
100
1.10
0.05
1.5
1.2
—
34.71
—
0
10
83
818
1.02
0.03
12.3
8.8
—
—
—
0
0
299
2974
1.01
0.03
5.9
4.5
34.13
34.56
g/l
0.64
264
2736
34
331
1.03
0.02
2.1
1.8
—
—
—
0
0
23
222
1.04
0.02
1.9
1.8
37.72
37.83
u/l
0.01
18
196
482
4808
1.01
0.01
9.2
7.2
87.08
80.93
u/l
1.25
448
4452
10
98
1.02
0.00
1.4
1.6
—
—
—
0
0
15
152
0.99
0.00
2.3
2.2
121.70
126.57
g/l
—
10
111
14
137
1.02
0.00
1.4
1.2
—
28.54
—
0
5
27
273
0.99
0.00
1.3
1.3
—
—
—
0
0
55
555
0.99
0.00
1.7
1.9
351.21
390.19
nmol/l
0.83
48
498
59
585
1.01
0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
15.20
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
57
0.88
-0.00
3.2
2.3
562.20
562.26
ml
—
5
35
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUVALV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUVALV | 2.207 [1.98, 2.46] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.169 |
During the follow-up period (1.1.1998 — 31.12.2019), 1537 out of 2635 females with I9_RHEUVALV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUVALV | 2.004 [1.75, 2.29] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 2107 males with I9_RHEUVALV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUVALV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | 0.411% |
| 5 | 1.219% | 2.429% |
| 10 | 2.95% | 6.713% |
| 15 | 5.653% | 11.989% |
| 20 | 10.282% | 19.825% |
Relationships between endpoints
↥Index endpoint: I9_RHEUVALV – Rheumatic valve diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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