localised scleroderma: Localized scleroderma is the skin localized form of scleroderma (see this term) characterized by fibrosis of the skin causing cutaneous plaques or strips.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
547 |
4. Check minimum number of eventsNone |
547 |
5. Include endpointsNone |
547 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L94
- Name in latin
- Scleroderma circumscriptum
Similar endpoints
↥List of similar endpoints to
Localized scleroderma [morphea]
based on the number of shared cases.
Similar with more cases:
- Other localized connective tissue disorders
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3160 | 2461 | 682 |
| Only index persons | 2953 | 2322 | 631 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.02 |
| Only index persons | 0.07 | 0.09 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.33 | 54.73 | 43.53 |
| Only index persons | 51.81 | 54.19 | 43.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 435 | 91 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.04 |
| Median age at first event (years) | 55.94 | 56.31 | 54.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 547
- Matched controls
- 5470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
4503599627370496.0
307.7
526
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.1
225.6
220
196
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
22.3
88.3
67
34
D07AD01
ATC
clobetasol; topical
5.6
79.2
205
527
D07AC01
ATC
betamethasone; topical
4.4
64.4
325
1365
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.3
55.1
202
661
L04AX03
ATC
methotrexate; systemic
4.8
45.2
119
298
P01BA02
ATC
hydroxychloroquine; oral
5.1
44.7
109
256
E0000UV, ,
ATC
3.4
42.1
329
1695
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
151.3
40.3
42
*
XQ848
NOMESCO Finland
Dermatological photography
10.2
40.3
47
50
D07AC13
ATC
mometasone; topical
3.1
34.9
237
1096
TQW80
NOMESCO Finland
Local dermatologic skincare
10.9
31.0
34
33
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.3
27.1
58
120
70100
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Seleroderma circumscriptum NUD
+∞
25.2
24
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.5
24.8
100
333
L94.1
ICD-10 Finland
Linear scleroderma
+∞
24.1
23
*
D02AE01
ATC
carbamide; topical
4.4
23.0
62
155
C08CA05
ATC
nifedipine; systemic
4.4
21.1
56
138
M34.1
ICD-10 Finland
CR(E)ST syndrome
29.4
21.1
28
10
I73.0
ICD-10 Finland
Raynaud syndrome
8.0
21.0
29
38
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
+∞
19.9
19
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
18.9
18
*
E000001, ,
ATC
2.5
18.4
149
715
D07AB08
ATC
desonide; topical
3.0
17.9
89
333
M34.0
ICD-10 Finland
Progressive systemic sclerosis
98.3
17.7
19
*
XPX04
NOMESCO Finland
Angioscopy
93.0
16.7
18
*
XX9XE
NOMESCO Finland
Other ultrasound examination
18.7
16.6
25
14
D02AX
ATC
Other emollients and protectives
5.2
15.4
32
64
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
14.6
14
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.3
14.4
58
191
D05AX02
ATC
calcipotriol; topical
4.6
13.7
33
75
H02AB06
ATC
prednisolone; systemic
2.0
13.2
277
1881
L04AA06
ATC
mycophenolic acid; systemic
12.0
12.9
23
20
E000002, ,
ATC
2.5
11.3
77
336
L04AA01
ATC
[U] ciclosporin
9.9
10.8
21
22
L04AX01
ATC
azathioprine; systemic
3.9
10.7
32
86
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
10.7
176
1085
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.3
10.6
20
20
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
10.2
179
1123
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
26.6
9.8
13
5
M13.9
ICD-10 Finland
Arthritis, unspecified
2.8
9.6
50
190
L30.8
ICD-10 Finland
Other specified dermatitis
4.4
9.5
24
57
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
9.2
247
1749
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
19.0
9.0
13
7
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.9
8.6
19
40
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.5
8.5
19
26
M34
ICD-10 Finland
Systemic sclerosis
91.4
8.4
9
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
8.4
8
*
XQ845
NOMESCO Finland
Dermatoscopy
7.3
8.3
19
27
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
17.5
8.1
12
7
L93.0
ICD-10 Finland
Discoid lupus erythematosus
33.9
8.1
10
*
L92.0
ICD-10 Finland
Granuloma annulare
22.4
8.0
11
5
L04AD01
ATC
ciclosporin; systemic
6.7
7.9
19
29
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
7.8
59
269
S99
ICPC
Skin disease other
4.4
7.7
19
44
E000007, ,
ATC
2.7
7.5
41
160
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
81.2
7.4
8
*
E000006, ,
ATC
2.4
7.4
50
217
SPAT1262
SPAT
Handing over of treatment supplies
2.0
7.4
92
511
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.2
7.3
19
46
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
7.3
7
*
L94.8
ICD-10 Finland
Other specified localized connective tissue disorders
+∞
7.3
7
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.0
7.2
20
51
S01
ICPC
Pain/tenderness of skin
3.1
7.2
30
101
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
7.2
130
813
L91.0
ICD-10 Finland
Hypertrophic scar
20.3
7.2
10
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
7.0
55
255
R60.0
ICD-10 Finland
Localized oedema
2.1
7.0
71
366
ZXC50
NOMESCO Finland
Cryotherapy
3.8
7.0
21
57
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
6.8
31
110
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
4.4
6.8
17
40
SBA00
NOMESCO Finland
Microbiological examinations
3.8
6.7
20
54
R06AE07
ATC
cetirizine; oral
1.6
6.7
253
1914
L01BA01
ATC
methotrexate; systemic
3.3
6.6
25
79
A02BC02
ATC
pantoprazole; systemic
1.6
6.5
363
3002
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
6.4
113
698
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
6.4
46
206
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
6.1
6.3
16
27
N03AX16
ATC
[U] pregabalin
1.7
6.3
132
857
J01FF01
ATC
clindamycin; systemic
1.7
6.3
146
975
H02AB04
ATC
methylprednisolone; systemic
1.9
6.3
81
454
M35.1
ICD-10 Finland
Other overlap syndromes
18.3
6.3
9
5
D05AX52
ATC
calcipotriol, combinations; topical
2.7
6.3
32
121
B07.9
ICD-10 Finland
Verruca simplex
3.2
6.2
24
77
R06AX27
ATC
desloratadine; oral
1.6
6.1
165
1143
M25.5
ICD-10 Finland
Pain in joint
1.6
6.0
187
1342
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
110
12.83
107.13
1.3
1.2
16.91
13.40
u/ml
—
7
7
130
175
9.43
95.41
1.4
1.3
0.30
2.04
u/ml
—
6
14
106
148
8.64
74.71
1.4
1.2
72.85
28.68
u/ml
—
8
5
103
141
8.77
73.76
1.4
1.2
11.51
2.82
u/ml
0.97
15
14
103
143
8.64
72.87
1.4
1.2
10.00
7.14
u/ml
0.14
17
22
81
113
8.24
56.61
1.4
1.2
28.96
55.61
u/ml
—
8
9
87
158
6.36
47.38
1.9
1.7
—
—
—
0
0
119
333
4.29
38.88
2.5
2.5
18.78
28.55
au/ml
—
10
21
405
2617
3.11
30.58
8.8
8.7
3.73
3.98
e9/l
2.16
371
2278
352
2147
2.79
28.95
7.3
5.2
55.82
56.82
%
0.95
339
1999
354
2166
2.80
28.92
7.6
5.5
29.65
28.74
%
0.92
342
2018
35
40
9.28
28.33
1.3
1.2
—
—
—
0
0
35
40
9.28
28.33
1.3
1.2
—
—
—
0
0
35
41
9.05
27.80
1.3
1.1
—
—
—
0
0
35
41
9.05
27.80
1.3
1.1
—
—
—
0
0
35
41
9.05
27.80
1.3
1.1
—
—
—
0
0
27
31
9.11
21.70
1.4
1.4
5.50
8.52
u/l
0.63
21
26
221
1290
2.20
17.09
2.8
2.0
167.74
155.42
u/l
0.12
210
1213
83
313
2.95
16.39
2.9
2.8
10.97
10.29
g/l
0.73
72
290
444
3474
2.48
15.68
6.5
4.0
11.57
11.82
mm/h
0.15
423
3190
21
12
18.15
13.93
1.3
1.1
8.86
9.88
ug/l
0.28
21
12
187
1106
2.05
13.29
2.9
2.3
1134.30
7016.75
umol/l
3.29
165
954
24
44
5.66
12.69
2.3
2.0
—
—
—
0
0
437
3521
2.20
12.37
8.4
6.7
75.96
76.83
u/l
0.18
422
3276
308
2252
1.84
10.93
4.2
3.6
0.00
0.00
estimate
-0.00
68
457
229
1540
1.84
10.57
3.9
3.4
171.81
93.87
e6/l
0.31
151
1047
277
1999
1.78
9.91
2.7
2.2
78.75
78.42
nmol/l
0.07
248
1780
145
861
1.93
9.74
1.5
1.3
13.43
31.56
iu/ml
5.29
44
278
27
69
4.06
9.70
1.4
1.1
2.33
1.63
u/ml
0.47
12
24
280
2046
1.75
9.43
3.1
2.6
93.27
92.54
ug/l
0.03
260
1862
302
2257
1.75
9.38
5.7
4.9
0.00
0.00
estimate
-0.00
61
429
113
624
2.02
9.31
2.5
2.0
14.19
13.03
umol/l
1.00
106
571
106
575
2.05
9.17
2.4
1.9
2.39
2.42
g/l
0.16
94
527
26
70
3.85
8.71
1.5
1.1
4.29
3.69
u/ml
0.18
14
32
302
2286
1.72
8.70
4.3
3.7
0.00
0.01
estimate
0.50
62
420
67
312
2.31
8.48
4.4
2.8
135.27
164.32
ng/l
0.31
61
288
443
3763
1.93
8.39
5.2
4.3
14.74
14.76
pmol/l
0.06
414
3417
291
2208
1.68
8.08
7.5
5.9
1.23
1.22
mmol/l
0.81
249
1881
169
1109
1.76
8.01
1.4
1.3
0.90
1.63
u/ml
0.79
41
286
175
1160
1.75
8.01
3.0
2.8
657.69
997.34
ng/l
1.54
146
970
142
887
1.81
7.95
2.5
2.3
5.51
7.06
e6/l
0.66
123
800
95
532
1.95
7.43
2.6
2.0
25.01
22.24
%
1.07
78
450
173
1172
1.70
7.19
3.1
2.8
0.25
0.42
e6/l
1.11
125
860
492
4405
2.16
7.02
6.4
5.0
1.92
1.86
mu/l
0.56
460
4022
25
78
3.31
6.78
2.2
3.4
56.48
56.55
%
0.01
25
78
184
1286
1.65
6.71
3.2
2.8
30.02
108.76
e6/l
0.83
139
966
65
329
2.11
6.70
2.4
2.9
67.22
67.51
g/l
0.10
59
297
368
3045
1.64
6.65
5.4
4.4
22.00
1621.75
e6/l
—
5
48
242
1821
1.59
6.46
2.2
1.9
98.18
95.95
pmol/l
0.30
116
859
213
1558
1.60
6.39
2.8
3.2
2.35
2.36
mmol/l
0.42
195
1356
24
76
3.26
6.36
2.2
3.3
3.79
4.04
e9/l
0.28
24
76
128
835
1.70
5.99
1.5
1.3
10.19
12.45
u/ml
0.15
49
310
205
1512
1.57
5.82
3.9
2.8
—
—
—
0
0
242
1854
1.55
5.79
4.9
3.9
35.92
35.95
g/l
0.03
229
1725
259
2017
1.54
5.74
6.6
5.2
1.22
1.22
mmol/l
0.56
237
1835
153
1061
1.61
5.60
2.5
2.1
3.09
3.12
mg/l
0.04
134
892
188
1371
1.57
5.55
3.4
2.9
6.92
6.98
mmol/l
0.06
157
1154
189
1382
1.56
5.51
2.7
2.3
53.44
63.89
u/l
1.55
172
1265
484
4395
1.88
5.32
14.3
11.5
82.42
82.23
ml/min/173m2
0.07
418
3516
34
146
2.42
5.19
2.0
1.6
592.00
200.00
titre
—
5
7
22
76
2.97
5.09
1.4
1.2
—
—
—
0
0
354
2994
1.52
5.04
3.3
2.8
46.36
42.53
u/l
0.30
333
2783
83
504
1.76
4.97
6.3
3.7
1.03
1.04
mmol/l
0.09
78
457
526
4944
2.66
4.97
13.9
9.6
25.44
24.77
u/l
0.56
511
4748
26
100
2.68
4.96
1.3
1.4
—
—
—
0
0
108
711
1.65
4.81
2.7
2.5
0.65
1.20
e6/l
2.77
57
378
224
1746
1.48
4.66
4.5
3.7
—
—
—
0
0
53
285
1.95
4.65
1.4
1.2
466.87
235.84
u/ml
0.31
46
264
17
53
3.28
4.65
1.2
1.4
—
—
—
0
0
17
53
3.28
4.65
1.2
1.4
—
—
—
0
0
499
4616
1.92
4.59
17.5
12.1
19.95
21.29
mg/l
0.40
416
3556
510
4755
2.07
4.55
18.5
13.8
3.93
3.94
mmol/l
0.39
498
4601
17
54
3.22
4.52
1.2
1.4
—
—
—
0
0
20
71
2.89
4.43
1.4
1.2
—
—
—
0
0
17
55
3.16
4.39
1.2
1.4
—
—
—
0
0
17
55
3.16
4.39
1.2
1.3
—
—
—
0
0
17
55
3.16
4.39
1.2
1.4
—
—
—
0
0
508
4740
2.01
4.35
18.1
13.7
139.71
139.74
mmol/l
0.07
496
4602
171
1278
1.49
4.32
1.7
1.6
1.42
1.35
mmol/l
0.45
134
1084
176
1335
1.47
4.10
4.1
3.6
5.86
8.16
mg/mmol
0.56
102
768
282
2335
1.43
4.09
5.5
5.5
10.25
10.44
umol/l
0.15
265
2200
163
1222
1.48
4.01
5.0
4.0
0.00
0.00
estimate
-0.00
64
422
34
164
2.14
4.01
1.7
1.8
—
—
—
0
0
98
672
1.56
3.65
4.7
2.8
0.81
0.81
mmol/l
0.08
90
631
125
904
1.50
3.64
1.4
1.5
—
—
—
0
0
18
68
2.70
3.59
1.1
1.0
—
—
—
0
0
8
13
6.23
3.51
1.3
1.0
—
—
—
0
0
446
4076
1.51
3.45
20.7
14.9
14.98
14.87
%
0.15
440
4007
141
1055
1.45
3.45
1.4
1.5
22.81
21.67
nmol/l
0.29
120
891
30
150
2.06
3.26
1.6
1.6
—
—
—
0
0
51
307
1.73
3.18
1.5
1.4
—
—
—
0
0
232
1916
1.37
3.16
13.6
12.3
1.23
1.20
inr
0.23
63
574
95
669
1.51
3.13
1.9
1.8
—
—
—
0
0
535
5161
2.67
3.06
25.7
18.4
258.71
257.77
e9/l
0.12
527
5025
535
5161
2.67
3.06
25.9
18.3
39.96
39.92
%
0.05
505
4830
535
5164
2.64
3.00
25.7
18.4
4.47
4.46
e12/l
0.05
527
5012
460
4266
1.49
2.96
6.8
5.3
39.65
39.05
mmol/mol
0.69
435
3948
535
5166
2.62
2.96
25.9
18.5
133.90
133.91
g/l
0.00
530
5086
31
164
1.94
2.91
2.3
1.7
—
—
—
0
0
131
1002
1.40
2.79
5.3
4.0
1.01
1.02
kg/l
0.22
14
142
123
932
1.41
2.77
1.5
1.7
86538887.06
16078880.19
pmol/l
0.38
104
765
24
118
2.08
2.76
1.7
4.0
1.26
2.63
ratio
—
5
10
10
29
3.49
2.70
1.2
1.2
—
—
—
0
0
24
120
2.05
2.65
2.1
4.0
29.94
92.43
mg/l
0.64
19
98
7
15
4.71
2.60
1.9
1.7
118.43
51.83
ug/l
—
7
15
16
69
2.36
2.50
1.0
1.0
1.76
1.65
u/ml
—
8
33
293
2564
1.31
2.49
5.0
4.1
6.77
6.52
mmol/l
1.17
278
2358
19
89
2.18
2.47
2.8
2.2
1.50
1.57
mg/l
0.11
19
80
46
291
1.63
2.43
9.7
4.5
9.82
8.59
mmol/l
0.74
40
275
8
22
3.67
2.37
1.8
1.6
—
—
—
0
0
48
310
1.60
2.34
3.4
3.3
4.63
4.55
pmol/l
0.07
42
275
62
426
1.51
2.31
2.9
3.2
—
—
—
0
0
20
99
2.06
2.29
1.2
1.3
—
—
—
0
0
6
13
4.65
2.27
1.3
1.2
—
—
—
0
0
6
13
4.65
2.27
1.3
1.2
—
—
—
0
0
106
810
1.38
2.26
4.8
3.4
21.06
235.51
ng/l
4.15
78
598
7
18
3.92
2.26
1.3
1.3
—
—
—
0
0
7
18
3.92
2.26
1.3
1.3
—
—
—
0
0
9
29
3.14
2.23
1.6
3.2
—
—
—
0
0
18
87
2.11
2.19
2.3
2.0
120.64
129.33
g/l
1.24
11
60
19
94
2.06
2.18
1.5
1.7
11797.85
19386.84
e6/l
0.33
13
61
103
789
1.38
2.16
1.7
1.7
1132.91
1156.43
nmol/l
0.07
77
576
55
375
1.52
2.14
1.3
1.2
132.58
151.62
iu/ml
0.15
19
153
108
836
1.36
2.12
2.7
2.7
2.46
2.45
mmol/l
0.15
97
728
11
43
2.59
2.09
1.4
1.9
34.20
60.14
%
—
5
29
53
362
1.51
2.05
3.2
3.3
1.24
1.23
mmol/l
0.43
46
315
21
112
1.91
1.99
1.2
1.1
—
—
—
0
0
58
407
1.48
1.98
2.6
2.2
25.94
36.10
u/l
1.57
51
340
21
114
1.88
1.90
2.5
2.4
—
—
—
0
0
86
655
1.37
1.88
3.1
2.6
5.09
3.86
e6/l
0.29
37
324
49
336
1.50
1.87
2.5
2.5
62.56
69.66
ml/min/173m2
0.45
16
137
9
34
2.67
1.87
1.2
1.4
—
—
—
0
0
476
4529
1.39
1.85
5.0
4.4
5.88
5.84
mmol/l
0.28
446
4124
21
115
1.86
1.85
1.2
1.2
—
—
—
0
0
9
35
2.60
1.81
2.2
1.7
—
—
—
0
0
53
375
1.46
1.75
2.1
2.1
0.23
0.22
g/l
0.97
47
352
6
18
3.36
1.75
1.0
1.0
—
—
—
0
0
9
36
2.52
1.74
1.9
1.2
—
—
—
0
0
172
1457
1.26
1.74
3.3
2.9
28.47
29.99
u/l
0.52
167
1385
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
96
1.90
1.72
3.9
2.4
0.45
0.39
u/ml
0.17
12
57
479
4587
1.36
1.56
4.9
4.3
4.62
4.80
mmol/l
3.55
447
4248
326
2989
1.22
1.53
3.3
3.1
—
—
—
0
0
5
15
3.35
1.52
3.2
1.8
—
—
—
0
0
5
15
3.35
1.52
3.2
1.8
—
—
—
0
0
5
15
3.35
1.52
3.2
1.8
—
—
—
0
0
486
4669
1.37
1.51
5.5
4.8
2.71
2.83
mmol/l
2.44
453
4302
32
211
1.55
1.49
1.2
1.3
22.27
29.15
iu/l
0.75
23
179
476
4561
1.34
1.49
4.8
4.2
1.51
1.55
mmol/l
1.04
443
4208
9
38
2.39
1.46
2.2
1.7
—
—
—
0
0
460
4390
1.30
1.46
4.2
3.8
1.30
1.26
mmol/l
0.63
426
4021
7
28
2.52
1.45
1.6
1.4
92.00
69.93
umol/l
—
7
28
240
2143
1.21
1.44
2.9
2.4
—
—
—
0
0
49
358
1.40
1.40
5.2
2.8
98.85
71.14
ng/l
1.36
44
319
61
467
1.34
1.32
1.7
1.8
—
—
—
0
0
14
76
1.86
1.31
3.4
2.3
14.64
16.07
%
—
8
34
60
460
1.34
1.29
1.7
1.7
—
—
—
0
0
24
155
1.57
1.25
1.3
1.3
193.11
254.20
miu/ml
0.60
12
75
9
45
2.02
1.24
1.2
1.1
—
—
—
0
0
33
232
1.45
1.18
1.3
1.7
—
—
—
0
0
11
57
1.95
1.17
1.0
1.1
—
—
—
0
0
7
30
2.35
1.12
1.0
1.3
—
—
—
0
0
31
219
1.44
1.09
4.4
2.9
2.37
1.90
mmol/l
0.22
21
167
5
21
2.39
1.09
1.8
1.2
3.02
2.00
mmol/l
—
5
21
46
351
1.34
1.05
4.1
2.7
1.61
2.29
mmol/l
0.60
38
279
30
213
1.43
1.04
3.1
2.3
0.13
0.17
e6/l
0.30
30
206
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
12
68
1.78
1.01
2.3
1.5
—
—
—
0
0
11
188
0.58
1.01
4.1
2.2
1.03
1.16
%
0.36
11
188
15
92
1.65
0.98
2.1
1.5
—
—
—
0
0
10
54
1.87
0.97
1.5
1.4
—
—
—
0
0
9
52
1.74
0.92
1.9
1.3
—
—
—
0
0
10
55
1.83
0.92
1.1
1.1
—
—
—
0
0
10
55
1.83
0.92
1.2
1.4
—
—
—
0
0
6
28
2.16
0.91
1.2
1.2
1.12
1.44
nmol/l
—
6
23
12
71
1.71
0.89
1.6
1.6
—
—
—
0
0
21
144
1.48
0.88
1.5
1.4
227.08
305.92
ug/g
1.03
12
83
6
30
2.01
0.87
3.0
2.3
—
—
—
0
0
14
88
1.61
0.85
3.1
3.1
24.76
25.57
mmol/l
0.30
14
88
15
97
1.56
0.82
2.1
1.5
—
—
—
0
0
23
164
1.42
0.81
1.6
1.7
—
—
—
0
0
6
33
1.83
0.79
1.2
1.8
—
—
—
0
0
6
33
1.83
0.79
1.0
1.0
—
—
—
0
0
0
26
0.00
0.78
0.0
1.5
—
—
—
0
0
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
6
34
1.77
0.76
1.7
1.2
1.77
1.23
promille
—
6
24
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
3.19
—
0
23
10
59
1.71
0.76
1.3
1.2
—
109.38
—
0
8
5
24
2.09
0.74
3.2
1.6
—
—
—
0
0
5
24
2.09
0.74
3.2
1.6
—
—
—
0
0
116
1028
1.16
0.72
2.0
1.6
0.79
1.05
mg/l
1.46
91
775
11
68
1.63
0.72
5.0
2.9
0.91
1.54
%
0.46
11
61
18
126
1.44
0.71
2.3
1.7
—
—
—
0
0
32
249
1.30
0.69
1.5
1.7
—
—
—
0
0
5
27
1.86
0.68
4.0
1.6
—
—
—
0
0
51
422
1.23
0.67
4.1
4.0
23.93
21.67
%
0.47
27
176
7
43
1.64
0.67
1.7
1.4
—
—
—
0
0
5
29
1.73
0.64
1.0
1.0
—
1.14
—
0
19
173
1595
1.12
0.61
3.3
3.4
65.03
32.65
ng/l
0.55
122
1052
13
88
1.49
0.61
1.9
1.7
—
—
—
0
0
15
105
1.44
0.60
2.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
4.3
—
207.70
—
0
20
24
184
1.32
0.59
2.0
2.1
540.37
5060.14
u/l
1.42
12
81
8
53
1.52
0.58
1.3
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
5.9
—
62.17
—
0
6
42
503
0.82
0.57
2.1
2.0
—
—
—
0
0
6
37
1.63
0.55
1.5
1.3
—
—
—
0
0
8
122
0.65
0.55
1.8
1.2
—
—
—
0
0
11
74
1.50
0.53
1.2
1.4
—
—
—
0
0
112
1016
1.13
0.52
1.6
1.4
—
—
—
0
0
11
75
1.48
0.51
1.5
1.6
—
—
—
0
0
10
68
1.48
0.47
2.2
1.5
—
—
—
0
0
10
68
1.48
0.47
2.2
1.5
—
—
—
0
0
37
312
1.20
0.44
3.1
2.7
0.95
0.72
ug/l
0.27
25
187
7
51
1.38
0.44
3.0
3.1
—
—
—
0
0
19
148
1.29
0.44
1.1
1.1
—
—
—
0
0
5
31
1.62
0.43
1.8
1.4
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
—
—
0
0
19
149
1.29
0.42
1.1
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
35.87
—
0
11
0
18
0.00
0.40
0.0
3.5
—
—
—
0
0
0
18
0.00
0.40
0.0
3.5
—
—
—
0
0
113
1053
1.09
0.34
3.1
2.1
—
—
—
0
0
23
191
1.21
0.34
1.3
1.4
—
—
—
0
0
49
548
0.88
0.32
2.0
2.1
—
—
—
0
0
61
554
1.11
0.30
5.9
6.1
—
—
—
0
0
37
325
1.15
0.30
2.2
3.2
23.56
55.98
u/ml
1.63
37
316
15
185
0.81
0.30
1.5
1.4
—
—
—
0
0
7
55
1.28
0.30
1.4
1.3
3.38
2.68
ug/l
—
7
47
10
76
1.32
0.28
1.0
1.1
—
—
—
0
0
8
62
1.29
0.28
1.3
1.3
—
—
—
0
0
31
272
1.15
0.26
1.7
1.3
—
—
—
0
0
12
149
0.80
0.26
1.2
1.4
—
—
—
0
0
5
75
0.66
0.26
1.0
1.1
—
15.60
—
0
10
13
158
0.82
0.24
1.1
1.5
—
—
—
0
0
5
38
1.32
0.23
3.2
1.6
—
—
—
0
0
5
38
1.32
0.23
3.2
1.6
—
—
—
0
0
5
38
1.32
0.23
3.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
30
335
0.89
0.21
11.8
5.5
1.26
1.33
mmol/l
0.17
30
328
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
107.00
—
0
6
0
12
0.00
0.21
0.0
1.0
—
96.33
—
0
6
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
5.99
—
0
7
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
23.83
—
0
14
6
53
1.13
0.18
3.2
2.1
12.83
13.21
%
—
6
53
43
466
0.92
0.18
2.7
4.0
69.07
18.60
ug/l
0.34
35
378
38
414
0.91
0.18
1.7
1.7
—
—
—
0
0
8
72
1.11
0.16
1.5
1.1
—
—
—
0
0
9
82
1.10
0.15
1.7
1.4
—
—
—
0
0
9
82
1.10
0.15
1.7
1.4
—
—
—
0
0
13
150
0.86
0.15
1.2
1.4
—
—
—
0
0
13
150
0.86
0.15
1.2
1.4
—
—
—
0
0
14
122
1.15
0.14
1.0
1.1
—
—
—
0
0
13
149
0.87
0.13
1.2
1.4
—
—
—
0
0
22
242
0.91
0.13
1.5
1.5
—
—
—
0
0
35
326
1.08
0.12
1.9
2.2
44.25
5.77
ug/l
0.68
26
278
19
171
1.12
0.12
1.1
1.9
—
—
—
0
0
12
104
1.16
0.12
1.3
1.7
—
—
—
0
0
14
124
1.13
0.11
1.1
1.3
—
—
—
0
0
34
319
1.07
0.10
1.7
1.7
—
—
—
0
0
60
575
1.05
0.10
4.5
4.4
31.73
32.86
%
0.33
45
370
5
44
1.14
0.10
1.2
1.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.4
—
—
—
0
0
28
262
1.07
0.09
1.1
1.0
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
19
206
0.92
0.09
1.9
1.4
—
—
—
0
0
5
61
0.82
0.08
1.2
1.5
6.83
7.61
mmol/l
—
5
49
8
76
1.05
0.07
1.4
1.3
—
—
—
0
0
25
264
0.94
0.06
1.2
1.5
—
—
—
0
0
10
90
1.11
0.05
1.3
1.4
—
—
—
0
0
13
122
1.07
0.02
1.3
1.6
—
—
—
0
0
45
441
1.02
0.02
11.0
7.6
0.50
1.41
mmol/l
0.70
39
359
48
473
1.02
0.01
9.4
5.8
104.50
104.07
mmol/l
0.30
48
473
11
115
0.96
0.00
1.5
1.3
469.18
483.94
mg/l
0.05
11
106
10
104
0.96
0.00
1.2
1.3
987.70
177.06
e6/l
—
10
84
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
6.74
—
0
5
0
5
0.00
-0.00
0.0
3.6
—
68.82
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
0.71
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
83.60
—
0
5
8
82
0.98
-0.00
1.8
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
98.00
—
0
5
5
49
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
110.71
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_LOCALSCLERODERMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALSCLERODERMA | 1.057 [0.89, 1.26] | 0.536 |
| Birth year | 0.991 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 2016 females with L12_LOCALSCLERODERMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALSCLERODERMA | 1.088 [0.8, 1.49] | 0.599 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 560 males with L12_LOCALSCLERODERMA died.
Mortality risk
Mortality risk for people of age
years, who have L12_LOCALSCLERODERMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.212% |
| 5 | 0.556% | 1.342% |
| 10 | 1.324% | 3.33% |
| 15 | 2.594% | 6.147% |
| 20 | 4.421% | 10.464% |
Relationships between endpoints
↥Index endpoint: L12_LOCALSCLERODERMA – Localized scleroderma [morphea]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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