Degenerative and vascular disorders of ear

H8_DEGVASCEAR

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.0 Hospital discharge: ICD-9 — 3880X Cause of death: ICD-10 — H93.0 Cause of death: ICD-9 — 3880X 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	50

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H93
Name in latin: Morbositates degenerativae et vasculares auris

NAME	H8_DEGVASCEAR
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H930
HD_ICD_9	3880X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H930
COD_ICD_9	3880X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Degenerative and vascular disorders of ear based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	378	210	163
Only index persons	332	190	142
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.72	64.72	57.93
Only index persons	59.52	63.23	54.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	50	26	24
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	53.82	53.84	53.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
54: Matched controls
540

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H93.0

ICD-10 Finland

Degenerative and vascular disorders of ear

+∞

74.6

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

260.6

28.7

N07CA01

ATC

betahistine; oral

21.7

13.0

H93.1

ICD-10 Finland

Tinnitus

40.4

12.4

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

9.0

7.9

Z3229

NOMESCO Finland

Other healthcare associate professional

9.4

7.7

Z01.8

ICD-10 Finland

Other specified special examinations

5.4

7.1

H81.0

ICD-10 Finland

Ménière disease

78.8

6.6

Z01.1

ICD-10 Finland

Examination of ears and hearing

8.2

6.4

Z46.1

ICD-10 Finland

Fitting and adjustment of hearing aid

17.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3052851) Hemolysis interference index of Serum or Plasma

5.98

2.62

9.8

2.3

—

(3044640) Blood type and Crossmatch panel - Blood

109

2.52

2.56

2.2

2.1

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

118

2.46

2.50

2.3

2.5

55.64

54.91

u/l

0.05

109

(3024891) Influenza virus A+B Ag [Presence] in Specimen

4.68

2.21

1.0

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

187

2.19

2.07

8.3

6.6

1.24

1.22

mmol/l

1.07

156

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

208

2.15

1.97

4.8

7.0

10.85

10.09

umol/l

0.25

199

(3002385) Erythrocyte distribution width [Ratio]

348

2.43

1.75

23.1

18.5

15.11

14.83

0.13

343

(3002582) Erythrocytes [#/volume] in Urine

127

2.07

1.70

3.9

2.9

9.93

45.31

e6/l

0.68

(3024561) Albumin [Mass/volume] in Serum or Plasma

171

2.00

1.67

3.0

4.2

33.72

35.83

g/l

1.05

162

(3022217) INR in Platelet poor plasma by Coagulation assay

181

1.98

1.64

13.9

13.6

1.67

1.22

inr

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

147

1.98

1.58

1.9

2.1

117.03

100.91

pmol/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.56

1.56

1.2

3.3

23.72

24.05

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

148

1.97

1.55

3.8

3.0

—

(3018095) Leukocytes [#/volume] in Urine

149

1.95

1.51

4.6

3.4

25.16

54.44

e6/l

0.38

101

(3013707) Erythrocyte sedimentation rate by Westergren method

303

2.03

1.49

3.2

4.1

16.44

12.74

mm/h

0.55

274

(3023520) Reticulocytes [#/volume] in Blood

0.00

1.40

0.0

4.2

—

66.08

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.25

1.34

1.1

1.4

—

(3022145) Colonoscopy Study observation

2.29

1.25

1.0

1.2

—

(40768797) Stomach Pathology biopsy report

2.05

1.20

1.1

1.2

—

(3001604) Monocytes [#/volume] in Blood

197

1.74

1.15

5.1

6.8

0.61

0.59

e9/l

0.20

178

(3006315) Basophils [#/volume] in Blood

197

1.74

1.15

5.1

6.9

0.04

e9/l

0.45

179

(3013650) Neutrophils [#/volume] in Blood by Automated count

236

1.74

1.13

9.9

13.3

3.97

4.10

e9/l

0.14

208

(3013512) EKG study

110

1.80

1.07

4.9

3.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.05

1.07

1.3

1.6

—

(3012544) pH of Venous blood

2.08

1.01

1.3

4.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.01

0.0

1.5

—

(3000991) Gas panel - Venous blood

2.37

0.97

24.2

4.8

—

(3030467) Casts [#/volume] in Urine by Automated count

114

1.72

0.94

4.1

2.7

0.12

0.28

e6/l

0.70

(3025941) Bacteria identified in Stool by Culture

2.20

0.92

1.3

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

169

1.63

0.91

3.7

3.2

29.06

55.48

ng/l

0.45

108

(3002256) Pathology report gross observation

1.91

0.89

1.0

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.84

0.86

3.8

2.5

1.25

1.81

e6/l

—

(40768804) Tissue Pathology biopsy report

172

1.59

0.83

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.81

0.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

386

1.76

0.80

7.1

5.2

41.59

39.64

mmol/mol

0.85

359

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

413

1.77

0.76

5.6

4.8

2.79

2.69

mmol/l

0.32

382

(3004588) Protein electrophoresis panel - Serum or Plasma

2.10

0.75

1.4

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.86

0.75

3.4

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.81

0.73

2.0

1.8

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.01

0.72

1.0

3.7

5.32

5.04

kpa

—

(3023368) Bacteria identified in Blood by Culture

104

1.61

0.72

5.7

4.4

—

(3021589) Normoblasts [#/volume] in Blood

177

1.52

0.72

13.0

11.0

0.00

e9/l

0.50

151

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

255

1.51

0.70

2.8

3.1

—

(36660697) Celiac disease serology panel - Serum

1.86

0.68

1.4

1.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.74

0.66

4.1

2.3

4.30

6.81

umol/l

—

(3044889) 12 lead EKG panel

288

1.49

0.65

4.2

3.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

416

1.71

0.64

24.0

15.5

139.76

139.72

mmol/l

0.05

398

(3023103) Potassium [Moles/volume] in Serum or Plasma

420

1.64

0.64

24.2

15.4

3.97

3.99

mmol/l

0.23

403

(4035726) Immunohistochemistry procedure

1.73

0.63

1.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

407

1.63

0.62

5.2

4.4

1.40

1.44

mmol/l

0.33

376

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

395

1.62

0.61

4.9

3.9

1.51

1.29

mmol/l

1.02

366

(3000492) Spirometry study

1.75

0.59

1.3

1.8

—

(36304419) Bacteria [Presence] in Urine

120

1.47

0.54

3.9

2.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.56

0.53

4.2

3.1

45.83

35.94

u/l

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.56

0.53

2.3

4.5

12.85

7.72

ug/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

187

1.40

0.51

5.4

7.9

—

(40758558) Short blood count panel - Blood

104

1.47

0.49

5.8

9.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.55

0.48

1.7

1.5

2.60

2.71

g/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.5

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.41

0.0

2.9

—

4.02

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.47

0.40

1.0

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

274

1.31

0.37

4.3

4.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.40

0.33

1.1

1.6

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.29

0.31

1.7

2.4

2.75

2.42

g/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

135

1.26

0.25

2.7

883.45

1170.05

ng/l

0.32

120

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.24

0.22

1.0

1.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

120

1.23

0.19

3.5

3.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.19

0.19

2.1

2.5

11.27

12.89

umol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

163

1.16

0.13

3.4

3.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

173

1.15

0.13

2.5

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.10

0.10

3.2

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.07

0.10

3.0

1.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.04

0.09

3.7

2.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.06

0.07

2.8

1.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

119

1.12

0.06

4.7

3.2

4.72

7.12

mg/mmol

—

(1761868) Lipid panel - Serum or Plasma

170

1.09

0.05

3.8

2.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

142

1.08

0.03

2.3

3.3

2.39

2.35

mmol/l

—

126

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

104

1.07

0.01

3.2

3.7

14.72

22.66

—

(3026008) Bacteria identified in Urine by Culture

127

1.03

0.00

2.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.06

0.00

2.9

3.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.1

—

62.50

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.3

—

4.20

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3003694) ABO and Rh group [Type] in Blood

0.95

-0.00

1.2

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

2.8

—

31.83

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.25

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

9.80

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

6.22

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

2.1

—

36.27

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

-0.00

0.0

2.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

-0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.6

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

-0.00

0.0

3.2

—

84.80

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.59

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

0.98

-0.00

2.0

2.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.1

—

242.10

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

3.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

157.16

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.5

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.3

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

3.2

—

552.50

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

6.7

—

176.29

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

2.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.00

-0.00

1.3

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood

0.00

-0.00

0.0

2.8

—

6.80

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3044941) Cell count panel - Synovial fluid

0.00

-0.00

0.0

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

0.96

-0.00

3.2

1.9

274.40

98.51

ug/g

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.4

—

30.00

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.4

—

20.89

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

1.00

-0.00

2.0

1.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

3.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

2.8

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_DEGVASCEAR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DEGVASCEAR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_DEGVASCEAR – Degenerative and vascular disorders of ear

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Degenerative and vascular disorders of ear

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints