connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L94
- Name in latin
- Calcinosis cutis
Similar endpoints
↥List of similar endpoints to
Calcinosis cutis
based on the number of shared cases.
Similar with more cases:
- Other localized connective tissue disorders
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 288 | 172 | 115 |
| Only index persons | 267 | 159 | 108 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.69 | 68.70 | 58.79 |
| Only index persons | 64.73 | 68.91 | 58.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 35 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 65.16 | 67.86 | 61.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 50
- Matched controls
- 499
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L94.2
ICD-10 Finland
Calcinosis cutis
+∞
71.5
50
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
160.6
25.5
25
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
161.4
20.3
20
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
74.1
17.5
19
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
16.6
15
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
34.8
16.4
21
10
TK800
NOMESCO Finland
Hemodialysis
83.5
16.0
17
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
+∞
15.4
14
*
A46
ICD-10 Finland
Erysipelas
18.1
14.7
24
24
C03CA01
ATC
furosemide; systemic
12.3
14.7
36
86
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.3
14.3
23
22
Z49.1
ICD-10 Finland
Extracorporeal dialysis
189.4
14.2
14
*
A11CC03
ATC
alfacalcidol; systemic
45.6
13.6
16
5
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
94.7
13.4
14
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
52.1
13.1
15
*
S97
ICPC
Chronic ulcer skin
24.6
12.9
18
11
A12AA04
ATC
calcium carbonate; oral
154.1
12.0
12
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
154.1
12.0
12
*
V03AE02
ATC
sevelamer; oral
+∞
11.9
11
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
22.6
11.9
17
11
M04AA01
ATC
allopurinol; systemic
15.0
11.7
20
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
11.9
11.6
23
33
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
15.3
11.3
19
19
N18.8
ICD-10 Finland
Other chronic renal failure
77.0
11.2
12
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
77.0
11.2
12
*
137
Kela drug reimbursment
Uraemia requiring dialysis
137.7
10.9
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.9
10.5
26
54
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
51.3
10.5
12
*
L04AA06
ATC
mycophenolic acid; systemic
51.3
10.5
12
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
34.2
10.4
13
5
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
68.9
10.1
11
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
9.8
9.7
21
34
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
9.7
9
*
127
Kela drug reimbursment
Transplant complication
45.9
9.5
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.2
9.2
38
152
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
21.3
9.1
13
8
V03AE01
ATC
polystyrene sulfonate; oral
61.1
9.0
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
11.6
9.0
17
21
TPX10
NOMESCO Finland
Implantation of vascular injection port
15.6
8.7
14
12
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
15.6
8.7
14
12
NHQ40
NOMESCO Finland
Amputation of toe
107.4
8.7
9
*
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
107.4
8.7
9
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
107.4
8.7
9
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
8.6
8
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
8.6
8
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
+∞
8.6
8
*
C02AC05
ATC
moxonidine; oral
27.5
8.4
11
5
C08CA01
ATC
amlodipine; oral
6.1
8.4
32
113
205
Kela drug reimbursment
Chronic hypertension
5.9
7.9
28
88
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
30.5
7.9
10
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
14.1
7.8
13
12
TPH04
NOMESCO Finland
Cathetrisation of vein
6.7
7.8
22
52
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
15.3
7.6
12
10
B05DB
ATC
Hypertonic solutions
+∞
7.5
7
*
QDA10
NOMESCO Finland
Incision of skin of lower limb
+∞
7.5
7
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
7.5
7
*
B05DA
ATC
Isotonic solutions
+∞
7.5
7
*
I50.9
ICD-10 Finland
Heart failure, unspecified
7.7
7.4
18
34
B03XA02
ATC
darbepoetin alfa; parenteral
46.5
7.0
8
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
46.5
7.0
8
*
H05BX01
ATC
cinacalcet; oral
46.5
7.0
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
46.5
7.0
8
*
N02AA05
ATC
oxycodone; systemic
6.6
7.0
19
42
N02AX02
ATC
tramadol; systemic, rectal
5.0
6.8
31
122
J01FF01
ATC
clindamycin; systemic
5.4
6.8
24
73
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
79.6
6.6
7
*
L04AA01
ATC
[U] ciclosporin; systemic
79.6
6.6
7
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
79.6
6.6
7
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
10.9
6.5
12
14
XF600
NOMESCO Finland
Bloodpressure measurement
10.9
6.5
12
14
ZZA00
NOMESCO Finland
Split skin graft
31.0
6.4
8
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
+∞
6.4
6
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
+∞
6.4
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.4
6.3
17
37
J01MA12
ATC
levofloxacin; systemic
5.7
6.2
19
48
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
11.4
6.2
11
12
M10.9
ICD-10 Finland
Gout, unspecified
13.5
6.1
10
9
S18
ICPC
Laceration/cut
4.5
6.1
31
132
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
53
21.33
32.97
29.0
3.6
1.3
1.1
mmol/l
2.88
40
48
28
36
13.90
22.51
17.6
5.1
5.9
5.4
kpa
1.54
28
36
28
36
13.90
22.51
17.6
5.1
2.4
2.2
mmol/l
0.06
28
24
28
45
10.94
18.71
2.5
1.4
—
—
—
0
0
16
11
19.59
18.33
6.1
1.5
—
—
—
0
0
33
67
9.91
18.07
2.7
1.5
—
—
—
0
0
28
49
9.97
17.31
2.8
1.4
—
—
—
0
0
15
11
17.94
16.54
2.1
1.4
0.2
0.3
g/l
0.86
15
11
25
47
8.49
14.23
9.6
3.9
—
—
—
0
0
14
12
14.99
14.05
2.1
1.3
1.0
1.2
g/l
1.39
14
12
45
170
7.94
12.35
7.4
2.7
—
—
—
0
0
19
31
8.57
12.05
2.6
1.5
—
—
—
0
0
19
32
8.28
11.70
18.1
5.6
5.4
5.0
kpa
0.20
19
32
50
227
8.86
11.33
49.8
6.1
1.2
1.2
mmol/l
0.57
41
188
16
24
8.78
10.79
4.2
1.0
—
—
—
0
0
15
23
8.40
9.88
18.0
8.2
23.9
24.6
mmol/l
0.24
15
23
37
138
5.51
9.63
6.9
2.5
0.3
0.3
e6/l
0.16
30
100
12
6
24.55
8.89
1.9
1.2
—
—
—
0
0
13
20
8.05
8.45
2.5
1.3
—
—
—
0
0
25
77
4.90
7.95
5.2
2.5
0.5
1.2
e6/l
1.11
16
41
44
216
5.08
7.51
20.4
3.7
31.4
35.5
g/l
4.71
44
203
29
106
4.41
7.32
6.3
2.5
—
—
—
0
0
26
90
4.38
7.01
8.7
3.0
163.1
26.5
ng/l
0.68
26
71
10
14
8.40
6.92
1.9
1.1
—
—
—
0
0
10
14
8.40
6.92
2.5
1.6
—
—
—
0
0
15
33
5.75
6.91
6.4
4.0
37.7
72.4
ml/min/173m2
—
7
15
11
9
14.65
6.90
2.2
1.8
—
—
—
0
0
22
69
4.49
6.70
5.7
2.9
1.3
4.4
e6/l
1.02
13
34
9
5
20.81
6.48
3.9
2.0
—
—
—
0
0
6
0
+∞
6.35
1.8
0.0
64.3
—
u/l
—
6
0
6
0
+∞
6.35
1.8
0.0
16.3
—
u/l
—
6
0
43
226
4.33
6.25
8.9
4.2
—
—
—
0
0
11
20
6.53
6.06
22.2
4.3
0.7
0.7
%
0.03
11
20
11
20
6.53
6.06
17.2
2.9
23.9
24.2
mmol/l
0.12
11
20
12
24
6.02
6.04
2.9
1.5
—
—
—
0
0
32
144
3.67
5.71
5.4
3.3
11141.6
1314.2
ng/l
1.25
26
121
32
147
3.57
5.48
5.5
2.3
110.5
299.1
u/l
0.88
32
139
5
0
+∞
5.28
7.2
0.0
4.8
—
mmol/l
—
5
0
9
9
11.52
5.23
1.4
1.1
—
—
—
0
0
11
24
5.40
5.01
24.5
4.0
105.1
130.0
g/l
2.35
11
24
10
20
5.82
4.97
24.2
4.3
1.3
1.3
%
—
10
20
8
7
12.95
4.94
2.3
2.0
—
—
—
0
0
8
7
12.95
4.94
1.5
1.0
—
—
—
0
0
8
7
12.95
4.94
2.3
2.0
—
—
—
0
0
8
7
12.95
4.94
1.5
1.0
—
—
—
0
0
7
5
15.59
4.70
2.1
1.2
—
—
—
0
0
8
11
8.20
4.00
1.4
1.1
—
—
—
0
0
6
5
13.13
3.85
2.2
2.6
—
—
—
0
0
14
48
3.51
3.59
2.2
1.8
313.3
381.0
nmol/l
0.59
14
41
6
6
10.93
3.58
2.3
2.2
—
—
—
0
0
6
6
10.93
3.58
1.0
1.3
—
—
—
0
0
5
5
10.75
3.03
1.0
1.4
—
—
—
0
0
5
5
10.75
3.03
1.0
1.4
—
—
—
0
0
5
5
10.75
3.03
1.0
1.4
—
—
—
0
0
5
5
10.75
3.03
1.0
1.4
—
—
—
0
0
5
5
10.75
3.03
1.0
1.4
—
—
—
0
0
5
5
10.75
3.03
1.8
1.2
—
—
—
0
0
7
13
5.94
2.96
2.6
2.3
—
—
—
0
0
7
14
5.51
2.82
1.4
2.4
—
—
—
0
0
25
144
2.28
2.35
10.8
3.4
26.2
34.5
u/l
0.99
25
134
5
10
5.34
2.11
1.0
1.1
—
—
—
0
0
5
10
5.34
2.11
3.2
1.8
—
—
—
0
0
6
15
4.32
2.09
1.8
1.1
—
—
—
0
0
6
15
4.32
2.09
1.8
1.1
—
—
—
0
0
30
194
2.11
2.06
3.2
1.8
97.5
94.2
pmol/l
0.18
20
79
5
12
4.44
1.86
2.0
1.8
—
—
—
0
0
17
91
2.22
1.84
1.4
1.3
13.7
44.6
iu/ml
—
5
30
34
239
2.00
1.79
5.9
3.8
0.0
0.0
estimate
—
7
53
5
13
4.10
1.75
2.0
2.2
—
—
—
0
0
34
241
1.97
1.72
8.6
5.0
0.0
0.0
estimate
—
7
54
6
20
3.22
1.62
28.3
2.9
66.7
56.2
%
—
6
20
34
245
1.92
1.61
5.9
3.8
0.0
0.0
estimate
—
7
52
6
22
2.92
1.47
2.0
1.5
—
—
—
0
0
14
80
1.98
1.26
1.3
1.3
4.4
13.6
u/ml
—
7
35
36
279
1.74
1.22
3.3
2.8
—
—
—
0
0
6
27
2.36
0.96
2.3
2.6
0.2
0.1
e6/l
—
6
27
15
98
1.71
0.89
2.1
1.7
1585.9
1395.0
nmol/l
0.17
15
70
11
83
1.40
0.35
1.3
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
79.6
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.8
—
134.4
—
0
10
16
142
1.17
0.14
6.0
4.1
0.0
0.0
estimate
—
6
52
5
61
0.80
0.08
55.6
9.4
—
—
—
0
0
20
193
1.05
0.01
6.0
4.0
—
—
—
0
0
11
114
0.96
0.00
2.5
5.1
32.4
21.5
%
—
6
54
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
6
68
0.87
0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_CALCINOSISCUTIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_CALCINOSISCUTIS | 4.812 [1.96, 11.82] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.559 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 132 females with L12_CALCINOSISCUTIS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_CALCINOSISCUTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.542% | No data |
| 5 | 3.161% | No data |
| 10 | 7.911% | No data |
| 15 | 14.384% | No data |
| 20 | 23.902% | No data |
Relationships between endpoints
↥Index endpoint: L12_CALCINOSISCUTIS – Calcinosis cutis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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