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Dementia due to Parkinson's disease

PD_DEMENTIA

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

778

4. Check minimum number of events

None

778

5. Include endpoints

None

778

6. Filter based on genotype QC (FinnGen only)

778

Control definitions (FinnGen only)

Control exclude
G6_PARKINSON

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 778 271 507
Unadjusted period prevalence (%) 0.18 0.09 0.22
Median age at first event (years) 76.78 77.88 76.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
664
Matched controls
6641
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
323.0
600
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
+∞
323.0
286
*
G20
ICD-10 Finland
Parkinson disease
4503599627370496.0
323.0
630
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2169.3
323.0
626
48
N04BD01
ATC
selegiline; oral
912.7
323.0
304
6
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
323.0
536
*
N87
ICPC
Parkinsonism
382.4
289.0
272
12
N06DA03
ATC
rivastigmine; oral, transdermal
31.2
248.6
351
230
N04BD02
ATC
rasagiline; oral
+∞
179.5
164
*
N04BC05
ATC
pramipexole; oral
19.1
179.1
298
271
N04BC04
ATC
ropinirole; oral
139.0
153.0
159
15
N05AH04
ATC
quetiapine; oral
12.2
147.3
309
442
193
Kela drug reimbursment
Rasagiline
+∞
145.3
134
*
F02.39
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
131.8
122
*
N04BX02
ATC
entacapone; oral
1430.2
125.2
118
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
8.1
81.9
207
351
N03AE01
ATC
clonazepam; systemic
9.5
58.3
127
161
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
35.3
49.6
64
20
H02AA02
ATC
fludrocortisone; oral
35.3
49.6
64
20
N04BC09
ATC
rotigotine; transdermal
179.9
48.6
50
*
F02.30
ICD-10 Finland
Dementia in Parkinson's disease without additional symptoms
+∞
47.5
45
*
N04BB01
ATC
amantadine; oral
24.3
43.6
62
28
R53
ICD-10 Finland
Malaise and fatigue
3.5
43.0
259
1020
I95.1
ICD-10 Finland
Orthostatic hypotension
7.0
40.5
106
175
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.0
39.2
333
1649
N04BC06
ATC
cabergoline; oral (dopamine agonists)
137.9
37.1
39
*
R25.1
ICD-10 Finland
Tremor, unspecified
10.9
36.8
72
73
N04AA02
ATC
biperiden; systemic
20.1
35.9
54
29
AA1AD
NOMESCO Finland
CT of head and brain
2.9
34.1
284
1352
F02.32
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly hallucinations
+∞
33.6
32
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
33.4
242
1049
N04BC02
ATC
pergolide; oral
+∞
32.6
31
*
A06AD11
ATC
lactulose; oral
2.9
29.6
220
956
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
29.0
304
1621
G02CB01
ATC
bromocriptine; systemic
46.0
29.0
35
8
G04BD12
ATC
mirabegron; oral
3.6
28.4
143
467
F0232, G20
ICD-10 Finland
NA
+∞
27.3
26
*
F0230, G20
ICD-10 Finland
NA
+∞
27.3
26
*
AAG20
NOMESCO Finland
Stereotactic intracranial implantation of electrodes
+∞
25.2
24
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.4
25.0
98
254
SPAT1215
SPAT
Assessment of need for medical rehabilitation
5.6
23.8
72
141
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
43.3
23.8
29
7
S72.0
ICD-10 Finland
Fracture of neck of femur
4.4
22.8
87
219
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.2
22.3
55
82
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
15.8
22.2
36
24
S01.0
ICD-10 Finland
Open wound of scalp
3.7
21.5
102
313
SPAT1229
SPAT
Assessment of need for aid
3.3
21.0
115
393
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
20.7
247
1344
D21
ICPC
Swallowing problem
10.6
20.1
39
39
N05BA04
ATC
oxazepam; oral
2.4
20.0
205
1030
N29
ICPC
Neurological sympt/complt other
8.1
19.9
45
59
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
19.7
185
887
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
108.3
19.7
21
*
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
19.5
45
61
N06AX11
ATC
mirtazapine; oral
2.3
19.4
236
1290
N06AB10
ATC
escitalopram; oral
3.0
19.2
125
482
SPAT1216
SPAT
Assessment of functional ability
2.5
19.2
188
919
A28
ICPC
Limited function/disability NOS
2.4
19.1
207
1065
N19
ICPC
Speech disorder
12.3
19.0
34
29
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
+∞
18.8
18
*
SPAT1234
SPAT
Support of social functional capacity
3.7
18.7
87
261
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.2
18.6
104
361
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.6
18.1
54
104
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.5
17.9
89
282
W19
ICD-10 Finland
Unspecified fall
3.2
17.6
102
361
XF606
NOMESCO Finland
Ortostatic test
12.5
17.0
30
25
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
16.9
155
725
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
16.6
171
850
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.9
16.5
46
82
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
16.5
151
708
R1250
NOMESCO Finland
Evaluation of functional capability
8.7
16.4
35
42
F02.31
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly paranoidism
+∞
15.7
15
*
F02.3
ICD-10 Finland
Dementia in Parkinson disease
+∞
15.7
15
*
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
4.6
15.5
54
124
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.9
15.4
65
180
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
58.0
14.8
17
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
18.9
14.8
22
12
F02.34
ICD-10 Finland
Dementia in Parkinson's disease, other additional symptoms of mixed type
+∞
14.6
14
*
Z75.5
ICD-10 Finland
Holiday relief care
8.4
13.9
30
37
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
13.9
66
202
SPAT1167
SPAT
Insertion of urinary catheter
3.8
13.6
58
162
F0234, G20
ICD-10 Finland
NA
+∞
13.6
13
*
F023, G20
ICD-10 Finland
NA
+∞
13.6
13
*
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
26.4
13.4
18
7
N99
ICPC
Neurological disease other
10.8
13.3
25
24
SPAT1172
SPAT
Guidance concerning hydration
4.3
13.2
49
121
N05AX08
ATC
risperidone; systemic
2.8
13.1
91
361
N06AB04
ATC
citalopram; systemic
2.2
13.1
159
843
L28
ICPC
Limited function/disability (L)
2.1
12.4
170
945
C07AA05
ATC
propranolol; systemic
2.4
12.4
114
527
S06.0
ICD-10 Finland
Concussion
2.6
11.9
90
374
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
47.6
11.9
14
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.9
11.7
26
34
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
11.7
74
1474
U04
ICPC
Incontinence urine
3.4
11.7
56
173
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
6.7
11.7
29
45
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
66.1
11.6
13
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
11.5
144
769
G04BD09
ATC
trospium; oral
4.6
11.4
39
89
R4130
NOMESCO Finland
Speech therapy
5.1
11.3
35
72
R35
ICD-10 Finland
Polyuria
2.8
11.0
72
275
R41.0
ICD-10 Finland
Disorientation, unspecified
3.6
10.6
47
137
N05AH02
ATC
clozapine; systemic
14.5
10.5
17
12
R55
ICD-10 Finland
Syncope and collapse
2.2
10.4
117
593
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.6
10.4
75
305
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.8
10.3
67
254
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.9
10.0
40
107
N05AH03
ATC
olanzapine; systemic
4.1
9.9
38
98
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.4
9.8
86
388
S70.0
ICD-10 Finland
Contusion of hip
3.3
9.7
49
158
N30.0
ICD-10 Finland
Acute cystitis
2.2
9.7
110
560
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
9.5
55
196
WYA20
NOMESCO Finland
Home visit
4.4
9.4
33
78
N04BX01
ATC
tolcapone; oral
+∞
9.4
9
*
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
4.3
9.4
34
83
A04
ICPC
Weakness/tiredness general
2.1
9.1
114
606
N28
ICPC
Limited function/disability (N)
5.4
9.0
26
50
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.9
9.0
36
97
G04BD11
ATC
fesoterodine; oral
3.6
8.8
39
114
SPAT1254
SPAT
Administration of medicine
1.9
8.6
137
794
F06.0
ICD-10 Finland
Organic hallucinosis
27.9
8.5
11
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
8.4
95
483
N04BC01
ATC
bromocriptine; oral
+∞
8.3
8
*
N06DA02
ATC
donepezil; oral
2.2
8.1
82
397
NF1AA
NOMESCO Finland
Hip X-ray examination
2.2
8.1
84
411
E86
ICD-10 Finland
Volume depletion
3.3
7.9
38
120
Z50.5
ICD-10 Finland
Speech therapy
8.2
7.6
16
20
R44.1
ICD-10 Finland
Visual hallucinations
10.2
7.6
14
14
R32
ICD-10 Finland
Unspecified urinary incontinence
3.7
7.4
30
83
N30.9
ICD-10 Finland
Cystitis, unspecified
2.6
7.3
50
198
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.6
7.3
31
89
K59.0
ICD-10 Finland
Constipation
2.4
7.3
59
255
Y94.0
ICD-10 Finland
Accident at home
4.7
7.3
23
50
N06AX16
ATC
venlafaxine; oral
2.4
7.2
59
259
N86
ICPC
Multiple sclerosis
20.3
7.1
10
5
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
20.3
7.1
10
5
R13
ICD-10 Finland
Dysphagia
2.4
7.1
59
260
S01
ICD-10 Finland
Open wound of head
5.4
7.1
20
38
F05.9
ICD-10 Finland
Delirium, unspecified
3.5
7.1
31
91
130
Kela drug reimbursment
Malignant tumour
0.3
7.0
12
425
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
6.8
57
252
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.6
156
1020
P20
ICPC
Memory disturbance
1.7
6.6
136
857
XKD00
NOMESCO Finland
Uroflowmetry
1.7
6.5
165
1100
SPAT1053
SPAT
Memory test
1.7
6.5
169
1135
N06AX21
ATC
duloxetine; oral
2.3
6.5
57
258
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.7
6.5
131
820
I95.9
ICD-10 Finland
Hypotension, unspecified
4.1
6.4
23
57
N04AA01
ATC
trihexyphenidyl; oral
70.5
6.4
7
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
6.4
81
433
R47.1
ICD-10 Finland
Dysarthria and anarthria
5.3
6.4
18
35
SPAT1360
SPAT
Extensive global examination
2.1
6.3
66
325
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.9
6.3
36
128
N06AX03
ATC
mianserin; oral
2.9
6.3
36
128
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.2
537
4783
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.2
6.2
63
307
N06DX01
ATC
memantine; oral
1.9
6.2
87
483
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.0
98
570
F05.8
ICD-10 Finland
Other delirium
6.1
6.0
15
25
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
6.1
6.0
15
25
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
5.6
6.0
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
292
1700
2.15
22.05
2.1
1.8
1120.6
1183.5
nmol/l
0.51
192
1246
20
14
14.64
21.99
2.0
1.3
73.8
84.9
nmol/l
—
13
9
32
63
5.25
15.64
5.0
3.0
—
—
—
0
0
393
5034
0.56
14.19
3.6
4.7
1.4
1.4
mmol/l
0.20
321
4396
401
5100
0.56
13.99
3.5
4.8
4.2
4.3
mmol/l
0.81
329
4509
333
2286
1.80
13.88
4.8
3.8
—
—
—
0
0
385
4882
0.58
12.26
3.2
4.2
1.1
1.2
mmol/l
3.86
305
4212
429
5272
0.58
11.84
4.0
5.4
2.4
2.4
mmol/l
0.54
346
4623
107
1961
0.47
11.81
2.8
3.2
7.0
7.1
mmol/l
0.05
74
1574
109
1971
0.48
11.52
2.7
3.3
732.8
360.8
mg/l
0.23
63
1311
122
2102
0.50
11.08
3.8
4.0
6.0
9.4
mg/mmol
1.57
71
1373
315
2239
1.68
10.87
4.1
4.5
—
—
—
0
0
289
2015
1.69
10.68
2.8
2.2
341.9
268.9
u/l
0.47
266
1867
61
1339
0.41
10.64
1.2
1.6
1.0
1.3
mmol/l
2.85
52
1085
500
4186
1.54
7.55
7.4
5.4
6209.6
2626.8
e6/l
0.29
14
88
435
5118
0.66
7.32
6.2
6.9
40.9
41.8
mmol/mol
1.03
360
4571
460
5278
0.69
6.00
4.4
5.2
6.1
6.2
mmol/l
1.67
357
4600
363
2961
1.42
5.49
2.4
2.2
82.1
91.9
pmol/l
4.77
222
1541
257
1987
1.44
5.14
3.7
3.5
0.5
0.6
e6/l
0.54
201
1569
33
140
2.42
5.13
1.4
1.2
—
—
—
0
0
112
1656
0.62
5.13
2.1
3.1
10386.1
9682.1
umol/l
0.03
80
1362
40
790
0.48
5.05
3.9
3.9
3.2
31.6
ug/l
1.97
33
673
202
1524
1.44
4.53
4.1
3.1
610.3
561.8
mosm/kgh2o
2.85
171
1300
28
118
2.42
4.44
1.3
1.3
502.7
549.9
mg/l
0.32
23
111
18
461
0.38
4.38
1.1
1.4
—
—
—
0
0
212
1623
1.42
4.37
1.9
1.8
391.7
4415609.8
pmol/l
0.50
164
1291
37
706
0.50
4.22
1.2
1.2
84.0
40.1
iu/ml
0.32
12
226
273
2193
1.38
4.22
4.0
3.6
54.5
113.2
e6/l
1.02
217
1755
238
1873
1.39
4.16
3.8
3.5
—
—
—
0
0
87
1304
0.63
4.14
3.9
3.5
—
—
—
0
0
23
93
2.52
3.99
1.3
1.2
—
—
—
0
0
35
664
0.50
3.93
1.3
1.2
1.5
13.5
u/ml
3.62
12
208
16
409
0.38
3.89
1.4
1.5
—
—
—
0
0
169
2196
0.71
3.88
2.2
2.4
—
—
—
0
0
232
1837
1.37
3.86
1.7
1.7
17.5
19.5
nmol/l
1.40
203
1540
5
203
0.24
3.71
1.0
1.1
—
—
—
0
0
30
574
0.50
3.47
1.2
1.3
230.0
455.5
titre
—
8
139
469
4166
1.32
3.43
6.3
4.8
—
—
—
0
0
17
396
0.42
3.36
1.2
1.4
—
—
—
0
0
16
382
0.41
3.36
1.1
1.5
—
—
—
0
0
17
392
0.42
3.28
1.2
1.4
—
—
—
0
0
290
2433
1.31
3.15
4.6
4.1
119.3
141.9
e6/l
0.23
222
1846
22
98
2.28
3.15
1.1
1.3
3.7
4.0
mmol/l
0.72
17
88
152
1161
1.38
3.10
3.3
3.4
2.7
1.9
e6/l
0.58
87
704
23
106
2.21
3.05
1.2
1.3
1.7
83.5
e6/l
0.87
16
86
23
106
2.21
3.05
1.5
1.4
58.8
372.5
e6/l
1.16
18
87
10
29
3.48
3.05
1.1
1.0
141.4
131.7
nmol/l
—
10
29
130
1693
0.72
2.92
2.7
3.4
0.7
0.8
ug/l
0.57
87
1233
41
673
0.59
2.84
1.2
1.5
—
—
—
0
0
35
599
0.56
2.83
1.4
1.3
—
—
—
0
0
329
2836
1.28
2.83
5.5
4.5
45.7
58.5
ng/l
0.50
271
2260
335
2897
1.27
2.80
5.8
4.5
0.0
0.0
estimate
0.00
78
551
333
2878
1.27
2.79
5.6
4.4
0.0
0.0
estimate
0.00
73
566
329
2850
1.27
2.68
7.9
6.0
0.0
0.0
estimate
0.00
74
553
236
1970
1.28
2.58
2.2
2.2
2.8
3.2
mg/l
2.96
169
1652
12
44
2.75
2.55
1.3
1.2
—
—
—
0
0
526
5654
0.78
2.52
8.6
11.4
16.7
23.8
u/l
10.16
455
5377
366
4093
0.80
2.46
4.4
4.7
—
—
—
0
0
53
789
0.65
2.44
1.2
1.3
—
—
—
0
0
0
64
0.00
2.43
0.0
1.2
—
9.3
—
0
47
0
65
0.00
2.42
0.0
1.5
—
—
—
0
0
192
1576
1.29
2.37
3.3
2.7
4.2
4.4
e6/l
0.11
164
1392
15
65
2.33
2.32
1.3
1.1
330.8
348.0
nmol/l
—
8
54
184
1507
1.29
2.31
6.2
4.2
—
—
—
0
0
386
3446
1.24
2.30
5.0
6.9
1.2
1.2
mmol/l
0.74
295
2848
23
413
0.54
2.24
1.6
2.2
13.6
11.6
nmol/l
0.55
17
344
0
62
0.00
2.23
0.0
1.1
—
—
—
0
0
11
42
2.64
2.19
1.3
1.1
—
—
—
0
0
197
1648
1.26
2.07
5.8
4.7
0.0
0.0
estimate
0.00
66
515
23
126
1.85
2.00
2.4
2.7
—
—
—
0
0
30
182
1.67
1.87
3.4
5.4
1.9
2.8
mmol/l
1.25
23
121
73
539
1.39
1.86
6.8
4.1
—
—
—
0
0
42
278
1.54
1.86
2.3
2.2
491.9
660.4
ug/l
0.27
36
262
417
3809
1.20
1.82
5.0
5.1
6.5
7.0
mmol/l
8.23
391
3586
12
247
0.48
1.81
1.1
1.3
—
—
—
0
0
34
520
0.64
1.81
1.1
1.4
—
—
—
0
0
25
146
1.74
1.79
1.7
2.6
25.9
34.0
umol/l
1.53
16
117
0
47
0.00
1.71
0.0
1.2
—
—
—
0
0
332
2986
1.20
1.67
3.3
4.9
33.3
34.0
g/l
1.29
282
2753
347
3138
1.19
1.64
4.7
6.1
1.2
1.2
mmol/l
0.55
297
2793
37
246
1.53
1.63
8.6
5.4
—
—
—
0
0
5
128
0.39
1.50
1.0
1.1
—
—
—
0
0
153
1293
1.23
1.46
5.4
5.1
1.0
1.0
kg/l
1.27
19
203
67
515
1.33
1.37
1.7
2.0
408.4
390.2
nmol/l
0.30
48
456
40
284
1.43
1.32
5.2
4.7
25.9
24.9
mmol/l
1.19
34
259
7
150
0.46
1.32
3.0
2.6
—
—
—
0
0
26
171
1.54
1.24
2.4
4.5
—
—
—
0
0
92
750
1.26
1.23
2.7
3.6
2.8
1.9
mmol/l
1.79
76
585
221
2469
0.85
1.21
12.3
10.7
0.0
0.0
e9/l
1.13
174
2006
75
600
1.28
1.17
2.9
3.8
1.2
1.2
mmol/l
0.40
62
508
20
308
0.64
1.17
1.5
1.2
—
—
—
0
0
47
352
1.36
1.17
1.9
1.8
1.8
2.3
ug/l
0.18
30
296
0
33
0.00
1.16
0.0
2.4
—
—
—
0
0
0
35
0.00
1.15
0.0
2.4
—
670.1
—
0
15
0
36
0.00
1.14
0.0
1.6
—
—
—
0
0
53
681
0.76
1.12
2.3
6.6
10.4
12.1
mmol/l
1.03
44
640
231
2558
0.86
1.11
3.3
3.4
1771.2
2144.6
ng/l
0.60
190
2234
61
768
0.78
1.11
1.5
1.4
—
—
—
0
0
8
41
1.96
1.09
1.5
1.1
—
—
—
0
0
11
59
1.88
1.07
1.5
1.6
—
—
—
0
0
89
736
1.24
1.07
2.4
2.7
5.7
5.9
ug/l
0.05
39
628
38
508
0.74
1.06
2.0
3.8
0.8
0.9
%
—
8
177
19
288
0.65
1.05
1.1
1.3
—
—
—
0
0
5
22
2.28
1.03
1.6
1.1
—
—
—
0
0
307
3312
0.88
0.99
6.2
8.2
4.8
4.4
e9/l
1.22
255
2873
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
274
2974
0.88
0.97
4.1
5.8
2.7
5.0
ug/l
0.87
213
2594
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
228
2069
1.14
0.95
2.5
4.0
7.4
7.4
ph
1.55
49
394
81
674
1.23
0.94
4.8
4.7
—
—
—
0
0
70
842
0.81
0.88
1.2
1.5
2.2
2.9
g/l
1.85
31
476
11
180
0.61
0.87
2.2
3.1
8.1
7.6
kpa
0.52
11
159
34
441
0.76
0.81
2.1
3.7
2.7
0.6
%
—
7
126
14
211
0.66
0.79
2.0
3.4
24.8
24.9
mmol/l
0.03
14
175
0
24
0.00
0.79
0.0
1.2
—
24.4
—
0
19
0
24
0.00
0.79
0.0
1.8
—
64492.2
—
0
17
83
969
0.84
0.78
2.2
5.3
0.9
1.0
mmol/l
3.45
73
885
37
470
0.78
0.77
2.1
3.9
0.1
0.1
%
—
7
158
19
267
0.70
0.76
1.3
1.3
—
—
—
0
0
262
2816
0.90
0.76
4.4
5.0
0.0
0.0
e9/l
2.65
214
2397
52
633
0.81
0.76
3.1
8.3
—
—
—
0
0
474
4540
1.11
0.75
25.8
21.6
36.0
37.4
%
1.36
229
2586
17
243
0.69
0.75
2.1
2.2
—
—
—
0
0
261
2804
0.90
0.75
4.4
5.0
0.6
0.6
e9/l
1.77
213
2372
130
1458
0.87
0.74
5.8
6.3
—
—
—
0
0
154
1384
1.14
0.74
4.7
4.4
—
—
—
0
0
90
778
1.18
0.73
1.6
1.8
—
—
—
0
0
404
4231
0.91
0.69
3.5
4.1
13.3
16.1
mm/h
3.17
345
3803
406
4250
0.91
0.69
27.1
23.8
13.8
14.1
%
5.68
387
4135
29
222
1.32
0.69
2.7
2.5
4.3
4.2
pmol/l
0.25
21
191
247
2296
1.11
0.68
2.2
3.4
2.3
2.3
mmol/l
1.35
192
1956
112
993
1.15
0.67
1.6
2.5
1.6
1.8
%
1.15
84
875
568
5839
0.90
0.65
33.2
28.4
7.0
7.1
e9/l
0.21
534
5610
35
436
0.79
0.64
1.5
1.5
—
—
—
0
0
568
5837
0.90
0.63
33.4
28.6
126.1
130.7
g/l
12.15
540
5691
568
5836
0.90
0.63
33.0
28.3
30.6
30.5
pg
0.51
540
5692
568
5836
0.90
0.63
33.1
28.4
4.2
4.3
e12/l
10.67
535
5608
568
5835
0.90
0.62
33.0
28.3
92.3
92.1
fl
0.78
540
5693
568
5835
0.90
0.62
33.1
28.4
232.2
232.0
e9/l
0.01
534
5639
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
15.5
—
0
14
0
22
0.00
0.59
0.0
2.2
—
—
—
0
0
122
1099
1.13
0.59
1.7
3.0
0.8
0.8
mmol/l
0.42
103
1015
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
0.9
—
0
23
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
43
356
1.22
0.57
1.6
4.0
25.7
23.8
mmol/l
2.75
38
326
67
579
1.17
0.57
4.4
4.0
—
—
—
0
0
270
2860
0.91
0.56
4.8
5.1
1.5
1.8
e9/l
3.85
226
2477
5
88
0.57
0.56
1.0
1.3
—
—
—
0
0
47
557
0.83
0.56
2.4
4.0
69.6
101.1
ng/l
2.13
34
469
37
448
0.82
0.55
2.1
3.9
0.0
0.1
%
—
7
136
73
640
1.16
0.53
1.6
2.0
0.2
0.2
g/l
0.23
65
582
70
613
1.16
0.52
3.6
3.9
—
—
—
0
0
276
2910
0.92
0.51
4.9
5.1
0.2
0.2
e9/l
6.02
225
2510
30
368
0.81
0.51
2.2
3.1
—
—
—
0
0
566
5791
0.92
0.49
28.4
23.9
4.0
4.0
mmol/l
6.73
540
5605
563
5496
1.09
0.48
25.1
19.4
32.9
29.2
mg/l
1.51
515
4605
23
288
0.79
0.47
2.4
2.5
—
13.4
—
0
5
7
48
1.46
0.47
2.3
1.4
—
—
—
0
0
10
142
0.70
0.46
1.4
2.0
8.3
13.4
mg/l
—
10
128
8
117
0.68
0.46
1.1
1.4
—
—
—
0
0
8
117
0.68
0.46
2.0
2.3
56.0
63.3
%
—
8
117
39
458
0.84
0.44
2.1
1.9
251.9
167.1
ug/g
0.61
27
358
566
5782
0.92
0.44
28.4
23.7
139.8
139.5
mmol/l
2.34
541
5603
33
393
0.83
0.44
7.7
9.8
—
—
—
0
0
11
150
0.73
0.41
1.6
3.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
5
34
1.47
0.40
1.2
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
7
105
0.66
0.39
1.4
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
108.2
—
0
13
54
477
1.14
0.38
4.4
4.2
7.4
7.4
ph
—
9
55
8
113
0.70
0.37
1.3
2.7
—
—
—
0
0
24
198
1.22
0.36
1.8
3.6
—
—
—
0
0
254
2654
0.94
0.36
5.1
5.6
8.6
9.1
%
1.85
218
2449
253
2643
0.94
0.36
4.7
5.3
2.3
2.8
%
4.33
217
2435
20
162
1.24
0.36
2.4
2.6
16.8
15.3
%
—
9
77
9
124
0.72
0.35
1.3
1.5
—
—
—
0
0
23
190
1.22
0.35
13.4
14.8
—
—
—
0
0
409
3976
1.06
0.34
3.6
3.6
15.4
15.2
pmol/l
0.59
335
3446
99
1069
0.92
0.33
3.7
4.4
—
—
—
0
0
54
483
1.13
0.33
4.4
4.2
5.2
5.2
kpa
0.18
47
440
6
46
1.31
0.33
1.0
2.0
—
—
—
0
0
542
5521
0.94
0.33
24.6
19.0
—
—
—
0
0
154
1453
1.07
0.32
2.7
3.3
2.5
2.5
mmol/l
0.17
121
1262
121
1291
0.93
0.31
1.2
1.3
—
—
—
0
0
250
2401
1.06
0.31
2.6
2.8
164.1
164.5
ug/l
0.01
193
2131
16
197
0.81
0.31
1.1
1.1
97.4
121.1
iu/ml
—
5
63
7
100
0.70
0.30
3.0
2.9
—
—
—
0
0
217
2080
1.06
0.29
2.1
2.7
—
—
—
0
0
249
2585
0.95
0.29
5.0
5.3
0.5
0.6
%
1.71
214
2383
21
176
1.20
0.29
1.5
1.4
264.2
264.5
ug/g
0.00
13
104
254
2635
0.95
0.29
5.4
5.3
63.8
59.8
%
5.79
219
2429
92
988
0.92
0.28
1.6
2.0
—
—
—
0
0
147
1550
0.94
0.28
2.1
2.5
—
—
—
0
0
32
280
1.15
0.28
1.7
1.3
—
—
—
0
0
9
116
0.77
0.27
2.7
3.2
—
—
—
0
0
271
2802
0.95
0.27
3.6
4.5
—
—
—
0
0
261
2700
0.95
0.26
5.5
5.6
21.2
24.6
%
5.84
223
2471
99
927
1.08
0.26
4.4
6.6
5.1
5.0
kpa
0.28
92
882
79
733
1.09
0.26
1.7
2.6
59.3
68.3
e9/l
2.27
61
578
14
171
0.82
0.26
1.4
2.4
48.9
89.4
ug/min
—
5
101
36
404
0.89
0.26
1.4
2.0
1.5
1.5
g/l
0.17
25
351
99
928
1.08
0.26
4.5
6.6
11.4
11.4
kpa
0.01
91
884
46
416
1.11
0.25
3.5
3.1
0.5
0.4
e6/l
0.09
46
408
15
180
0.83
0.24
1.1
1.6
—
—
—
0
0
19
161
1.18
0.24
1.1
2.7
—
—
—
0
0
12
97
1.24
0.23
1.7
1.1
—
—
—
0
0
42
381
1.11
0.22
2.6
2.6
—
—
—
0
0
60
556
1.09
0.21
1.6
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
173.2
—
0
5
0
10
0.00
0.21
0.0
1.0
—
1385.5
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
8
103
0.77
0.21
1.3
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
49.8
—
0
13
0
14
0.00
0.20
0.0
1.4
—
1.9
—
0
14
98
929
1.06
0.20
4.5
6.7
1.8
1.2
mmol/l
1.18
79
707
48
442
1.09
0.20
5.4
3.7
—
—
—
0
0
9
114
0.79
0.20
1.1
1.4
—
—
—
0
0
196
2026
0.96
0.20
5.1
4.6
—
—
—
0
0
6
50
1.20
0.19
1.2
1.7
—
—
—
0
0
6
51
1.18
0.19
1.0
1.8
—
—
—
0
0
19
165
1.16
0.19
8.2
4.1
23.8
30.2
mg/l
0.44
13
111
6
52
1.16
0.19
1.3
1.2
—
—
nmol/l
—
0
0
10
82
1.22
0.17
1.5
2.0
—
—
—
0
0
6
77
0.78
0.15
1.2
1.4
—
—
—
0
0
11
93
1.19
0.14
1.4
1.4
—
—
—
0
0
7
90
0.78
0.14
1.0
1.0
—
—
—
0
0
74
773
0.95
0.12
2.3
2.9
238.5
263.3
ng/l
0.17
66
706
126
1222
1.04
0.12
1.7
1.7
1.8
1.5
mg/l
0.22
98
975
43
405
1.07
0.12
8.1
4.5
—
—
—
0
0
17
153
1.11
0.11
1.5
1.6
—
—
—
0
0
115
1184
0.97
0.10
1.8
2.5
11.1
11.9
umol/l
0.66
93
1078
67
698
0.96
0.10
1.6
2.8
11.6
10.5
umol/l
0.12
53
607
144
1405
1.03
0.10
4.1
4.1
72.0
285.7
ng/l
3.49
129
1255
5
46
1.09
0.09
1.0
1.9
—
—
—
0
0
6
57
1.05
0.08
2.2
1.7
264.8
327.2
mu/l
—
6
52
6
58
1.03
0.08
1.5
1.4
—
—
—
0
0
6
73
0.82
0.07
1.3
3.6
—
—
—
0
0
8
74
1.08
0.07
2.5
2.4
—
—
—
0
0
12
108
1.11
0.07
1.2
1.2
—
—
—
0
0
101
1034
0.97
0.07
2.0
2.6
21.3
21.7
%
0.12
71
874
7
85
0.82
0.07
1.9
5.5
—
—
—
0
0
35
334
1.05
0.07
3.3
3.4
4.0
4.1
e9/l
0.07
15
227
107
1093
0.98
0.06
1.8
2.5
2.1
2.2
g/l
2.04
80
994
37
354
1.05
0.06
5.1
4.3
—
—
—
0
0
16
149
1.08
0.05
1.3
1.6
18458.6
19138.0
e6/l
—
10
102
33
318
1.04
0.04
3.8
4.1
—
—
—
0
0
21
200
1.05
0.03
1.1
3.8
—
—
—
0
0
488
4898
0.99
0.03
4.7
4.6
2.0
2.1
mu/l
1.10
405
4277
195
1934
1.01
0.03
2.3
2.5
53.4
56.9
u/l
0.39
177
1774
16
169
0.95
0.03
1.1
1.2
—
—
—
0
0
331
3295
1.01
0.02
3.6
6.1
12.3
12.8
umol/l
0.35
296
3104
309
3077
1.01
0.02
12.5
12.5
1.4
1.4
inr
0.37
85
846
92
911
1.01
0.01
1.2
1.2
0.6
1.4
u/ml
1.90
20
211
66
668
0.99
0.01
1.5
2.8
64.8
65.8
g/l
0.35
47
591
27
277
0.97
0.01
1.3
3.5
26.1
53.8
mg/l
1.59
19
225
199
1999
0.99
0.01
4.8
5.2
—
—
—
0
0
415
4158
1.00
0.01
28.0
26.4
330.2
330.7
g/l
0.48
394
4111
27
276
0.98
0.00
1.3
3.5
50.8
85.8
mg/l
0.77
20
221
11
107
1.03
0.00
1.6
2.7
5.0
4.7
e9/l
0.08
11
107
157
1565
1.00
0.00
3.3
4.1
78.9
80.3
%
0.31
150
1530
25
248
1.01
0.00
1.4
2.6
35.3
36.4
g/l
0.28
13
205
11
111
0.99
0.00
1.7
3.1
56.2
61.8
%
0.64
11
111
460
4604
1.00
0.00
4.9
7.6
83.6
82.2
u/l
0.19
402
4276
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
8.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
78
0.90
0.00
1.9
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
18.1
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
5
54
0.93
0.00
1.2
1.6
8.1
11.3
%
—
5
54
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
73
0.96
0.00
1.1
1.2
—
—
—
0
0
6
62
0.97
0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
6
64
0.94
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: PD_DEMENTIA – Dementia due to Parkinson's disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).