Degenerative and vascular disorders of ear

H8_DEGVASCEAR

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.0 Hospital discharge: ICD-9 — 3880X Cause of death: ICD-10 — H93.0 Cause of death: ICD-9 — 3880X 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H93
Name in latin: Morbositates degenerativae et vasculares auris

NAME	H8_DEGVASCEAR
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H930
HD_ICD_9	3880X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H930
COD_ICD_9	3880X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Degenerative and vascular disorders of ear based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	378	210	163
Only index persons	332	190	142
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.72	64.72	57.93
Only index persons	59.52	63.23	54.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	28	26
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	53.55	51.67	55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

108

2.55

2.62

2.2

2.1

—

(3052851) Hemolysis interference index of Serum or Plasma

5.98

2.62

10.3

2.3

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

119

2.43

2.45

2.3

2.5

55.6

54.8

u/l

0.06

110

(3024891) Influenza virus A+B Ag [Presence] in Specimen

4.68

2.21

1.0

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

191

2.12

1.92

8.3

6.5

1.2

mmol/l

1.07

160

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

211

2.10

1.87

4.8

7.2

10.9

10.1

umol/l

0.25

201

(3002582) Erythrocytes [#/volume] in Urine

128

2.05

1.66

3.9

2.8

9.9

45.6

e6/l

0.68

(3024561) Albumin [Mass/volume] in Serum or Plasma

174

1.95

1.57

3.0

4.1

33.6

35.8

g/l

1.09

165

(3009542) Hematocrit [Volume Fraction] of Blood

373

2.24

1.54

23.4

15.3

41.2

40.5

0.38

286

(3032080) INR in Blood by Coagulation assay

150

1.93

1.48

9.2

7.8

1.7

1.2

inr

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

150

1.93

1.48

3.8

2.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

151

1.91

1.44

1.9

2.1

117.0

100.7

pmol/l

—

(3013707) Erythrocyte sedimentation rate by Westergren method

305

2.00

1.44

3.2

4.1

16.4

12.7

mm/h

0.55

276

(3002385) Erythrocyte distribution width [Ratio]

338

2.09

1.41

24.0

19.0

14.0

13.8

0.27

333

(3023520) Reticulocytes [#/volume] in Blood

0.00

1.40

0.0

4.2

—

66.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.26

1.39

14.7

25.3

—

1.5

—

(3018095) Leukocytes [#/volume] in Urine

153

1.88

1.37

4.6

3.3

25.2

54.2

e6/l

0.38

101

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.25

1.34

1.1

1.4

—

(40768797) Stomach Pathology biopsy report

1.98

1.11

1.1

1.2

—

(3001604) Monocytes [#/volume] in Blood

200

1.70

1.07

5.1

6.7

0.6

e9/l

0.28

179

(3006315) Basophils [#/volume] in Blood

200

1.70

1.07

5.1

6.9

0.0

e9/l

0.48

180

(3007853) Bacteria identified in Skin by Aerobe culture

2.05

1.07

1.3

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

239

1.70

1.06

9.9

13.5

4.0

4.1

e9/l

0.13

210

(42870588) Differential panel, method unspecified - Blood

128

1.75

1.05

5.2

6.5

—

(3013512) EKG study

111

1.78

1.04

4.9

3.6

—

(3012544) pH of Venous blood

2.08

1.01

1.3

4.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.01

0.0

1.5

—

(3000991) Gas panel - Venous blood

2.37

0.97

24.2

4.8

—

(3022145) Colonoscopy Study observation

2.06

0.94

1.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

2.20

0.92

1.3

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

169

1.63

0.91

3.7

3.3

29.1

55.4

ng/l

0.45

108

(3030467) Casts [#/volume] in Urine by Automated count

116

1.68

0.88

4.1

2.7

0.1

0.3

e6/l

0.71

(3002256) Pathology report gross observation

1.87

0.87

1.0

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.81

0.82

3.8

2.5

1.3

1.8

e6/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

385

1.77

0.82

7.2

5.2

41.6

39.7

mmol/mol

0.84

358

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.81

0.0

1.5

—

(40768804) Tissue Pathology biopsy report

173

1.57

0.81

1.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

414

1.75

0.76

5.6

4.8

2.8

2.7

mmol/l

0.35

383

(3004588) Protein electrophoresis panel - Serum or Plasma

2.10

0.75

1.4

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.81

0.73

3.4

3.0

—

(3021589) Normoblasts [#/volume] in Blood

177

1.52

0.72

13.0

11.1

0.0

e9/l

0.50

151

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.76

0.71

2.0

1.7

—

(3023368) Bacteria identified in Blood by Culture

105

1.59

0.70

5.7

4.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

256

1.50

0.68

2.8

3.2

—

(36660697) Celiac disease serology panel - Serum

1.80

0.65

1.4

1.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.70

0.65

4.1

2.2

4.3

6.7

umol/l

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

416

1.71

0.64

24.0

15.7

139.8

139.7

mmol/l

0.08

398

(3023103) Potassium [Moles/volume] in Serum or Plasma

420

1.64

0.64

24.2

15.6

4.0

mmol/l

0.25

403

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

408

1.62

0.62

5.2

4.3

1.4

mmol/l

0.34

377

(3015736) pH of Urine

163

1.47

0.61

2.9

3.4

—

(3000492) Spirometry study

1.80

0.60

1.3

1.8

—

(3044889) 12 lead EKG panel

291

1.45

0.59

4.2

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

397

1.58

0.58

4.9

3.8

1.5

1.3

mmol/l

1.06

368

(36304419) Bacteria [Presence] in Urine

122

1.44

0.50

3.9

2.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.53

0.45

1.7

1.5

2.6

2.7

g/l

—

(4035726)

1.67

0.44

1.0

1.2

—

(40758558) Short blood count panel - Blood

107

1.42

0.43

5.8

9.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.43

0.39

1.0

1.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.52

0.37

4.2

3.1

45.8

35.7

u/l

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.44

0.36

2.3

4.7

12.9

7.4

ug/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.40

0.33

1.1

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

277

1.28

0.32

4.3

4.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.29

0.31

1.7

2.4

2.8

2.4

g/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.24

0.22

1.0

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

137

1.24

0.22

2.7

883.5

1180.0

ng/l

0.34

122

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.8

—

21.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

119

1.24

0.20

3.5

3.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.19

0.19

2.1

2.5

11.3

12.9

umol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

173

1.15

0.13

3.6

3.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

164

1.15

0.11

3.4

3.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.07

0.10

3.2

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.05

0.09

3.0

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.05

0.08

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.06

0.07

2.8

1.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

119

1.12

0.06

4.7

3.4

4.7

7.3

mg/mmol

—

(1761868) Lipid panel - Serum or Plasma

170

1.09

0.05

3.8

2.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

104

1.07

0.01

3.2

3.7

14.7

22.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

144

1.06

0.01

2.3

3.5

2.4

mmol/l

—

129

(3026008) Bacteria identified in Urine by Culture

127

1.03

0.00

2.8

2.7

—

(3012516) Albumin [Mass/volume] in Urine

108

1.02

0.00

3.6

2.7

55.3

40.8

mg/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

102

0.98

0.00

2.9

3.5

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

2.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.7

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

30.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.4

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.3

—

4.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.1

—

62.5

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.1

—

242.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(21494755) Public health laboratory ask at order entry panel

1.00

0.00

2.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.7

—

176.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

2.8

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.3

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

1.3

—

(3042936) Bacteria identified in Isolate by Culture

0.98

0.00

2.0

2.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.8

—

31.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.2

—

(44790048)

0.00

0.0

2.0

—

(3003694) ABO and Rh group [Type] in Blood

0.94

0.00

1.2

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

0.96

0.00

3.2

1.9

274.4

97.0

ug/g

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.90

0.00

2.9

6.6

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.0

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

0.0

3.2

—

84.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

3.7

1.9

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

9.8

—

(44790047)

0.00

0.0

2.0

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(44790049)

0.00

0.0

2.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(44806118)

0.00

0.0

2.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.2

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

6.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_DEGVASCEAR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DEGVASCEAR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_DEGVASCEAR – Degenerative and vascular disorders of ear

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Degenerative and vascular disorders of ear

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints