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This is a non-core endpoint: only basic statistics are computed.

Degenerative and vascular disorders of ear

H8_DEGVASCEAR

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H93.0
  • Hospital discharge: ICD-9 3880X
  • Cause of death: ICD-10 H93.0
  • Cause of death: ICD-9 3880X

2 out of 7 registries used, show all original rules.

54

4. Check minimum number of events

None

54

5. Include endpoints

None

54

6. Filter based on genotype QC (FinnGen only)

54

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H93
Name in latin
Morbositates degenerativae et vasculares auris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 378 210 163
Only index persons 332 190 142
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.72 64.72 57.93
Only index persons 59.52 63.23 54.56

-FinnGen-

Key figures

All Female Male
Number of individuals 54 28 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 53.55 51.67 55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
108
2.55
2.62
2.2
2.1
—
—
—
0
0
6
11
5.98
2.62
10.3
2.3
—
—
—
0
0
22
119
2.43
2.45
2.3
2.5
55.6
54.8
u/l
0.06
22
110
6
14
4.68
2.21
1.0
1.3
—
—
—
0
0
31
211
2.10
1.87
4.8
7.2
10.9
10.1
umol/l
0.25
31
201
21
128
2.05
1.66
3.9
2.8
9.9
45.6
e6/l
0.68
16
95
26
174
1.95
1.57
3.0
4.1
33.6
35.8
g/l
1.09
26
165
45
373
2.24
1.54
23.4
15.3
41.2
40.5
%
0.38
34
286
23
150
1.93
1.48
9.2
7.8
1.7
1.2
inr
—
6
41
23
151
1.91
1.44
1.9
2.1
117.0
100.7
pmol/l
—
7
73
39
305
2.00
1.44
3.2
4.1
16.4
12.7
mm/h
0.55
34
276
42
338
2.09
1.41
24.0
19.0
14.0
13.8
%
0.27
42
333
0
37
0.00
1.40
0.0
4.2
—
66.1
—
0
26
11
55
2.26
1.39
14.7
25.3
—
1.5
—
0
7
23
153
1.88
1.37
4.6
3.3
25.2
54.2
e6/l
0.38
16
101
9
44
2.25
1.34
1.1
1.4
—
—
—
0
0
12
68
1.98
1.11
1.1
1.2
—
—
—
0
0
27
200
1.70
1.07
5.1
6.7
0.6
0.6
e9/l
0.28
22
179
27
200
1.70
1.07
5.1
6.9
0.0
0.0
e9/l
0.48
22
180
9
48
2.05
1.07
1.3
1.6
—
—
—
0
0
31
239
1.70
1.06
9.9
13.5
4.0
4.1
e9/l
0.13
26
210
19
128
1.75
1.05
5.2
6.5
—
—
—
0
0
17
111
1.78
1.04
4.9
3.6
—
—
—
0
0
7
36
2.08
1.01
1.3
4.1
—
—
—
0
0
6
27
2.37
0.97
24.2
4.8
—
—
—
0
0
8
42
2.06
0.94
1.0
1.2
—
—
—
0
0
6
29
2.20
0.92
1.3
1.2
—
—
—
0
0
23
169
1.63
0.91
3.7
3.3
29.1
55.4
ng/l
0.45
16
108
17
116
1.68
0.88
4.1
2.7
0.1
0.3
e6/l
0.71
12
80
8
46
1.87
0.87
1.0
1.3
—
—
—
0
0
44
385
1.77
0.82
7.2
5.2
41.6
39.7
mmol/mol
0.84
38
358
23
173
1.57
0.81
1.8
1.8
—
—
—
0
0
46
414
1.75
0.76
5.6
4.8
2.8
2.7
mmol/l
0.35
40
383
5
25
2.10
0.75
1.4
1.9
—
—
—
0
0
23
177
1.52
0.72
13.0
11.1
0.0
0.0
e9/l
0.50
18
151
7
42
1.76
0.71
2.0
1.7
—
—
—
0
0
15
105
1.59
0.70
5.7
4.3
—
—
—
0
0
5
29
1.80
0.65
1.4
1.2
—
—
—
0
0
8
50
1.70
0.65
4.1
2.2
4.3
6.7
umol/l
—
8
45
46
416
1.71
0.64
24.0
15.7
139.8
139.7
mmol/l
0.08
46
398
46
420
1.64
0.64
24.2
15.6
4.0
4.0
mmol/l
0.25
46
403
45
408
1.62
0.62
5.2
4.3
1.4
1.4
mmol/l
0.34
40
377
21
163
1.47
0.61
2.9
3.4
—
—
—
0
0
6
35
1.80
0.60
1.3
1.8
—
—
—
0
0
34
291
1.45
0.59
4.2
3.8
—
—
—
0
0
44
397
1.58
0.58
4.9
3.8
1.5
1.3
mmol/l
1.06
39
368
16
122
1.44
0.50
3.9
2.5
—
—
—
0
0
10
70
1.53
0.45
1.7
1.5
2.6
2.7
g/l
—
5
42
5
31
1.67
0.44
1.0
1.2
—
—
—
0
0
14
107
1.42
0.43
5.8
9.3
—
—
—
0
0
5
36
1.43
0.39
1.0
1.6
—
—
—
0
0
6
43
1.44
0.36
2.3
4.7
12.9
7.4
ug/l
—
6
37
7
52
1.40
0.33
1.1
1.6
—
—
—
0
0
31
277
1.28
0.32
4.3
4.2
—
—
—
0
0
7
56
1.29
0.31
1.7
2.4
2.8
2.4
g/l
—
7
51
5
41
1.24
0.22
1.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.8
—
21.6
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
14
119
1.24
0.20
3.5
3.1
—
—
—
0
0
7
60
1.19
0.19
2.1
2.5
11.3
12.9
umol/l
—
7
54
13
119
1.12
0.06
4.7
3.4
4.7
7.3
mg/mmol
—
8
74
18
170
1.09
0.05
3.8
2.8
—
—
—
0
0
15
144
1.06
0.01
2.3
3.5
2.4
2.4
mmol/l
—
10
129
13
127
1.03
0.00
2.8
2.7
—
—
—
0
0
11
108
1.02
0.00
3.6
2.7
55.3
40.8
mg/l
—
6
69
10
102
0.98
0.00
2.9
3.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
30.0
—
0
7
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
4.2
—
0
8
0
8
0.00
0.00
0.0
3.1
—
62.5
—
0
8
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
2.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
6
61
0.98
0.00
2.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
31.8
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
9
95
0.94
0.00
1.2
1.5
—
—
—
0
0
5
52
0.96
0.00
3.2
1.9
274.4
97.0
ug/g
—
5
44
9
98
0.90
0.00
2.9
6.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
84.8
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
6.2
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_DEGVASCEAR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DEGVASCEAR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_DEGVASCEAR – Degenerative and vascular disorders of ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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