Post-traumatic hydrocephalus, unspecified

G6_HCPOSTRAU

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G91.3 Cause of death: ICD-10 — G91.3 2 out of 7 registries used, show all original rules.	95
4. Check minimum number of events None	95
5. Include endpoints None	95
6. Filter based on genotype QC (FinnGen only)	93

Control definitions (FinnGen only)

Control exclude: G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G91
Name in latin: Hydrocephalia posttraumatica non specificata

NAME	G6_HCPOSTRAU
CONTROL_EXCLUDE	G6_HYDROCEPH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G913
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G913
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Post-traumatic hydrocephalus, unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	825	244	570
Only index persons	682	217	465
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.02
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	60.74	61.47	60.20
Only index persons	60.24	61.26	59.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	93	27	66
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	65.18	59.98	67.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G91.3

ICD-10 Finland

Post-traumatic hydrocephalus, unspecified

+∞

136.9

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

+∞

68.1

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

+∞

30.9

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

28.6

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

334.4

26.0

T90.5

ICD-10 Finland

Sequelae of intracranial injury

111.4

24.0

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

27.6

23.3

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

27.6

23.3

AA1AD

NOMESCO Finland

CT of head and brain

7.8

22.7

171

AAF00

NOMESCO Finland

Ventriculostomy

+∞

21.7

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

+∞

20.6

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

+∞

19.4

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

6.7

19.2

200

ZXD05

NOMESCO Finland

Urgent procedure

6.3

17.9

197

S06.3

ICD-10 Finland

Focal brain injury

73.0

16.4

S06.2

ICD-10 Finland

Diffuse brain injury

175.9

14.9

AA1AA

NOMESCO Finland

Head X-ray examination

63.3

14.3

AAF15

NOMESCO Finland

Ventriculoatrial shunt

+∞

13.9

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

+∞

12.8

L28

ICPC

Limited function/disability (L)

5.0

12.4

108

ZXE10

NOMESCO Finland

More than one and less than three hours

4.4

11.7

219

W19

ICD-10 Finland

Unspecified fall

5.8

11.2

K90

ICPC

Stroke/cerebrovascular accident

21.0

11.2

WYA30

NOMESCO Finland

Treatment of a patient needing special arrangements

6.2

10.4

N06AB04

ATC

citalopram; systemic

4.4

10.3

106

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

6.3

10.1

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

5.9

9.8

AAD10

NOMESCO Finland

Evacuation of chronic subdural haematoma

24.7

9.6

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

+∞

9.5

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.5

9.2

S06.6

ICD-10 Finland

Traumatic subarachnoid haemorrhage

27.1

9.2

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.9

9.1

133

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.1

8.8

100

X59

ICD-10 Finland

Exposure to unspecified factor

4.1

8.6

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

8.5

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

7.9

8.4

S06.0

ICD-10 Finland

Concussion

4.8

8.1

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

17.5

7.4

WX730

NOMESCO Finland

Conventional respirator

+∞

7.4

N99

ICPC

Neurological disease other

32.8

7.3

AAD05

NOMESCO Finland

Evacuation of acute subdural haematoma

43.3

6.9

N18

ICPC

Paralysis/weakness

13.6

6.8

N05BA01

ATC

diazepam; systemic, rectal

4.1

6.7

N06AX11

ATC

mirtazapine; oral

3.1

6.7

185

A28

ICPC

Limited function/disability NOS

3.5

6.7

112

SPAT1216

SPAT

Assessment of functional ability

3.6

6.5

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

74.7

6.5

WX408

NOMESCO Finland

General anesthesy, balanced

3.2

6.4

154

N05BA04

ATC

oxazepam; oral

3.2

6.3

136

N39.4

ICD-10 Finland

Other specified urinary incontinence

6.2

N03AX14

ATC

levetiracetam; systemic

8.2

6.2

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.4

6.1

Z2445

NOMESCO Finland

Psychologist

9.0

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

46.79

16.08

1.8

1.6

—

(3044290) Cell count panel - Cerebral spinal fluid

19.09

13.33

2.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

22.57

8.72

1.8

1.3

—

(3023410) Appearance of Cerebral spinal fluid

14.02

5.70

2.4

1.3

—

(3018418) pH of Serum or Plasma

188

2.36

3.73

5.7

4.3

7.39

7.40

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

115

2.45

3.24

6.8

3.6

0.85

0.82

mmol/l

0.76

106

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.62

3.08

2.0

1.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

302

2.01

2.81

10.5

5.7

1.21

mmol/l

0.18

273

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

116

2.30

2.75

2.0

1.9

—

(3023183) Ammonium ion [Moles/volume] in Plasma

4.63

2.52

1.6

2.2

33.86

35.55

umol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.35

2.42

2.1

1.8

—

(3026008) Bacteria identified in Urine by Culture

211

1.95

2.36

2.7

3.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

359

1.83

2.18

21.6

15.9

1.21

1.31

inr

0.33

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.25

2.11

2.1

1.8

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

5.21

2.09

5.0

3.4

308.60

327.50

umol/l

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.95

0.0

1.5

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

110

2.04

1.91

10.9

5.4

0.98

1.06

mmol/l

0.51

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

348

1.69

1.73

10.9

6.5

1.21

mmol/l

0.16

299

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.54

1.68

1.5

1.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.11

1.58

4.4

3.9

—

(40761535) Cells panel - Urine sediment

2.18

1.51

2.8

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.84

1.46

1.2

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

1.38

0.0

2.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

689

0.62

1.37

4.3

5.1

2.38

2.62

mmol/l

1.42

627

(1761868) Lipid panel - Serum or Plasma

232

0.53

1.34

2.4

3.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.18

0.0

6.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

1.18

0.0

4.2

—

368.32

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

1.16

0.0

1.1

—

(3021589) Normoblasts [#/volume] in Blood

326

1.52

1.16

9.5

9.8

0.00

0.01

e9/l

0.52

268

(3044640) Blood type and Crossmatch panel - Blood

217

1.56

1.13

4.9

2.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

668

0.66

1.10

4.2

4.5

1.32

1.40

mmol/l

0.77

609

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

666

0.67

1.06

4.4

4.8

5.71

6.04

mmol/l

1.94

606

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

306

0.63

1.05

3.3

4.4

19.10

20.91

—

142

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

637

0.68

1.04

6.0

6.3

40.42

41.10

mmol/mol

0.21

583

(36304419) Bacteria [Presence] in Urine

204

1.53

1.01

4.4

2.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.80

1.01

11.0

9.8

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.99

0.0

3.8

—

1.42

—

(40768804) Tissue Pathology biopsy report

259

0.62

0.99

2.0

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

153

1.57

0.97

3.6

2.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

308

1.45

0.95

3.5

4.0

56.50

67.52

ng/l

0.13

230

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

670

0.68

0.95

4.2

4.6

4.09

4.45

mmol/l

2.17

616

(3029937) Albumin [Presence] in Urine by Test strip

189

1.52

0.95

4.3

3.6

0.00

estimate

-0.00

(3022313) Gas panel - Capillary blood

2.14

0.91

4.3

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

284

1.43

0.87

4.2

3.0

—

(3023368) Bacteria identified in Blood by Culture

230

1.44

0.84

8.4

4.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.79

0.0

1.3

—

(3000991) Gas panel - Venous blood

1.78

0.79

22.0

6.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

652

0.72

0.79

4.3

4.1

1.36

1.27

mmol/l

0.51

592

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.78

0.0

3.9

—

7.95

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

143

1.50

0.78

5.2

3.0

—

(3045414) Leukocytes [Presence] in Urine

2.14

0.75

1.8

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.67

0.75

1.4

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.86

0.74

12.6

7.4

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.59

0.70

15.5

5.5

14.60

11.19

kpa

1.09

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.59

0.70

15.5

5.5

4.85

4.98

kpa

0.13

(40761536) Microorganisms panel - Urine sediment

1.63

0.61

3.0

3.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.3

—

1.12

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.61

0.0

3.5

—

105.75

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.61

0.0

1.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.61

0.0

3.5

—

4.06

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.61

0.0

3.4

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.60

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.60

0.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.60

0.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.59

0.0

1.4

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

0.53

0.59

2.6

1.3

—

(3019225) pH of Specimen

1.47

0.54

4.6

5.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

335

0.77

0.51

9.2

6.4

—

(3042936) Bacteria identified in Isolate by Culture

112

1.40

0.48

4.0

2.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.46

0.45

6.1

3.9

5.99

5.73

kpa

0.35

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

293

1.25

0.42

2.0

96.56

92.43

pmol/l

0.24

152

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.40

0.0

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

343

1.23

0.40

4.6

3.6

0.00

0.01

estimate

0.49

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.2

—

0.25

—

(40768800) Prostate Pathology biopsy report

0.00

0.39

0.0

1.2

—

(40768797) Stomach Pathology biopsy report

1.35

0.34

1.5

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.37

0.34

3.3

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.32

0.31

1.3

2.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

420

0.84

0.30

15.1

8.7

4.66

4.28

e9/l

0.40

363

(40758558) Short blood count panel - Blood

178

1.23

0.29

15.4

6.5

—

(3009261) Glucose [Presence] in Urine by Test strip

352

1.18

0.29

4.5

3.6

0.00

estimate

-0.00

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

171

0.79

0.29

1.5

1.6

1.62

1.28

mmol/l

—

141

(3022145) Colonoscopy Study observation

1.28

0.26

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

316

1.17

0.26

3.4

2.5

—

(3002256) Pathology report gross observation

0.73

0.25

1.5

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.30

0.23

4.8

2.9

0.46

0.67

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

368

1.15

0.23

2.7

2.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

103

0.76

0.22

5.5

3.7

194.63

241.46

u/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.23

0.22

4.8

2.9

1.02

1.36

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

178.44

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

3.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

2.7

—

4.71

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

469

1.14

0.21

4.8

4.3

—

(3013512) EKG study

227

0.85

0.21

4.0

4.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

2.7

—

57.23

—

(3022621) pH of Urine by Test strip

1.24

0.20

2.2

2.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

225

0.86

0.19

5.0

3.0

26.10

29.03

u/l

0.68

212

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

274

1.14

0.18

4.0

3.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.14

0.15

1.6

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

347

1.11

0.14

5.4

5.0

0.00

estimate

-0.00

(3013707) Erythrocyte sedimentation rate by Westergren method

520

0.92

0.11

3.4

4.2

12.09

12.53

mm/h

0.08

471

(3044889) 12 lead EKG panel

500

0.92

0.11

4.7

4.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

737

0.90

0.10

29.7

18.1

85.44

85.27

umol/l

0.01

737

(3019060) Gas panel - Arterial blood

1.12

0.09

5.2

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.15

0.08

1.4

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

245

1.08

0.08

2.4

3.2

2019.14

1747.43

ng/l

0.13

200

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

654

0.93

0.07

23.5

14.9

83.08

77.83

ml/min/173m2

0.84

538

(40761511) CBC panel - Blood by Automated count

727

1.08

0.06

19.2

14.8

—

(3002385) Erythrocyte distribution width [Ratio]

594

0.94

0.06

30.1

18.4

14.93

14.87

0.03

581

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

487

1.06

0.05

3.7

15.05

14.78

pmol/l

0.30

425

(3041096) Erythrocytes [Presence] in Urine by Automated

209

0.95

0.03

3.0

3.7

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

619

0.96

0.03

4.5

4.4

1.69

2.09

mu/l

2.37

546

(3019198) Lymphocytes [#/volume] in Blood

359

0.96

0.03

11.2

5.7

1.93

1.92

e9/l

0.01

322

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

704

1.03

0.00

27.5

15.3

27.52

25.77

mg/l

0.14

567

(3012516) Albumin [Mass/volume] in Urine

202

0.99

0.00

3.3

3.2

85.79

351.08

mg/l

0.46

146

(3013115) Eosinophils [#/volume] in Blood

362

0.99

0.00

11.0

5.9

0.21

0.20

e9/l

0.16

318

(3006315) Basophils [#/volume] in Blood

351

1.00

0.00

11.1

5.7

0.04

e9/l

0.29

304

(3001122) Ferritin [Mass/volume] in Serum or Plasma

289

1.00

0.00

4.3

2.6

137.58

126.89

ug/l

0.15

264

(3001604) Monocytes [#/volume] in Blood

353

0.99

0.00

11.1

5.6

0.60

0.59

e9/l

0.02

306

(46235355) HIV 1 and 2 tests - Meaningful Use set

106

1.04

0.00

1.8

1.7

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.6

—

13.20

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

2.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.94

0.00

2.2

2.0

9.54

9.02

g/l

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.3

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.95

0.00

5.5

3.1

6.02

4.16

kpa

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

2.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.3

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

41840.00

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

3.0

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

2.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

68.80

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

2.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

80.60

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.0

1.8

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.3

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

2.2

—

32.11

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

23.57

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

3.0

—

(3003694) ABO and Rh group [Type] in Blood

170

1.00

-0.00

1.4

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.89

-0.00

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

2.3

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.0

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.84

-0.00

2.2

4.1

75.40

258.64

ng/l

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

220

1.00

-0.00

3.7

3.9

15.80

10.09

mg/mmol

0.20

147

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.2

—

180.62

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCPOSTRAU and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HCPOSTRAU	3.131 [2.25, 4.35]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.551

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 207 females with G6_HCPOSTRAU died.

Males

Parameter	HR [95% CI]	p-value
G6_HCPOSTRAU	4.172 [3.17, 5.49]	< 0.001
Birth year	0.983 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 486 males with G6_HCPOSTRAU died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCPOSTRAU.

N-year risk	Females	Males
1	0.262%	0.89%
5	1.526%	4.357%
10	4.536%	10.32%
15	9.383%	18.425%
20	16.445%	30.377%

Relationships between endpoints

↥

Index endpoint: G6_HCPOSTRAU – Post-traumatic hydrocephalus, unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Post-traumatic hydrocephalus, unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints