Juvenile dermatomyositis

M13_JUVDERMATOMYO

juvenile dermatomyositis: Juvenile dermatomyositis (JDM) is the early-onset form of dermatomyositis (DM, see this term), a systemic, autoimmune inflammatory muscle disorder, characterized by proximal muscle weakness, evocative skin lesion, and systemic manifestations.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M33.0 Hospital discharge: ICD-9 — 7103A Cause of death: ICD-10 — M33.0 Cause of death: ICD-9 — 7103A 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M33
Name in latin: Dermatomyositis juvenilis

NAME	M13_JUVDERMATOMYO
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M330
HD_ICD_9	7103A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M330
COD_ICD_9	7103A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Juvenile dermatomyositis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	274	169	105
Only index persons	232	146	86
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.01	0.00
Median age at first event (years)
Whole population	-	14.41	14.08
Only index persons	14.40	14.59	14.09

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	28	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	23.00	13.58	39.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

+∞

9.72

1.1

0.0

—

(3037522) Nuclear Ab [Titer] in Serum

4.67

5.21

2.3

1.6

560.0

448.0

titre

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

10.94

5.05

2.1

1.0

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

13.52

4.44

1.9

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.42

3.43

11.0

3.7

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

9.67

3.37

1.5

1.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

7.32

3.32

1.3

1.4

0.2

g/l

—

(42870588) Differential panel, method unspecified - Blood

115

3.10

3.31

14.2

6.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

9.18

2.82

5.0

2.5

4.8

5.5

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

9.18

2.82

5.4

2.8

62.4

60.5

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

3.53

2.82

6.8

3.8

249.0

226.9

u/l

0.45

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.69

2.24

2.0

2.4

4.2

2.6

mg/l

1.96

(3029937) Albumin [Presence] in Urine by Test strip

2.61

2.20

8.4

2.9

0.0

estimate

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.86

1.91

1.2

1.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

145

2.23

1.79

3.0

3.2

70.9

60.4

ug/l

0.24

139

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

315

0.48

1.53

3.8

3.9

2.9

2.7

mmol/l

0.50

297

(3018095) Leukocytes [#/volume] in Urine

126

2.08

1.50

3.0

4.5

24.6

e6/l

2.05

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

314

0.48

1.50

3.9

3.6

4.5

4.6

mmol/l

0.12

297

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.38

1.48

1.2

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

313

0.49

1.46

3.9

3.5

1.3

1.5

mmol/l

1.75

294

(40758558) Short blood count panel - Blood

111

2.05

1.41

9.1

7.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

160

1.92

1.25

8.0

4.4

0.0

estimate

—

(3013512) EKG study

2.20

1.25

2.5

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

116

1.93

1.22

1.6

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.01

1.19

5.5

2.4

—

(3035350) Ketones [Presence] in Urine by Test strip

162

1.88

1.19

7.1

3.0

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

162

1.88

1.19

7.0

3.0

0.0

estimate

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

144

1.88

1.18

5.2

8.2

1.2

mmol/l

0.38

128

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

118

1.89

1.15

5.6

3.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.55

1.12

1.0

1.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.55

1.12

1.2

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

112

1.84

1.06

8.8

2.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.06

1.02

1.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.85

1.01

1.3

1.8

—

(3032080) INR in Blood by Coagulation assay

114

1.80

0.99

7.5

4.3

1.4

1.1

inr

—

(3022145) Colonoscopy Study observation

2.23

0.93

1.7

1.5

—

(3015736) pH of Urine

125

1.74

0.92

6.3

3.0

—

(36304419) Bacteria [Presence] in Urine

100

1.76

0.88

2.5

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

294

0.60

0.85

3.5

3.3

1.4

1.2

mmol/l

0.29

276

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.81

0.0

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

236

1.67

0.79

6.3

4.0

—

(3042936) Bacteria identified in Isolate by Culture

1.84

0.74

4.0

1.7

—

(3026008) Bacteria identified in Urine by Culture

1.67

0.73

3.7

2.3

—

(40761536) Microorganisms panel - Urine sediment

1.96

0.71

3.6

2.7

—

(1761868) Lipid panel - Serum or Plasma

112

0.55

0.70

1.3

2.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.81

0.66

1.2

1.4

—

(3003396) Base excess in Arterial blood by calculation

1.81

0.66

5.0

6.8

0.7

0.8

mmol/l

—

(3009508) Creatinine [Moles/volume] in Urine

0.51

0.64

5.4

4.0

4.3

8.4

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

1.75

0.63

3.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.62

0.0

1.2

—

(3023368) Bacteria identified in Blood by Culture

1.60

0.54

5.5

3.5

—

(3018418) pH of Serum or Plasma

1.57

0.54

4.4

2.9

7.4

—

(36660697) Celiac disease serology panel - Serum

1.66

0.52

1.0

1.1

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

328

1.54

0.44

15.6

13.0

140.2

139.6

mmol/l

0.61

318

(3023103) Potassium [Moles/volume] in Serum or Plasma

329

1.52

0.44

15.9

13.0

3.9

mmol/l

0.30

316

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.5

—

1.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.42

0.0

1.7

—

2.9

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.42

0.0

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.42

0.0

9.4

—

0.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

293

0.72

0.39

4.2

4.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.45

0.36

2.3

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

121

1.36

0.34

1.5

2.0

—

(40768804) Tissue Pathology biopsy report

115

1.32

0.28

1.7

1.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.25

0.27

1.7

3.6

349.0

10288.1

umol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.70

0.27

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.71

0.25

1.7

1.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

126

1.29

0.25

5.9

3.6

29.5

28.1

u/l

0.18

119

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.40

0.24

3.8

13.3

25.4

24.5

mmol/l

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

2.9

—

326.7

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

4.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.7

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

2.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.20

0.0

1.1

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.20

0.20

1.5

4.2

29.8

29.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.20

0.20

2.0

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

281

0.82

0.19

4.3

4.2

42.0

38.0

mmol/mol

0.98

268

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.22

0.18

1.5

—

(40761511) CBC panel - Blood by Automated count

362

1.36

0.17

17.3

10.2

—

(3044889) 12 lead EKG panel

210

0.83

0.17

3.9

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.25

0.15

2.4

2.2

—

(3044640) Blood type and Crossmatch panel - Blood

125

0.84

0.12

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.81

0.08

11.3

3.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

173

1.07

0.02

5.8

3.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

341

0.99

0.00

17.2

14.2

40.2

39.9

0.11

280

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

315

0.95

0.00

5.5

4.7

1.4

1.8

mu/l

1.29

295

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.1

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

98.4

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.86

0.00

1.2

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

33.3

—

(3033658) Prothrombin time (PT) actual/Normal

0.96

0.00

3.0

6.0

93.2

94.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4268621)

0.00

0.0

2.1

—

(4198724)

0.00

0.0

1.1

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

3.7

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.6

—

(4146454)

0.00

0.0

3.4

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.6

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

3.8

—

(3003694) ABO and Rh group [Type] in Blood

130

1.00

0.00

1.4

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

367

1.05

0.00

20.4

8.9

27.0

25.8

u/l

0.18

355

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.0

2.0

—

9.8

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.97

0.00

1.4

1.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

9.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

17.4

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.0

—

78.6

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.7

—

21.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(4094501)

0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

3.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

4.6

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.98

0.00

1.4

2.0

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

31.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.3

—

107.7

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

3.1

—

3.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(4306422)

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_JUVDERMATOMYO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_JUVDERMATOMYO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_JUVDERMATOMYO – Juvenile dermatomyositis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Juvenile dermatomyositis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints