Acne keloid

L12_ACNEKELOID

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L73.0 Hospital discharge: ICD-9 — 7061D Hospital discharge: ICD-8 — 70611 Cause of death: ICD-10 — L73.0 Cause of death: ICD-9 — 7061D Cause of death: ICD-8 — 70611 2 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints None	59
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L73
Name in latin: Acne cheloides (scleroticans nuchae)

NAME	L12_ACNEKELOID
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L730
HD_ICD_9	7061D
HD_ICD_8	70611
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L730
COD_ICD_9	7061D
COD_ICD_8	70611
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acne keloid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	511	157	348
Only index persons	476	151	325
Unadjusted period prevalence (%)
Whole population	0.01	0.00	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	35.43	37.86	34.35
Only index persons	35.04	38.25	33.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	25	34
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	37.37	40.98	34.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
560

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L73.0

ICD-10 Finland

Acne keloid

+∞

70.6

L70.0

ICD-10 Finland

Acne vulgaris

+∞

11.9

D10BA01

ATC

isotretinoin; oral

11.9

10.1

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

9.4

9.3

J01AA07

ATC

tetracycline; systemic

7.6

9.3

L73.8

ICD-10 Finland

Other specified follicular disorders

+∞

7.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

4.7

6.9

111

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.85

6.01

2.5

1.5

—

(3033658) Prothrombin time (PT) actual/Normal

121

2.66

3.14

2.6

3.1

105.3

96.5

0.83

121

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

173

2.49

2.94

2.0

1.8

91.4

96.7

pmol/l

0.29

(42870588) Differential panel, method unspecified - Blood

160

2.43

2.76

6.6

6.7

—

(36660697) Celiac disease serology panel - Serum

3.24

2.64

1.2

1.3

—

(3022621) pH of Urine by Test strip

4.04

2.46

4.5

2.0

—

(3012516) Albumin [Mass/volume] in Urine

2.48

2.46

5.1

3.4

24.8

758.0

mg/l

0.52

(3028707) Methadone [Presence] in Urine by Screen method

5.95

2.26

3.2

2.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

101

2.30

2.12

6.5

4.1

2.6

9.1

mg/mmol

1.09

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.64

2.03

2.4

1.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.54

2.02

2.8

1.6

15.4

14.4

umol/l

0.13

(3028300) Cannabinoids [Presence] in Urine

3.03

1.71

2.7

1.5

—

(3016879) Cocaine [Presence] in Urine

3.03

1.71

2.4

1.5

—

(3027008) Opiates [Presence] in Urine

3.03

1.71

2.6

1.5

—

(3022313) Gas panel - Capillary blood

3.80

1.65

6.6

3.4

—

(3027944) Amphetamines [Presence] in Urine

2.91

1.64

2.6

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

2.91

1.64

2.6

1.5

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.37

1.56

3.2

2.8

38.3

30.9

u/l

0.31

(3037121) Protein [Mass/volume] in Urine

3.54

1.55

8.8

4.8

0.1

g/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.54

1.55

1.0

1.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

421

2.23

1.50

5.1

4.2

1.5

1.8

mu/l

0.79

388

(3037467) Urinalysis macro (dipstick) panel - Urine

309

1.91

1.48

7.1

4.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.92

1.47

3.0

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

280

1.86

1.45

6.1

4.4

—

38.7

—

(3000494) Fungus identified in Specimen by Culture

2.27

1.43

1.5

—

(3023368) Bacteria identified in Blood by Culture

119

1.88

1.33

4.4

4.6

—

(3011288) Drugs identified in Urine by Screen method

2.94

1.31

3.6

1.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

480

2.47

1.30

19.1

12.7

139.4

139.7

mmol/l

0.31

468

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

210

1.75

1.26

3.4

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

466

2.35

1.23

19.4

13.2

40.3

41.6

0.66

381

(3044889) 12 lead EKG panel

299

1.76

1.22

3.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.21

1.21

3.9

3.7

—

(3000330) Specific gravity of Urine by Test strip

2.63

1.17

2.6

4.3

—

(3006504) Eosinophils/100 leukocytes in Blood

234

1.68

1.12

7.5

7.1

2.5

2.8

0.37

224

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.39

1.05

6.0

5.1

—

(3021589) Normoblasts [#/volume] in Blood

209

1.65

1.04

10.9

11.0

0.0

e9/l

0.50

171

(40768804) Tissue Pathology biopsy report

182

1.65

1.02

1.6

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

490

2.20

1.01

20.0

12.5

30.6

24.0

mg/l

0.40

373

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.92

0.98

1.2

1.5

—

(3037522) Nuclear Ab [Titer] in Serum

1.92

0.98

1.1

1.5

—

411.8

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.36

0.96

5.2

4.3

4.4

4.8

pmol/l

—

(3006315) Basophils [#/volume] in Blood

241

1.60

0.96

7.2

7.4

0.0

e9/l

0.14

220

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

365

1.66

0.90

9.7

7.8

78.7

76.6

u/l

0.18

350

(3042936) Bacteria identified in Isolate by Culture

1.85

0.90

3.0

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

284

1.57

0.88

13.6

12.8

4.1

3.9

e9/l

0.21

253

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.04

0.87

1.2

1.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.78

0.86

2.6

2.7

0.3

2.2

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

100

1.67

0.83

4.1

3.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

100

1.67

0.83

1.9

1.5

2.9

2.6

g/l

—

(3044640) Blood type and Crossmatch panel - Blood

145

1.57

0.80

1.9

2.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.28

0.78

1.4

3423.0

171.5

u/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.68

0.72

2.6

2.4

0.0

0.8

e6/l

—

(3026008) Bacteria identified in Urine by Culture

113

1.57

0.71

3.7

3.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.73

0.63

5.6

2.3

—

(21494755) Public health laboratory ask at order entry panel

0.52

0.62

1.2

1.3

—

(3000492) Spirometry study

1.56

0.60

1.4

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.59

0.0

1.3

—

364.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.58

1.4

1.5

—

(3003338) MCHC [Mass/volume]

435

1.55

0.58

21.3

15.6

337.1

334.0

g/l

1.66

435

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

101

1.51

0.56

1.2

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

110

1.49

0.56

2.0

2.5

313.9

980.5

ng/l

—

(3002385) Erythrocyte distribution width [Ratio]

415

1.49

0.55

22.8

15.7

13.2

13.5

1.20

407

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

166

1.41

0.54

5.0

2.8

—

(3032080) INR in Blood by Coagulation assay

166

1.41

0.54

4.7

5.1

1.1

inr

—

(3002256) Pathology report gross observation

1.63

0.51

1.1

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.45

0.47

3.3

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.44

0.44

1.7

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.56

0.42

1.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.42

0.0

7.5

—

1.7

—

(40761535) Cells panel - Urine sediment

1.51

0.41

9.2

3.4

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.51

0.41

7.0

2.5

5.4

5.6

kpa

—

(40758558) Short blood count panel - Blood

126

1.37

0.41

8.5

8.7

—

(3012544) pH of Venous blood

1.42

0.39

7.0

2.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

185

1.30

0.36

2.9

2.5

67.4

74.6

nmol/l

0.64

170

(3015736) pH of Urine

176

1.30

0.35

5.1

3.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

112

1.33

0.32

3.1

3.3

19.2

23.0

—

(3018095) Leukocytes [#/volume] in Urine

169

1.28

0.31

4.9

3.4

26.9

11.3

e6/l

0.31

118

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

170

1.27

0.30

3.5

3.1

11.1

26.2

ng/l

3.25

104

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.32

0.26

2.1

1.5

—

(36304419) Bacteria [Presence] in Urine

134

1.27

0.26

3.3

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

392

1.25

0.26

3.5

3.3

—

(3013512) EKG study

124

0.77

0.24

5.9

3.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.21

0.22

2.0

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

1.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.21

0.0

1.8

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.4

—

(4094501)

0.00

0.21

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

174

0.82

0.21

5.7

3.6

—

(3022145) Colonoscopy Study observation

1.28

0.21

1.2

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.25

0.21

2.0

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.25

0.21

2.0

1.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.19

0.18

1.6

1.9

—

(1761868) Lipid panel - Serum or Plasma

202

0.84

0.18

2.6

2.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

124

1.17

0.12

2.6

2.0

—

(3003694) ABO and Rh group [Type] in Blood

136

1.14

0.10

1.5

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.04

0.08

1.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.09

0.08

3.5

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

111

0.88

0.07

2.9

5.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

104

1.07

0.01

2.4

2.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

459

1.01

0.00

18.5

11.1

88.2

89.6

ml/min/173m2

0.16

379

(4146454)

0.00

0.0

3.2

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(44806118)

0.00

0.0

1.7

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.8

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.4

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

3.0

—

1.5

—

(44790049)

0.00

0.0

1.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.6

—

15.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.9

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

326.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.9

—

88.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.01

0.00

2.9

2.1

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

15.7

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.4

—

4.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.6

—

11.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

2.3

—

(44790047)

0.00

0.0

1.7

—

(44790048)

0.00

0.0

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

1.2

—

28.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.2

—

33.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

130

1.00

0.00

5.2

3.2

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.8

—

16.6

—

(4306422)

0.00

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

3.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.3

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.4

—

108.8

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.97

0.00

2.7

2.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.4

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACNEKELOID and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACNEKELOID.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_ACNEKELOID – Acne keloid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acne keloid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints