Relapsing fevers

AB1_RELAP_FEVER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A68 Hospital discharge: ICD-9 — 08[7] Hospital discharge: ICD-8 — 08[8] Cause of death: ICD-10 — A68 Cause of death: ICD-9 — 08[7] Cause of death: ICD-8 — 08[8] 2 out of 7 registries used, show all original rules.	77
4. Check minimum number of events None	77
5. Include endpoints None	77
6. Filter based on genotype QC (FinnGen only)	77

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_SPIROCHAETAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF6

NAME	AB1_RELAP_FEVER
CONTROL_EXCLUDE	AB1_OTHER_SPIROCHAETAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A68
HD_ICD_9	08[7]
HD_ICD_8	08[8]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A68
COD_ICD_9	08[7]
COD_ICD_8	08[8]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Relapsing fevers based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1554	730	818
Only index persons	1206	570	636
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	6.22	6.04	5.90
Only index persons	6.60	7.00	6.25

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	77	43	34
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	29.93	20.65	41.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
68: Matched controls
677

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A68.9

ICD-10 Finland

Relapsing fever, unspecified

+∞

44.8

0879X

ICD-9 Finland

Relapsing fever, unspecified

+∞

23.2

R50.9

ICD-10 Finland

Fever, unspecified

10.1

14.0

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

4.3

6.5

EMB10

NOMESCO Finland

Tonsillectomy

7.4

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3028026) IgM [Mass/volume] in Serum or Plasma

3.72

3.33

1.3

1.5

1.3

1.2

g/l

0.19

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

8.80

2.79

1.4

1.0

—

(42870588) Differential panel, method unspecified - Blood

198

2.05

2.35

5.9

5.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.31

2.23

1.5

1.3

19.7

40.5

iu/ml

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.45

2.16

1.3

1.2

g/l

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.49

2.04

1.9

2.2

21.7

23.7

0.24

(40760892) CBC W Ordered Manual Differential panel - Blood

135

2.00

1.90

3.6

5.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.45

1.85

1.1

1.2

94.3

573.3

u/ml

0.53

(3027945) Reticulocytes/100 erythrocytes in Blood

2.45

1.85

4.5

2.8

1.4

1.7

1.00

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.11

1.78

1.4

1.3

0.9

9.6

u/ml

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.10

1.77

1.3

0.2

g/l

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

1.57

0.0

1.7

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

3.49

1.55

1.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.97

1.50

2.0

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

155

1.80

1.46

2.4

4.0

17.1

39.0

ng/l

0.83

(3003327) Ova and parasites identified in Stool by Light microscopy

2.55

1.43

1.0

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.74

1.39

1.5

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

109

1.85

1.34

2.3

2.0

1.0

mg/l

0.02

(40768797) Stomach Pathology biopsy report

2.07

1.31

1.3

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.90

1.30

1.4

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.00

1.21

6.7

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.60

1.17

1.4

1.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.91

1.15

2.2

2.1

13.5

13.6

umol/l

0.01

(3015736) pH of Urine

231

1.57

1.08

4.6

3.1

—

(40758558) Short blood count panel - Blood

151

1.64

1.06

7.0

6.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.36

1.05

5.8

41.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

162

1.60

1.00

2.0

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.04

1.00

1.9

3.7

—

0.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

254

1.52

0.98

6.6

7.6

10.1

10.9

umol/l

0.31

243

(3032080) INR in Blood by Coagulation assay

181

1.56

0.97

4.0

8.3

1.0

1.2

inr

2.19

(36304419) Bacteria [Presence] in Urine

149

1.56

0.88

3.7

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

222

1.49

0.86

5.9

3.4

—

(3023368) Bacteria identified in Blood by Culture

124

1.59

0.85

5.8

4.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

439

1.48

0.83

5.7

4.1

13.2

9.4

mm/h

0.94

412

(3003396) Base excess in Arterial blood by calculation

1.74

0.81

7.0

21.0

1.3

1.5

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.83

0.78

1.8

1.3

—

(3025159) Blasts/100 leukocytes in Blood

1.83

0.78

2.0

4.6

—

0.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

182

1.46

0.74

5.7

3.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

164

1.48

0.73

4.7

2.9

—

(3000850) Epithelial cells [#/volume] in Urine

113

1.53

0.68

3.3

2.6

3.7

5.5

e6/l

0.89

(3037467) Urinalysis macro (dipstick) panel - Urine

377

1.39

0.67

6.6

4.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

185

1.43

0.67

1.8

—

(3018095) Leukocytes [#/volume] in Urine

195

1.42

0.66

4.2

3.4

50.4

35.1

e6/l

0.20

134

(3021601) Nitrite [Presence] in Urine by Test strip

281

1.38

0.64

7.0

4.6

0.0

estimate

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.63

0.63

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

503

1.42

0.62

4.3

3.7

—

(3026782) Osmolality of Urine

1.52

0.62

3.6

2.7

542.1

579.7

mosm/kgh2o

0.28

(40761536) Microorganisms panel - Urine sediment

1.60

0.62

6.5

3.1

—

(40768443) Skin Pathology biopsy report

0.00

0.61

0.0

1.3

—

(3013512) EKG study

117

1.46

0.58

3.1

3.6

—

(3025941) Bacteria identified in Stool by Culture

1.72

0.58

1.5

1.2

—

(3000494) Fungus identified in Specimen by Culture

1.57

0.57

1.7

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

286

1.34

0.56

5.5

3.4

0.0

estimate

—

(4010399)

1.58

0.54

1.3

1.5

—

(3000991) Gas panel - Venous blood

1.58

0.54

15.2

15.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

184

1.36

0.51

2.6

1.8

95.4

91.2

pmol/l

0.21

108

(3035350) Ketones [Presence] in Urine by Test strip

289

1.32

0.51

5.5

3.3

0.0

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

596

1.44

0.50

16.8

12.5

20.5

20.4

mg/l

0.01

456

(3012516) Albumin [Mass/volume] in Urine

121

1.41

0.49

6.1

3.0

71.9

554.9

mg/l

0.46

(3009542) Hematocrit [Volume Fraction] of Blood

567

1.36

0.45

14.7

13.0

38.6

40.1

0.48

467

(3019060) Gas panel - Arterial blood

1.65

0.44

2.0

17.9

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.46

0.43

2.7

2.4

4.8

5.1

e6/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

106

1.39

0.43

1.8

1.7

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

161

1.33

0.43

6.8

2.6

57.3

52.9

u/l

0.28

150

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.50

0.41

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

2.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

1.41

0.41

3.2

4.1

16.9

20.7

—

(3042936) Bacteria identified in Isolate by Culture

1.45

0.39

2.9

2.6

—

(3008898) HLA-B27 [Presence]

1.42

0.39

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

127

1.33

0.37

8.7

3.6

10.1

5.2

mg/mmol

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.36

0.34

1.0

1.8

20.1

20.5

iu/l

—

(1761868) Lipid panel - Serum or Plasma

215

1.24

0.32

2.6

2.3

—

(3012544) pH of Venous blood

1.35

0.32

8.3

5.2

—

(3022145) Colonoscopy Study observation

1.33

0.31

1.1

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

505

0.82

0.30

14.0

10.7

84.7

91.5

ml/min/173m2

1.65

391

(3033658) Prothrombin time (PT) actual/Normal

132

1.27

0.28

5.8

4.1

100.9

91.9

1.27

132

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

1.21

0.28

5.0

4.5

—

(21494755) Public health laboratory ask at order entry panel

1.30

0.27

1.6

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

115

1.27

0.26

1.6

3.3

343.6

771.6

ng/l

1.52

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.29

0.24

1.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.29

0.24

2.5

3.8

35.5

509.5

ng/l

—

(40761511) CBC panel - Blood by Automated count

624

0.83

0.21

14.7

10.3

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.21

0.0

3.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.4

—

(40768804) Tissue Pathology biopsy report

226

0.84

0.21

2.3

1.9

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.7

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.1

—

68.9

—

(3021589) Normoblasts [#/volume] in Blood

284

1.15

0.19

9.4

8.1

0.0

e9/l

0.00

225

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.25

0.19

9.9

2.1

35.3

33.9

u/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

141

0.82

0.18

2.3

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

168

1.17

0.18

2.2

2.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.14

0.17

2.8

1.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

238

1.14

0.16

3.5

2.5

75.1

71.3

nmol/l

0.37

220

(36660697) Celiac disease serology panel - Serum

1.11

0.15

1.9

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.79

0.15

1.6

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

103

1.20

0.15

1.2

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

530

1.13

0.13

16.1

14.5

13.4

13.5

0.16

521

(3044889) 12 lead EKG panel

359

1.12

0.13

2.5

3.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.19

0.11

2.9

2.4

0.5

1.0

e6/l

—

(40761535) Cells panel - Urine sediment

1.07

0.09

5.6

2.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.14

0.09

1.2

1.4

—

(3000492) Spirometry study

1.06

0.09

1.7

1.5

—

(3002256) Pathology report gross observation

1.10

0.08

1.4

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.83

0.08

1.5

1.6

—

(3026008) Bacteria identified in Urine by Culture

147

1.11

0.08

3.8

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

153

0.90

0.08

2.4

2.3

—

(3029937) Albumin [Presence] in Urine by Test strip

158

1.10

0.06

8.4

3.6

0.0

estimate

—

(3003694) ABO and Rh group [Type] in Blood

168

1.09

0.06

1.8

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

121

1.09

0.04

2.2

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

129

1.01

0.00

1.8

1.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

402

0.99

0.00

3.7

3.1

58.9

36.1

u/l

0.58

382

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.5

—

16.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

21.9

—

1455.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.5

—

713.4

—

(4198724)

0.00

0.0

2.6

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.1

—

7.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

196.9

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

113.7

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

40.3

—

150.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.99

0.00

2.6

1.9

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.9

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.00

0.00

4.8

3.9

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

18.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.00

0.00

1.7

2.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

9.4

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

8.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

2.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.4

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

8.5

—

0.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

130

1.00

0.00

6.2

3.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

7.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

32.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.5

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.0

1.4

—

91.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.98

0.00

2.2

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.95

0.00

2.2

1.5

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.6

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

4.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_RELAP_FEVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_RELAP_FEVER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_RELAP_FEVER – Relapsing fevers

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Relapsing fevers

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints