Rheumatic fever without mention of heart involvement

I9_RHEUFEVWITHOUTHEART

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I00, I00+J17.8, I00+L54.0, I02.9 Hospital discharge: ICD-9 — 390 Hospital discharge: ICD-8 — 390 Cause of death: ICD-10 — I00, I00+J17.8, I00+L54.0, I02.9 Cause of death: ICD-9 — 390 Cause of death: ICD-8 — 390 2 out of 7 registries used, show all original rules.	123
4. Check minimum number of events None	123
5. Include endpoints None	123
6. Filter based on genotype QC (FinnGen only)	123

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2

NAME	I9_RHEUFEVWITHOUTHEART
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I00\|I029
HD_ICD_9	390
HD_ICD_8	390
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I00\|I029
COD_ICD_9	390
COD_ICD_8	390
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rheumatic fever without mention of heart involvement based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1291	714	563
Only index persons	971	550	421
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	36.50	39.46	32.27
Only index persons	30.76	33.43	27.27

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	123	69	54
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	28.34	29.68	26.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
113: Matched controls
1131

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

39097

ICD-8 Finland

Rheumatic fever without mention of heart involvement, Suspecta

+∞

40.0

39099

ICD-8 Finland

Rheumatic fever without mention of heart involvement, Unspecified

+∞

26.0

I00

ICD-10 Finland

Rheumatic fever without mention of heart involvement

+∞

23.8

L54.0*I00

ICD-10 Finland

Erythema marginatum in acute rheumatic fever

+∞

8.4

3900A

ICD-9 Finland

Rheumatic fever without mention of heart involvement[FEBRIS RHEUMATICA, MORBO CORDIS NON INDICATO]

+∞

7.4

71239

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD

73.8

6.5

I02.9

ICD-10 Finland

Rheumatic chorea without heart involvement

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000991) Gas panel - Venous blood

2.50

2.84

7.2

8.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

137

2.14

2.72

1.9

—

(3032080) INR in Blood by Coagulation assay

370

1.82

2.65

8.9

8.2

1.3

1.2

inr

0.19

118

(3007853) Bacteria identified in Skin by Aerobe culture

113

2.16

2.45

2.0

1.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

148

1.96

2.21

3.2

2.6

13.5

13.9

umol/l

0.11

133

(3009508) Creatinine [Moles/volume] in Urine

284

1.67

1.82

4.2

3.1

7.1

7.8

mmol/l

0.53

233

(3012516) Albumin [Mass/volume] in Urine

276

1.67

1.80

3.4

3.3

16.6

283.3

mg/l

0.62

179

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.00

1.77

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

269

1.66

1.75

1.5

1.7

1.3

1.4

mmol/l

0.21

222

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.03

1.75

2.1

2.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

289

1.63

1.69

4.6

4.1

2.9

9.4

mg/mmol

1.67

184

(3037522) Nuclear Ab [Titer] in Serum

122

1.87

1.68

1.6

1.4

448.0

517.5

titre

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.27

1.67

11.4

5.4

24.6

25.0

mmol/l

0.15

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

282

1.62

1.64

2.5

2.0

138.0

223.8

u/l

0.62

263

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.95

1.52

1.3

1.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

718

1.55

1.39

4.7

4.2

12.2

12.1

mm/h

0.03

653

(42870588) Differential panel, method unspecified - Blood

321

1.52

1.35

8.7

5.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

443

1.49

1.33

8.7

6.8

1.2

mmol/l

0.51

379

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.18

1.33

1.3

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.57

1.32

1.0

1.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.85

1.30

3.0

2.3

68.1

60.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.85

1.30

1.0

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

494

1.47

1.28

8.5

6.2

2.0

1.8

e9/l

1.54

443

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

101

1.79

1.28

1.7

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.06

1.26

1.0

1.6

—

(1616796) Gas panel - Central venous blood

2.70

1.23

6.8

3.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.70

1.23

1.0

1.2

—

(3013115) Eosinophils [#/volume] in Blood

499

1.44

1.19

9.5

6.5

0.2

e9/l

0.20

447

(3012544) pH of Venous blood

1.80

1.17

2.6

4.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.33

1.12

2.3

1.7

0.2

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.26

1.10

2.3

1.7

1.0

1.1

g/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

107

1.68

1.06

1.7

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

281

1.45

1.05

4.2

3.0

0.7

0.4

e6/l

0.41

213

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.80

1.03

2.0

2.2

3.5

7.5

ug/l

1.64

(3019060) Gas panel - Arterial blood

1.88

1.02

3.4

4.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

211

1.49

1.01

2.7

2.2

—

(3001604) Monocytes [#/volume] in Blood

481

1.39

1.00

8.8

6.2

0.6

e9/l

0.29

423

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

754

1.42

0.97

9.0

7.4

73.1

78.2

u/l

0.97

696

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

169

1.52

0.97

1.4

1.3

1.6

8.7

u/ml

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

169

1.52

0.97

4.0

3.4

2750.1

179.7

ng/l

0.45

137

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

204

0.59

0.97

3.6

2.9

0.9

0.8

ug/l

—

135

(3019309) Folate [Moles/volume] in Red Blood Cells

178

1.51

0.96

2.2

1.7

1646.8

1270.1

nmol/l

0.70

142

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.28

0.95

1.3

1.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.28

0.95

1.3

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.20

0.93

1.3

1.9

—

(3023368) Bacteria identified in Blood by Culture

253

1.42

0.88

6.1

4.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

578

1.35

0.87

12.3

10.2

4.0

4.1

e9/l

0.08

505

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.98

0.85

2.3

2.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.98

0.85

1.7

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.68

0.85

1.4

1.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.79

0.84

6.3

7.4

—

(36304419) Bacteria [Presence] in Urine

274

1.39

0.83

4.3

2.8

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.92

0.83

3.5

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.78

0.0

1.6

—

(3024928) Oxygen saturation in Venous blood

2.22

0.77

3.0

2.3

—

(3021901) Oxygen saturation in Capillary blood

2.13

0.75

4.6

2.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.64

0.75

1.3

1.6

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

135

1.48

0.74

3.7

2.6

2.3

g/l

0.90

121

(3021589) Normoblasts [#/volume] in Blood

450

1.31

0.74

14.8

10.0

0.0

e9/l

0.41

369

(4094501)

2.04

0.73

1.0

1.1

—

(3018095) Leukocytes [#/volume] in Urine

357

1.32

0.69

4.3

3.6

54.5

58.6

e6/l

0.05

257

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.89

0.69

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

407

1.30

0.66

1.9

2.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.61

0.62

2.8

0.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.54

0.60

2.8

1.3

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

307

1.29

0.59

4.3

3.1

15.7

47.8

e6/l

1.23

241

(3026493) Urate [Moles/volume] in Serum or Plasma

279

1.30

0.59

2.7

8987.7

5400.3

umol/l

0.16

234

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

929

1.35

0.59

6.3

5.5

40.7

40.2

mmol/mol

0.14

866

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

897

1.33

0.59

4.2

4.5

1.8

1.9

mu/l

0.64

812

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.70

0.57

2.7

2.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

143

1.39

0.57

1.5

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

341

0.77

0.55

5.4

5.0

1.9

2.2

ug/l

0.34

301

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.46

0.54

8.2

2.8

5.2

5.0

kpa

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

665

1.24

0.52

2.7

2.9

43.5

46.4

u/l

0.16

623

(46235355) HIV 1 and 2 tests - Meaningful Use set

137

1.37

0.51

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

129

1.37

0.49

1.2

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

353

1.24

0.48

4.9

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

382

1.24

0.48

2.0

1.9

92.9

95.5

pmol/l

0.07

171

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.43

0.48

1.8

1.6

—

(3018418) pH of Serum or Plasma

288

1.25

0.46

4.7

4.2

7.4

—

(3029937) Albumin [Presence] in Urine by Test strip

269

0.78

0.44

5.9

4.0

0.0

estimate

0.00

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

115

1.35

0.41

1.5

1.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.40

0.0

2.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.45

0.40

1.4

2.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.39

0.0

1.5

—

(3019225) pH of Specimen

1.39

0.37

5.3

3.5

—

(3013512) EKG study

276

1.22

0.37

4.4

3.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

383

1.19

0.36

4.5

3.8

29.1

45.6

ng/l

0.74

265

(4035726)

1.35

0.35

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

288

1.20

0.34

3.2

2.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

166

1.24

0.32

3.4

2.5

1.1

e6/l

0.02

(3026008) Bacteria identified in Urine by Culture

300

1.18

0.31

3.4

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

665

1.16

0.31

5.1

4.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

121

1.27

0.30

8.4

6.0

1.1

1.0

mmol/l

0.69

112

(3044889) 12 lead EKG panel

686

1.16

0.30

4.5

3.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.26

0.30

1.9

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

128

0.76

0.28

11.3

7.5

—

(3022145) Colonoscopy Study observation

113

1.27

0.28

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.29

0.27

1.4

1.6

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.27

0.26

1.2

2.3

13.8

9.8

g/l

—

(40758558) Short blood count panel - Blood

256

1.17

0.26

16.2

6.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

228

1.18

0.25

5.7

6.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.20

0.25

1.7

1.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

0.73

0.25

1.2

2.4

64.1

66.5

g/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

100

968

1.18

0.24

4.9

4.5

1.4

1.5

mmol/l

0.40

880

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

1.25

0.24

4.5

3.6

—

(3045414) Leukocytes [Presence] in Urine

1.33

0.23

1.4

1.8

—

(3020891) Body temperature

1.26

0.22

4.0

4.6

—

(21494755) Public health laboratory ask at order entry panel

101

0.78

0.22

1.1

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(4062490)

0.00

0.21

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.9

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

100

971

1.17

0.21

4.8

4.5

4.6

4.7

mmol/l

0.02

891

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.21

0.0

1.2

—

7.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

267

0.87

0.19

5.7

4.6

22.9

21.8

0.10

134

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.22

0.18

1.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.22

0.18

1.1

1.7

1.4

1.1

g/l

—

(3002256) Pathology report gross observation

110

1.20

0.18

1.3

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

441

1.11

0.17

4.2

4.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.75

0.17

1.4

2.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

149

1.16

0.16

3.8

2.7

2.9

2.7

e6/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

947

1.12

0.14

5.2

4.6

6.1

6.0

mmol/l

0.37

863

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.21

0.14

2.5

3.3

59.2

66.2

ml/min/173m2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

281

0.91

0.12

3.9

3.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

172

1.12

0.12

1.4

1.3

9.8

35.4

iu/ml

—

(3000492) Spirometry study

1.18

0.11

1.8

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

101

992

1.11

0.11

5.4

5.0

2.7

mmol/l

0.01

904

(40768443) Skin Pathology biopsy report

1.17

0.10

1.0

1.1

—

(3022313) Gas panel - Capillary blood

1.14

0.10

9.8

2.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.15

0.09

1.1

1.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

102

1035

0.91

0.09

22.0

16.3

81.3

77.6

umol/l

0.44

102

1035

(3021601) Nitrite [Presence] in Urine by Test strip

492

1.06

0.08

5.4

5.0

0.0

estimate

—

100

(3011397) Hemoglobin [Presence] in Urine by Test strip

225

1.08

0.08

4.0

3.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.03

0.08

1.6

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.81

0.08

1.0

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

955

1.08

0.07

19.2

14.1

18.7

22.1

mg/l

0.70

748

(3023520) Reticulocytes [#/volume] in Blood

1.09

0.07

9.4

3.5

74.0

76.2

e9/l

—

(4010399)

1.06

0.07

1.4

1.3

—

(40761535) Cells panel - Urine sediment

1.03

0.07

4.4

3.8

—

(40761536) Microorganisms panel - Urine sediment

0.84

0.07

9.4

3.9

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

105

1039

1.08

0.05

14.1

10.4

28.0

25.3

u/l

0.41

100

1004

(3009261) Glucose [Presence] in Urine by Test strip

498

1.04

0.04

4.1

3.7

0.0

estimate

—

(3003694) ABO and Rh group [Type] in Blood

240

1.05

0.04

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

569

1.04

0.03

6.4

4.5

6.5

6.7

mmol/l

0.24

532

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

940

1.05

0.03

4.4

4.0

1.4

1.3

mmol/l

0.59

854

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

939

0.96

0.03

18.6

13.1

78.3

81.3

ml/min/173m2

0.68

766

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.08

0.02

1.9

2.0

333.2

392.4

nmol/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

107

0.93

0.02

7.8

3.1

2.4

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

492

1.03

0.02

4.1

3.7

0.0

estimate

—

100

(40768797) Stomach Pathology biopsy report

143

1.06

0.01

1.2

1.3

—

(40761511) CBC panel - Blood by Automated count

100

1006

0.97

0.00

17.8

13.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

194

0.98

0.00

1.0

1.3

0.7

0.9

u/ml

—

(1761868) Lipid panel - Serum or Plasma

378

1.01

0.00

2.2

2.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

873

0.99

0.00

20.2

14.3

38.4

40.5

0.98

637

(3031040) Bacteria [#/volume] in Urine by Automated count

643

0.99

0.00

5.3

4.1

—

573.6

—

(3042936) Bacteria identified in Isolate by Culture

138

1.02

0.00

3.1

2.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

185

0.97

0.00

1.2

1.4

3.6

2.9

g/l

0.31

108

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

384

0.98

0.00

4.6

3.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

594

0.99

0.00

2.6

2.8

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.02

0.00

2.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.9

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

300

1.00

0.00

2.3

3.1

29.0

31.7

u/l

0.25

282

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.98

0.00

2.7

5.0

98.1

79.6

ng/l

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.3

—

(3022621) pH of Urine by Test strip

1.00

0.00

4.3

2.1

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.0

—

3.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.9

—

(3003329) Lymphocytes/100 leukocytes in Synovial fluid

0.00

0.0

1.7

—

25.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

11.7

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(4306422)

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.6

—

213.6

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.9

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(4024509)

0.00

0.0

1.0

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

10.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(3000012) Reticulocyte production index

0.00

0.0

1.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

17.1

—

1590.6

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.6

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

86.5

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.7

—

783.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

504.8

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.6

—

(3000330) Specific gravity of Urine by Test strip

0.98

0.00

2.6

3.8

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.9

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.1

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(4027681)

0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.7

—

14.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUFEVWITHOUTHEART and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_RHEUFEVWITHOUTHEART	2.023 [1.5, 2.72]	< 0.001
Birth year	0.999 [0.99, 1.01]	0.863

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 253 females with I9_RHEUFEVWITHOUTHEART died.

Males

Parameter	HR [95% CI]	p-value
I9_RHEUFEVWITHOUTHEART	1.981 [1.33, 2.95]	< 0.001
Birth year	0.983 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 180 males with I9_RHEUFEVWITHOUTHEART died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUFEVWITHOUTHEART.

N-year risk	Females	Males
1	0.15%	0.323%
5	1.268%	2.127%
10	3.63%	5.092%
15	6.593%	9.279%
20	11.567%	15.75%

Relationships between endpoints

↥

Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rheumatic fever without mention of heart involvement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints