polyneuropathy: A disease or disorder affecting more than one nerve.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
56 |
4. Check minimum number of eventsNone |
56 |
5. Include endpointsNone |
56 |
6. Filter based on genotype QC (FinnGen only) |
53 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G60
- Name in latin
- Neuropathia progressiva idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic progressive neuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 509 | 207 | 286 |
| Only index persons | 283 | 119 | 164 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.12 | 66.65 | 65.56 |
| Only index persons | 57.39 | 56.76 | 57.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 53 | 21 | 32 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 57.45 | 58.46 | 56.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G60.3
ICD-10 Finland
Idiopathic progressive neuropathy
+∞
43.5
36
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
+∞
26.1
23
*
3564A
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Idiopathic progressive polyneuropathy
+∞
22.4
20
*
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
10.8
10
*
N03AX16
ATC
[U] pregabalin
5.3
8.3
24
70
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
7.4
7
*
SPAT1236
SPAT
Informing family of child’s disability
35.0
7.4
9
*
N03AE01
ATC
clonazepam; systemic
12.1
6.4
11
11
G60.9
ICD-10 Finland
Hereditary and idiopathic neuropathy, unspecified
+∞
6.4
6
*
N03AX12
ATC
[U] gabapentin; oral
4.5
6.3
20
61
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
17.5
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
170
3.55
5.07
3.0
3.5
—
—
—
0
0
27
127
3.17
4.28
3.4
3.2
0.06
0.33
e6/l
1.27
22
101
17
63
3.44
3.92
2.4
3.2
0.49
1.10
e6/l
1.26
12
40
13
35
4.52
3.92
3.9
4.1
4.77
4.58
kpa
0.13
13
35
13
39
4.02
3.52
4.2
3.9
5.90
5.37
kpa
0.85
13
39
10
25
4.63
3.27
3.5
3.0
133.10
121.88
g/l
—
10
25
8
16
5.64
3.18
1.1
1.8
—
—
—
0
0
9
21
4.89
3.15
4.6
4.1
59.27
54.32
%
—
9
21
9
21
4.89
3.15
3.9
4.1
26.96
23.20
mmol/l
—
9
21
5
6
8.98
2.80
1.4
2.0
—
—
—
0
0
5
6
8.98
2.80
1.4
2.0
—
—
—
0
0
11
37
3.44
2.67
1.4
3.4
68.68
67.86
g/l
0.13
11
31
14
62
2.68
2.30
2.6
3.4
0.06
2.11
e6/l
—
9
39
9
31
3.26
2.19
1.8
1.4
—
—
—
0
0
7
23
3.33
1.87
3.1
2.8
1.11
1.20
%
—
7
23
21
123
2.13
1.85
3.0
3.1
38.05
36.13
u/l
0.06
21
117
10
46
2.43
1.50
1.1
1.4
—
—
—
0
0
36
271
1.92
1.48
3.6
4.7
6.74
6.70
mmol/l
0.03
36
256
16
93
2.01
1.40
1.8
2.2
—
—
—
0
0
11
56
2.20
1.33
1.4
1.3
1.32
3.82
u/ml
—
6
21
18
112
1.89
1.29
1.6
1.5
17.60
21.00
nmol/l
0.31
18
95
8
41
2.11
1.14
2.9
1.6
—
—
—
0
0
6
27
2.36
0.97
2.2
3.8
0.23
0.13
e6/l
—
6
27
25
187
1.61
0.91
2.8
2.5
—
—
—
0
0
24
180
1.58
0.85
2.2
1.9
98.53
93.50
pmol/l
0.24
18
91
6
32
1.98
0.84
3.7
2.3
1.48
1.56
%
—
6
22
22
164
1.56
0.79
7.5
4.4
—
—
—
0
0
9
58
1.66
0.74
3.2
6.9
104.00
104.36
mmol/l
—
9
58
16
113
1.58
0.71
2.6
2.9
304.00
4160.26
umol/l
0.51
16
85
7
43
1.72
0.70
3.6
1.8
—
—
—
0
0
6
34
1.85
0.61
5.8
4.5
2.85
1.80
mmol/l
—
6
28
26
212
1.42
0.57
2.5
2.5
—
—
—
0
0
10
66
1.63
0.57
6.1
8.2
—
—
—
0
0
9
63
1.51
0.56
3.1
1.9
—
—
—
0
0
6
39
1.60
0.55
3.3
1.2
—
—
—
0
0
7
47
1.56
0.50
2.0
2.7
7.29
10.17
umol/l
—
7
38
5
31
1.67
0.44
1.6
1.3
—
—
—
0
0
5
36
1.43
0.39
3.8
2.4
23.00
30.67
u/l
—
5
27
6
46
1.34
0.34
2.5
1.7
389.33
358.28
nmol/l
—
6
40
45
474
0.74
0.29
33.9
23.2
130.73
134.16
g/l
1.03
45
468
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
4.85
—
0
10
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
39
367
1.21
0.20
23.8
19.3
14.29
14.97
%
0.49
39
362
18
158
1.21
0.19
3.6
4.4
23.32
21.32
%
0.31
13
80
45
449
1.01
0.00
25.8
18.5
139.80
139.58
mmol/l
0.26
45
433
45
451
0.99
0.00
25.2
18.3
3.96
4.02
mmol/l
0.71
45
435
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.1
—
142.86
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint G6_IPNEUROP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have G6_IPNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: G6_IPNEUROP – Idiopathic progressive neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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