Ototoxic hearing loss

H8_HL_OTOTOX

nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H91.0# Cause of death: ICD-10 — H91.0# 2 out of 7 registries used, show all original rules.	67
4. Check minimum number of events None	67
5. Include endpoints None	67
6. Filter based on genotype QC (FinnGen only)	67

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H91
Name in latin: Hypacusis ototoxica

NAME	H8_HL_OTOTOX
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H910
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H910
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ototoxic hearing loss based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Ototoxic hearing loss, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	494	281	211
Only index persons	427	248	179
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	66.06	68.61	62.66
Only index persons	65.57	67.99	62.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	67	39	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	59.57	59.43	59.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
57: Matched controls
569

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H91.0

ICD-10 Finland

Ototoxic hearing loss

+∞

81.7

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

432.0

27.1

UDC00

NOMESCO Finland

Ear microscopy

41.1

10.9

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

8.5

H81.0

ICD-10 Finland

Ménière disease

91.5

7.6

Z01.1

ICD-10 Finland

Examination of ears and hearing

9.7

7.5

DFF00

NOMESCO Finland

Pure tone audiometry

23.7

7.4

H91.1

ICD-10 Finland

Presbycusis

16.6

7.2

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

144

2.17

2.27

4.4

4.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

246

2.00

2.03

11.3

8.0

1.2

mmol/l

0.64

201

(4010399)

2.90

1.95

1.3

—

(3023520) Reticulocytes [#/volume] in Blood

2.76

1.94

9.4

3.2

81.0

75.1

e9/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.13

1.77

2.6

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.22

1.76

2.5

1.9

—

(3019225) pH of Specimen

2.56

1.69

11.1

5.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.77

1.64

1.4

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.77

1.56

3.3

7.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.29

1.46

1.2

2.1

—

(3032080) INR in Blood by Coagulation assay

201

1.78

1.45

17.0

10.1

1.7

1.3

inr

—

(3022145) Colonoscopy Study observation

2.33

1.42

1.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.09

1.38

1.8

2.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.91

1.31

1.8

2.4

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.94

1.17

13.5

6.9

1.1

mmol/l

0.06

(3026008) Bacteria identified in Urine by Culture

167

1.68

1.14

3.5

3.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

339

1.64

1.11

6.0

4.6

—

31.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.05

1.00

1.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.34

0.96

1.5

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.80

0.79

2.8

1.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

449

1.57

0.78

3.5

4.0

1.4

1.3

mmol/l

0.30

396

(3012544) pH of Venous blood

1.78

0.77

17.1

4.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.70

0.76

3.1

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

472

1.59

0.75

4.2

4.5

4.6

mmol/l

0.13

422

(3000494) Fungus identified in Specimen by Culture

1.67

0.75

1.1

1.5

—

(1761868) Lipid panel - Serum or Plasma

163

0.61

0.72

3.5

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

349

1.45

0.71

5.9

4.7

—

(3000991) Gas panel - Venous blood

1.70

0.69

19.7

6.5

—

(3022313) Gas panel - Capillary blood

1.78

0.65

6.4

6.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

114

0.57

0.65

14.1

5.1

—

(3042936) Bacteria identified in Isolate by Culture

1.63

0.64

2.6

1.9

—

(3002582) Erythrocytes [#/volume] in Urine

161

1.44

0.62

3.1

3.0

20.2

44.6

e6/l

0.52

125

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.61

0.0

3.2

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.61

0.0

3.2

—

3.8

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.61

0.0

2.3

—

4.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.61

0.0

1.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.55

0.60

2.3

4.4

8.2

14.7

ug/l

—

(40768797) Stomach Pathology biopsy report

1.58

0.57

1.1

1.3

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

516

1.52

0.55

28.9

17.5

138.2

139.6

mmol/l

1.58

500

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

119

1.45

0.55

3.4

4.8

20.0

22.2

—

(3000850) Epithelial cells [#/volume] in Urine

111

1.45

0.52

2.3

2.5

4.0

4.5

e6/l

0.10

(3023103) Potassium [Moles/volume] in Serum or Plasma

518

1.49

0.51

29.8

17.5

4.0

mmol/l

0.09

501

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

204

1.36

0.51

1.8

2.0

102.3

96.9

pmol/l

0.19

102

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.55

0.50

1.3

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

112

1.44

0.50

2.7

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

158

1.38

0.49

2.9

2.4

—

(3022621) pH of Urine by Test strip

1.55

0.49

6.7

2.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

215

1.34

0.49

5.4

3.6

29.7

37.9

ng/l

0.21

148

(3009542) Hematocrit [Volume Fraction] of Blood

445

1.38

0.48

22.6

16.7

37.1

38.4

0.32

315

(3020564) Creatinine [Moles/volume] in Serum or Plasma

520

1.47

0.48

26.5

17.2

88.3

78.2

umol/l

0.60

520

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.66

0.44

1.4

2.3

—

(40768804) Tissue Pathology biopsy report

180

1.33

0.43

2.7

1.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

502

1.39

0.42

24.6

15.3

21.4

22.6

mg/l

0.12

396

(3002256) Pathology report gross observation

1.38

0.42

1.4

1.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.42

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.42

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.42

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.42

0.0

1.3

—

(3009508) Creatinine [Moles/volume] in Urine

144

1.34

0.41

4.6

3.0

5.6

7.6

mmol/l

1.07

116

(40761511) CBC panel - Blood by Automated count

514

1.39

0.40

19.1

14.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.43

0.39

2.1

1.7

—

(3048689) Calprotectin [Mass/mass] in Stool

0.64

0.38

2.2

1.8

123.4

80.7

ug/g

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

484

1.33

0.37

4.7

5.0

2.6

2.7

mmol/l

0.34

429

(36304419) Bacteria [Presence] in Urine

137

1.32

0.37

3.2

2.9

—

(40761536) Microorganisms panel - Urine sediment

1.37

0.35

5.8

3.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

466

1.29

0.33

4.4

1.5

mmol/l

0.05

413

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.39

0.32

1.6

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.33

0.31

2.6

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

228

1.23

0.29

5.4

4.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

480

1.26

0.28

4.5

4.8

6.0

mmol/l

0.11

426

(3018095) Leukocytes [#/volume] in Urine

192

1.22

0.25

3.6

58.8

62.9

e6/l

0.04

137

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

290

0.83

0.25

3.7

3.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.38

0.24

1.4

1.6

—

(36660697) Celiac disease serology panel - Serum

1.34

0.24

2.0

1.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.21

0.22

15.0

2.4

63.3

64.8

g/l

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

2.7

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.21

0.0

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.27

0.21

1.0

1.5

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

35.8

—

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.20

0.0

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.5

—

(40768443) Skin Pathology biopsy report

0.00

0.20

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.20

0.0

1.2

—

(3003694) ABO and Rh group [Type] in Blood

142

0.81

0.20

1.5

—

(3035941) MCH [Entitic mass]

549

1.26

0.20

34.9

21.9

29.8

30.2

0.86

537

(3000963) Hemoglobin [Mass/volume] in Blood

549

1.26

0.20

35.8

22.1

129.4

133.3

g/l

1.01

536

(3024731) MCV [Entitic volume]

549

1.26

0.20

34.9

22.0

89.6

90.7

1.28

537

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.19

1.6

1.4

—

(40758558) Short blood count panel - Blood

127

0.84

0.14

18.4

7.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

251

1.13

0.13

7.5

5.6

0.0

estimate

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.08

0.09

1.3

2.0

24.8

26.5

u/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.76

0.08

12.0

8.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.10

0.08

4.1

3.4

—

(3009261) Glucose [Presence] in Urine by Test strip

256

1.09

0.08

5.6

4.0

0.0

estimate

—

(3044889) 12 lead EKG panel

354

0.92

0.07

4.5

3.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.84

0.07

1.3

1.7

—

(3015736) pH of Urine

199

1.08

0.05

3.7

3.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

140

1.09

0.05

4.9

4.1

7.2

9.8

mg/mmol

—

(3035350) Ketones [Presence] in Urine by Test strip

251

1.06

0.03

5.7

3.9

0.0

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

122

1.08

0.03

6.5

3.1

—

(3012516) Albumin [Mass/volume] in Urine

133

1.07

0.02

4.1

3.1

63.3

64.0

mg/l

—

(3013512) EKG study

143

1.06

0.02

5.7

4.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

183

1.05

0.01

4.3

3.1

—

(3029937) Albumin [Presence] in Urine by Test strip

142

0.98

0.00

6.5

3.5

0.0

estimate

—

(3002385) Erythrocyte distribution width [Ratio]

421

0.99

0.00

25.5

18.6

13.9

13.8

0.21

411

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

187

1.02

0.00

7.1

4.2

—

(42870588) Differential panel, method unspecified - Blood

175

0.96

0.00

7.1

5.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

455

1.04

0.00

18.2

14.2

68.1

78.3

ml/min/173m2

1.73

350

(3041096) Erythrocytes [Presence] in Urine by Automated

135

1.05

0.00

4.4

4.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

2.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.5

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

28.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.0

—

90.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(4306422)

0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.6

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.3

—

(4146454)

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.8

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.2

—

199.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.8

—

12.4

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.8

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

207.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_HL_OTOTOX and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_HL_OTOTOX	1.148 [0.87, 1.51]	0.324
Birth year	0.997 [0.99, 1.01]	0.517

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.

Males

Parameter	HR [95% CI]	p-value
H8_HL_OTOTOX	1.377 [0.94, 2.03]	0.104
Birth year	0.988 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_OTOTOX.

N-year risk	Females	Males
1	0.153%	0.281%
5	0.764%	1.75%
10	1.721%	4.524%
15	3.425%	8.169%
20	5.855%	13.591%

Relationships between endpoints

↥

Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ototoxic hearing loss

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints