This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Profound mental retardation
F5_PRORET
mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
41 |
4. Check minimum number of eventsNone |
41 |
5. Include endpointsNone |
41 |
6. Filter based on genotype QC (FinnGen only) |
41 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F70-F79
- Name in latin
- Retardatio mentalis profunda
Similar endpoints
↥List of similar endpoints to
Profound mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation, excluding more controls
- Mental retardation, wide definition
- Psychiatric diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3013 | 1422 | 1589 |
| Only index persons | 2026 | 948 | 1078 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 23.23 | 24.05 | 22.46 |
| Only index persons | 24.02 | 25.08 | 23.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 41 | 22 | 19 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 23.28 | 30.73 | 14.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
39
3.49
2.72
15.8
5.3
24.8
25.2
mmol/l
0.07
11
39
24
140
2.72
2.46
11.0
7.0
1.2
1.2
mmol/l
0.06
18
125
20
107
2.70
2.42
4.6
3.4
—
—
—
0
0
19
101
2.64
2.31
1.7
1.8
104.1
96.7
pmol/l
—
8
46
6
15
4.49
2.12
1.0
1.5
—
—
—
0
0
6
15
4.49
2.12
15.2
18.2
0.8
0.7
%
—
6
15
6
16
4.20
2.01
15.2
17.2
0.9
2.0
%
—
6
16
8
31
2.95
1.77
11.5
5.3
24.9
24.5
mmol/l
—
8
31
7
25
3.16
1.74
13.1
15.4
4.9
5.3
kpa
—
7
25
7
26
3.03
1.66
4.6
3.1
—
—
—
0
0
10
46
2.55
1.54
1.9
1.8
—
—
—
0
0
5
105
0.40
1.24
2.4
1.7
—
—
—
0
0
10
51
2.27
1.23
3.7
3.1
1.0
0.9
e6/l
—
5
31
13
76
2.04
1.16
2.1
1.7
3.0
2.7
mg/l
0.15
13
68
0
30
0.00
1.02
0.0
1.5
—
—
—
0
0
21
152
1.78
0.97
6.0
3.4
0.0
0.0
estimate
—
6
28
21
155
1.73
0.88
7.2
4.9
0.0
0.0
estimate
—
6
28
6
32
2.02
0.85
1.7
1.3
—
—
—
0
0
21
157
1.69
0.83
6.0
3.4
0.0
0.0
estimate
—
6
25
19
145
1.58
0.65
3.3
3.6
—
—
—
0
0
6
34
1.89
0.62
20.5
5.6
—
—
—
0
0
15
110
1.57
0.60
6.1
3.4
—
—
—
0
0
5
31
1.70
0.45
1.4
1.3
—
—
—
0
0
0
15
0.00
0.42
0.0
1.9
—
—
—
0
0
36
334
1.64
0.40
26.6
12.6
139.3
139.6
mmol/l
0.20
36
325
25
218
1.38
0.37
10.8
8.2
4.5
3.8
e9/l
0.42
25
184
36
337
1.56
0.29
26.4
12.6
4.0
3.9
mmol/l
1.50
36
328
25
276
0.76
0.29
3.6
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
17.1
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
2.4
—
0
5
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
49.6
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
23
241
0.90
0.06
5.6
3.6
10.5
9.0
mm/h
0.30
23
226
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
12.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
89.6
—
0
8
0
5
0.00
0.00
0.0
6.4
—
194.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
38.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
0.00
1.5
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
36
356
1.09
0.00
22.9
12.1
62.1
69.8
umol/l
1.17
36
356
0
5
0.00
0.00
0.0
1.0
—
18.4
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_PRORET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PRORET | 11.864 [6.57, 21.41] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 180 out of 557 females with F5_PRORET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PRORET | 10.607 [7.03, 15.99] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 614 males with F5_PRORET died.
Mortality risk
Mortality risk for people of age
years, who have F5_PRORET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.125% | 1.791% |
| 5 | 6.26% | 10.254% |
| 10 | 15.144% | 24.518% |
| 15 | 27.127% | 43.214% |
| 20 | 43.132% | 60.983% |
Relationships between endpoints
↥Index endpoint: F5_PRORET – Profound mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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