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Use of pergolide

PDMED_PERGOLIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC N04BC02

1 out of 7 registries used, show all original rules.

89

4. Check minimum number of events

Min. number of events 3
89

5. Include endpoints

None

89

6. Filter based on genotype QC (FinnGen only)

88

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 88 30 58
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 61.12 57.05 63.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
89
Matched controls
890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04BC02
ATC
pergolide; oral
+∞
126.2
89
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
895.9
97.8
83
13
G20
ICD-10 Finland
Parkinson disease
666.4
93.5
80
11
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
582.0
92.4
83
20
N04BD01
ATC
selegiline; oral
519.2
83.1
72
7
N04BC05
ATC
pramipexole; oral
41.8
73.9
60
42
N04BX02
ATC
entacapone; oral
527.3
54.6
49
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
338.9
52.1
48
*
N04BB01
ATC
amantadine; oral
113.1
33.9
35
5
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
201.0
28.5
28
*
N04BD02
ATC
rasagiline; oral
381.3
28.5
27
*
193
Kela drug reimbursment
Rasagiline
323.6
25.0
24
*
N04BC04
ATC
ropinirole; oral
114.0
24.1
25
*
N87
ICPC
Parkinsonism
85.5
23.3
25
*
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
254.3
20.5
20
*
G02CB01
ATC
bromocriptine; systemic
119.2
18.3
19
*
N03AE01
ATC
clonazepam; systemic
17.8
15.9
25
19
N04BC06
ATC
cabergoline; oral
+∞
13.9
13
*
AAG20
NOMESCO Finland
Stereotactic intracranial implantation of electrodes
164.0
13.9
14
*
N04AA02
ATC
biperiden; systemic
38.4
13.1
16
5
N06DA03
ATC
rivastigmine; oral, transdermal
11.5
12.2
23
26
N05AH04
ATC
quetiapine; oral
5.5
11.4
28
69
N04BC01
ATC
bromocriptine; oral
+∞
10.6
10
*
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
111.4
9.6
10
*
A06AD11
ATC
lactulose; oral
4.0
9.3
39
144
H02AA02
ATC
fludrocortisone; oral
21.4
9.2
13
7
N04BC09
ATC
rotigotine; transdermal
+∞
8.5
8
*
N04BX01
ATC
tolcapone; oral
+∞
8.5
8
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
5.2
8.1
19
44
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
33.0
7.3
9
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
6.7
6.5
16
28
N04AA01
ATC
trihexyphenidyl; oral
+∞
6.3
6
*
N04C02, ,
ATC
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
503
0.48
2.86
3.9
5.5
5.85
6.16
mmol/l
1.15
28
433
33
486
0.49
2.64
4.9
6.7
38.88
42.16
mmol/mol
2.10
28
436
7
18
4.13
2.30
4.0
3.7
—
—
—
0
0
0
56
0.00
2.15
0.0
1.2
—
—
—
0
0
40
532
0.55
2.02
20.7
20.5
67.78
85.96
umol/l
8.17
40
532
0
51
0.00
1.96
0.0
1.8
—
403.04
—
0
45
8
173
0.41
1.84
1.6
2.9
8.01
7.10
mmol/l
—
8
141
0
47
0.00
1.76
0.0
3.9
—
—
—
0
0
28
401
0.56
1.73
3.4
4.1
12.82
15.60
mm/h
0.57
22
349
26
380
0.55
1.73
3.4
4.5
—
—
—
0
0
6
20
3.14
1.61
3.3
1.8
—
—
—
0
0
13
68
2.07
1.42
2.1
1.6
—
—
—
0
0
42
526
0.62
1.40
13.5
16.6
—
—
—
0
0
7
145
0.44
1.35
4.1
4.1
—
—
—
0
0
41
511
0.63
1.29
20.5
17.4
28.20
26.92
mg/l
0.10
35
421
10
181
0.50
1.27
5.1
4.9
—
—
—
0
0
5
113
0.41
1.23
1.0
1.3
—
—
—
0
0
0
32
0.00
0.97
0.0
1.3
—
—
—
0
0
34
423
0.68
0.93
23.0
20.2
15.34
15.16
%
0.06
34
412
6
30
2.07
0.89
1.0
1.5
—
—
—
0
0
0
24
0.00
0.80
0.0
1.3
—
—
—
0
0
0
26
0.00
0.80
0.0
3.4
—
0.86
—
0
26
24
302
0.72
0.65
5.8
8.4
3.52
4.46
e9/l
2.36
19
257
18
132
1.46
0.63
3.5
3.5
98.94
81.71
%
1.95
18
127
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
0
21
0.00
0.61
0.0
1.2
—
—
—
0
0
0
21
0.00
0.61
0.0
3.5
—
0.21
—
0
8
8
53
1.56
0.60
2.4
3.6
—
—
—
0
0
32
381
0.75
0.59
7.6
4.5
—
—
—
0
0
0
23
0.00
0.59
0.0
1.1
—
203.97
—
0
6
9
134
0.63
0.57
1.1
1.5
1.24
1.26
mmol/l
—
9
105
15
195
0.72
0.48
1.5
2.5
—
—
—
0
0
5
31
1.65
0.44
1.2
1.4
—
—
—
0
0
5
33
1.54
0.42
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
57.07
—
0
15
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
2.51
—
0
9
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
8.16
—
0
16
0
16
0.00
0.41
0.0
4.2
—
1.34
—
0
16
0
16
0.00
0.41
0.0
1.9
—
4.79
—
0
16
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
22
182
1.28
0.38
2.4
2.0
—
—
—
0
0
7
97
0.70
0.33
1.0
2.6
12.07
12.54
umol/l
—
7
88
28
244
1.22
0.31
2.6
2.1
73.88
89.71
pmol/l
1.39
20
118
11
137
0.78
0.26
1.5
3.2
351.45
5417.23
umol/l
0.79
11
110
20
231
0.83
0.26
5.7
10.1
0.00
0.00
e9/l
0.71
15
189
18
155
1.20
0.22
2.7
3.5
—
—
—
0
0
5
42
1.20
0.22
1.4
1.5
—
—
—
0
0
5
42
1.20
0.22
1.8
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
9.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
1.13
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
0.28
—
0
10
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
89.47
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
1.49
—
0
12
0
12
0.00
0.21
0.0
4.3
—
105.58
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
4.3
—
11.50
—
0
12
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
15.30
—
0
5
17
148
1.18
0.18
1.8
1.8
18.90
21.03
nmol/l
0.28
17
116
7
59
1.20
0.18
1.6
1.7
—
—
—
0
0
23
206
1.16
0.18
7.6
3.4
—
—
—
0
0
19
169
1.16
0.16
2.7
3.6
0.43
0.59
e6/l
0.28
11
134
17
191
0.86
0.15
5.1
4.1
—
—
—
0
0
21
232
0.88
0.15
3.9
5.5
—
—
—
0
0
7
87
0.79
0.15
1.0
2.7
22.50
23.04
%
—
7
75
7
63
1.12
0.08
1.3
1.5
—
—
—
0
0
14
128
1.11
0.07
6.1
7.4
—
—
—
0
0
17
182
0.92
0.06
2.3
4.2
—
7.40
—
0
32
37
383
0.94
0.06
8.9
5.3
—
741.82
—
0
11
20
210
0.94
0.04
4.9
4.6
784.29
78.91
e6/l
0.91
11
159
24
249
0.95
0.03
5.0
4.9
0.04
0.04
e9/l
0.10
19
210
24
248
0.96
0.02
5.0
4.9
0.49
0.61
e9/l
1.92
19
209
19
185
1.03
0.00
3.7
3.8
51.31
370.88
e6/l
0.46
12
147
0
6
0.00
0.00
0.0
2.3
—
66.50
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
270.14
—
0
7
0
6
0.00
0.00
0.0
2.3
—
5.78
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
31.33
—
0
6
0
6
0.00
0.00
0.0
2.8
—
4.25
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
0.49
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
2.83
—
0
8
0
5
0.00
-0.00
0.0
14.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
13
130
1.00
-0.00
3.5
4.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
10.68
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
25.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.8
3.8
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: PDMED_PERGOLIDE – Use of pergolide

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).