Ototoxic hearing loss

H8_HL_OTOTOX

nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H91.0#
  • Cause of death: ICD-10 H91.0#

2 out of 7 registries used, show all original rules.

67

4. Check minimum number of events

None

67

5. Include endpoints

None

67

6. Filter based on genotype QC (FinnGen only)

67

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H91
Name in latin
Hypacusis ototoxica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 494 281 211
Only index persons 427 248 179
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 66.06 68.61 62.66
Only index persons 65.57 67.99 62.22

-FinnGen-

Key figures

All Female Male
Number of individuals 67 39 28
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 59.57 59.43 59.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
569
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H91.0
ICD-10 Finland
Ototoxic hearing loss
+∞
81.7
57
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
432.0
27.1
25
*
UDC00
NOMESCO Finland
Ear microscopy
41.1
10.9
13
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
8.5
8
*
H81.0
ICD-10 Finland
Ménière disease
91.5
7.6
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.7
7.5
15
20
DFF00
NOMESCO Finland
Pure tone audiometry
23.7
7.4
10
5
H91.1
ICD-10 Finland
Presbycusis
16.6
7.2
11
8
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
6.4
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
144
2.17
2.27
4.4
4.1
—
—
—
0
0
9
34
2.90
1.95
1.3
1.3
—
—
—
0
0
10
40
2.76
1.94
9.4
3.2
81.0
75.1
e9/l
—
10
31
10
43
2.56
1.69
11.1
5.6
—
—
—
0
0
29
201
1.78
1.45
17.0
10.1
1.7
1.3
inr
—
9
61
10
47
2.33
1.42
1.0
1.3
—
—
—
0
0
13
74
1.94
1.17
13.5
6.9
1.1
1.1
mmol/l
0.06
13
67
24
167
1.68
1.14
3.5
3.1
—
—
—
0
0
42
339
1.64
1.11
6.0
4.6
—
31.5
—
0
8
51
449
1.57
0.78
3.5
4.0
1.4
1.3
mmol/l
0.30
44
396
10
60
1.78
0.77
17.1
4.6
—
—
—
0
0
53
472
1.59
0.75
4.2
4.5
4.5
4.6
mmol/l
0.13
46
422
9
57
1.67
0.75
1.1
1.5
—
—
—
0
0
11
163
0.61
0.72
3.5
3.1
—
—
—
0
0
41
349
1.45
0.71
5.9
4.7
—
—
—
0
0
7
43
1.70
0.69
19.7
6.5
—
—
—
0
0
5
29
1.78
0.65
6.4
6.0
—
—
—
0
0
7
114
0.57
0.65
14.1
5.1
—
—
—
0
0
11
72
1.63
0.64
2.6
1.9
—
—
—
0
0
21
161
1.44
0.62
3.1
3.0
20.2
44.6
e6/l
0.52
16
125
0
20
0.00
0.61
0.0
2.3
—
4.1
—
0
15
0
21
0.00
0.61
0.0
1.1
—
—
—
0
0
8
54
1.55
0.60
2.3
4.4
8.2
14.7
ug/l
—
8
44
9
60
1.58
0.57
1.1
1.3
—
—
—
0
0
56
516
1.52
0.55
28.9
17.5
138.2
139.6
mmol/l
1.58
56
500
15
111
1.45
0.52
2.3
2.5
4.0
4.5
e6/l
0.10
15
99
56
518
1.49
0.51
29.8
17.5
4.0
4.0
mmol/l
0.09
56
501
25
204
1.36
0.51
1.8
2.0
102.3
96.9
pmol/l
0.19
14
102
10
68
1.55
0.50
1.3
1.6
—
—
—
0
0
20
158
1.38
0.49
2.9
2.4
—
—
—
0
0
7
47
1.55
0.49
6.7
2.7
—
—
—
0
0
26
215
1.34
0.49
5.4
3.6
29.7
37.9
ng/l
0.21
17
148
49
445
1.38
0.48
22.6
16.7
37.1
38.4
%
0.32
27
315
56
520
1.47
0.48
26.5
17.2
88.3
78.2
umol/l
0.60
56
520
22
180
1.33
0.43
2.7
1.9
—
—
—
0
0
54
502
1.39
0.42
24.6
15.3
21.4
22.6
mg/l
0.12
46
396
8
60
1.38
0.42
1.4
1.1
—
—
—
0
0
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
18
144
1.34
0.41
4.6
3.0
5.6
7.6
mmol/l
1.07
13
116
55
514
1.39
0.40
19.1
14.8
—
—
—
0
0
11
81
1.43
0.39
2.1
1.7
—
—
—
0
0
5
75
0.64
0.38
2.2
1.8
123.4
80.7
ug/g
—
5
58
52
484
1.33
0.37
4.7
5.0
2.6
2.7
mmol/l
0.34
45
429
17
137
1.32
0.37
3.2
2.9
—
—
—
0
0
6
45
1.37
0.35
5.8
3.3
—
—
—
0
0
50
466
1.29
0.33
4.4
4.4
1.5
1.5
mmol/l
0.05
43
413
7
52
1.39
0.32
1.6
1.8
—
—
—
0
0
7
54
1.33
0.31
2.6
1.6
—
—
—
0
0
51
480
1.26
0.28
4.5
4.8
6.0
6.0
mmol/l
0.11
45
426
22
192
1.22
0.25
3.6
3.6
58.8
62.9
e6/l
0.04
16
137
5
37
1.38
0.24
1.4
1.6
—
—
—
0
0
5
38
1.34
0.24
2.0
1.2
—
—
—
0
0
5
42
1.21
0.22
15.0
2.4
63.3
64.8
g/l
—
5
37
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.27
0.21
1.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
12
142
0.81
0.20
1.5
1.5
—
—
—
0
0
57
549
1.26
0.20
34.9
21.9
29.8
30.2
pg
0.86
57
537
57
549
1.26
0.20
35.8
22.1
129.4
133.3
g/l
1.01
57
536
57
549
1.26
0.20
34.9
22.0
89.6
90.7
fl
1.28
57
537
11
127
0.84
0.14
18.4
7.3
—
—
—
0
0
27
251
1.13
0.13
7.5
5.6
0.0
0.0
estimate
—
7
46
27
256
1.09
0.08
5.6
4.0
0.0
0.0
estimate
—
7
43
34
354
0.92
0.07
4.5
3.8
—
—
—
0
0
21
199
1.08
0.05
3.7
3.6
—
—
—
0
0
15
140
1.09
0.05
4.9
4.1
7.2
9.8
mg/mmol
—
8
90
26
251
1.06
0.03
5.7
3.9
0.0
0.0
estimate
—
7
46
13
122
1.08
0.03
6.5
3.1
—
—
—
0
0
14
133
1.07
0.02
4.1
3.1
63.3
64.0
mg/l
—
8
87
15
143
1.06
0.02
5.7
4.4
—
—
—
0
0
14
142
0.98
0.00
6.5
3.5
0.0
0.0
estimate
—
7
42
42
421
0.99
0.00
25.5
18.6
13.9
13.8
%
0.21
42
411
17
175
0.96
0.00
7.1
5.1
—
—
—
0
0
14
135
1.05
0.00
4.4
4.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
90.1
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.8
—
0
5
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
12.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
207.8
—
0
5

Mortality – FinRegistry

Association

Association between endpoint H8_HL_OTOTOX and mortality.

Females

Parameter HR [95% CI] p-value
H8_HL_OTOTOX 1.148 [0.87, 1.51] 0.324
Birth year 0.997 [0.99, 1.01] 0.517

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.

Males

Parameter HR [95% CI] p-value
H8_HL_OTOTOX 1.377 [0.94, 2.03] 0.104
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_OTOTOX.

N-year risk Females Males
1 0.153% 0.281%
5 0.764% 1.75%
10 1.721% 4.524%
15 3.425% 8.169%
20 5.855% 13.591%

Relationships between endpoints

Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data