connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Other localized connective tissue disorders
DOID EFO Endpoint Browser PheWeb
L12_LOCALDCONNECTISSUEOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
716 |
4. Check minimum number of eventsNone |
716 |
5. Include endpoints |
736 |
6. Filter based on genotype QC (FinnGen only) |
706 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Aliae morbositates localisatae textus connectivi
Similar endpoints
↥List of similar endpoints to
Other localized connective tissue disorders
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4269 | 3191 | 1056 |
| Only index persons | 3949 | 2982 | 967 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.03 |
| Only index persons | 0.09 | 0.11 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 53.91 | 55.68 | 48.45 |
| Only index persons | 53.10 | 55.18 | 46.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 706 | 559 | 147 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.07 |
| Median age at first event (years) | 56.56 | 56.64 | 56.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 736
- Matched controls
- 7360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.8
312.2
299
259
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
6047.9
307.7
526
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
32.8
113.2
74
25
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
17.4
84.0
71
45
D07AD01
ATC
clobetasol; topical
4.7
78.6
246
717
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
37.4
78.3
49
14
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
+∞
72.1
68
*
L94.2
ICD-10 Finland
Calcinosis cutis
+∞
71.0
67
*
D07AC01
ATC
betamethasone; topical
3.8
69.3
406
1810
P01BA02
ATC
hydroxychloroquine; oral
5.5
68.6
152
330
L04AX03
ATC
methotrexate; systemic
4.9
61.2
160
398
L04AA06
ATC
mycophenolic acid; systemic
16.9
57.7
49
31
L94.8
ICD-10 Finland
Other specified localized connective tissue disorders
+∞
57.0
54
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
55.4
248
905
XX9XE
NOMESCO Finland
Other ultrasound examination
21.6
51.7
39
19
E0000UV, ,
ATC
3.1
49.8
423
2228
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
111.8
48.4
52
5
TQW80
NOMESCO Finland
Local dermatologic skincare
11.9
47.1
49
44
D07AC13
ATC
mometasone; topical
2.9
42.1
308
1462
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.1
41.9
39
29
L94.1
ICD-10 Finland
Linear scleroderma
+∞
41.0
39
*
C08CA05
ATC
nifedipine; systemic
5.4
40.4
86
177
L04AA01
ATC
[U] ciclosporin
13.8
40.2
38
29
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.7
40.2
79
151
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.8
40.0
145
451
XQ848
NOMESCO Finland
Dermatological photography
7.9
39.5
56
76
TK800
NOMESCO Finland
Hemodialysis
13.4
38.6
37
29
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
12.6
35.2
35
29
L04AX01
ATC
azathioprine; systemic
5.8
34.4
66
123
I73.0
ICD-10 Finland
Raynaud syndrome
9.8
33.8
40
43
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
11.4
33.1
35
32
M34.1
ICD-10 Finland
CR(E)ST syndrome
36.3
29.9
38
11
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.0
29.2
90
248
L04AD01
ATC
ciclosporin; systemic
9.1
27.4
34
39
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.4
27.3
56
111
M34.0
ICD-10 Finland
Progressive systemic sclerosis
139.9
25.8
27
*
D02AX
ATC
Other emollients and protectives
6.2
25.5
45
77
A11CC03
ATC
alfacalcidol; systemic
7.9
25.3
35
46
70100
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Seleroderma circumscriptum NUD
+∞
25.1
24
*
S97
ICPC
Chronic ulcer skin
4.6
24.9
62
145
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
35.9
24.4
31
9
A46
ICD-10 Finland
Erysipelas
2.9
24.2
128
493
D02AE01
ATC
carbamide; topical
3.8
23.6
77
220
D07AB08
ATC
desonide; topical
3.0
23.1
118
446
H02AB06
ATC
prednisolone; systemic
2.1
22.1
390
2549
E000001, ,
ATC
2.4
22.0
192
945
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.0
21.9
66
178
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
226.5
21.7
22
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
118.6
21.7
23
*
N18.8
ICD-10 Finland
Other chronic renal failure
8.1
21.4
29
37
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
21.3
369
2385
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
43.0
20.6
25
6
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.0
20.3
97
352
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
19.9
19
*
M13.9
ICD-10 Finland
Arthritis, unspecified
3.3
19.6
80
264
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
18.7
52
132
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.2
18.5
79
268
J01FF01
ATC
clindamycin; systemic
2.1
18.4
230
1299
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
27.5
17.9
24
9
196
Kela drug reimbursment
Paricalcitol and cinacalcet
68.3
17.8
20
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
19.9
17.0
25
13
A12AA04
ATC
calcium carbonate; oral
14.5
16.9
28
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
16.8
246
1465
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.9
16.7
26
39
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.7
16.6
31
56
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
30.8
16.2
21
7
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
15.9
108
469
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
15.9
51
144
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
15.8
301
1951
XPX04
NOMESCO Finland
Angioscopy
61.4
15.8
18
*
V03AE02
ATC
sevelamer; oral
34.2
15.8
20
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
15.8
87
340
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
15.5
52
151
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
15.4
89
357
127
Kela drug reimbursment
Transplant complication
13.4
15.3
26
20
NHQ40
NOMESCO Finland
Amputation of toe
18.9
14.8
22
12
137
Kela drug reimbursment
Uraemia requiring dialysis
25.6
14.7
20
8
C03CA01
ATC
furosemide; systemic
2.0
14.5
218
1300
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
14.4
88
362
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
14.1
239
1481
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.1
14.1
60
203
H02AB04
ATC
methylprednisolone; systemic
2.3
14.0
124
605
S18
ICPC
Laceration/cut
1.8
13.9
346
2416
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.4
13.8
51
158
M04AA01
ATC
allopurinol; systemic
2.5
13.7
92
396
L01BA01
ATC
methotrexate; systemic
3.9
13.7
41
110
D05AX02
ATC
calcipotriol; topical
4.0
13.5
39
102
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
26.3
13.4
18
7
L93.0
ICD-10 Finland
Discoid lupus erythematosus
40.9
13.2
16
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.8
13.2
69
262
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
12.8
106
502
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
132.2
12.5
13
*
E000002, ,
ATC
2.3
12.5
98
453
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.1
12.2
21
35
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
12.7
12.2
21
17
E000006, ,
ATC
2.7
12.1
69
274
L84
ICD-10 Finland
Corns and callosities
4.3
12.1
31
74
H05BX01
ATC
cinacalcet; oral
21.7
12.0
17
8
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
21.7
12.0
17
8
B03XA02
ATC
darbepoetin alfa; parenteral
5.1
12.0
25
50
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
11.7
46
148
Z94.0
ICD-10 Finland
Kidney transplant status
16.7
11.7
18
11
WW200
NOMESCO Finland
Immunization
4.9
11.5
25
52
L94.3
ICD-10 Finland
Sclerodactyly
+∞
11.5
11
*
V03AE03
ATC
lanthanum carbonate; oral
121.8
11.5
12
*
Z2221
NOMESCO Finland
Medical doctor
1.8
11.4
215
1363
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
11.4
287
1979
R4190
NOMESCO Finland
Nutritional therapy
3.6
11.3
38
111
Z49.2
ICD-10 Finland
Other dialysis
25.5
11.2
15
6
N03AX16
ATC
[U] pregabalin
1.9
11.1
188
1150
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.4
11.1
28
66
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
11.0
45
149
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
10.9
271
1858
R4120
NOMESCO Finland
Occupational therapy
2.6
10.8
62
247
L89
ICD-10 Finland
Decubitus ulcer and pressure area
18.1
10.8
16
9
N18.0
ICD-10 Finland
End-stage renal disease
18.1
10.8
16
9
L91.0
ICD-10 Finland
Hypertrophic scar
21.8
10.7
15
7
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.2
10.7
28
68
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
60.9
10.6
12
*
M34
ICD-10 Finland
Systemic sclerosis
60.9
10.6
12
*
L95.8
ICD-10 Finland
Other vasculitis limited to skin
60.9
10.6
12
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
10.6
175
1062
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.1
10.6
29
73
J01MA02
ATC
ciprofloxacin; systemic
1.7
10.5
276
1915
L95.0
ICD-10 Finland
Livedoid vasculitis
+∞
10.4
10
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
10.4
10
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
10.4
87
412
V03AE01
ATC
polystyrene sulfonate; oral
12.3
10.4
18
15
B05DB
ATC
Hypertonic solutions
33.0
10.4
13
*
L92.0
ICD-10 Finland
Granuloma annulare
23.7
10.3
14
6
E000007, ,
ATC
2.8
10.3
53
200
H02AB07
ATC
prednisone; oral
2.0
10.1
113
600
R06AE07
ATC
cetirizine; oral
1.7
10.0
342
2533
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.0
145
842
B07.9
ICD-10 Finland
Verruca simplex
3.6
10.0
33
95
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.6
9.8
23
51
M35.1
ICD-10 Finland
Other overlap syndromes
20.4
9.8
14
7
ZXE00
NOMESCO Finland
One hour or less
1.7
9.8
287
2040
J01DB01
ATC
cefalexin; oral
1.9
9.8
610
5286
SPAT1262
SPAT
Handing over of treatment supplies
1.9
9.6
128
722
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
4.3
9.4
24
57
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
9.4
44
157
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.8
9.4
28
75
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
12.6
9.4
16
13
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.2
9.4
20
25
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.0
9.4
20
41
XQ845
NOMESCO Finland
Dermatoscopy
5.0
9.4
20
41
R60.0
ICD-10 Finland
Localized oedema
2.1
9.3
95
488
M10.9
ICD-10 Finland
Gout, unspecified
2.8
9.0
44
161
B05DA
ATC
Isotonic solutions
18.9
9.0
13
7
A07AA02
ATC
nystatin; oral
2.5
8.9
55
227
TQW40
NOMESCO Finland
Remowal of suture of skin
2.5
8.9
59
252
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
8.1
8.9
19
24
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.9
8.8
26
69
A28
ICPC
Limited function/disability NOS
1.9
8.8
122
696
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
8.8
58
247
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
8.7
72
339
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
14.2
8.7
14
10
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
50.6
8.7
10
*
L04AD02
ATC
tacrolimus; systemic
11.7
8.6
15
13
Z49.0
ICD-10 Finland
Preparatory care for dialysis
20.3
8.5
12
6
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
20.3
8.5
12
6
ZXC50
NOMESCO Finland
Cryotherapy
3.6
8.5
27
76
UJF32
NOMESCO Finland
Coloscopy
1.7
8.5
188
1235
A02BC02
ATC
pantoprazole; systemic
1.6
8.4
491
4074
M25.5
ICD-10 Finland
Pain in joint
1.6
8.4
247
1744
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.1
8.4
23
58
R06AX27
ATC
desloratadine; oral
1.7
8.4
218
1492
M10.0
ICD-10 Finland
Idiopathic gout
3.7
8.3
26
72
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
8.3
8
*
3AC01, ,
NOMESCO Finland
10.9
8.3
15
14
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.5
8.2
50
205
WX213
NOMESCO Finland
Lower leg blockade
14.7
8.2
13
9
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
14.7
8.2
13
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
8.1
46
182
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
8.3
8.1
17
21
TK820
NOMESCO Finland
Peritoneal dialysis
33.7
8.1
10
*
NGQ20
NOMESCO Finland
Amputation of lower leg
17.4
8.1
12
7
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.0
7.9
22
56
CKC12
NOMESCO Finland
Photocoagulation of retina
3.0
7.9
34
116
QDA10
NOMESCO Finland
Incision of skin of lower limb
13.2
7.9
13
10
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
13.2
7.9
13
10
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
7.9
327
2494
H02AB09
ATC
hydrocortisone; systemic
3.9
7.8
23
61
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.9
7.8
23
61
ZZA00
NOMESCO Finland
Split skin graft
3.7
7.8
24
66
H3603, E103,
ICD-10 Finland
15.2
7.7
12
8
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
45.5
7.7
9
*
R4110
NOMESCO Finland
Physiotherapy
1.6
7.7
202
1381
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
7.7
92
499
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.9
7.6
22
58
M79.6
ICD-10 Finland
Pain in limb
1.5
7.5
313
2383
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.4
7.4
26
78
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
80.9
7.4
8
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
80.9
7.4
8
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
7.4
36
132
L88
ICPC
Rheumatoid/seropositive arthritis
2.8
7.4
37
138
S21
ICPC
Skin texture symptom/complaint
1.8
7.3
108
628
E000003, ,
ATC
2.7
7.3
39
150
L94
ICD-10 Finland
Other localized connective tissue disorders
+∞
7.3
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.3
182
1227
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
15.9
7.2
11
7
NG4AA
NOMESCO Finland
Lower leg X-ray examination
3.1
7.2
29
95
L50.9
ICD-10 Finland
Urticaria, unspecified
2.9
7.2
33
117
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.5
7.2
24
70
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.4
7.2
25
75
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
30.3
7.2
9
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
30.3
7.2
9
*
Z3231
NOMESCO Finland
Registered nurse
1.6
7.2
188
1283
N02AX02
ATC
tramadol; systemic, rectal
1.5
7.1
297
2254
L71.8
ICD-10 Finland
Other rosacea
4.1
7.1
19
47
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
7.1
59
279
321
Kela drug reimbursment
Paricalcitol and cinacalcet
12.2
7.1
12
10
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.9
7.1
14
16
S99
ICPC
Skin disease other
3.6
7.0
23
66
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
7.0
120
731
L30.8
ICD-10 Finland
Other specified dermatitis
3.3
6.9
26
82
N03AX12
ATC
[U] gabapentin; oral
1.7
6.8
126
783
A02BC05
ATC
esomeprazole; systemic
1.5
6.8
297
2270
RJ412, ,
NOMESCO Finland
40.4
6.8
8
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
16.9
6.8
10
6
TK810
NOMESCO Finland
Hemofiltration
16.9
6.8
10
6
C08CA02
ATC
felodipine; oral
2.1
6.7
66
333
SBA00
NOMESCO Finland
Microbiological examinations
3.4
6.7
24
73
ZX120
NOMESCO Finland
Intravenous
2.0
6.7
71
369
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.8
6.7
98
568
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.6
151
992
J01MA12
ATC
levofloxacin; systemic
1.7
6.6
123
766
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.2
6.6
17
41
L17
ICPC
Foot/toe symptom/complaint
1.6
6.6
211
1506
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.9
6.6
19
50
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
3.7
6.5
20
55
TQW11
NOMESCO Finland
Vacuum treatment of wound
3.7
6.5
20
55
205
Kela drug reimbursment
Chronic hypertension
1.6
6.5
169
1148
L53.9
ICD-10 Finland
Erythematous condition, unspecified
5.8
6.5
17
30
J04BA02
ATC
dapsone; oral
14.5
6.4
10
7
RJ411, ,
NOMESCO Finland
14.5
6.4
10
7
NFQ20
NOMESCO Finland
Amputation of femur
14.5
6.4
10
7
SPAT1255
SPAT
Intravenous administration of medicine
2.3
6.4
46
205
S29
ICPC
Skin symptom/complaint other
1.7
6.4
134
862
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.4
410
3377
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
6.3
247
1838
RD210, ,
NOMESCO Finland
3.9
6.3
18
47
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
6.3
86
488
QXA05
NOMESCO Finland
Skin division, unspecified location
18.2
6.3
9
5
L88
ICD-10 Finland
Pyoderma gangrenosum
+∞
6.3
6
*
L94.5
ICD-10 Finland
Poikiloderma vasculare atrophicans
+∞
6.3
6
*
L94.4
ICD-10 Finland
Gottron papules
+∞
6.3
6
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.8
6.3
31
115
K29.7
ICD-10 Finland
Gastritis, unspecified
2.8
6.3
31
115
D03BA02
ATC
collagenase; topical
26.9
6.2
8
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
6.4
6.2
15
24
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
6.2
56
275
H53.1
ICD-10 Finland
Subjective visual disturbances
2.2
6.1
52
248
A10AC01
ATC
insulin (human); parenteral
2.1
6.1
55
269
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
6.1
53
256
K65.0
ICD-10 Finland
Acute peritonitis
8.7
6.1
12
14
N02BF01
ATC
gabapentin; oral
2.0
6.1
67
354
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
10.1
6.0
11
11
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
6.0
111
688
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
127
13.50
138.26
1.3
1.2
14.63
10.78
u/ml
—
10
9
165
224
9.21
119.79
1.4
1.3
0.36
1.84
u/ml
—
8
16
135
174
9.28
101.53
1.4
1.2
56.14
22.66
u/ml
—
11
8
131
163
9.56
101.30
1.4
1.2
9.52
2.74
u/ml
0.95
19
18
131
166
9.38
99.80
1.4
1.2
8.50
6.49
u/ml
0.13
24
26
104
129
9.22
80.06
1.4
1.2
22.94
45.65
u/ml
0.49
12
11
116
197
6.80
67.50
2.5
1.7
—
—
—
0
0
52
49
11.34
48.44
1.2
1.2
—
—
—
0
0
52
49
11.34
48.44
1.2
1.2
—
—
—
0
0
52
50
11.11
47.78
1.3
1.2
—
—
—
0
0
52
50
11.11
47.78
1.3
1.2
—
—
—
0
0
52
50
11.11
47.78
1.3
1.2
—
—
—
0
0
483
2819
3.08
45.92
10.6
5.5
2.95
2.77
%
0.91
467
2615
485
2867
3.03
44.48
10.3
5.4
57.06
56.97
%
0.06
467
2669
488
2904
3.02
44.03
10.7
5.6
28.29
28.41
%
0.09
471
2708
551
3516
3.26
43.67
12.1
8.7
3.91
4.01
e9/l
0.61
509
3069
132
424
3.58
34.45
2.4
2.4
18.78
27.15
au/ml
—
10
26
120
379
3.59
32.02
1.3
1.3
19.86
39.14
au/ml
—
5
25
34
41
8.65
26.31
1.7
1.4
5.34
7.77
u/l
0.70
26
35
276
1502
2.34
25.68
3.5
2.4
881.73
6673.05
umol/l
4.46
247
1302
118
424
3.12
25.31
3.3
2.9
11.64
10.41
g/l
1.45
104
387
176
790
2.61
24.87
4.6
2.0
2.29
2.38
g/l
1.29
159
720
185
862
2.53
24.11
4.6
2.1
12.73
12.98
umol/l
0.19
174
787
300
1761
2.19
22.61
3.1
2.0
157.54
207.44
u/l
0.52
287
1663
599
4633
2.57
22.53
6.9
4.0
14.56
12.11
mm/h
3.04
571
4267
162
730
2.56
22.50
4.9
2.1
22.36
22.39
%
0.01
140
618
114
439
2.89
21.48
3.2
2.9
65.88
67.41
g/l
1.01
104
393
67
189
3.80
20.89
1.9
1.5
410.00
143.64
titre
—
8
11
399
2669
2.08
20.80
3.2
2.3
77.47
78.27
nmol/l
0.23
360
2388
601
4749
2.45
19.94
11.1
6.8
77.50
77.48
u/l
0.00
579
4438
154
724
2.43
19.29
15.2
4.0
1.12
1.05
mmol/l
2.17
148
660
325
2086
2.00
18.27
5.5
3.4
136.66
125.81
e6/l
0.05
222
1432
391
2715
1.94
17.09
4.2
2.6
112.96
98.37
ug/l
1.14
365
2479
105
440
2.62
16.64
4.1
3.0
303.72
176.91
ng/l
0.48
98
404
40
92
4.54
16.33
1.4
1.2
2.28
1.74
u/ml
0.51
18
31
415
2993
1.89
15.61
14.9
6.1
1.22
1.22
mmol/l
0.43
351
2542
41
103
4.16
14.96
1.3
1.2
—
—
—
0
0
417
3046
1.85
14.71
4.4
3.6
0.00
0.00
estimate
0.50
91
609
29
56
5.35
14.48
2.3
2.1
—
—
—
0
0
238
1462
1.93
14.46
2.8
2.1
3.02
3.06
mg/l
0.10
210
1234
54
170
3.35
14.24
3.5
2.0
512.65
241.97
ug/l
0.54
49
160
97
427
2.46
13.79
21.1
5.3
12.10
8.91
mmol/l
4.35
91
405
56
184
3.21
13.79
3.0
2.4
1.75
0.84
g/l
0.53
51
165
208
1239
1.95
13.74
1.8
1.5
2.57
2.31
g/l
0.36
121
718
36
88
4.25
13.62
1.4
1.2
3.58
3.52
u/ml
0.02
19
40
412
3048
1.80
13.45
6.0
4.9
0.00
0.00
estimate
0.50
83
570
203
1208
1.94
13.41
3.6
2.3
5.21
7.09
e6/l
1.25
182
1081
58
201
3.05
13.06
2.7
2.1
3.08
3.00
g/l
0.27
53
182
191
1123
1.95
13.03
1.4
1.3
15.44
30.74
iu/ml
4.00
56
374
253
1631
1.84
12.97
3.4
2.8
2610.26
1036.26
ng/l
1.23
215
1351
106
499
2.31
12.95
9.3
3.0
138.20
74.72
ng/l
5.02
98
449
414
3090
1.78
12.90
4.4
3.6
0.00
0.01
estimate
0.50
84
554
249
1600
1.84
12.88
4.7
2.8
0.27
0.44
e6/l
1.60
189
1183
266
1755
1.81
12.55
4.8
2.8
29.29
89.98
e6/l
0.89
209
1320
374
2725
1.76
12.54
13.8
5.3
1.22
1.22
mmol/l
0.62
344
2482
59
213
2.92
12.37
2.7
2.1
3.55
3.57
g/l
0.04
54
195
304
2094
1.77
12.35
3.5
3.2
2.35
2.36
mmol/l
0.37
278
1837
59
214
2.91
12.26
2.7
2.1
7.23
7.49
g/l
0.48
54
195
59
214
2.91
12.26
2.7
2.1
—
—
—
0
0
117
592
2.16
11.96
4.0
2.7
1.87
1.85
%
0.08
104
524
300
2076
1.75
11.87
5.6
2.8
—
—
—
0
0
35
94
3.86
11.69
1.5
1.2
—
—
—
0
0
511
4116
1.79
11.66
6.0
4.4
14.56
1370.23
e6/l
—
9
60
21
19
11.34
11.59
1.3
1.2
8.86
9.16
ug/l
0.09
21
19
51
177
3.02
11.46
2.7
2.0
36.73
38.18
g/l
0.88
46
158
55
200
2.89
11.38
2.7
2.1
10.70
10.25
g/l
0.20
50
180
350
2553
1.71
11.28
7.7
4.1
35.34
35.82
g/l
0.93
331
2380
156
906
1.92
10.83
2.1
1.7
—
—
—
0
0
163
961
1.89
10.81
3.8
2.5
0.74
1.19
e6/l
1.49
95
518
409
3142
1.68
10.61
6.5
5.6
10.15
10.73
umol/l
0.73
386
2980
334
2446
1.67
10.32
2.3
1.9
97.86
96.51
pmol/l
0.21
173
1190
47
166
2.96
10.25
4.1
3.9
70.54
85.87
mg/l
0.15
38
134
45
156
3.01
10.14
1.7
1.3
—
—
—
0
0
46
163
2.94
9.98
4.0
3.9
1.26
2.21
ratio
—
5
16
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
41
138
3.09
9.72
10.9
2.6
0.40
0.39
u/ml
0.03
24
75
46
166
2.89
9.67
4.2
3.9
48.97
43.09
mg/l
0.11
38
133
21
44
4.88
9.58
1.7
2.5
—
—
—
0
0
349
2626
1.63
9.41
17.9
12.7
1.26
1.20
inr
0.51
97
778
35
111
3.26
9.16
3.3
3.1
55.86
57.53
%
0.30
35
111
152
922
1.82
9.08
6.2
2.9
0.80
0.82
mmol/l
1.07
144
867
104
557
2.01
9.05
2.3
1.9
327.29
383.70
nmol/l
2.13
98
515
265
1876
1.64
9.04
4.1
3.0
6.71
7.04
mmol/l
0.60
221
1589
34
107
3.28
9.01
3.0
3.0
3.79
4.23
e9/l
0.67
34
107
108
592
1.97
8.80
4.6
3.2
—
—
—
0
0
171
1085
1.75
8.74
1.4
1.3
9.01
12.50
u/ml
0.32
63
403
207
1390
1.68
8.59
1.7
1.5
21.01
21.67
nmol/l
0.21
179
1172
579
5008
1.73
8.44
5.1
4.2
14.76
14.79
pmol/l
0.08
540
4547
213
1448
1.66
8.41
1.3
1.3
0.82
1.63
u/ml
1.12
49
370
82
417
2.09
8.20
2.0
1.4
—
—
—
0
0
96
518
1.98
8.16
2.7
2.1
0.22
0.22
g/l
0.51
88
488
37
133
2.88
7.86
4.8
3.3
2.09
1.52
mg/l
1.90
37
122
430
3500
1.55
7.64
8.1
4.2
6.82
6.56
mmol/l
1.53
412
3237
39
148
2.73
7.50
1.4
1.3
—
—
—
0
0
96
537
1.91
7.34
3.1
2.2
28.14
36.58
u/l
1.51
81
449
257
1892
1.55
7.06
3.1
2.4
55.25
61.86
u/l
1.14
236
1737
250
1831
1.55
7.02
4.8
3.7
25.95
8.12
mg/mmol
1.86
157
1088
239
1735
1.56
6.97
4.4
3.1
113.97
291.56
mg/l
1.04
155
1036
89
494
1.91
6.96
13.8
2.9
1.85
2.07
mmol/l
0.22
81
397
674
6194
2.05
6.93
24.8
12.4
21.60
21.46
mg/l
0.04
574
4812
31
110
2.90
6.76
2.0
1.9
120.07
128.01
g/l
1.33
15
77
140
900
1.69
6.69
4.3
2.6
4.21
3.46
e6/l
0.27
74
457
27
89
3.11
6.68
13.3
4.2
1836.43
528.00
iu/ml
—
7
9
42
177
2.46
6.57
1.5
1.6
0.06
0.10
iu/ml
—
7
33
206
1465
1.56
6.51
6.8
3.4
94.46
93.88
%
0.13
200
1417
47
210
2.32
6.47
2.3
1.7
—
—
—
0
0
105
632
1.77
6.33
2.0
1.7
—
—
—
0
0
44
193
2.36
6.32
1.9
1.6
—
—
—
0
0
646
5890
1.79
6.31
6.2
5.0
1.94
1.87
mu/l
0.93
604
5377
18
47
3.90
6.29
1.9
1.6
—
—
—
0
0
55
266
2.15
6.28
1.9
2.0
36.32
40.87
u/l
0.68
50
232
6
0
+∞
6.26
4.8
0.0
—
—
—
0
0
6
0
+∞
6.26
5.0
0.0
494.00
—
umol/l
—
6
0
106
642
1.76
6.26
2.0
1.7
—
—
—
0
0
17
43
4.02
6.19
1.2
1.4
—
—
—
0
0
643
5864
1.76
6.15
20.7
11.8
79.74
81.80
ml/min/173m2
1.33
561
4733
162
1103
1.60
6.13
5.2
3.6
84.38
314.86
ng/l
2.38
130
832
703
6609
2.42
6.10
16.9
9.7
25.42
24.95
u/l
0.40
682
6365
61
311
2.05
6.08
4.7
2.9
1.77
2.03
mmol/l
0.19
42
237
37
157
2.43
5.73
1.5
1.1
—
—
—
0
0
36
151
2.46
5.72
2.5
2.7
—
—
—
0
0
40
177
2.33
5.65
2.2
2.0
10.71
11.49
mg/l
0.19
35
162
156
1076
1.57
5.55
1.8
1.7
1248.83
1202.31
nmol/l
0.19
124
796
61
322
1.98
5.54
1.7
1.6
—
—
—
0
0
467
4014
1.45
5.37
3.9
2.9
58.77
44.33
u/l
1.41
438
3736
32
131
2.51
5.36
1.8
1.6
12069.82
17959.21
e6/l
0.37
22
90
18
53
3.46
5.33
1.9
1.5
—
—
—
0
0
684
6406
1.96
5.30
27.4
14.1
3.95
3.95
mmol/l
0.24
667
6214
682
6388
1.92
5.18
26.8
14.1
139.47
139.68
mmol/l
1.20
665
6213
25
92
2.78
5.15
2.0
1.5
—
—
—
0
0
31
129
2.46
5.03
1.9
1.5
—
—
—
0
0
30
124
2.48
4.94
1.9
1.5
—
—
—
0
0
33
143
2.37
4.91
2.3
1.6
—
—
—
0
0
15
33
4.62
4.88
1.2
1.1
1.02
1.07
ratio
—
5
10
24
89
2.75
4.88
1.2
1.1
—
—
—
0
0
216
1639
1.45
4.79
4.9
3.9
0.00
0.01
estimate
0.69
85
563
250
1959
1.42
4.62
4.7
2.9
28.64
30.85
u/l
0.91
242
1856
15
36
4.23
4.53
1.3
1.2
—
—
—
0
0
101
658
1.62
4.53
4.5
2.4
6.04
7.18
umol/l
0.53
94
559
29
124
2.39
4.46
1.6
1.7
—
—
—
0
0
222
1716
1.42
4.39
1.8
1.7
1.41
1.35
mmol/l
0.48
179
1454
156
1129
1.48
4.37
2.7
2.6
2.47
2.45
mmol/l
0.95
142
987
25
101
2.53
4.34
1.8
1.6
—
—
—
0
0
14
41
3.46
4.20
1.3
1.2
—
—
—
0
0
12
25
4.86
4.20
1.8
1.8
—
—
—
0
0
12
25
4.86
4.20
1.8
1.8
—
—
—
0
0
344
2878
1.37
4.19
3.5
2.5
—
—
—
0
0
10
17
5.95
4.14
2.1
1.7
—
—
—
0
0
10
17
5.95
4.14
2.1
1.7
—
—
—
0
0
14
36
3.94
4.01
1.4
1.9
509.67
522.75
e6/l
—
9
28
9
14
6.49
3.99
1.1
1.3
—
—
—
0
0
10
18
5.62
3.98
2.1
1.7
—
—
—
0
0
288
2358
1.36
3.96
4.5
3.7
—
—
—
0
0
20
76
2.68
3.92
1.3
1.3
—
—
—
0
0
20
76
2.68
3.92
1.7
1.4
—
—
—
0
0
20
76
2.68
3.92
1.3
1.3
—
—
—
0
0
65
392
1.72
3.92
1.4
1.2
513.70
230.32
u/ml
0.48
57
358
73
457
1.66
3.84
3.3
2.4
55.63
69.12
ml/min/173m2
1.81
30
193
20
77
2.64
3.83
1.3
1.3
—
—
—
0
0
20
77
2.64
3.83
1.3
1.3
—
—
—
0
0
20
78
2.61
3.74
1.3
1.3
—
—
—
0
0
20
78
2.61
3.74
1.3
1.3
—
—
—
0
0
616
5715
1.48
3.74
7.2
5.4
39.96
39.34
mmol/mol
0.81
581
5302
18
67
2.73
3.68
1.1
1.1
—
—
—
0
0
19
73
2.65
3.66
1.3
1.4
—
—
—
0
0
157
1178
1.42
3.60
1.4
1.5
—
—
—
0
0
11
26
4.28
3.51
2.6
1.9
91.55
47.45
ug/l
0.63
11
26
184
1425
1.39
3.51
4.0
2.1
—
—
—
0
0
21
87
2.46
3.50
2.0
1.4
—
—
—
0
0
21
87
2.46
3.50
2.0
1.4
—
—
—
0
0
167
1279
1.40
3.39
1.5
1.7
62937501.23
30237411.83
pmol/l
0.21
143
1055
589
5458
1.40
3.25
28.7
15.1
15.05
14.88
%
0.31
581
5358
110
788
1.47
3.22
1.8
2.1
215.76
117.69
ug/g
1.13
92
607
10
25
4.04
3.09
1.2
1.4
106.40
167.99
mmol/24h
—
10
25
174
1362
1.36
3.08
2.3
1.7
0.82
1.10
mg/l
1.95
136
1024
74
494
1.55
3.03
6.4
3.5
1.24
1.23
mmol/l
0.36
63
429
64
413
1.60
3.02
3.4
3.3
4.53
4.51
pmol/l
0.03
57
369
10
26
3.88
2.99
2.1
1.5
—
—
—
0
0
10
26
3.88
2.99
2.1
1.5
—
—
—
0
0
8
17
4.75
2.92
1.3
1.2
—
—
—
0
0
21
96
2.22
2.85
1.2
1.4
—
—
—
0
0
11
33
3.37
2.82
1.2
1.2
—
—
—
0
0
21
97
2.20
2.79
1.4
1.2
301.47
247.28
u/ml
0.29
15
56
10
29
3.48
2.70
2.1
1.6
40.00
24.20
u/ml
—
5
5
22
106
2.11
2.65
1.5
1.3
—
—
—
0
0
22
106
2.11
2.65
1.5
1.3
—
—
—
0
0
11
35
3.17
2.65
2.1
1.7
—
—
—
0
0
13
49
2.68
2.63
3.0
2.2
—
—
—
0
0
712
6913
1.92
2.60
35.8
18.7
39.46
39.82
%
0.85
671
6449
712
6915
1.91
2.57
34.6
18.7
257.36
256.85
e9/l
0.07
699
6735
19
88
2.19
2.53
1.0
1.0
1.62
1.86
u/ml
—
9
37
712
6918
1.90
2.52
34.6
18.7
4.40
4.46
e12/l
2.39
699
6720
437
3946
1.26
2.50
3.2
3.1
—
—
—
0
0
21
102
2.09
2.49
1.4
1.2
—
—
—
0
0
712
6921
1.88
2.47
34.9
18.8
131.92
133.92
g/l
3.32
704
6813
12
45
2.69
2.46
2.3
1.5
—
—
—
0
0
12
45
2.69
2.46
2.3
1.5
—
—
—
0
0
12
45
2.69
2.46
2.3
1.5
—
—
—
0
0
644
6131
1.40
2.41
5.1
4.3
4.55
4.78
mmol/l
7.24
602
5676
9
27
3.36
2.40
1.9
3.1
656.11
996.22
u/ml
—
9
27
32
183
1.78
2.39
1.5
1.4
235.85
303.47
ug/g
1.20
20
106
8
22
3.66
2.37
1.3
1.1
—
—
—
0
0
8
22
3.66
2.37
1.3
1.1
—
—
—
0
0
640
6092
1.39
2.35
5.0
4.3
1.49
1.54
mmol/l
2.15
599
5604
619
5869
1.34
2.26
4.4
3.8
1.29
1.26
mmol/l
0.54
577
5364
653
6244
1.41
2.26
5.5
4.8
2.63
2.82
mmol/l
6.68
610
5745
67
469
1.47
2.24
21.1
5.8
1.24
1.35
mmol/l
0.58
67
457
9
29
3.13
2.23
1.2
1.2
—
—
—
0
0
9
29
3.13
2.23
1.2
1.2
—
—
—
0
0
22
115
1.94
2.17
2.5
2.3
266.06
63.27
ug/min
0.46
14
70
20
101
2.01
2.17
1.3
1.3
—
—
—
0
0
14
61
2.32
2.15
1.0
1.0
1.48
1.49
g/l
0.03
14
56
14
61
2.32
2.15
1.6
1.5
—
—
—
0
0
44
286
1.57
2.08
3.1
2.4
0.16
0.17
e6/l
0.04
44
277
24
132
1.85
2.06
1.3
1.3
—
—
—
0
0
15
69
2.20
2.05
1.3
1.4
—
—
—
0
0
32
194
1.68
1.99
1.4
1.3
168.49
245.87
miu/ml
0.99
15
91
633
6050
1.33
1.96
5.0
4.4
5.92
5.87
mmol/l
0.44
593
5511
62
441
1.44
1.94
2.3
2.1
24.95
6.95
ug/l
0.61
51
385
6
16
3.77
1.94
1.2
2.0
—
—
—
0
0
9
33
2.75
1.93
1.4
1.5
89.44
72.79
umol/l
—
9
33
9
33
2.75
1.93
1.6
1.3
2.48
2.01
mmol/l
—
9
33
163
1346
1.27
1.92
5.3
4.0
1.01
1.02
kg/l
0.28
21
206
86
651
1.36
1.89
19.0
5.8
102.99
104.07
mmol/l
1.26
86
651
41
271
1.54
1.83
1.3
1.3
23.58
28.96
iu/l
0.43
31
226
19
102
1.89
1.77
3.3
2.2
14.50
15.85
%
0.92
11
46
16
81
2.00
1.75
1.1
1.1
—
—
—
0
0
7
24
2.93
1.72
1.0
1.3
—
—
—
0
0
16
83
1.95
1.65
1.3
1.4
—
—
—
0
0
14
69
2.05
1.65
1.4
1.7
40.71
60.92
%
—
7
48
65
482
1.38
1.64
1.3
1.2
158.89
159.10
iu/ml
0.00
24
196
5
14
3.59
1.62
1.6
1.1
—
—
—
0
0
15
77
1.97
1.60
1.7
1.4
—
—
—
0
0
32
210
1.55
1.51
1.6
1.7
—
—
—
0
0
6
21
2.87
1.51
1.0
1.0
—
—
—
0
0
10
45
2.24
1.47
1.6
1.4
—
—
—
0
0
11
52
2.13
1.45
1.9
1.2
—
—
—
0
0
14
73
1.94
1.44
1.0
1.1
—
—
—
0
0
78
612
1.31
1.39
12.4
7.3
0.49
1.23
mmol/l
0.74
67
499
245
2198
1.17
1.23
3.9
3.3
59.52
33.71
ng/l
0.65
175
1466
12
64
1.89
1.18
1.2
1.4
31.08
31.77
pg
0.14
12
64
33
235
1.42
1.10
1.8
2.2
8963.39
4272.13
u/l
0.23
14
106
5
21
2.39
1.09
2.0
2.9
46520.00
36823.81
ug/l
—
5
21
37
275
1.36
0.99
20.6
7.8
23.65
24.45
mmol/l
0.65
37
266
11
61
1.82
0.99
1.9
1.4
—
—
—
0
0
11
61
1.82
0.99
1.9
1.4
—
—
—
0
0
79
653
1.24
0.97
1.5
1.7
1.58
1.42
%
0.96
73
578
7
36
1.95
0.97
4.0
1.5
—
—
—
0
0
7
37
1.90
0.94
1.1
1.1
—
—
—
0
0
27
195
1.40
0.87
1.3
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
30
2.01
0.87
1.2
1.2
—
—
—
0
0
8
44
1.83
0.86
1.1
1.2
0.94
1.31
nmol/l
—
8
39
27
196
1.39
0.85
1.3
1.1
—
—
—
0
0
6
31
1.94
0.84
1.5
1.3
—
—
—
0
0
6
32
1.88
0.82
1.5
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
2.0
—
36.31
—
0
19
0
26
0.00
0.78
0.0
1.2
—
111.38
—
0
21
24
175
1.38
0.75
2.2
1.8
3.40
5.16
iu/l
—
6
59
5
25
2.01
0.72
1.0
1.5
—
—
—
0
0
5
25
2.01
0.72
1.0
1.1
—
—
—
0
0
11
68
1.63
0.72
3.3
2.0
164.27
210.92
pmol/l
0.31
11
63
53
639
0.82
0.71
1.9
2.0
—
—
—
0
0
5
26
1.93
0.70
1.0
1.2
82.72
156.06
iu/ml
—
5
26
22
161
1.38
0.69
2.2
1.7
—
—
—
0
0
7
42
1.67
0.68
1.1
2.0
—
—
—
0
0
10
62
1.62
0.65
3.1
3.1
—
—
—
0
0
6
104
0.57
0.62
1.0
1.1
—
16.38
—
0
16
5
30
1.67
0.61
2.8
5.0
—
—
—
0
0
60
700
0.84
0.59
1.9
2.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
0.27
—
0
17
6
36
1.67
0.56
1.5
1.3
—
—
—
0
0
40
330
1.22
0.56
1.8
1.4
—
—
—
0
0
6
40
1.50
0.51
1.0
1.0
—
—
—
0
0
9
65
1.39
0.50
1.2
1.1
—
—
—
0
0
42
353
1.20
0.50
1.7
1.3
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
7
45
1.56
0.49
1.6
1.2
1.65
1.16
promille
—
7
34
81
722
1.14
0.48
9.0
6.1
—
—
—
0
0
37
310
1.20
0.46
1.5
1.7
—
—
—
0
0
7
51
1.38
0.44
1.1
1.4
30438.86
138076.33
e6/l
—
7
33
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
2.2
1.3
26.00
30.31
umol/l
—
5
32
21
261
0.80
0.42
2.0
1.4
—
—
—
0
0
18
228
0.78
0.42
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
22.43
—
0
17
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
58
515
1.14
0.38
2.9
2.7
0.88
0.72
ug/l
0.30
41
307
15
191
0.78
0.37
1.1
1.5
—
—
—
0
0
14
179
0.78
0.36
1.1
1.4
—
—
—
0
0
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
—
—
—
0
0
136
1277
1.08
0.33
1.6
1.4
—
—
—
0
0
77
705
1.10
0.32
3.9
4.0
24.66
21.68
%
0.85
44
298
28
326
0.85
0.31
1.3
1.5
—
—
—
0
0
28
243
1.16
0.27
1.5
1.7
3.14
2.66
mg/l
0.30
23
184
12
96
1.25
0.24
1.0
1.1
—
—
—
0
0
15
180
0.83
0.24
1.1
1.4
—
—
—
0
0
15
180
0.83
0.24
1.1
1.4
—
—
—
0
0
6
84
0.71
0.24
1.2
1.4
6.96
7.23
mmol/l
—
6
71
17
143
1.19
0.23
1.4
1.2
11.11
9.85
u/l
0.17
12
113
15
179
0.83
0.23
1.1
1.4
—
—
—
0
0
12
97
1.24
0.23
1.4
1.8
—
—
—
0
0
27
238
1.14
0.22
1.4
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
68
636
1.08
0.20
2.7
3.9
46.04
26.10
ug/l
0.18
54
521
82
779
1.06
0.16
4.6
4.4
33.13
33.13
%
0.00
62
518
45
422
1.07
0.13
2.0
3.5
28.48
50.22
u/ml
1.14
45
407
31
335
0.92
0.13
1.1
1.0
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
8
74
1.08
0.07
1.4
1.3
3.34
2.88
ug/l
—
8
62
18
167
1.08
0.07
1.4
1.2
—
—
—
0
0
9
103
0.87
0.06
1.9
1.6
—
—
—
0
0
52
536
0.97
0.05
1.6
1.6
—
—
—
0
0
41
397
1.03
0.04
1.7
1.8
—
—
—
0
0
23
221
1.04
0.03
1.2
1.8
—
—
—
0
0
25
257
0.97
0.01
26.4
2.3
1.10
1.21
%
0.36
25
257
11
116
0.95
0.00
1.4
1.5
—
—
—
0
0
16
154
1.04
0.00
1.0
1.1
—
—
—
0
0
16
156
1.03
0.00
1.4
1.5
—
—
—
0
0
13
132
0.98
0.00
1.5
1.7
—
—
—
0
0
16
158
1.01
0.00
1.1
1.3
—
—
—
0
0
6
68
0.88
0.00
3.2
2.0
12.83
13.22
%
—
6
68
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
81
0.99
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
5.39
—
0
8
0
8
0.00
-0.00
0.0
1.5
—
0.63
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
11.66
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_LOCALDCONNECTISSUEOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALDCONNECTISSUEOTH | 1.609 [1.39, 1.87] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 414 out of 2658 females with L12_LOCALDCONNECTISSUEOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALDCONNECTISSUEOTH | 1.885 [1.5, 2.36] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 878 males with L12_LOCALDCONNECTISSUEOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_LOCALDCONNECTISSUEOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.253% |
| 5 | 0.812% | 1.947% |
| 10 | 1.838% | 5.043% |
| 15 | 3.557% | 9.345% |
| 20 | 6.019% | 15.559% |
Relationships between endpoints
↥Index endpoint: L12_LOCALDCONNECTISSUEOTH – Other localized connective tissue disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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