polyneuropathy: A disease or disorder affecting more than one nerve.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
54 |
4. Check minimum number of eventsNone |
54 |
5. Include endpointsNone |
54 |
6. Filter based on genotype QC (FinnGen only) |
54 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G60
- Name in latin
- Neuropathia progressiva idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic progressive neuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 509 | 207 | 286 |
| Only index persons | 283 | 119 | 164 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.12 | 66.65 | 65.56 |
| Only index persons | 57.39 | 56.76 | 57.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 54 | 23 | 31 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 57.08 | 57.78 | 56.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
11
18
7.42
6.72
2.8
2.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
32
163
3.36
4.55
3.1
3.6
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
9
14
7.46
4.18
6.6
4.8
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
7
7
11.24
4.14
4.4
5.3
mmol/l
7.5
8.4
—
7
7
(3004119) Hemoglobin [Mass/volume] in Venous blood
10
24
4.89
4.08
3.5
3.1
g/l
133.1
122.8
—
10
24
(3024354) Oxygen [Partial pressure] in Venous blood
12
34
4.25
4.03
4.2
4.2
kpa
4.7
4.5
0.12
12
34
(3008037) Lactate [Moles/volume] in Venous blood
7
8
9.82
3.89
4.4
4.8
mmol/l
1.7
1.5
—
7
8
(3030467) Casts [#/volume] in Urine by Automated count
25
122
2.95
3.64
3.5
3.3
e6/l
0.1
0.3
1.10
20
97
(3012544) pH of Venous blood
12
37
3.88
3.59
4.4
4.1
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
12
38
3.77
3.46
4.4
4.0
kpa
5.9
5.4
0.80
12
38
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
16
62
3.25
3.42
2.4
3.3
e6/l
0.5
1.1
1.11
11
40
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
9
21
4.92
3.16
4.6
4.1
%
59.3
54.3
—
9
21
(3027273) Bicarbonate [Moles/volume] in Venous blood
9
21
4.92
3.16
3.9
4.1
mmol/l
27.0
23.2
—
9
21
(36304419) Bacteria [Presence] in Urine
23
115
2.74
3.11
3.3
3.4
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
17
5.32
3.05
1.1
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
11
36
3.58
3.00
1.3
2.5
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
6
9
7.33
2.95
8.2
6.1
—
—
—
0
0
(3020630) Protein [Mass/volume] in Serum or Plasma
11
38
3.38
2.77
1.4
3.4
g/l
68.7
67.7
0.16
11
32
(3018095) Leukocytes [#/volume] in Urine
27
155
2.48
2.69
4.1
4.2
e6/l
11.2
48.1
1.61
22
117
(3037467) Urinalysis macro (dipstick) panel - Urine
40
279
2.67
2.58
6.5
4.5
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
5
8
6.74
2.42
1.0
1.1
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
6
14
4.68
2.21
1.0
1.1
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
9
31
3.27
2.19
1.8
1.4
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
19
101
2.36
2.16
2.9
3.0
e6/l
4.4
4.3
0.04
19
89
(3007853) Bacteria identified in Skin by Aerobe culture
11
46
2.75
2.00
1.9
2.0
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
7
22
3.50
1.95
3.1
2.9
%
1.1
1.2
—
7
22
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
7
22
3.50
1.95
3.1
2.9
%
0.8
0.8
—
7
22
(3019150) Specific gravity of Urine by Refractometry
17
90
2.30
1.92
6.0
5.3
kg/l
1.0
1.0
—
9
11
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
13
61
2.49
1.90
2.6
3.5
e6/l
0.1
2.1
—
8
39
(3015736) pH of Urine
25
156
2.12
1.90
7.3
4.1
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
20
115
2.17
1.86
2.2
3.2
u/l
28.6
36.5
0.63
20
109
(3023368) Bacteria identified in Blood by Culture
21
128
2.05
1.66
4.7
4.7
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
11
52
2.40
1.57
1.5
1.3
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
10
46
2.44
1.50
1.2
1.7
—
—
—
0
0
(40761535) Cells panel - Urine sediment
9
41
2.43
1.45
3.3
3.9
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
21
137
1.87
1.32
5.3
4.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
15
88
1.98
1.28
1.9
2.2
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
18
113
1.89
1.27
1.6
1.5
nmol/l
17.6
21.0
0.31
18
95
(3041096) Erythrocytes [Presence] in Urine by Automated
18
113
1.89
1.27
5.9
3.8
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
27
195
1.77
1.21
6.0
5.1
%
59.4
57.7
0.37
27
188
(3042936) Bacteria identified in Isolate by Culture
10
52
2.13
1.15
1.8
2.0
—
—
—
0
0
(3013512) EKG study
21
143
1.77
1.13
6.3
4.6
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
34
266
1.75
1.12
3.7
4.7
mmol/l
6.8
6.7
0.12
34
252
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
9
45
2.20
1.12
1.1
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
9
45
2.20
1.12
1.2
1.5
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
26
192
1.68
1.03
6.1
5.2
%
2.6
2.8
0.12
26
183
(3019069) Monocytes/100 leukocytes in Blood
26
193
1.67
1.01
6.2
5.5
%
9.3
8.7
0.39
26
184
(3030981) Hyaline casts [#/volume] in Urine by Automated count
6
27
2.37
0.97
2.2
3.8
e6/l
0.2
0.1
—
6
27
(3022313) Gas panel - Capillary blood
6
29
2.20
0.92
5.2
4.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
24
178
1.63
0.91
4.5
4.2
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
14
90
1.75
0.89
3.3
4.9
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
18
125
1.66
0.88
5.0
3.1
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
22
162
1.60
0.85
7.5
4.4
—
—
—
0
0
(3026782) Osmolality of Urine
14
93
1.68
0.79
3.9
3.2
mosm/kgh2o
586.7
576.3
0.05
14
78
(3007164) IgA [Mass/volume] in Serum or Plasma
12
77
1.72
0.76
1.9
1.4
g/l
2.9
3.4
—
7
40
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
39
1.91
0.76
2.6
1.6
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
5
25
2.10
0.75
2.2
1.3
g/l
2.2
1.1
—
5
19
(3026493) Urate [Moles/volume] in Serum or Plasma
16
112
1.61
0.75
2.6
2.9
umol/l
304.0
4203.5
0.50
16
84
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
42
1.76
0.71
1.0
1.4
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
5
27
1.94
0.70
4.0
2.0
g/l
14.3
9.8
—
5
22
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
23
179
1.50
0.67
2.3
1.9
pmol/l
98.5
93.8
0.23
18
92
(3044889) 12 lead EKG panel
25
301
0.68
0.63
4.0
4.2
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
5
30
1.73
0.63
1.0
2.5
%
1.3
1.5
—
5
20
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
20
0.00
0.62
0.0
1.7
—
—
—
0
0
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
6
34
1.86
0.61
5.8
4.5
mmol/l
2.8
1.8
—
6
28
(3014111) Lactate [Moles/volume] in Serum or Plasma
6
35
1.80
0.60
1.3
4.5
mmol/l
1.4
1.6
—
6
35
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
10
66
1.63
0.57
6.1
8.2
—
—
—
0
0
(3000991) Gas panel - Venous blood
6
38
1.65
0.56
3.7
5.8
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
39
1.60
0.55
3.3
1.2
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
45
1.64
0.51
1.3
1.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
16
124
1.41
0.45
2.1
2.4
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
24
200
1.36
0.45
2.4
2.5
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
31
1.67
0.44
1.6
1.3
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
5
33
1.57
0.42
1.2
1.4
—
—
—
0
0
(3012501) Base excess in Blood by calculation
0
16
0.00
0.42
0.0
2.3
—
3.0
—
0
11
(3027315) Oxygen [Partial pressure] in Blood
0
16
0.00
0.42
0.0
2.3
—
7.7
—
0
16
(3013290) Carbon dioxide [Partial pressure] in Blood
0
16
0.00
0.42
0.0
2.3
—
5.3
—
0
16
(3014218) Bicarbonate [Moles/volume] standard in Arterial blood
0
18
0.00
0.40
0.0
6.7
—
25.0
—
0
18
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
6
41
1.52
0.37
3.3
1.8
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
38
346
1.33
0.36
21.4
16.3
%
34.5
39.4
0.95
19
224
(3036481) Cortisol [Moles/volume] in Serum or Plasma
6
46
1.34
0.34
2.5
1.7
nmol/l
389.3
358.3
—
6
40
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
6
46
1.34
0.34
1.2
2.7
umol/l
5.8
10.3
—
6
37
(3019225) pH of Specimen
6
46
1.34
0.34
2.7
4.6
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
61
1.36
0.30
2.9
1.9
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
43
454
0.74
0.29
33.0
23.6
g/l
130.5
133.7
0.88
43
448
(3035941) MCH [Entitic mass]
43
454
0.74
0.29
32.8
23.4
pg
30.2
30.4
0.20
43
448
(3022217) INR in Platelet poor plasma by Coagulation assay
8
65
1.27
0.29
61.1
32.5
—
1.5
—
0
6
(3007461) Platelets [#/volume] in Blood
43
453
0.75
0.27
33.0
23.5
e9/l
247.8
244.6
0.10
43
445
(3003694) ABO and Rh group [Type] in Blood
11
87
1.33
0.27
1.5
1.4
—
—
—
0
0
(3024731) MCV [Entitic volume]
43
453
0.75
0.27
32.8
23.5
fl
91.1
91.4
0.12
43
447
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
6
82
0.70
0.26
6.3
3.5
mmol/l
2.5
2.5
—
6
70
(40768804) Tissue Pathology biopsy report
14
164
0.80
0.22
2.3
2.1
—
—
—
0
0
(3002256) Pathology report gross observation
5
42
1.21
0.22
1.0
1.2
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
0
11
0.00
0.21
0.0
3.9
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
(3022145) Colonoscopy Study observation
6
50
1.22
0.20
1.5
1.3
—
—
—
0
0
(4034850)
0
14
0.00
0.20
0.0
20.8
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
36
340
1.18
0.16
22.8
19.7
%
13.7
13.7
0.01
36
333
(3018418) pH of Serum or Plasma
14
124
1.17
0.13
3.4
4.5
—
7.4
—
0
28
(4035726)
5
48
1.05
0.09
1.0
1.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
15
138
1.12
0.07
3.1
3.4
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
42
428
0.92
0.03
19.1
16.3
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
43
433
0.97
0.00
25.2
18.8
mmol/l
139.8
139.6
0.19
43
418
(40758558) Short blood count panel - Blood
10
105
0.94
0.00
9.9
6.9
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
43
435
0.94
0.00
24.6
18.6
mmol/l
4.0
4.0
0.38
43
420
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
11
112
0.98
0.00
3.5
2.7
ug/l
1.3
0.8
0.45
11
80
(3030905) Polymorphonuclear cells [#/volume] in Blood
0
7
0.00
0.00
0.0
1.6
—
4.3
—
0
7
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(4146454)
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
7
0.00
0.00
0.0
5.1
—
142.9
—
0
7
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
0
7
0.00
0.00
0.0
1.9
—
60.6
—
0
7
(3022806) Fractional oxyhemoglobin in Capillary blood
0
8
0.00
0.00
0.0
1.1
—
90.0
—
0
8
(3024928) Oxygen saturation in Venous blood
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027456) Digoxin [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.2
—
0.7
—
0
6
(3011397) Hemoglobin [Presence] in Urine by Test strip
9
90
1.00
0.00
8.8
4.2
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
5
0.00
0.00
0.0
14.6
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
9
0.00
0.00
0.0
1.6
—
5.3
—
0
9
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3034274) Bile acid [Moles/volume] in Serum --fasting
0
5
0.00
0.00
0.0
3.0
—
10.0
—
0
5
(3016244) Insulin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
11.3
—
0
5
(3045424) Erythrocytes [Presence] in Urine
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_IPNEUROP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have G6_IPNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: G6_IPNEUROP – Idiopathic progressive neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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