Family history of mental and behavioural disorders

Z21_FAMILY_HISTORY_MENTAL_BEHAVIOURAL_DISORD

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Z81 Cause of death: ICD-10 — Z81 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	75

Control definitions (FinnGen only)

Control exclude: Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_FAMILY_PERSONAL_HISTORY_CERTA_CONDI_INFLUENCI_HEALTH_STATUS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z[8-9]

NAME	Z21_FAMILY_HISTORY_MENTAL_BEHAVIOURAL_DISORD
CONTROL_EXCLUDE	Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_FAMILY_PERSONAL_HISTORY_CERTA_CONDI_INFLUENCI_HEALTH_STATUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Z81
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Z81
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Family history of mental and behavioural disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	75	59	16
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	31.52	30.42	35.55

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
64: Matched controls
638

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z81.8

ICD-10 Finland

Family history of other mental and behavioural disorders

+∞

30.7

Z81.0

ICD-10 Finland

Family history of mental retardation

+∞

24.5

Z31.5

ICD-10 Finland

Genetic counselling

18.4

15.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

17.64

5.54

1.1

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

7.54

2.59

1.0

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

5.33

2.45

8.5

5.7

27.10

24.89

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.51

2.40

1.3

—

(3032080) INR in Blood by Coagulation assay

159

2.09

2.26

3.1

4.3

1.05

1.13

inr

0.64

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

205

1.98

2.11

3.1

3.4

—

(3034770) Mitochondria Ab [Titer] in Serum

5.27

2.10

2.0

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

156

2.02

2.05

2.8

3.1

—

(3037522) Nuclear Ab [Titer] in Serum

2.25

1.85

1.7

1.6

160.00

762.00

titre

—

(40760892) CBC W Ordered Manual Differential panel - Blood

138

1.96

1.79

6.1

4.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

4.04

1.74

12.6

2.5

0.78

—

(3031040) Bacteria [#/volume] in Urine by Automated count

398

1.88

1.73

5.3

3.9

—

59.71

—

(3021601) Nitrite [Presence] in Urine by Test strip

283

1.79

1.66

4.3

5.0

0.00

estimate

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

170

1.81

1.54

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

290

1.72

1.47

2.8

3.4

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

291

1.71

1.45

3.0

3.6

0.00

estimate

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

263

1.71

1.44

10.6

5.7

1.21

1.22

mmol/l

0.57

227

(3019550) Sodium [Moles/volume] in Serum or Plasma

583

2.10

1.41

15.0

10.0

139.56

139.67

mmol/l

0.18

565

(3025941) Bacteria identified in Stool by Culture

2.63

1.33

1.7

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.90

1.30

2.6

1.3

—

(3015736) pH of Urine

232

1.66

1.29

2.2

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

417

1.70

1.29

6.2

4.2

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

588

2.02

1.28

15.0

9.9

3.88

3.90

mmol/l

0.30

566

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.09

1.24

1.5

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.05

1.19

1.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.90

1.19

2.0

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.83

1.18

1.5

1.4

—

(3016502) Oxygen saturation in Arterial blood

2.38

1.14

7.7

7.2

95.83

96.36

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.23

1.09

1.3

1.4

—

(3026008) Bacteria identified in Urine by Culture

168

1.63

1.08

3.0

2.6

—

(3029937) Albumin [Presence] in Urine by Test strip

143

1.65

1.05

3.0

3.7

0.00

estimate

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

215

1.57

1.03

1.9

2.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

111

1.69

0.98

2.1

1.7

1.03

0.88

mg/l

0.18

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.33

0.96

3.2

2.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

155

1.59

0.96

1.6

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.83

0.86

1.9

3.1

—

(40761511) CBC panel - Blood by Automated count

655

2.03

0.85

16.0

8.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.78

0.84

1.9

1.6

—

(3023520) Reticulocytes [#/volume] in Blood

1.93

0.76

3.6

2.3

65.27

81.96

e9/l

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

2.07

0.74

1.2

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.78

0.72

2.6

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

489

1.47

0.70

5.9

4.1

14.62

14.49

pmol/l

0.14

448

(3020779) Urea [Moles/volume] in Serum or Plasma

1.65

0.67

17.9

4.9

9.67

5.88

mmol/l

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.65

0.62

3.6

2.2

7489.00

7487.66

u/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

179

1.41

0.61

1.3

1.4

1.79

1.87

g/l

0.10

(3027945) Reticulocytes/100 erythrocytes in Blood

1.54

0.59

6.1

4.0

1.68

—

(3003694) ABO and Rh group [Type] in Blood

208

1.38

0.59

2.0

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.72

0.58

1.5

2.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.63

0.56

1.2

1.4

—

(3022313) Gas panel - Capillary blood

1.58

0.54

8.0

6.5

—

(3008898) HLA-B27 [Presence]

1.54

0.53

1.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

1.57

0.53

1.3

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

111

1.44

0.52

3.1

3.5

1.34

21.48

mg/mmol

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.61

0.50

1.6

1.4

—

(3023368) Bacteria identified in Blood by Culture

1.46

0.50

2.8

3.7

—

(3026782) Osmolality of Urine

112

1.42

0.49

3.2

2.6

520.20

571.72

mosm/kgh2o

0.41

(3009343) pH of Capillary blood

1.50

0.48

7.6

6.0

—

(3044889) 12 lead EKG panel

322

1.29

0.46

3.3

2.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

150

1.36

0.46

4.4

2.9

16.06

25.04

ng/l

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.51

0.45

1.5

1.6

—

(3002256) Pathology report gross observation

1.48

0.44

1.0

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

179

1.32

0.44

2.1

1.8

95.58

93.36

pmol/l

0.08

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.45

0.44

1.3

1.4

—

(4035726)

1.55

0.42

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.37

0.42

1.5

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

0.07

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.41

0.0

1.4

—

0.89

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

1.16

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

2.67

—

(4094501)

0.00

0.41

0.0

1.1

—

(3019225) pH of Specimen

1.50

0.37

4.2

3.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.33

0.34

7.3

5.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.33

0.34

1.5

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

234

1.24

0.33

2.6

1.8

—

(40768804) Tissue Pathology biopsy report

224

0.80

0.31

1.2

1.8

—

(3013115) Eosinophils [#/volume] in Blood

334

1.21

0.30

12.0

6.0

0.22

0.19

e9/l

0.35

293

(3000850) Epithelial cells [#/volume] in Urine

123

1.27

0.28

3.3

2.6

3.19

6.58

e6/l

1.28

110

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.69

0.27

1.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

105

1.29

0.27

1.7

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.23

0.26

1.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

153

1.23

0.25

2.0

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

606

0.81

0.24

18.7

11.7

38.36

39.05

0.21

498

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

548

0.83

0.24

4.1

4.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

107

1.26

0.23

1.3

4.62

12.37

u/ml

—

(3006315) Basophils [#/volume] in Blood

321

1.17

0.22

10.5

5.6

0.03

0.04

e9/l

0.91

273

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

165

1.20

0.22

2.2

2.4

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.00

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.00

—

(4268621)

0.00

0.21

0.0

1.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.00

—

(4198724)

0.00

0.21

0.0

1.1

—

(3006504) Eosinophils/100 leukocytes in Blood

302

1.17

0.21

11.5

5.6

3.61

2.80

1.04

280

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.6

—

(3018010) Neutrophils/100 leukocytes in Blood

312

1.16

0.21

11.4

5.5

55.61

53.85

0.38

293

(3001604) Monocytes [#/volume] in Blood

322

1.16

0.21

10.5

5.6

0.58

0.56

e9/l

0.17

274

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.30

0.21

9.5

3.0

80.33

60.63

ng/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.21

0.0

2.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.27

0.21

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.27

0.21

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.27

0.21

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.27

0.21

1.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.20

0.0

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.22

0.20

1.2

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

196

1.17

0.19

4.5

3.2

—

(36660697) Celiac disease serology panel - Serum

1.24

0.19

1.4

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

183

0.84

0.19

2.2

2.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.14

0.18

1.4

1.6

—

(3000991) Gas panel - Venous blood

0.74

0.18

12.6

7.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

631

1.23

0.17

15.2

9.6

13.78

20.14

mg/l

1.58

453

(3019069) Monocytes/100 leukocytes in Blood

308

1.13

0.15

12.4

5.7

9.19

8.05

1.18

287

(42870588) Differential panel, method unspecified - Blood

210

1.14

0.14

9.7

4.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

137

0.85

0.13

1.8

1.6

—

(3002030) Lymphocytes/100 leukocytes in Blood

321

1.11

0.12

11.6

5.5

29.51

31.73

0.54

302

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

115

0.85

0.11

3.3

2.0

—

(3022096) Basophils/100 leukocytes in Blood

293

1.10

0.10

11.4

5.6

0.72

0.67

0.23

271

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.12

0.10

1.6

1.2

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.09

0.10

1.2

1.3

630.90

673.67

u/ml

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.14

0.09

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.04

0.08

3.0

4.8

2.14

1.70

ug/l

—

(36304419) Bacteria [Presence] in Urine

174

0.90

0.08

5.1

3.1

—

(1761868) Lipid panel - Serum or Plasma

184

0.90

0.08

2.5

2.1

—

(3022145) Colonoscopy Study observation

1.08

0.08

1.1

1.3

—

(40768797) Stomach Pathology biopsy report

1.05

0.08

1.3

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.85

0.07

2.9

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

131

0.90

0.06

2.1

—

(40758558) Short blood count panel - Blood

171

0.92

0.05

12.8

8.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

269

1.07

0.05

4.6

3.9

—

(3013512) EKG study

123

1.07

0.02

8.3

3.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

489

1.01

0.00

10.4

8.3

90.06

94.21

ml/min/173m2

0.47

373

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

157

1.02

0.00

1.7

1.4

—

(3018095) Leukocytes [#/volume] in Urine

231

0.99

0.00

4.7

3.9

97.58

39.27

e6/l

0.27

156

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3016879) Cocaine [Presence] in Urine

0.98

0.00

1.4

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(4281824)

0.00

0.0

1.3

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.1

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.52

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

0.0

6.2

—

9.32

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.3

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3027008) Opiates [Presence] in Urine

0.92

0.00

1.4

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.7

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

5.8

—

0.88

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

3.5

—

43.83

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

3.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1752.00

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

25.50

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3011048) Pyruvate [Moles/volume] in Blood

0.00

0.0

1.4

—

100.80

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3013247) Albumin in CSF/Albumin in Serum or Plasma

0.00

0.0

1.0

—

11.12

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.00

0.00

1.9

2.2

—

(3012544) pH of Venous blood

0.89

0.00

14.9

4.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

133.57

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

1.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

2.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

12.77

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.6

—

(3002621) Streptococcal DNAse B [Units/volume] in Serum

0.00

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.7

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

2.4

—

66.29

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3028300) Cannabinoids [Presence] in Urine

0.92

0.00

1.4

1.3

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.0

—

0.64

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

140

1.00

0.00

3.1

3.3

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.8

—

39.50

—

(3000764) Benzodiazepines [Presence] in Urine

0.92

0.00

1.4

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.7

—

47.53

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_FAMILY_HISTORY_MENTAL_BEHAVIOURAL_DISORD – Family history of mental and behavioural disorders

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Family history of mental and behavioural disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Family history of mental and behavioural disorders (Z21_FAMILY_HISTORY_MENTAL_BEHAVIOURAL_DISORD)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints