Acne keloid

L12_ACNEKELOID

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L73.0
  • Hospital discharge: ICD-9 7061D
  • Hospital discharge: ICD-8 70611
  • Cause of death: ICD-10 L73.0
  • Cause of death: ICD-9 7061D
  • Cause of death: ICD-8 70611

2 out of 7 registries used, show all original rules.

61

4. Check minimum number of events

None

61

5. Include endpoints

None

61

6. Filter based on genotype QC (FinnGen only)

57

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L73
Name in latin
Acne cheloides (scleroticans nuchae)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 511 157 348
Only index persons 476 151 325
Unadjusted period prevalence (%)
Whole population 0.01 0.00 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 35.43 37.86 34.35
Only index persons 35.04 38.25 33.56

-FinnGen-

Key figures

All Female Male
Number of individuals 57 25 32
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 36.60 40.98 33.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
61
Matched controls
610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L73.0
ICD-10 Finland
Acne keloid
+∞
77.7
57
*
D10BA01
ATC
isotretinoin; oral
15.7
13.2
22
21
J01AA07
ATC
tetracycline; systemic
7.5
12.8
25
52
L70.0
ICD-10 Finland
Acne vulgaris
65.8
10.0
11
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
9.1
9.6
21
33
L73.8
ICD-10 Finland
Other specified follicular disorders
90.7
7.6
8
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.2
6.6
16
39
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.9
6.4
34
149
D07XC01
ATC
betamethasone; topical
7.0
6.2
15
27

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
43
4.69
5.81
2.5
1.5
—
—
—
0
0
24
127
2.47
2.78
2.6
3.2
105.29
96.05
%
0.90
24
127
30
179
2.33
2.63
2.0
1.8
91.41
96.68
pmol/l
0.28
14
88
21
107
2.47
2.61
5.7
4.2
3.48
8.60
mg/mmol
0.81
13
70
11
40
3.13
2.43
1.2
1.3
—
—
—
0
0
8
24
3.67
2.27
4.5
1.9
—
—
—
0
0
7
20
3.81
2.12
2.7
4.3
—
—
—
0
0
19
101
2.28
2.11
5.1
3.6
24.84
698.77
mg/l
0.52
12
63
5
12
4.43
1.86
3.2
2.2
—
—
—
0
0
34
236
2.00
1.85
6.3
7.2
—
—
—
0
0
13
62
2.39
1.81
2.8
1.6
15.45
14.19
umol/l
0.17
13
56
7
25
3.03
1.70
2.4
1.6
—
—
—
0
0
42
321
1.99
1.66
7.0
4.2
—
—
—
0
0
5
14
3.79
1.65
6.6
3.4
—
—
—
0
0
52
438
2.27
1.63
5.0
4.2
1.59
1.78
mu/l
0.47
47
403
5
16
3.31
1.47
8.8
4.6
0.12
0.11
g/l
—
5
7
6
23
2.78
1.40
3.0
1.5
—
—
—
0
0
11
55
2.22
1.37
1.5
1.5
—
—
—
0
0
30
216
1.77
1.33
10.4
11.0
0.00
0.00
e9/l
0.50
23
178
56
500
2.46
1.29
18.8
12.7
139.50
139.66
mmol/l
0.18
56
487
27
190
1.76
1.29
1.7
1.8
—
—
—
0
0
5
19
2.77
1.24
1.2
1.2
—
—
—
0
0
32
240
1.70
1.19
7.3
7.1
2.49
2.75
%
0.39
32
231
19
123
1.79
1.18
4.4
4.6
—
—
—
0
0
7
30
2.50
1.17
2.7
1.6
—
—
—
0
0
7
30
2.50
1.17
2.6
1.6
—
—
—
0
0
7
30
2.50
1.17
2.4
1.5
—
—
—
0
0
7
31
2.42
1.14
2.6
1.5
—
—
—
0
0
7
31
2.42
1.14
2.6
1.5
—
—
—
0
0
12
67
1.98
1.14
2.8
1.5
—
—
—
0
0
37
292
1.68
1.12
6.1
4.3
—
38.67
—
0
6
5
21
2.50
1.11
3.6
1.9
—
—
—
0
0
37
293
1.67
1.09
12.9
12.3
4.01
3.92
e9/l
0.10
32
261
32
247
1.62
1.02
7.0
7.1
0.04
0.04
e9/l
0.17
27
226
56
507
2.27
1.01
19.6
12.4
29.40
23.87
mg/l
0.34
48
388
45
380
1.70
0.99
9.3
7.8
78.63
76.28
u/l
0.22
40
367
38
309
1.61
0.96
3.3
3.3
—
—
—
0
0
11
64
1.88
0.93
1.1
1.5
—
411.76
—
0
17
6
29
2.18
0.92
5.2
4.2
4.40
4.69
pmol/l
—
6
24
11
65
1.84
0.89
1.2
1.6
—
—
—
0
0
17
115
1.66
0.89
3.7
3.2
—
—
—
0
0
8
48
1.77
0.82
1.1
1.2
—
—
—
0
0
0
24
0.00
0.81
0.0
1.3
—
364.53
—
0
12
15
102
1.62
0.77
4.1
3.4
—
—
—
0
0
5
91
0.51
0.74
1.2
1.3
—
—
—
0
0
50
447
1.66
0.73
20.6
15.4
337.00
334.18
g/l
1.51
50
447
5
26
2.00
0.72
1.4
1.4
3423.00
164.68
u/ml
—
5
19
15
105
1.57
0.68
1.9
1.5
2.91
2.55
g/l
—
10
69
20
150
1.50
0.67
1.9
2.1
—
—
—
0
0
49
441
1.56
0.64
21.8
15.5
13.76
14.61
%
0.73
49
436
9
59
1.62
0.58
1.3
1.4
—
—
—
0
0
22
173
1.42
0.58
4.7
3.4
23.95
11.11
e6/l
0.30
15
121
9
63
1.50
0.55
1.4
1.5
—
—
—
0
0
24
199
1.34
0.45
5.4
8.6
1.09
1.13
inr
—
10
58
5
32
1.61
0.43
3.0
3.5
1.22
1.44
mmol/l
—
5
32
0
15
0.00
0.42
0.0
3.4
—
4.00
—
0
15
0
17
0.00
0.41
0.0
7.1
—
1.67
—
0
17
5
35
1.47
0.40
9.2
3.4
—
—
—
0
0
5
36
1.42
0.39
7.0
2.4
5.42
5.58
kpa
—
5
36
6
42
1.47
0.37
1.8
1.6
—
—
—
0
0
16
130
1.31
0.33
8.5
8.3
—
—
—
0
0
7
54
1.33
0.32
3.3
1.9
—
—
—
0
0
13
103
1.33
0.31
1.7
1.5
—
—
—
0
0
5
38
1.34
0.24
1.2
1.4
—
—
—
0
0
5
38
1.34
0.24
7.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
6
49
1.25
0.21
1.2
1.3
—
—
—
0
0
16
138
1.22
0.20
3.3
2.4
—
—
—
0
0
15
130
1.20
0.18
2.5
2.1
—
—
—
0
0
16
141
1.18
0.16
1.5
1.3
—
—
—
0
0
11
93
1.22
0.16
2.1
1.5
—
—
—
0
0
20
180
1.17
0.16
3.5
3.0
11.15
25.36
ng/l
3.12
13
110
25
233
1.12
0.11
5.3
3.5
0.00
0.00
estimate
—
5
44
5
47
1.07
0.09
4.4
6.4
103.80
104.72
mmol/l
—
5
47
15
137
1.13
0.08
4.9
3.2
—
—
—
0
0
12
130
0.90
0.05
5.4
3.5
—
—
—
0
0
20
209
0.94
0.03
3.1
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
11.58
—
0
6
0
6
0.00
0.00
0.0
1.7
—
33.00
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.55
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
28.56
—
0
9
0
7
0.00
-0.00
0.0
2.4
—
227.43
—
0
7
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
108.78
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
295.39
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.93
—
0
5
0
7
0.00
-0.00
0.0
2.6
—
15.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
1.53
—
0
7
0
7
0.00
-0.00
0.0
2.9
—
88.46
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
4.01
—
0
9

Mortality – FinRegistry

Association

Association between endpoint L12_ACNEKELOID and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACNEKELOID.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ACNEKELOID – Acne keloid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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