Sequelae of malnutrition and other nutritional deficiencies

E4_SEQUMAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E64
  • Cause of death: ICD-10 E64

2 out of 7 registries used, show all original rules.

81

4. Check minimum number of events

None

81

5. Include endpoints

None

81

6. Filter based on genotype QC (FinnGen only)

81

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E50-E64
Name in latin
Sequelae malnutritionis et aliarum deficientiarum nutritionalium

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1025 566 443
Only index persons 738 414 324
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 73.60 76.42 70.18
Only index persons 72.79 75.38 69.48

-FinnGen-

Key figures

All Female Male
Number of individuals 81 37 44
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 67.48 59.65 74.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
75
Matched controls
749
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E64.9
ICD-10 Finland
Sequelae of unspecified nutritional deficiency
+∞
75.1
59
*
D64.9
ICD-10 Finland
Anaemia, unspecified
11.8
17.8
37
57
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
6.9
34
128

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3009445) Proteinase 3 Ab [Units/volume] in Serum
10
17
6.57
5.78
1.2
1.2
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
31
147
2.80
4.52
3.6
2.1
mg/l
3.0
2.8
0.18
25
127
(40760888) Immunoglobulin light chains.free panel - Serum
8
10
8.72
4.16
3.9
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
13
41
3.59
3.68
3.5
2.2
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
23
104
2.69
3.58
3.7
5.0
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
7
11
6.84
3.26
1.1
1.1
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
40
243
2.28
3.25
6.9
6.1
e9/l
0.0
0.0
0.41
33
214
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
64
2.87
3.10
4.5
3.8
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
36
215
2.21
2.99
5.4
3.3
—
—
—
0
0
(1616796) Gas panel - Central venous blood
7
13
5.78
2.93
2.9
2.6
—
—
—
0
0
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
5
6
8.77
2.78
3.2
1.7
pg
32.8
32.3
—
5
6
(3013115) Eosinophils [#/volume] in Blood
39
251
2.07
2.60
7.8
6.2
e9/l
0.1
0.2
0.27
34
223
(3019198) Lymphocytes [#/volume] in Blood
39
251
2.07
2.60
7.5
6.1
e9/l
1.5
1.7
1.11
34
228
(3001604) Monocytes [#/volume] in Blood
38
244
2.05
2.53
7.2
6.0
e9/l
0.5
0.6
2.17
33
214
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
24
129
2.22
2.52
2.0
1.8
mg/l
1.3
1.7
0.34
19
110
(3042111) Morphology [Interpretation] in Bone marrow Narrative
6
12
5.30
2.45
1.2
1.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
29
173
2.05
2.32
6.8
4.9
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
28
169
2.00
2.15
5.5
3.2
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
5
10
5.25
2.10
2.6
1.3
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
35
230
1.92
2.10
5.5
2.4
ug/l
240.0
117.0
1.30
30
209
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
26
3.30
2.07
4.2
2.6
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
13
59
2.43
1.96
1.2
1.4
—
232.9
—
0
17
(3012501) Base excess in Blood by calculation
6
17
3.72
1.87
5.3
2.6
mmol/l
1.6
1.9
—
6
10
(3027315) Oxygen [Partial pressure] in Blood
6
17
3.72
1.87
5.3
2.6
kpa
6.8
8.4
—
6
17
(3013290) Carbon dioxide [Partial pressure] in Blood
6
17
3.72
1.87
5.3
2.6
kpa
5.3
4.9
—
6
17
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
29
185
1.88
1.87
4.7
3.3
ng/l
3653.9
1919.7
0.45
24
160
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
10
41
2.64
1.83
6.0
7.9
mmol/l
24.9
25.0
—
10
41
(3000991) Gas panel - Venous blood
11
48
2.49
1.79
12.9
11.3
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
25
154
1.90
1.78
4.8
3.9
estimate
0.0
0.0
—
9
53
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
7
25
2.96
1.69
7.4
3.7
mmol/l
1.9
2.3
—
7
20
(3018418) pH of Serum or Plasma
27
175
1.81
1.63
10.8
3.6
ph
7.4
7.4
—
10
38
(46235355) HIV 1 and 2 tests - Meaningful Use set
15
79
2.10
1.62
2.7
1.8
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
6
20
3.15
1.61
1.2
1.0
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
5
15
3.48
1.54
6.8
2.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
26
170
1.78
1.51
3.3
2.5
—
—
—
0
0
(3012095) Magnesium [Moles/volume] in Serum or Plasma
17
97
1.95
1.49
4.8
3.7
mmol/l
0.8
0.8
0.35
17
88
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
37
269
1.69
1.48
16.2
6.5
mmol/l
1.2
1.2
0.59
30
220
(3026008) Bacteria identified in Urine by Culture
28
190
1.72
1.43
4.4
3.5
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
30
211
1.67
1.33
4.8
4.4
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
6
24
2.62
1.33
3.0
2.8
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
5
18
2.89
1.30
1.2
1.2
—
—
—
0
0
(3015736) pH of Urine
30
215
1.63
1.23
4.3
3.8
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
10
50
2.14
1.22
5.3
4.0
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
21
138
1.70
1.18
5.7
3.8
—
—
—
0
0
(3019060) Gas panel - Arterial blood
8
40
2.11
1.16
2.0
3.9
—
—
—
0
0
(40758558) Short blood count panel - Blood
21
139
1.69
1.15
9.9
6.9
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
26
183
1.62
1.13
9.3
5.6
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
12
67
1.93
1.12
1.4
1.3
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
7
32
2.30
1.11
3.6
2.7
e6/l
0.1
0.2
—
7
32
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
9
45
2.12
1.09
2.0
1.5
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
5
22
2.35
1.05
3.0
2.2
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
7
35
2.09
1.03
2.7
1.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
9
49
1.94
1.03
3.0
3.6
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
10
54
1.97
1.02
8.5
4.1
mmol/l
1.2
1.2
—
10
48
(3037467) Urinalysis macro (dipstick) panel - Urine
46
377
1.51
1.00
7.0
4.8
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
11
62
1.90
1.00
2.1
4.7
ug/l
10.5
76.0
—
6
53
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
29
0.00
1.00
0.0
1.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
13
78
1.79
0.98
1.8
2.3
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
20
137
1.61
0.96
2.1
1.7
nmol/l
1305.7
1209.3
0.09
15
107
(3021601) Nitrite [Presence] in Urine by Test strip
36
284
1.48
0.92
8.1
5.5
estimate
0.0
0.0
—
10
55
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
38
308
1.44
0.83
3.8
3.0
u/l
96.9
54.4
0.50
33
288
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
6
33
1.88
0.81
14.3
3.3
mmol/l
23.8
24.4
—
6
33
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
6
33
1.88
0.81
4.0
8.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
12
75
1.70
0.80
2.5
1.8
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
35
282
1.42
0.78
6.1
4.0
estimate
0.0
0.0
—
10
55
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
12
76
1.68
0.77
2.5
1.9
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
24
2.15
0.76
2.6
2.5
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
9
56
1.68
0.75
2.1
1.4
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
17
119
1.54
0.74
3.0
2.6
—
—
—
0
0
(3022145) Colonoscopy Study observation
9
57
1.65
0.74
1.2
1.3
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
15
102
1.58
0.74
1.6
1.3
g/l
2.6
2.5
—
6
52
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
30
240
1.40
0.68
4.9
4.0
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
35
289
1.37
0.65
6.2
4.0
estimate
0.0
0.0
—
9
52
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
54
1.53
0.59
1.6
1.5
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
28
227
1.36
0.58
2.7
2.1
pmol/l
89.8
89.3
0.02
19
115
(3013512) EKG study
20
153
1.41
0.57
4.2
5.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
30
246
1.35
0.57
17.6
7.4
inr
1.5
1.2
0.83
16
78
(3012544) pH of Venous blood
9
59
1.59
0.57
16.1
3.6
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
6
39
1.58
0.54
1.2
1.4
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
9
64
1.46
0.54
2.4
1.7
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
6
40
1.54
0.53
1.7
1.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
14
103
1.43
0.49
3.2
1.9
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
7
48
1.50
0.48
1.3
1.1
—
—
—
0
0
(3022621) pH of Urine by Test strip
7
49
1.47
0.47
5.9
3.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
8
55
1.50
0.45
1.1
1.3
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
23
189
1.30
0.42
2.7
2.2
u/l
107.2
323.2
1.48
23
178
(3000494) Fungus identified in Specimen by Culture
8
59
1.39
0.42
1.9
1.3
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
37
326
1.25
0.39
9.0
5.3
mmol/l
7.2
6.8
0.43
37
305
(3044889) 12 lead EKG panel
40
356
1.24
0.39
5.1
4.3
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
16
127
1.32
0.37
2.0
1.3
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
45
492
0.81
0.37
4.2
4.8
mmol/l
6.2
6.0
0.18
36
433
(3019832) Treponema pallidum Ab [Presence] in Serum
6
43
1.43
0.36
1.0
1.7
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
44
477
0.83
0.30
4.1
4.5
mmol/l
1.5
1.5
0.19
38
425
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
45
484
0.84
0.27
5.5
4.6
mu/l
2.2
1.9
0.30
39
421
(3041096) Erythrocytes [Presence] in Urine by Automated
18
152
1.24
0.26
4.9
3.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
27
300
0.85
0.23
3.8
2.7
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
47
498
0.87
0.20
4.3
5.1
mmol/l
2.5
2.6
0.28
39
444
(3050129) First trimester maternal screen panel - Serum or Plasma
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(4035726)
6
52
1.17
0.19
1.2
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
8
68
1.20
0.17
2.4
1.6
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
14
161
0.84
0.17
5.9
4.6
%
26.7
21.3
—
5
89
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
49
514
0.88
0.16
38.8
17.1
mg/l
31.9
25.9
0.57
44
418
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
53
551
0.89
0.14
14.8
11.3
u/l
25.4
24.2
0.21
47
527
(40768804) Tissue Pathology biopsy report
20
218
0.89
0.12
2.1
2.0
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
45
469
0.91
0.11
37.6
16.4
ml/min/173m2
72.8
76.6
0.31
37
383
(1761868) Lipid panel - Serum or Plasma
13
145
0.88
0.10
2.8
3.5
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
7
65
1.08
0.08
13.7
9.0
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
16
147
1.11
0.08
3.9
3.1
mg/l
136.2
501.6
0.36
11
89
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
83
0.83
0.07
2.6
1.7
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
52
534
0.93
0.07
31.6
15.8
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
46
474
0.93
0.07
6.1
6.2
mmol/mol
41.1
41.0
0.02
37
438
(3013707) Erythrocyte sedimentation rate by Westergren method
40
391
1.05
0.03
5.3
4.0
mm/h
17.7
13.6
0.79
35
352
(3009542) Hematocrit [Volume Fraction] of Blood
46
459
1.01
0.00
40.6
18.4
%
36.5
38.7
0.67
27
303
(3024522) Salmonella sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
6.4
—
0
7
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3005988) Vibrio sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002256) Pathology report gross observation
6
63
0.95
0.00
1.0
1.3
—
—
—
0
0
(3035947) Staphylolysin Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(44790049)
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.6
—
10.3
—
0
9
(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(44806118)
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3012568) Campylobacter sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(4268621)
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(44790048)
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3025468) Yersinia sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
6
0.00
0.00
0.0
5.3
—
91.3
—
0
6
(44790047)
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
8
0.00
0.00
0.0
3.6
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3044941) Cell count panel - Synovial fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_SEQUMAL and mortality.

Females

Parameter HR [95% CI] p-value
E4_SEQUMAL 2.544 [1.9, 3.41] < 0.001
Birth year 0.997 [0.99, 1.01] 0.426

During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 483 females with E4_SEQUMAL died.

Males

Parameter HR [95% CI] p-value
E4_SEQUMAL 3.135 [2.06, 4.76] < 0.001
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 380 males with E4_SEQUMAL died.

Mortality risk

Mortality risk for people of age

years, who have E4_SEQUMAL.

N-year risk Females Males
1 0.212% 0.748%
5 1.486% 4.033%
10 3.966% 9.774%
15 7.901% 17.424%
20 13.061% 28.764%

Relationships between endpoints

Index endpoint: E4_SEQUMAL – Sequelae of malnutrition and other nutritional deficiencies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data