This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Dementia due to Parkinson's disease
PD_DEMENTIA
obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
778 |
4. Check minimum number of eventsNone |
778 |
5. Include endpointsNone |
778 |
6. Filter based on genotype QC (FinnGen only) |
778 |
Control definitions (FinnGen only)
- Control exclude
- G6_PARKINSON
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Dementia due to Parkinson's disease
based on the number of shared cases.
Similar with more cases:
- Dementia due to Parkinsons disease, excluding more controls
- Dementia in other diseases classified elsewhere
- Any dementia, excluding more controls
- Any dementia
- Dementia
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 778 | 271 | 507 |
| Unadjusted period prevalence (%) | 0.18 | 0.09 | 0.22 |
| Median age at first event (years) | 76.78 | 77.88 | 76.19 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 664
- Matched controls
- 6641
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04BD01
ATC
selegiline; oral
912.7
323.0
304
6
G20
ICD-10 Finland
Parkinson disease
4503599627370496.0
323.0
630
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2169.3
323.0
626
48
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
+∞
323.0
286
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
323.0
600
*
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
323.0
536
*
N87
ICPC
Parkinsonism
382.4
289.0
272
12
N06DA03
ATC
rivastigmine; oral, transdermal
31.2
248.6
351
230
N04BD02
ATC
rasagiline; oral
+∞
179.5
164
*
N04BC05
ATC
pramipexole; oral
19.1
179.1
298
271
N04BC04
ATC
ropinirole; oral
139.0
153.0
159
15
N05AH04
ATC
quetiapine; oral
12.2
147.3
309
442
193
Kela drug reimbursment
Rasagiline
+∞
145.3
134
*
F02.39
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
131.8
122
*
N04BX02
ATC
entacapone; oral
1430.2
125.2
118
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
8.1
81.9
207
351
N03AE01
ATC
clonazepam; systemic
9.5
58.3
127
161
H02AA02
ATC
fludrocortisone; oral
35.3
49.6
64
20
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
35.3
49.6
64
20
N04BC09
ATC
rotigotine; transdermal
179.9
48.6
50
*
F02.30
ICD-10 Finland
Dementia in Parkinson's disease without additional symptoms
+∞
47.5
45
*
N04BB01
ATC
amantadine; oral
24.3
43.6
62
28
R53
ICD-10 Finland
Malaise and fatigue
3.5
43.0
259
1020
I95.1
ICD-10 Finland
Orthostatic hypotension
7.0
40.5
106
175
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.0
39.2
333
1649
N04BC06
ATC
cabergoline; oral (dopamine agonists)
137.9
37.1
39
*
R25.1
ICD-10 Finland
Tremor, unspecified
10.9
36.8
72
73
N04AA02
ATC
biperiden; systemic
20.1
35.9
54
29
AA1AD
NOMESCO Finland
CT of head and brain
2.9
34.1
284
1352
F02.32
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly hallucinations
+∞
33.6
32
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
33.4
242
1049
N04BC02
ATC
pergolide; oral
+∞
32.6
31
*
A06AD11
ATC
lactulose; oral
2.9
29.6
220
956
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
29.0
304
1621
G02CB01
ATC
bromocriptine; systemic
46.0
29.0
35
8
G04BD12
ATC
mirabegron; oral
3.6
28.4
143
467
F0232, G20
ICD-10 Finland
NA
+∞
27.3
26
*
F0230, G20
ICD-10 Finland
NA
+∞
27.3
26
*
AAG20
NOMESCO Finland
Stereotactic intracranial implantation of electrodes
+∞
25.2
24
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.4
25.0
98
254
SPAT1215
SPAT
Assessment of need for medical rehabilitation
5.6
23.8
72
141
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
43.3
23.8
29
7
S72.0
ICD-10 Finland
Fracture of neck of femur
4.4
22.8
87
219
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.2
22.3
55
82
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
15.8
22.2
36
24
S01.0
ICD-10 Finland
Open wound of scalp
3.7
21.5
102
313
SPAT1229
SPAT
Assessment of need for aid
3.3
21.0
115
393
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
20.7
247
1344
D21
ICPC
Swallowing problem
10.6
20.1
39
39
N05BA04
ATC
oxazepam; oral
2.4
20.0
205
1030
N29
ICPC
Neurological sympt/complt other
8.1
19.9
45
59
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
19.7
185
887
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
108.3
19.7
21
*
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
19.5
45
61
N06AX11
ATC
mirtazapine; oral
2.3
19.4
236
1290
N06AB10
ATC
escitalopram; oral
3.0
19.2
125
482
SPAT1216
SPAT
Assessment of functional ability
2.5
19.2
188
919
A28
ICPC
Limited function/disability NOS
2.4
19.1
207
1065
N19
ICPC
Speech disorder
12.3
19.0
34
29
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
+∞
18.8
18
*
SPAT1234
SPAT
Support of social functional capacity
3.7
18.7
87
261
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.2
18.6
104
361
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.6
18.1
54
104
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.5
17.9
89
282
W19
ICD-10 Finland
Unspecified fall
3.2
17.6
102
361
XF606
NOMESCO Finland
Ortostatic test
12.5
17.0
30
25
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
16.9
155
725
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
16.6
171
850
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.9
16.5
46
82
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
16.5
151
708
R1250
NOMESCO Finland
Evaluation of functional capability
8.7
16.4
35
42
F02.31
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly paranoidism
+∞
15.7
15
*
F02.3
ICD-10 Finland
Dementia in Parkinson disease
+∞
15.7
15
*
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
4.6
15.5
54
124
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.9
15.4
65
180
Z2445
NOMESCO Finland
Psychologist
8.4
15.2
33
41
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
58.0
14.8
17
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
18.9
14.8
22
12
F02.34
ICD-10 Finland
Dementia in Parkinson's disease, other additional symptoms of mixed type
+∞
14.6
14
*
Z75.5
ICD-10 Finland
Holiday relief care
8.4
13.9
30
37
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
13.9
66
202
SPAT1167
SPAT
Insertion of urinary catheter
3.8
13.6
58
162
F0234, G20
ICD-10 Finland
NA
+∞
13.6
13
*
F023, G20
ICD-10 Finland
NA
+∞
13.6
13
*
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
26.4
13.4
18
7
N99
ICPC
Neurological disease other
10.8
13.3
25
24
SPAT1172
SPAT
Guidance concerning hydration
4.3
13.2
49
121
N05AX08
ATC
risperidone; systemic
2.8
13.1
91
361
N06AB04
ATC
citalopram; systemic
2.2
13.1
159
843
L28
ICPC
Limited function/disability (L)
2.1
12.4
170
945
C07AA05
ATC
propranolol; systemic
2.4
12.4
114
527
S06.0
ICD-10 Finland
Concussion
2.6
11.9
90
374
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
47.6
11.9
14
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.9
11.7
26
34
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
11.7
74
1474
U04
ICPC
Incontinence urine
3.4
11.7
56
173
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
6.7
11.7
29
45
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
66.1
11.6
13
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
11.5
144
769
G04BD09
ATC
trospium; oral
4.6
11.4
39
89
R4130
NOMESCO Finland
Speech therapy
5.1
11.3
35
72
R35
ICD-10 Finland
Polyuria
2.8
11.0
72
275
R41.0
ICD-10 Finland
Disorientation, unspecified
3.6
10.6
47
137
N05AH02
ATC
clozapine; systemic
14.5
10.5
17
12
R55
ICD-10 Finland
Syncope and collapse
2.2
10.4
117
593
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.6
10.4
75
305
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.8
10.3
67
254
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.9
10.0
40
107
N05AH03
ATC
olanzapine; systemic
4.1
9.9
38
98
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.4
9.8
86
388
S70.0
ICD-10 Finland
Contusion of hip
3.3
9.7
49
158
N30.0
ICD-10 Finland
Acute cystitis
2.2
9.7
110
560
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
9.5
55
196
WYA20
NOMESCO Finland
Home visit
4.4
9.4
33
78
N04BX01
ATC
tolcapone; oral
+∞
9.4
9
*
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
4.3
9.4
34
83
A04
ICPC
Weakness/tiredness general
2.1
9.1
114
606
N28
ICPC
Limited function/disability (N)
5.4
9.0
26
50
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.9
9.0
36
97
G04BD11
ATC
fesoterodine; oral
3.6
8.8
39
114
SPAT1254
SPAT
Administration of medicine
1.9
8.6
137
794
F06.0
ICD-10 Finland
Organic hallucinosis
27.9
8.5
11
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
8.4
95
483
N04BC01
ATC
bromocriptine; oral
+∞
8.3
8
*
N06DA02
ATC
donepezil; oral
2.2
8.1
82
397
NF1AA
NOMESCO Finland
Hip X-ray examination
2.2
8.1
84
411
E86
ICD-10 Finland
Volume depletion
3.3
7.9
38
120
Z50.5
ICD-10 Finland
Speech therapy
8.2
7.6
16
20
R44.1
ICD-10 Finland
Visual hallucinations
10.2
7.6
14
14
R32
ICD-10 Finland
Unspecified urinary incontinence
3.7
7.4
30
83
N30.9
ICD-10 Finland
Cystitis, unspecified
2.6
7.3
50
198
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.6
7.3
31
89
K59.0
ICD-10 Finland
Constipation
2.4
7.3
59
255
Y94.0
ICD-10 Finland
Accident at home
4.7
7.3
23
50
N06AX16
ATC
venlafaxine; oral
2.4
7.2
59
259
N86
ICPC
Multiple sclerosis
20.3
7.1
10
5
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
20.3
7.1
10
5
R13
ICD-10 Finland
Dysphagia
2.4
7.1
59
260
S01
ICD-10 Finland
Open wound of head
5.4
7.1
20
38
F05.9
ICD-10 Finland
Delirium, unspecified
3.5
7.1
31
91
130
Kela drug reimbursment
Malignant tumour
0.3
7.0
12
425
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
6.8
57
252
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.6
156
1020
P20
ICPC
Memory disturbance
1.7
6.6
136
857
XKD00
NOMESCO Finland
Uroflowmetry
1.7
6.5
165
1100
SPAT1053
SPAT
Memory test
1.7
6.5
169
1135
N06AX21
ATC
duloxetine; oral
2.3
6.5
57
258
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.7
6.5
131
820
I95.9
ICD-10 Finland
Hypotension, unspecified
4.1
6.4
23
57
N04AA01
ATC
trihexyphenidyl; oral
70.5
6.4
7
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
6.4
81
433
R47.1
ICD-10 Finland
Dysarthria and anarthria
5.3
6.4
18
35
SPAT1360
SPAT
Extensive global examination
2.1
6.3
66
325
N06AX03
ATC
mianserin; oral
2.9
6.3
36
128
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.9
6.3
36
128
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.2
537
4783
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.2
6.2
63
307
N06DX01
ATC
memantine; oral
1.9
6.2
87
483
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.0
98
570
F05.8
ICD-10 Finland
Other delirium
6.1
6.0
15
25
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
6.1
6.0
15
25
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
5.6
6.0
16
29
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: PD_DEMENTIA – Dementia due to Parkinson's disease
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).