Sequelae of malnutrition and other nutritional deficiencies

E4_SEQUMAL

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E64 Cause of death: ICD-10 — E64 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E50-E64
Name in latin: Sequelae malnutritionis et aliarum deficientiarum nutritionalium

NAME	E4_SEQUMAL
CONTROL_EXCLUDE	E4_NUTRIDEF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E64
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E64
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sequelae of malnutrition and other nutritional deficiencies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1025	566	443
Only index persons	738	414	324
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	73.60	76.42	70.18
Only index persons	72.79	75.38	69.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	37	44
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	67.48	59.65	74.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
75: Matched controls
749

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E64.9

ICD-10 Finland

Sequelae of unspecified nutritional deficiency

+∞

75.1

D64.9

ICD-10 Finland

Anaemia, unspecified

11.8

17.8

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

4.0

6.9

128

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3009445) Proteinase 3 Ab [Units/volume] in Serum

6.57

5.78

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

147

2.80

4.52

3.6

2.1

3.0

2.8

mg/l

0.18

127

(40760888) Immunoglobulin light chains.free panel - Serum

8.72

4.16

3.9

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.59

3.68

3.5

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

104

2.69

3.58

3.7

5.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.84

3.26

1.1

—

(3006315) Basophils [#/volume] in Blood

243

2.28

3.25

6.9

6.1

0.0

e9/l

0.41

214

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.87

3.10

4.5

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

215

2.21

2.99

5.4

3.3

—

(1616796) Gas panel - Central venous blood

5.78

2.93

2.9

2.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

8.77

2.78

3.2

1.7

32.8

32.3

—

(3013115) Eosinophils [#/volume] in Blood

251

2.07

2.60

7.8

6.2

0.1

0.2

e9/l

0.27

223

(3019198) Lymphocytes [#/volume] in Blood

251

2.07

2.60

7.5

6.1

1.5

1.7

e9/l

1.11

228

(3001604) Monocytes [#/volume] in Blood

244

2.05

2.53

7.2

6.0

0.5

0.6

e9/l

2.17

214

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

129

2.22

2.52

2.0

1.8

1.3

1.7

mg/l

0.34

110

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.30

2.45

1.2

1.1

—

(3023368) Bacteria identified in Blood by Culture

173

2.05

2.32

6.8

4.9

—

(36304419) Bacteria [Presence] in Urine

169

2.00

2.15

5.5

3.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

5.25

2.10

2.6

1.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

230

1.92

2.10

5.5

2.4

240.0

117.0

ug/l

1.30

209

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.30

2.07

4.2

2.6

—

(3037522) Nuclear Ab [Titer] in Serum

2.43

1.96

1.2

1.4

—

232.9

—

(3012501) Base excess in Blood by calculation

3.72

1.87

5.3

2.6

1.6

1.9

mmol/l

—

(3027315) Oxygen [Partial pressure] in Blood

3.72

1.87

5.3

2.6

6.8

8.4

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.72

1.87

5.3

2.6

5.3

4.9

kpa

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

185

1.88

1.87

4.7

3.3

3653.9

1919.7

ng/l

0.45

160

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.64

1.83

6.0

7.9

24.9

25.0

mmol/l

—

(3000991) Gas panel - Venous blood

2.49

1.79

12.9

11.3

—

(3029937) Albumin [Presence] in Urine by Test strip

154

1.90

1.78

4.8

3.9

0.0

estimate

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.96

1.69

7.4

3.7

1.9

2.3

mmol/l

—

(3018418) pH of Serum or Plasma

175

1.81

1.63

10.8

3.6

7.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.10

1.62

2.7

1.8

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.15

1.61

1.2

1.0

—

(3024928) Oxygen saturation in Venous blood

3.48

1.54

6.8

2.3

—

(3044640) Blood type and Crossmatch panel - Blood

170

1.78

1.51

3.3

2.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.95

1.49

4.8

3.7

0.8

mmol/l

0.35

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

269

1.69

1.48

16.2

6.5

1.2

mmol/l

0.59

220

(3026008) Bacteria identified in Urine by Culture

190

1.72

1.43

4.4

3.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

211

1.67

1.33

4.8

4.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.62

1.33

3.0

2.8

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.89

1.30

1.2

—

(3015736) pH of Urine

215

1.63

1.23

4.3

3.8

—

(40761536) Microorganisms panel - Urine sediment

2.14

1.22

5.3

4.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

138

1.70

1.18

5.7

3.8

—

(3019060) Gas panel - Arterial blood

2.11

1.16

2.0

3.9

—

(40758558) Short blood count panel - Blood

139

1.69

1.15

9.9

6.9

—

(42870588) Differential panel, method unspecified - Blood

183

1.62

1.13

9.3

5.6

—

(40768797) Stomach Pathology biopsy report

1.93

1.12

1.4

1.3

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.30

1.11

3.6

2.7

0.1

0.2

e6/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.12

1.09

2.0

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.35

1.05

3.0

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.09

1.03

2.7

1.8

—

(40761535) Cells panel - Urine sediment

1.94

1.03

3.0

3.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.97

1.02

8.5

4.1

1.2

mmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

377

1.51

1.00

7.0

4.8

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.90

1.00

2.1

4.7

10.5

76.0

ug/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

1.00

0.0

1.5

—

(3042936) Bacteria identified in Isolate by Culture

1.79

0.98

1.8

2.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

137

1.61

0.96

2.1

1.7

1305.7

1209.3

nmol/l

0.09

107

(3021601) Nitrite [Presence] in Urine by Test strip

284

1.48

0.92

8.1

5.5

0.0

estimate

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

308

1.44

0.83

3.8

3.0

96.9

54.4

u/l

0.50

288

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.88

0.81

14.3

3.3

23.8

24.4

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.88

0.81

4.0

8.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.70

0.80

2.5

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

282

1.42

0.78

6.1

4.0

0.0

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.68

0.77

2.5

1.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.15

0.76

2.6

2.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.68

0.75

2.1

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

119

1.54

0.74

3.0

2.6

—

(3022145) Colonoscopy Study observation

1.65

0.74

1.2

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

102

1.58

0.74

1.6

1.3

2.6

2.5

g/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

240

1.40

0.68

4.9

4.0

—

(3009261) Glucose [Presence] in Urine by Test strip

289

1.37

0.65

6.2

4.0

0.0

estimate

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.53

0.59

1.6

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

227

1.36

0.58

2.7

2.1

89.8

89.3

pmol/l

0.02

115

(3013512) EKG study

153

1.41

0.57

4.2

5.1

—

(3032080) INR in Blood by Coagulation assay

246

1.35

0.57

17.6

7.4

1.5

1.2

inr

0.83

(3012544) pH of Venous blood

1.59

0.57

16.1

3.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.58

0.54

1.2

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.46

0.54

2.4

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.54

0.53

1.7

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

103

1.43

0.49

3.2

1.9

—

(36660697) Celiac disease serology panel - Serum

1.50

0.48

1.3

1.1

—

(3022621) pH of Urine by Test strip

1.47

0.47

5.9

3.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.50

0.45

1.1

1.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

189

1.30

0.42

2.7

2.2

107.2

323.2

u/l

1.48

178

(3000494) Fungus identified in Specimen by Culture

1.39

0.42

1.9

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.39

0.0

1.4

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.39

0.0

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

326

1.25

0.39

9.0

5.3

7.2

6.8

mmol/l

0.43

305

(3044889) 12 lead EKG panel

356

1.24

0.39

5.1

4.3

—

(3003694) ABO and Rh group [Type] in Blood

127

1.32

0.37

2.0

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

492

0.81

0.37

4.2

4.8

6.2

6.0

mmol/l

0.18

433

(3019832) Treponema pallidum Ab [Presence] in Serum

1.43

0.36

1.0

1.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

477

0.83

0.30

4.1

4.5

1.5

mmol/l

0.19

425

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

484

0.84

0.27

5.5

4.6

2.2

1.9

mu/l

0.30

421

(3041096) Erythrocytes [Presence] in Urine by Automated

152

1.24

0.26

4.9

3.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

300

0.85

0.23

3.8

2.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

498

0.87

0.20

4.3

5.1

2.5

2.6

mmol/l

0.28

444

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.20

0.0

1.1

—

(4035726)

1.17

0.19

1.2

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.20

0.17

2.4

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

161

0.84

0.17

5.9

4.6

26.7

21.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

514

0.88

0.16

38.8

17.1

31.9

25.9

mg/l

0.57

418

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

551

0.89

0.14

14.8

11.3

25.4

24.2

u/l

0.21

527

(40768804) Tissue Pathology biopsy report

218

0.89

0.12

2.1

2.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

469

0.91

0.11

37.6

16.4

72.8

76.6

ml/min/173m2

0.31

383

(1761868) Lipid panel - Serum or Plasma

145

0.88

0.10

2.8

3.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.08

0.08

13.7

9.0

—

(3012516) Albumin [Mass/volume] in Urine

147

1.11

0.08

3.9

3.1

136.2

501.6

mg/l

0.36

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.83

0.07

2.6

1.7

—

(40761511) CBC panel - Blood by Automated count

534

0.93

0.07

31.6

15.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

474

0.93

0.07

6.1

6.2

41.1

41.0

mmol/mol

0.02

438

(3013707) Erythrocyte sedimentation rate by Westergren method

391

1.05

0.03

5.3

4.0

17.7

13.6

mm/h

0.79

352

(3009542) Hematocrit [Volume Fraction] of Blood

459

1.01

0.00

40.6

18.4

36.5

38.7

0.67

303

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

6.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3002256) Pathology report gross observation

0.95

0.00

1.0

1.3

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.1

—

(44790049)

0.00

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

10.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.4

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(44806118)

0.00

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(4268621)

0.00

0.0

1.7

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.0

—

(44790048)

0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.3

—

91.3

—

(44790047)

0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.6

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.7

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_SEQUMAL and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	2.544 [1.9, 3.41]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.426

During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 483 females with E4_SEQUMAL died.

Males

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	3.135 [2.06, 4.76]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 380 males with E4_SEQUMAL died.

Mortality risk

Mortality risk for people of age

years, who have E4_SEQUMAL.

N-year risk	Females	Males
1	0.212%	0.748%
5	1.486%	4.033%
10	3.966%	9.774%
15	7.901%	17.424%
20	13.061%	28.764%

Relationships between endpoints

↥

Index endpoint: E4_SEQUMAL – Sequelae of malnutrition and other nutritional deficiencies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sequelae of malnutrition and other nutritional deficiencies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints