No definition available.
Dementia due to Parkinsons disease, excluding more controls
PD_DEMENTIA_EXMORE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- G6_PARKINSON, F5_PSYCH, NEURODIS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Dementia due to Parkinsons disease, excluding more controls
based on the number of shared cases.
Similar with more cases:
- Dementia due to Parkinson's disease
- Dementia in other diseases classified elsewhere
- Any dementia, excluding more controls
- Any dementia
- Dementia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9967 | 4278 | 5570 |
| Only index persons | 8196 | 3544 | 4652 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.12 | 0.16 |
| Only index persons | 0.16 | 0.13 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 77.63 | 78.85 | 76.70 |
| Only index persons | 77.59 | 78.87 | 76.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 778 | 271 | 507 |
| Unadjusted period prevalence (%) | 0.18 | 0.09 | 0.22 |
| Median age at first event (years) | 76.78 | 77.88 | 76.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 664
- Matched controls
- 6639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04BD01
ATC
selegiline; oral
5021.9
323.0
304
*
N06DA03
ATC
rivastigmine; oral, transdermal
1833.7
323.0
351
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
6732.6
323.0
626
16
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
323.0
536
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
323.0
600
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
+∞
323.0
286
*
G20
ICD-10 Finland
Parkinson disease
4503599627370496.0
323.0
630
*
N87
ICPC
Parkinsonism
+∞
309.2
272
*
N05AH04
ATC
quetiapine; oral
48.8
252.2
309
116
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
229.9
207
*
N04BC05
ATC
pramipexole; oral
38.9
229.6
298
136
N04BD02
ATC
rasagiline; oral
+∞
179.5
164
*
N04BC04
ATC
ropinirole; oral
689.5
168.0
159
*
193
Kela drug reimbursment
Rasagiline
+∞
145.2
134
*
F02.39
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
131.7
122
*
AA1AD
NOMESCO Finland
CT of head and brain
11.1
130.5
284
418
N04BX02
ATC
entacapone; oral
+∞
127.2
118
*
R53
ICD-10 Finland
Malaise and fatigue
7.4
92.5
259
525
N03AE01
ATC
clonazepam; systemic
25.5
89.1
127
61
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.5
84.4
333
1023
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
316.0
83.6
83
*
N06DX01
ATC
memantine; oral
90.9
79.3
87
11
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.4
78.0
242
544
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
146.9
74.7
78
6
N06DA02
ATC
donepezil; oral
66.6
71.6
82
14
S06.0
ICD-10 Finland
Concussion
34.5
69.0
90
30
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
356.6
64.6
64
*
I95.1
ICD-10 Finland
Orthostatic hypotension
15.5
62.7
106
80
N05AX08
ATC
risperidone; systemic
23.2
62.6
91
45
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
77.9
62.5
70
10
H02AA02
ATC
fludrocortisone; oral
78.3
57.2
64
9
N04AA02
ATC
biperiden; systemic
583.9
55.4
54
*
N06AX11
ATC
mirtazapine; oral
4.5
54.8
236
720
A06AD11
ATC
lactulose; oral
4.8
54.7
220
626
R25.1
ICD-10 Finland
Tremor, unspecified
29.7
53.4
72
27
N04BC09
ATC
rotigotine; transdermal
+∞
52.8
50
*
N05BA04
ATC
oxazepam; oral
4.8
52.5
205
563
N06AB10
ATC
escitalopram; oral
8.2
52.3
125
183
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
51.6
304
1216
A28
ICPC
Limited function/disability NOS
4.5
49.0
207
609
SPAT1216
SPAT
Assessment of functional ability
4.8
48.7
188
505
F02.30
ICD-10 Finland
Dementia in Parkinson's disease without additional symptoms
+∞
47.5
45
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
10.1
47.2
98
112
N06AB04
ATC
citalopram; systemic
5.1
45.0
159
385
N04BB01
ATC
amantadine; oral
26.2
44.5
62
26
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
44.2
42
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
20.8
44.1
66
35
SPAT1229
SPAT
Assessment of need for aid
6.4
41.0
115
209
F32.9
ICD-10 Finland
Depressive episode, unspecified
25.8
40.9
57
24
SPAT1234
SPAT
Support of social functional capacity
9.5
40.7
87
104
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.1
40.7
185
570
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
7.2
40.5
104
167
XA800
NOMESCO Finland
Neuropsychological investigation
80.4
40.4
45
6
SPAT1215
SPAT
Assessment of need for medical rehabilitation
13.1
40.1
72
61
S01.0
ICD-10 Finland
Open wound of scalp
7.2
39.8
102
163
G04BD12
ATC
mirabegron; oral
4.9
39.6
143
350
N04BC06
ATC
cabergoline; oral (dopamine agonists)
410.3
39.5
39
*
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
8.1
38.0
89
124
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.3
37.9
247
1012
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
37.8
144
371
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
23.4
37.6
54
25
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.3
36.7
155
441
F03
ICD-10 Finland
Unspecified dementia
27.7
35.9
49
19
P20
ICPC
Memory disturbance
4.6
35.6
136
350
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.9
35.4
171
548
G02CB01
ATC
bromocriptine; systemic
365.4
35.3
35
*
N29
ICPC
Neurological sympt/complt other
34.3
34.9
45
14
SPAT1231
SPAT
Assessment of adjustments needed in living environment
17.0
34.4
55
35
N19
ICPC
Speech disorder
354.2
34.2
34
*
L28
ICPC
Limited function/disability (L)
3.7
33.9
170
560
F02.32
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly hallucinations
+∞
33.6
32
*
N05AH03
ATC
olanzapine; systemic
67.0
33.4
38
6
W19
ICD-10 Finland
Unspecified fall
5.6
32.7
102
209
N04BC02
ATC
pergolide; oral
+∞
32.6
31
*
S72.0
ICD-10 Finland
Fracture of neck of femur
6.7
32.4
87
147
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.8
31.7
151
474
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
31.5
30
*
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
+∞
30.4
29
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
18.9
30.1
46
26
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
47.4
29.9
36
8
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.4
29.6
81
140
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
29.4
28
*
G47.3
ICD-10 Finland
Sleep apnoea
13.7
29.4
51
40
R41.0
ICD-10 Finland
Disorientation, unspecified
14.0
27.3
47
36
F0230, G20
ICD-10 Finland
NA
+∞
27.3
26
*
F0232, G20
ICD-10 Finland
NA
+∞
27.3
26
*
D21
ICPC
Swallowing problem
22.9
27.2
39
18
F05.9
ICD-10 Finland
Delirium, unspecified
64.8
27.2
31
5
N06AX16
ATC
venlafaxine; oral
8.4
26.3
59
76
Z75.5
ICD-10 Finland
Holiday relief care
62.7
26.2
30
5
A04
ICPC
Weakness/tiredness general
4.0
26.1
114
327
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
9.8
26.0
53
58
SPAT1254
SPAT
Administration of medicine
3.5
25.9
137
462
G40.9
ICD-10 Finland
Epilepsy, unspecified
270.4
25.9
26
*
SPAT1053
SPAT
Memory test
3.1
25.8
169
665
SPAT1245
SPAT
Provision of support and information to patient’s family members
6.8
25.8
67
108
G30.1
ICD-10 Finland
Alzheimer disease with late onset
23.7
25.5
36
16
WYA20
NOMESCO Finland
Home visit
31.5
25.2
33
11
AAG20
NOMESCO Finland
Stereotactic intracranial implantation of electrodes
+∞
25.2
24
*
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
6.7
24.9
65
105
R4130
NOMESCO Finland
Speech therapy
23.0
24.6
35
16
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
24.1
23
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.2
23.7
95
251
R55
ICD-10 Finland
Syncope and collapse
3.5
23.2
117
378
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
+∞
23.0
22
*
SPAT1172
SPAT
Guidance concerning hydration
9.0
23.0
49
58
XF606
NOMESCO Finland
Ortostatic test
31.3
23.0
30
10
N99
ICPC
Neurological disease other
86.5
22.8
25
*
C07AA05
ATC
propranolol; systemic
3.5
22.5
114
369
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
+∞
22.0
21
*
N03AG01
ATC
valproic acid; systemic, rectal
64.8
22.0
25
*
R41.3
ICD-10 Finland
Other amnesia
19.2
21.9
33
18
N06AX21
ATC
duloxetine; oral
6.5
21.6
57
94
N28
ICPC
Limited function/disability (N)
44.9
21.5
26
6
R1250
NOMESCO Finland
Evaluation of functional capability
15.3
21.4
35
24
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
6.9
21.3
54
84
N02BE01
ATC
paracetamol; systemic, rectal
2.5
21.2
537
4170
SPAT1167
SPAT
Insertion of urinary catheter
6.1
20.9
58
102
S70.0
ICD-10 Finland
Contusion of hip
7.5
20.5
49
70
N39.4
ICD-10 Finland
Other specified urinary incontinence
4.5
20.2
75
184
K90
ICPC
Stroke/cerebrovascular accident
41.4
19.6
24
6
N30.0
ICD-10 Finland
Acute cystitis
3.2
19.6
110
383
E86
ICD-10 Finland
Volume depletion
10.0
19.1
38
40
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
17.8
18.8
29
17
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
+∞
18.8
18
*
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
+∞
18.8
18
*
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
+∞
18.8
18
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
195.1
18.6
19
*
K91
ICPC
Cerebrovascular disease
195.1
18.6
19
*
N05BA06
ATC
lorazepam; systemic, sublingual
5.6
18.4
55
106
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.4
18.4
49
82
P70
ICPC
Dementia
25.9
18.3
25
10
SPAT1305
SPAT
Counselling and guidance related to physical exercise
3.6
18.2
86
262
R35
ICD-10 Finland
Polyuria
4.2
18.1
72
188
N05AH02
ATC
clozapine; systemic
+∞
17.8
17
*
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
+∞
17.8
17
*
U04
ICPC
Incontinence urine
5.2
17.7
56
116
G72.8
ICD-10 Finland
Other specified myopathies
184.6
17.6
18
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
12.4
17.5
31
26
F05.1
ICD-10 Finland
Delirium superimposed on dementia
+∞
16.7
16
*
N05BA01
ATC
diazepam; systemic, rectal
3.2
16.5
94
329
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.8
16.5
47
86
M48.0
ICD-10 Finland
Spinal stenosis
3.0
16.4
102
379
N03AF02
ATC
oxcarbazepine; oral
61.5
15.8
18
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
6.7
15.7
40
63
F02.3
ICD-10 Finland
Dementia in Parkinson disease
+∞
15.7
15
*
F02.31
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly paranoidism
+∞
15.7
15
*
F05.8
ICD-10 Finland
Other delirium
+∞
15.7
15
*
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
27.0
15.7
21
8
G30.8
ICD-10 Finland
Other Alzheimer disease
22.7
15.6
22
10
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
163.6
15.5
16
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.9
15.5
98
368
R47.1
ICD-10 Finland
Dysarthria and anarthria
46.1
15.1
18
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
7.3
15.1
36
52
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.8
15.0
26
21
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.1
14.9
36
53
F02.34
ICD-10 Finland
Dementia in Parkinson's disease, other additional symptoms of mixed type
+∞
14.6
14
*
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
+∞
14.6
14
*
N03AX12
ATC
gabapentin; oral
3.0
14.6
91
337
R13
ICD-10 Finland
Dysphagia
4.0
14.6
59
157
K59.0
ICD-10 Finland
Constipation
3.9
14.3
59
160
N06AX03
ATC
mianserin; oral
6.6
14.2
36
57
NF1AA
NOMESCO Finland
Hip X-ray examination
3.0
13.8
84
307
G04BD09
ATC
trospium; oral
5.8
13.8
39
71
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
13.7
100
407
R42
ICD-10 Finland
Dizziness and giddiness
2.3
13.7
140
687
F22.0
ICD-10 Finland
Delusional disorder
76.7
13.6
15
*
N03AX16
ATC
pregabalin; oral
2.4
13.6
126
586
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
+∞
13.6
13
*
F0234, G20
ICD-10 Finland
NA
+∞
13.6
13
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
13.6
13
*
F023, G20
ICD-10 Finland
NA
+∞
13.6
13
*
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
6.7
13.5
34
53
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
142.7
13.5
14
*
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
142.7
13.5
14
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.3
13.2
31
44
G25.0
ICD-10 Finland
Essential tremor
12.5
13.2
23
19
G56.0
ICD-10 Finland
Carpal tunnel syndrome
8.5
13.1
28
34
J01EA01
ATC
trimethoprim; systemic
2.1
12.8
169
928
K59.09
ICD-10 Finland
Constipation, unspecified
3.7
12.6
56
162
N06AX12
ATC
bupropion; oral
17.7
12.6
19
11
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
12.5
12
*
85000
ICD-8 Finland
Concussion, Current or unspecified
+∞
12.5
12
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
12.5
74
1503
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
132.3
12.5
13
*
R60.0
ICD-10 Finland
Localized oedema
2.7
12.4
91
374
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
12.3
67
227
B01AC07
ATC
dipyridamole; systemic
3.7
12.3
55
160
F01.9
ICD-10 Finland
Vascular dementia, unspecified
38.3
12.2
15
*
N05CD07
ATC
temazepam; oral
2.5
12.2
103
456
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
12.2
158
860
R32
ICD-10 Finland
Unspecified urinary incontinence
6.6
12.0
30
47
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
11.8
111
521
G04CA02
ATC
tamsulosin; oral
1.9
11.8
240
1547
UKC02
NOMESCO Finland
Cystoscopy
2.1
11.7
156
855
R56.8
ICD-10 Finland
Other and unspecified convulsions
8.3
11.6
25
31
Y94.0
ICD-10 Finland
Accident at home
9.5
11.6
23
25
130
Kela drug reimbursment
Malignant tumour
0.2
11.5
12
558
N30.9
ICD-10 Finland
Cystitis, unspecified
3.7
11.4
50
144
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.4
11.4
18
12
J01CA08
ATC
pivmecillinam; oral
1.9
11.3
195
1180
N05CF01
ATC
zopiclone; oral
1.9
11.3
211
1314
SPAT1360
SPAT
Extensive global examination
3.0
11.3
66
235
P29
ICPC
Psychological sympt/compl other
13.0
11.2
19
15
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
11.1
107
507
N06AA12
ATC
doxepin; systemic
4.6
11.1
38
87
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
6.6
10.9
27
42
Z50.5
ICD-10 Finland
Speech therapy
18.2
10.8
16
9
R44.1
ICD-10 Finland
Visual hallucinations
28.5
10.8
14
5
N02AA05
ATC
oxycodone; systemic
2.1
10.6
126
654
R33
ICD-10 Finland
Retention of urine
2.5
10.6
83
354
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
10.5
115
578
I95.9
ICD-10 Finland
Hypotension, unspecified
7.9
10.5
23
30
R1260
NOMESCO Finland
Evaluation of communicative skills
7.9
10.5
23
30
F06.0
ICD-10 Finland
Organic hallucinosis
111.6
10.4
11
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
111.6
10.4
11
*
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
111.6
10.4
11
*
30041
ICD-8 Finland
Neuroses, Depressiva
+∞
10.4
10
*
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
+∞
10.4
10
*
N86
ICPC
Multiple sclerosis
+∞
10.4
10
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
10.4
262
1791
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.1
10.2
131
705
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.9
10.2
63
233
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
11.5
10.1
18
16
SPAT1262
SPAT
Handing over of treatment supplies
2.1
10.1
128
682
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
10.0
221
1445
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
17.0
9.9
15
9
F06.7
ICD-10 Finland
Mild cognitive disorder
12.4
9.9
17
14
S01.9
ICD-10 Finland
Open wound of head, part unspecified
8.9
9.8
20
23
F34.1
ICD-10 Finland
Dysthymia
55.8
9.7
11
*
C03CA01
ATC
furosemide; systemic
1.7
9.6
284
2025
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
9.6
92
435
XKD00
NOMESCO Finland
Uroflowmetry
1.9
9.5
165
989
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
9.5
168
1015
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
101.4
9.4
10
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
101.4
9.4
10
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
+∞
9.4
9
*
F99
ICD-10 Finland
Mental disorder, not otherwise specified
+∞
9.4
9
*
N04BX01
ATC
tolcapone; oral
+∞
9.4
9
*
F0029, G308
ICD-10 Finland
NA
+∞
9.4
9
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
9.4
9
*
G35
ICD-10 Finland
Multiple sclerosis
+∞
9.4
9
*
G04BD11
ATC
fesoterodine; oral
3.8
9.4
39
108
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
9.7
9.3
18
19
J01DB01
ATC
cefalexin; oral
1.7
9.3
445
3619
S01
ICD-10 Finland
Open wound of head
7.9
9.2
20
26
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
11.7
9.1
16
14
F32.1
ICD-10 Finland
Moderate depressive episode
37.2
9.0
11
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
9.0
32
77
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
24.4
8.9
12
5
M54.5
ICD-10 Finland
Low back pain
1.9
8.9
149
882
R23
ICPC
Voice symptom/complaint
8.8
8.8
18
21
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
8.7
89
432
N18
ICPC
Paralysis/weakness
14.3
8.7
14
10
M01AH02
ATC
rofecoxib; oral
2.2
8.7
93
461
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
7.8
8.7
19
25
G04BD07
ATC
tolterodine; oral
3.0
8.6
49
171
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.9
8.6
27
57
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
8.4
8.6
18
22
N06DA04
ATC
galantamine; oral
20.3
8.5
12
6
S72.1
ICD-10 Finland
Pertrochanteric fracture
4.2
8.5
31
77
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
91.1
8.4
9
*
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
91.1
8.4
9
*
G04BD04
ATC
oxybutynin; oral, transdermal
2.9
8.4
49
175
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
8.0
8.4
18
23
N05AB03
ATC
perphenazine; systemic, rectal
13.0
8.4
14
11
SPAT1263
SPAT
Sampling
1.7
8.4
242
1694
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
+∞
8.3
8
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
+∞
8.3
8
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
+∞
8.3
8
*
I63.8
ICD-10 Finland
Other cerebral infarction
+∞
8.3
8
*
N04BC01
ATC
bromocriptine; oral
+∞
8.3
8
*
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
+∞
8.3
8
*
SPAT1125
SPAT
Stoma care and guidance
5.3
8.2
24
47
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.2
8.2
42
138
G04BD08
ATC
solifenacin; oral
2.7
8.2
53
203
SPAT1301
SPAT
No procedures
1.7
8.2
198
1319
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
33.8
8.1
10
*
N03AX09
ATC
lamotrigine; oral
33.8
8.1
10
*
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
22.3
8.0
11
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
8.0
70
317
TAB00
NOMESCO Finland
Lumbar puncture
7.9
7.9
17
22
N06AB03
ATC
fluoxetine; oral
3.0
7.9
45
158
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.9
7.9
128
749
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
11.0
7.8
14
13
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
11.0
7.8
14
13
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.0
7.8
44
153
R11
ICD-10 Finland
Nausea and vomiting
2.8
7.6
46
169
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.8
7.6
48
180
S40.0
ICD-10 Finland
Contusion of shoulder and upper arm
4.4
7.6
26
61
R29.6
ICD-10 Finland
Tendency to fall, not elsewhere classified
25.3
7.6
10
*
S22.3
ICD-10 Finland
Fracture of rib
2.9
7.5
44
158
N06AX26
ATC
vortioxetine; oral
7.2
7.5
17
24
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
80.9
7.4
8
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
80.9
7.4
8
*
G30.0
ICD-10 Finland
Alzheimer disease with early onset
80.9
7.4
8
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.0
7.3
22
45
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
11.0
7.3
13
12
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
+∞
7.3
7
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
+∞
7.3
7
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.3
7
*
Z60.8
ICD-10 Finland
Other problems related to social environment
+∞
7.3
7
*
F06.2
ICD-10 Finland
Organic delusional [schizophrenia-like] disorder
+∞
7.3
7
*
N05AX12
ATC
aripiprazole; systemic
+∞
7.3
7
*
G21.8
ICD-10 Finland
Other secondary parkinsonism
+∞
7.3
7
*
N04AA01
ATC
trihexyphenidyl; oral
+∞
7.3
7
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
15.9
7.2
11
7
H50.31
ICD-10 Finland
Intermittent exotropia
30.3
7.2
9
*
N05AF03
ATC
chlorprothixene; systemic
30.3
7.2
9
*
N03AX14
ATC
levetiracetam; systemic
30.3
7.2
9
*
SPAT1279
SPAT
Preparation of immediate hospitalisation
8.0
7.1
15
19
A02BC05
ATC
esomeprazole; systemic
1.6
7.1
209
1457
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.5
7.0
55
234
N03AF01
ATC
carbamazepine; oral, rectal
5.3
7.0
20
39
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.5
6.9
30
88
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
6.9
37
127
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
16.9
6.8
10
6
N06AB06
ATC
sertraline; oral
3.5
6.7
29
85
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.5
6.7
16
25
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.9
6.6
101
577
N06AA09
ATC
amitriptyline; systemic
2.6
6.6
46
184
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
6.6
44
174
S20.2
ICD-10 Finland
Contusion of thorax
3.4
6.5
29
87
SPAT1050
SPAT
Extensive neurological examination
5.4
6.5
18
34
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
5.8
6.5
17
30
EBA00
NOMESCO Finland
Extraction of tooth
1.7
6.5
150
976
N40
ICD-10 Finland
Hyperplasia of prostate
1.6
6.5
212
1515
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
70.5
6.4
7
*
LAITO
NOMESCO Finland
NA
70.5
6.4
7
*
S63.1
ICD-10 Finland
Dislocation of finger
7.5
6.4
14
19
S09.9
ICD-10 Finland
Unspecified injury of head
14.5
6.4
10
7
SPAT1304
SPAT
Counselling and guidance related to ageing
2.2
6.4
64
309
M01AC06
ATC
meloxicam; systemic, rectal
1.6
6.4
180
1237
M54
ICD-10 Finland
Dorsalgia
2.3
6.3
54
242
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
6.3
78
408
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
6.3
51
222
H50.52
ICD-10 Finland
Exophoria
18.2
6.3
9
5
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
6.3
6
*
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
6.3
6
*
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
+∞
6.3
6
*
F009, G309
ICD-10 Finland
NA
+∞
6.3
6
*
F0009, G300
ICD-10 Finland
NA
+∞
6.3
6
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
6.3
6
*
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
+∞
6.3
6
*
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
+∞
6.3
6
*
S00.0
ICD-10 Finland
Superficial injury of scalp
5.1
6.2
18
36
D12
ICPC
Constipation
3.3
6.2
29
91
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
6.2
53
239
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.9
6.1
35
125
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
5.0
6.1
18
37
N30
ICD-10 Finland
Cystitis
2.7
6.1
39
149
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.1
170
1164
N06AG02
ATC
moclobemide; oral
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint PD_DEMENTIA_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD_DEMENTIA_EXMORE | 4.002 [3.47, 4.62] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 2678 out of 3661 females with PD_DEMENTIA_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD_DEMENTIA_EXMORE | 4.506 [3.75, 5.41] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 3543 out of 4687 males with PD_DEMENTIA_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have PD_DEMENTIA_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 1.034% |
| 5 | 2.261% | 5.714% |
| 10 | 5.45% | 13.843% |
| 15 | 10.744% | 24.757% |
| 20 | 18.651% | 38.964% |
Relationships between endpoints
↥Index endpoint: PD_DEMENTIA_EXMORE – Dementia due to Parkinsons disease, excluding more controls
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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