Sequelae of malnutrition and other nutritional deficiencies

E4_SEQUMAL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E64 Cause of death: ICD-10 — E64 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	78

Control definitions (FinnGen only)

Control exclude: E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E50-E64
Name in latin: Sequelae malnutritionis et aliarum deficientiarum nutritionalium

NAME	E4_SEQUMAL
CONTROL_EXCLUDE	E4_NUTRIDEF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E64
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E64
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sequelae of malnutrition and other nutritional deficiencies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1025	566	443
Only index persons	738	414	324
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	73.60	76.42	70.18
Only index persons	72.79	75.38	69.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	78	36	42
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	67.77	60.42	74.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
810

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E64.9

ICD-10 Finland

Sequelae of unspecified nutritional deficiency

+∞

79.9

D64.9

ICD-10 Finland

Anaemia, unspecified

10.1

23.9

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

4.0

8.5

148

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

6.6

6.8

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

7.4

6.5

E64.3

ICD-10 Finland

Sequelae of rickets

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

145

2.84

4.66

3.6

2.1

3.01

2.86

mg/l

0.15

125

(40760888) Immunoglobulin light chains.free panel - Serum

8.72

4.16

3.9

1.7

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

6.17

4.12

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.58

3.24

3.5

2.2

—

(3006315) Basophils [#/volume] in Blood

244

2.26

3.21

6.9

6.1

0.03

0.04

e9/l

0.34

215

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.87

3.10

4.5

3.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.27

3.09

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

216

2.20

2.95

5.3

3.3

—

(1616796) Gas panel - Central venous blood

5.78

2.93

2.9

2.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

8.77

2.78

3.2

1.7

32.80

32.33

—

(3013115) Eosinophils [#/volume] in Blood

252

2.06

2.56

7.8

6.3

0.15

0.16

e9/l

0.27

224

(40760892) CBC W Ordered Manual Differential panel - Blood

235

2.06

2.54

8.9

6.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

129

2.22

2.52

2.0

1.9

1.32

1.66

mg/l

0.32

110

(3001604) Monocytes [#/volume] in Blood

245

2.04

2.49

7.2

6.0

0.49

0.60

e9/l

2.17

215

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.30

2.45

1.2

1.1

—

(3023368) Bacteria identified in Blood by Culture

174

2.04

2.28

6.8

4.9

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

228

1.94

2.17

5.5

2.3

240.04

118.18

ug/l

1.28

207

(36304419) Bacteria [Presence] in Urine

170

1.99

2.11

5.5

3.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

5.25

2.10

2.6

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.30

2.07

4.3

2.6

—

(3037522) Nuclear Ab [Titer] in Serum

2.39

1.90

1.2

1.4

—

232.94

—

(3027315) Oxygen [Partial pressure] in Blood

3.72

1.87

5.3

2.6

6.77

8.37

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.72

1.87

5.3

2.6

5.35

4.91

kpa

—

(3012501) Base excess in Blood by calculation

3.72

1.87

5.3

2.6

1.60

1.93

mmol/l

—

(3000991) Gas panel - Venous blood

2.55

1.87

12.9

11.5

—

(3029937) Albumin [Presence] in Urine by Test strip

152

1.93

1.85

4.8

3.9

0.00

estimate

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

186

1.87

1.83

4.7

3.3

3653.92

1908.33

ng/l

0.46

161

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.16

1.73

2.7

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.64

1.71

6.0

7.9

24.88

24.98

mmol/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.96

1.69

7.4

3.7

1.87

2.27

mmol/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.15

1.61

1.2

1.0

—

(3026008) Bacteria identified in Urine by Culture

193

1.78

1.60

4.3

3.5

—

(3018418) pH of Serum or Plasma

176

1.80

1.60

10.8

3.5

7.38

7.41

—

(3044640) Blood type and Crossmatch panel - Blood

169

1.79

1.55

3.3

2.5

—

(3024928) Oxygen saturation in Venous blood

3.48

1.54

6.8

2.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

269

1.69

1.48

16.2

6.5

1.20

1.21

mmol/l

0.60

223

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.86

1.46

3.0

2.7

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.93

1.45

4.8

3.7

0.79

0.82

mmol/l

0.44

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

210

1.68

1.36

4.8

4.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.89

1.30

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

136

1.73

1.25

5.7

3.8

—

(3019060) Gas panel - Arterial blood

2.16

1.19

2.0

3.9

—

(40761536) Microorganisms panel - Urine sediment

2.10

1.17

5.3

4.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.59

1.17

3.0

2.3

—

(40758558) Short blood count panel - Blood

140

1.68

1.12

9.9

6.9

—

(40768797) Stomach Pathology biopsy report

1.93

1.12

1.4

1.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.12

1.09

2.0

1.5

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.22

1.08

3.6

2.6

0.06

0.20

e6/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.09

1.03

2.7

1.8

—

(40761535) Cells panel - Urine sediment

1.94

1.03

3.0

3.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

376

1.52

1.02

7.0

4.7

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.97

1.02

8.5

4.1

1.24

1.21

mmol/l

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.90

1.00

2.1

4.7

10.55

75.95

ug/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

1.00

0.0

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

136

1.62

0.99

2.1

1.7

1305.67

1214.97

nmol/l

0.08

106

(3042936) Bacteria identified in Isolate by Culture

1.77

0.95

1.8

2.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

283

1.49

0.94

8.1

5.5

0.00

estimate

—

(3022217) INR in Platelet poor plasma by Coagulation assay

289

1.44

0.83

30.7

15.5

1.53

1.21

inr

1.17

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.88

0.81

4.0

8.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.70

0.80

2.5

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

282

1.42

0.78

6.1

4.0

0.00

estimate

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.82

0.78

14.3

3.2

23.83

24.38

mmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.75

0.78

2.1

1.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

311

1.42

0.77

3.8

3.0

96.91

54.04

u/l

0.50

291

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.68

0.77

2.5

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

119

1.54

0.74

3.0

2.6

—

(3022145) Colonoscopy Study observation

1.65

0.74

1.2

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.06

0.74

2.6

2.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

238

1.41

0.72

3.1

2.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

103

1.56

0.71

1.6

1.3

2.55

2.46

g/l

—

(3009261) Glucose [Presence] in Urine by Test strip

288

1.38

0.67

6.2

4.0

0.00

estimate

—

(3026493) Urate [Moles/volume] in Serum or Plasma

134

1.44

0.60

3.2

2.6

406.89

6123.47

umol/l

0.79

108

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.53

0.59

1.1

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.53

0.59

1.6

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

227

1.36

0.58

2.7

2.1

89.77

89.26

pmol/l

0.02

115

(3012544) pH of Venous blood

1.59

0.57

16.1

3.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.62

0.55

1.2

1.4

—

(3013512) EKG study

154

1.40

0.55

4.2

5.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.58

0.54

1.7

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.46

0.54

2.4

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

103

1.43

0.49

3.2

1.9

—

(3022621) pH of Urine by Test strip

1.47

0.47

5.9

3.0

—

(36660697) Celiac disease serology panel - Serum

1.47

0.47

1.3

1.1

—

(3000494) Fungus identified in Specimen by Culture

1.39

0.42

1.9

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.4

—

(3003694) ABO and Rh group [Type] in Blood

125

1.35

0.41

2.0

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

325

1.25

0.40

9.0

5.3

6.98

6.83

mmol/l

0.18

306

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.39

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.39

0.0

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

191

1.29

0.39

2.7

2.2

107.17

321.41

u/l

1.48

180

(3044889) 12 lead EKG panel

357

1.24

0.37

5.0

4.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.50

0.37

1.0

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

492

0.81

0.37

4.2

4.9

6.16

6.00

mmol/l

0.18

433

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

478

0.83

0.31

4.1

4.5

1.49

1.46

mmol/l

0.20

426

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

486

0.83

0.29

5.5

4.6

2.15

1.95

mu/l

0.27

423

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.26

0.28

2.4

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

302

0.84

0.25

3.8

2.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

153

1.23

0.25

4.9

3.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

499

0.86

0.22

4.3

5.1

2.46

2.55

mmol/l

0.29

445

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.2

—

(4035726) Immunohistochemistry procedure

1.17

0.19

1.2

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

161

0.84

0.17

5.9

4.6

26.74

21.32

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

514

0.88

0.16

38.8

17.1

31.87

25.89

mg/l

0.57

417

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

551

0.89

0.14

14.8

11.3

25.43

24.29

u/l

0.20

527

(40768804) Tissue Pathology biopsy report

218

0.89

0.12

2.1

2.0

—

(1761868) Lipid panel - Serum or Plasma

146

0.87

0.11

2.8

3.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

468

0.91

0.10

37.6

16.5

72.84

76.67

ml/min/173m2

0.32

384

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.10

0.08

13.6

9.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

475

0.93

0.08

6.1

41.11

40.95

mmol/mol

0.03

439

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.83

0.07

2.6

1.7

—

(40761511) CBC panel - Blood by Automated count

534

0.93

0.07

31.6

15.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

390

1.05

0.03

5.3

4.0

17.66

13.49

mm/h

0.81

351

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.3

—

91.33

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

3.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.2

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

10.30

—

(3002256) Pathology report gross observation

0.95

-0.00

1.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.0

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

6.36

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.7

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3044941) Cell count panel - Synovial fluid

0.00

-0.00

0.0

1.3

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_SEQUMAL and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	2.544 [1.9, 3.41]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.426

During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 483 females with E4_SEQUMAL died.

Males

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	3.135 [2.06, 4.76]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 380 males with E4_SEQUMAL died.

Mortality risk

Mortality risk for people of age

years, who have E4_SEQUMAL.

N-year risk	Females	Males
1	0.212%	0.748%
5	1.486%	4.033%
10	3.966%	9.774%
15	7.901%	17.424%
20	13.061%	28.764%

Relationships between endpoints

↥

Index endpoint: E4_SEQUMAL – Sequelae of malnutrition and other nutritional deficiencies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sequelae of malnutrition and other nutritional deficiencies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints