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Localized scleroderma [morphea]

DOID EFO Endpoint Browser PheWeb

L12_LOCALSCLERODERMA

localised scleroderma: Localized scleroderma is the skin localized form of scleroderma (see this term) characterized by fibrosis of the skin causing cutaneous plaques or strips.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L94.0
  • Hospital discharge: ICD-9 — 7010A
  • Hospital discharge: ICD-8 — 70100
  • Cause of death: ICD-10 — L94.0
  • Cause of death: ICD-9 — 7010A
  • Cause of death: ICD-8 — 70100

2 out of 7 registries used, show all original rules.

519

4. Check minimum number of events

None

519

5. Include endpoints

None

519

6. Filter based on genotype QC (FinnGen only)

519

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L94
Name in latin
Scleroderma circumscriptum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3160 2461 682
Only index persons 2953 2322 631
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.02
Only index persons 0.07 0.09 0.02
Median age at first event (years)
Whole population 52.33 54.73 43.53
Only index persons 51.81 54.19 43.06

-FinnGen-

Key figures

All Female Male
Number of individuals 519 429 90
Unadjusted period prevalence (%) 0.13 0.15 0.04
Median age at first event (years) 55.18 55.81 52.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
473
Matched controls
4728
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
323.0
452
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.9
112.3
184
154
D07AD01
ATC
clobetasol; topical
6.1
50.7
161
369
D07AC01
ATC
betamethasone; topical
4.0
42.9
258
1099
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
24.2
38.0
54
25
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.5
36.5
153
453
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
103.1
35.3
38
*
D07AC13
ATC
mometasone; topical
3.5
32.3
209
882
E0000UV
ATC
NA
3.1
29.8
258
1321
P01BA02
ATC
hydroxychloroquine; oral
5.2
27.3
91
206
70100
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Seleroderma circumscriptum NUD
+∞
25.2
24
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.7
24.9
92
231
L94.1
ICD-10 Finland
Linear scleroderma
+∞
21.0
20
*
M34.1
ICD-10 Finland
CR(E)ST syndrome
39.2
21.0
26
7
XQ848
NOMESCO Finland
Dermatological photography
11.0
19.0
36
35
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
+∞
18.9
18
*
C08CA05
ATC
nifedipine; systemic
5.4
17.0
52
105
E000001
ATC
NA
2.7
16.6
136
617
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
6.0
16.3
46
84
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
15.7
15
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
88.0
15.7
17
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
14.7
81
281
D02AE01
ATC
carbamide; topical
4.2
14.5
57
150
H02AB06
ATC
prednisolone; systemic
2.1
13.9
239
1532
TQW80
NOMESCO Finland
Local dermatologic skincare
10.5
13.1
25
25
XX9XE
NOMESCO Finland
Other ultrasound examination
16.0
12.7
20
13
L92.0
ICD-10 Finland
Granuloma annulare
+∞
11.5
11
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
122.8
11.5
12
*
D07AB08
ATC
desonide; topical
2.9
10.9
71
275
D02AX
ATC
Other emollients and protectives
6.0
10.7
29
51
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
10.5
201
1298
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
10.4
148
851
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.4
10.2
50
159
I73.0
ICD-10 Finland
Raynaud syndrome
7.8
9.5
21
28
D05AX02
ATC
calcipotriol; topical
5.1
9.5
29
60
M34
ICD-10 Finland
Systemic sclerosis
+∞
9.4
9
*
L93.0
ICD-10 Finland
Discoid lupus erythematosus
+∞
9.4
9
*
L04AA01
ATC
[U] ciclosporin; systemic
9.8
9.3
18
19
E000002
ATC
NA
2.6
9.3
70
295
XPX04
NOMESCO Finland
Angioscopy
16.0
9.1
14
9
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
24.5
8.9
12
5
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
8.1
54
211
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.3
8.1
15
15
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
22.5
8.0
11
5
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
7.6
146
921
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
25.5
7.6
10
*
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
81.3
7.4
8
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
16.0
7.3
11
7
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.4
7.1
61
276
SPAT1262
SPAT
Handing over of treatment supplies
2.1
7.1
86
456
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.3
6.7
15
21
N03AX16
ATC
pregabalin; oral
1.9
6.5
111
668
J01FF01
ATC
clindamycin; systemic
1.8
6.5
122
760
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
70.7
6.4
7
*
L80
ICD-10 Finland
Vitiligo
70.7
6.4
7
*
E000003
ATC
NA
3.6
6.4
27
78
E000006
ATC
NA
2.6
6.4
45
184
L04AA06
ATC
mycophenolic acid; systemic
6.7
6.4
15
23
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
6.3
6
*
L94.8
ICD-10 Finland
Other specified localized connective tissue disorders
+∞
6.3
6
*
E000007
ATC
NA
2.7
6.1
39
151
M25.5
ICD-10 Finland
Pain in joint
1.7
6.1
144
962
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
6.0
40
159

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
151
10.92
104.73
1.4
1.2
—
—
—
0
0
233
590
6.35
94.16
1.8
1.3
995.1
557.3
titre
1.67
73
133
121
165
9.26
87.77
1.4
1.3
0.3
2.3
u/ml
—
6
12
94
138
8.10
63.22
1.4
1.2
13.1
2.8
u/ml
1.02
13
14
94
140
7.98
62.40
1.4
1.2
10.4
7.7
u/ml
0.12
14
23
112
311
4.32
37.00
2.5
2.5
23.1
18.3
au/ml
—
6
11
354
2101
3.15
33.07
7.5
5.3
0.5
0.6
e9/l
0.27
327
1818
360
2163
3.17
32.79
7.6
5.3
1.9
2.0
e9/l
0.55
336
1903
354
2114
3.12
32.45
7.6
5.3
0.0
0.0
e9/l
0.10
326
1826
359
2200
3.05
30.65
7.8
5.5
0.2
0.2
e9/l
0.37
332
1934
327
1914
2.92
30.26
7.6
5.3
0.8
0.7
%
0.54
316
1771
332
1996
2.84
28.53
7.8
5.6
8.4
8.4
%
0.07
322
1862
382
2478
3.05
28.33
8.9
8.6
3.7
4.0
e9/l
2.15
351
2169
330
1986
2.82
28.16
7.7
5.3
3.0
2.8
%
0.87
318
1839
335
2041
2.81
27.74
7.7
5.4
29.6
28.7
%
0.79
324
1896
333
2024
2.80
27.68
7.4
5.1
55.7
56.8
%
0.96
321
1887
259
1397
2.70
27.19
7.7
5.1
—
—
—
0
0
32
40
8.46
24.13
1.3
1.1
—
—
—
0
0
36
57
6.71
22.10
1.3
1.2
—
—
—
0
0
211
1235
2.19
16.23
2.8
2.0
171.4
157.4
u/l
0.13
200
1161
289
1914
2.15
16.14
10.3
8.6
0.0
0.0
e9/l
0.77
246
1560
77
298
2.86
14.49
3.0
2.7
11.0
10.2
g/l
0.73
66
276
173
971
2.17
14.48
4.9
4.3
—
—
—
0
0
418
3301
2.37
13.77
6.5
3.9
11.6
11.7
mm/h
0.08
397
3027
389
3013
2.16
12.97
5.9
4.2
—
—
—
0
0
24
44
5.67
12.70
2.3
2.0
—
—
—
0
0
177
1049
2.04
12.52
2.9
2.3
1192.5
7441.7
umol/l
3.28
154
897
63
242
2.82
11.96
1.8
1.6
1.4
1.4
g/l
0.03
54
222
12
10
12.26
11.78
1.3
1.1
—
—
—
0
0
411
3341
2.11
10.78
8.5
6.7
76.5
76.4
u/l
0.01
396
3104
219
1463
1.86
10.46
4.0
3.4
178.1
92.3
e6/l
0.34
145
1002
148
887
1.94
9.76
1.7
1.5
2.6
2.3
g/l
0.27
82
518
140
829
1.94
9.54
1.5
1.3
13.1
31.9
iu/ml
5.28
40
265
84
412
2.24
9.46
2.0
1.4
—
—
—
0
0
287
2149
1.75
8.85
4.0
3.6
0.0
0.0
estimate
0.00
55
417
264
1935
1.74
8.75
3.1
2.6
94.6
92.1
ug/l
0.12
245
1765
25
66
3.93
8.61
1.5
1.1
4.3
4.1
u/ml
0.04
14
27
8
0
+∞
8.35
1.1
0.0
—
—
—
0
0
64
295
2.33
8.32
4.5
2.9
140.3
165.0
ng/l
0.24
58
270
105
592
1.97
8.14
2.6
2.0
13.9
13.0
umol/l
0.59
98
535
244
1777
1.70
8.06
2.0
2.0
—
—
—
0
0
277
2088
1.70
8.04
7.7
5.8
1.2
1.2
mmol/l
0.73
235
1758
98
545
1.98
7.89
2.5
2.0
2.4
2.4
g/l
0.41
87
499
65
310
2.25
7.80
4.4
3.9
0.4
0.0
%
0.48
15
67
136
847
1.82
7.73
2.5
2.3
5.7
7.3
e6/l
0.59
114
754
160
1048
1.76
7.67
1.4
1.3
0.8
1.7
u/ml
1.04
38
278
188
1291
1.72
7.60
4.5
3.3
7.4
7.4
ph
0.01
33
236
282
2157
1.67
7.58
5.5
4.9
0.0
0.0
estimate
0.00
57
415
69
344
2.16
7.42
4.6
3.8
0.7
0.9
%
0.15
17
95
64
312
2.20
7.28
4.4
3.8
0.7
0.3
%
0.23
13
63
66
326
2.17
7.27
4.7
3.8
0.1
0.1
%
0.35
17
84
166
1116
1.72
7.18
3.1
2.8
0.2
0.4
e6/l
1.20
117
822
417
3574
1.85
7.15
5.3
4.3
14.8
14.8
pmol/l
0.07
389
3245
282
2183
1.64
7.02
4.1
3.7
0.0
0.0
estimate
0.00
58
407
162
1089
1.71
6.98
6.5
6.3
—
—
—
0
0
25
77
3.36
6.92
2.2
3.5
56.5
56.2
%
0.03
25
77
89
501
1.94
6.87
2.6
2.0
24.9
22.2
%
0.96
73
424
177
1225
1.68
6.81
3.3
2.9
31.2
106.1
e6/l
0.73
132
929
352
2894
1.67
6.80
5.3
4.4
22.0
1729.0
e6/l
—
5
45
24
75
3.31
6.50
2.2
3.3
3.8
3.9
e9/l
0.15
24
75
230
1726
1.60
6.27
2.2
1.9
97.9
96.6
pmol/l
0.15
111
820
464
4174
2.05
6.10
6.4
5.1
1.9
1.9
mu/l
0.55
433
3806
160
1111
1.64
5.94
3.2
2.7
—
—
—
0
0
202
1490
1.58
5.81
2.8
3.1
2.4
2.4
mmol/l
0.26
186
1289
123
804
1.69
5.74
1.5
1.3
11.0
12.8
u/ml
0.11
45
296
60
313
2.04
5.73
2.4
2.8
67.1
67.3
g/l
0.08
54
282
145
996
1.63
5.57
2.5
2.1
3.1
3.1
mg/l
0.02
127
835
12
25
4.89
5.52
1.4
2.1
—
—
—
0
0
32
130
2.56
5.48
2.8
1.7
21.4
20.2
s
1.68
27
117
14
34
4.20
5.39
1.5
1.2
2.5
2.6
g/l
—
9
27
14
34
4.20
5.39
1.5
1.2
0.3
0.3
g/l
—
9
27
14
34
4.20
5.39
1.5
1.2
—
—
—
0
0
14
34
4.20
5.39
1.5
1.2
6.8
7.0
g/l
—
9
27
245
1912
1.53
5.37
6.8
5.1
1.2
1.2
mmol/l
0.45
223
1724
230
1772
1.54
5.34
4.9
3.9
35.8
36.0
g/l
0.24
217
1645
143
990
1.61
5.29
3.9
3.7
—
—
—
0
0
53
273
2.05
5.24
2.5
2.3
—
—
—
0
0
178
1318
1.53
4.86
2.6
2.3
53.2
56.0
u/l
0.80
161
1205
86
533
1.74
4.82
2.8
1.9
—
—
—
0
0
116
783
1.62
4.71
2.7
2.4
516.5
530.6
mosm/kgh2o
0.32
96
668
96
618
1.68
4.68
4.7
2.8
0.8
0.8
mmol/l
0.55
87
577
18
58
3.18
4.68
2.3
1.3
0.9
0.6
g/l
—
10
51
80
497
1.72
4.44
1.8
1.4
—
—
—
0
0
175
1314
1.50
4.39
3.4
2.9
7.0
7.0
mmol/l
0.01
143
1097
22
83
2.72
4.38
1.8
1.8
—
—
—
0
0
50
270
1.94
4.36
1.4
1.2
459.6
248.9
u/ml
0.26
44
248
17
56
3.10
4.28
1.3
1.1
—
—
—
0
0
63
370
1.80
4.24
1.2
1.2
—
—
—
0
0
202
1571
1.47
4.22
7.0
7.7
1.2
1.2
inr
0.05
53
468
498
4702
2.46
4.20
13.9
9.6
25.5
24.7
u/l
0.66
483
4514
136
978
1.53
4.15
4.2
3.8
—
—
—
0
0
8
10
8.10
4.07
1.5
2.1
—
—
—
0
0
483
4516
2.00
4.04
18.8
13.7
3.9
3.9
mmol/l
0.54
471
4369
162
1215
1.48
4.03
1.7
1.6
1.4
1.4
mmol/l
0.62
126
1027
472
4386
1.84
3.95
17.7
12.0
20.2
21.1
mg/l
0.26
396
3372
71
441
1.71
3.94
1.7
1.5
—
—
—
0
0
18
65
2.83
3.89
1.9
1.4
—
—
—
0
0
481
4502
1.93
3.84
18.4
13.7
139.8
139.8
mmol/l
0.03
469
4370
11
29
3.85
3.82
1.6
1.6
1.0
1.1
e9/l
—
5
12
267
2216
1.42
3.82
5.5
5.4
10.3
10.4
umol/l
0.06
250
2083
8
13
6.23
3.51
1.3
1.0
—
—
—
0
0
8
13
6.23
3.51
1.3
1.0
—
—
—
0
0
8
13
6.23
3.51
1.3
1.0
—
—
—
0
0
166
1282
1.43
3.47
4.3
3.8
6.1
7.9
mg/mmol
0.41
98
737
158
1220
1.42
3.28
3.6
3.0
29.4
226.5
mg/l
1.21
97
709
17
66
2.63
3.24
1.2
1.2
—
—
—
0
0
342
3016
1.39
3.15
4.3
3.6
—
—
—
0
0
133
1003
1.44
3.12
1.4
1.5
23.4
21.7
nmol/l
0.46
114
846
37
203
1.89
3.12
1.1
1.0
—
—
—
0
0
61
389
1.64
3.09
1.4
1.4
—
—
—
0
0
62
398
1.63
3.06
3.0
2.5
1.6
1.8
%
1.24
53
353
13
45
2.94
3.04
1.7
1.4
—
—
—
0
0
151
1171
1.41
3.03
4.6
3.9
0.0
0.0
estimate
0.00
60
408
283
2437
1.35
2.93
5.1
4.1
6.8
6.5
mmol/l
1.30
268
2235
23
111
2.12
2.77
1.5
4.0
1.3
2.6
ratio
—
5
10
7
14
5.05
2.73
1.0
1.4
—
0.2
%
—
0
5
22
105
2.14
2.72
1.1
1.1
—
—
—
0
0
116
878
1.41
2.64
1.5
1.7
92783932.6
6944898.1
pmol/l
0.45
97
720
46
285
1.67
2.62
2.7
2.5
57.8
73.3
e9/l
3.84
32
218
507
4903
2.47
2.62
25.9
18.3
258.7
257.5
e9/l
0.16
499
4770
23
114
2.06
2.60
1.8
3.9
30.5
42.4
mg/l
0.77
18
93
507
4905
2.45
2.58
25.7
18.2
30.1
30.2
pg
0.23
502
4827
507
4905
2.45
2.58
25.7
18.2
90.9
90.9
fl
0.03
502
4828
29
157
1.90
2.58
1.7
1.6
—
—
—
0
0
44
271
1.68
2.56
9.9
4.6
10.0
8.6
mmol/l
0.90
38
256
507
4906
2.45
2.56
25.8
18.3
4.5
4.5
e12/l
0.12
499
4758
507
4907
2.44
2.54
25.9
18.3
6.5
6.6
e9/l
0.11
497
4759
90
655
1.45
2.53
1.5
1.6
—
—
—
0
0
404
3716
1.39
2.53
21.8
15.1
13.7
13.6
%
0.64
397
3642
507
4908
2.43
2.52
26.0
18.4
133.9
134.0
g/l
0.03
502
4829
8
21
3.85
2.47
1.3
1.6
—
—
—
0
0
102
764
1.42
2.46
4.8
3.5
21.5
221.7
ng/l
3.70
76
565
18
83
2.21
2.43
2.3
2.0
120.6
129.2
g/l
1.21
11
58
18
84
2.18
2.37
2.9
2.3
1.5
1.5
mg/l
0.06
18
75
18
84
2.18
2.37
1.7
4.6
—
—
—
0
0
435
4067
1.43
2.35
6.9
5.3
39.8
39.1
mmol/mol
0.81
410
3763
81
587
1.45
2.33
2.0
2.2
243.3
111.0
ug/g
1.14
67
454
45
289
1.61
2.26
2.1
2.8
4.0
4.0
e9/l
0.06
38
225
148
1194
1.34
2.25
3.7
3.2
—
—
—
0
0
87
645
1.42
2.22
1.3
1.2
—
—
—
0
0
483
4623
1.65
2.22
16.1
11.4
—
—
—
0
0
45
292
1.59
2.17
3.1
3.3
4.6
4.6
pmol/l
0.03
39
260
51
342
1.54
2.14
3.3
3.4
1.2
1.2
mmol/l
0.51
44
297
52
351
1.54
2.12
1.3
1.2
139.3
154.6
iu/ml
0.11
18
143
22
117
1.92
2.09
3.6
2.8
—
—
—
0
0
21
110
1.95
2.08
1.4
1.2
—
826.0
—
0
5
16
76
2.14
2.04
1.8
2.4
—
—
—
0
0
54
371
1.51
2.04
1.6
1.3
—
—
—
0
0
120
952
1.34
2.03
4.7
4.0
1.0
1.0
kg/l
0.12
13
133
36
225
1.64
2.02
2.2
2.4
—
—
—
0
0
453
4299
1.42
1.94
5.0
4.4
5.9
5.9
mmol/l
0.19
424
3911
7
22
3.21
1.88
1.9
1.0
—
—
—
0
0
168
1412
1.28
1.85
3.3
3.0
—
—
—
0
0
10
40
2.53
1.84
1.4
1.9
34.2
62.2
%
—
5
28
10
40
2.53
1.84
2.0
2.8
—
—
—
0
0
96
747
1.35
1.84
1.8
1.7
1059.5
1176.4
nmol/l
0.55
72
546
9
35
2.60
1.81
1.6
1.1
—
—
—
0
0
100
787
1.34
1.78
1.6
1.8
—
—
—
0
0
6
18
3.36
1.75
2.2
5.1
—
—
—
0
0
101
810
1.31
1.58
2.7
2.7
2.5
2.5
mmol/l
0.23
91
707
49
350
1.44
1.56
2.1
2.1
0.2
0.2
g/l
0.55
43
327
0
42
0.00
1.53
0.0
1.0
—
1.5
—
0
12
7
27
2.61
1.52
2.1
1.2
—
—
—
0
0
13
65
2.03
1.50
1.6
1.9
—
—
—
0
0
13
66
1.99
1.44
3.6
3.0
—
—
—
0
0
51
374
1.40
1.43
3.6
3.6
—
—
—
0
0
40
282
1.45
1.38
1.3
1.4
—
—
—
0
0
14
75
1.89
1.35
3.4
2.3
14.6
16.0
%
—
8
33
68
528
1.33
1.35
1.2
1.2
—
—
—
0
0
227
2031
1.21
1.34
4.4
3.8
—
—
—
0
0
454
4361
1.33
1.34
4.9
4.3
4.6
4.8
mmol/l
2.94
423
4028
32
217
1.51
1.34
4.3
3.1
7.4
7.4
ph
—
8
30
153
1318
1.23
1.32
3.2
2.2
—
—
—
0
0
9
43
2.11
1.31
1.3
1.2
—
—
—
0
0
8
34
2.37
1.29
1.0
3.0
—
—
—
0
0
44
321
1.41
1.28
3.3
3.3
—
—
—
0
0
23
146
1.60
1.28
3.4
2.9
0.3
0.2
g/l
—
8
48
461
4445
1.33
1.26
5.5
4.8
2.7
2.8
mmol/l
1.66
429
4085
451
4336
1.31
1.26
4.8
4.3
1.5
1.6
mmol/l
1.24
419
3991
30
204
1.50
1.25
3.1
2.2
0.1
0.2
e6/l
0.30
30
197
8
36
2.24
1.24
1.0
1.1
—
—
—
0
0
22
140
1.60
1.22
1.2
1.3
167.0
245.8
miu/ml
—
10
68
5
20
2.51
1.15
1.2
1.3
—
—
—
0
0
45
337
1.37
1.14
5.5
2.8
102.0
73.4
ng/l
1.25
40
298
11
58
1.92
1.13
3.1
2.8
—
—
—
0
0
35
253
1.41
1.10
1.1
1.2
—
—
—
0
0
435
4180
1.25
1.10
4.2
3.8
1.3
1.3
mmol/l
0.63
402
3819
5
21
2.39
1.09
2.4
5.6
7.4
7.4
ph
—
5
6
10
180
0.55
1.09
4.1
2.2
1.0
1.2
%
—
10
180
44
333
1.35
1.06
4.1
2.8
1.8
2.4
mmol/l
0.56
35
256
42
316
1.36
1.05
1.4
1.2
—
—
—
0
0
9
47
1.93
1.02
1.1
1.3
30.4
31.3
pg
—
9
47
9
48
1.89
1.01
2.3
2.0
—
—
—
0
0
7
35
2.01
1.00
7.0
2.5
—
—
—
0
0
113
975
1.20
0.95
2.1
1.6
0.8
1.1
mg/l
1.35
88
738
139
1223
1.19
0.95
3.8
3.6
—
—
—
0
0
9
51
1.78
0.95
2.2
2.3
—
—
—
0
0
28
201
1.42
0.93
1.2
1.3
23.2
29.5
iu/l
0.62
21
170
6
28
2.16
0.91
1.2
1.2
1.1
1.4
nmol/l
—
6
23
6
29
2.08
0.89
1.2
1.2
—
—
—
0
0
20
136
1.49
0.88
1.3
1.4
227.1
305.8
ug/g
1.03
12
77
6
30
2.01
0.87
1.7
1.2
1.8
1.3
promille
—
6
20
17
112
1.54
0.86
1.8
2.7
—
—
—
0
0
58
476
1.25
0.80
27.1
22.8
1.3
1.2
inr
—
7
71
0
24
0.00
0.79
0.0
1.0
—
0.7
—
0
5
6
33
1.83
0.79
1.8
1.2
—
—
—
0
0
11
174
0.62
0.78
3.8
2.2
0.8
0.7
%
0.69
11
169
44
351
1.28
0.77
4.0
2.9
—
—
—
0
0
11
67
1.66
0.75
1.5
1.5
—
—
—
0
0
5
24
2.09
0.74
1.0
1.3
—
—
—
0
0
10
159
0.62
0.73
2.0
2.9
1610.4
1027.4
u/ml
—
10
133
7
40
1.76
0.71
8.7
3.4
—
—
—
0
0
9
57
1.59
0.71
1.0
1.0
—
—
—
0
0
33
417
0.78
0.69
1.4
1.4
—
—
—
0
0
166
1520
1.14
0.66
3.3
3.4
66.7
32.4
ng/l
0.57
118
1001
7
44
1.60
0.65
1.1
1.3
—
—
—
0
0
7
44
1.60
0.65
1.0
1.0
—
—
—
0
0
5
29
1.73
0.64
1.6
1.3
—
—
—
0
0
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
10
63
1.60
0.62
1.3
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
36
291
1.25
0.60
11.9
6.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
0.1
—
0
8
6
35
1.72
0.58
1.0
1.0
—
—
—
0
0
6
35
1.72
0.58
3.0
2.6
—
—
—
0
0
22
168
1.32
0.56
1.9
2.0
253.5
5681.2
u/l
—
10
72
10
66
1.53
0.53
1.0
1.2
—
—
—
0
0
30
242
1.25
0.52
1.2
1.7
—
—
—
0
0
36
297
1.23
0.52
3.2
2.7
1.0
0.7
ug/l
0.26
25
172
7
110
0.63
0.49
1.7
4.6
3.9
3.8
mmol/l
—
7
102
7
48
1.46
0.47
2.0
2.4
—
—
—
0
0
23
184
1.26
0.44
1.1
1.1
—
—
—
0
0
49
425
1.17
0.44
5.2
3.8
—
—
—
0
0
14
104
1.36
0.43
3.6
3.8
—
—
—
0
0
57
503
1.15
0.41
1.3
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
8
60
1.34
0.40
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
35.3
—
0
12
12
159
0.75
0.39
1.2
1.3
—
—
—
0
0
29
243
1.20
0.38
5.7
6.3
—
—
—
0
0
108
1001
1.10
0.36
3.1
2.1
—
—
—
0
0
6
47
1.28
0.32
1.2
2.9
2.7
3.4
nmol/l
—
6
47
20
165
1.22
0.31
4.8
3.0
—
—
—
0
0
409
4015
1.09
0.31
20.1
13.3
39.8
39.7
%
0.03
285
2926
56
505
1.12
0.31
1.7
1.7
—
—
—
0
0
8
106
0.75
0.29
1.6
1.2
—
—
—
0
0
18
149
1.22
0.28
1.1
1.1
—
—
—
0
0
9
118
0.76
0.27
1.6
1.2
—
—
—
0
0
35
310
1.14
0.26
1.9
2.2
44.3
5.2
ug/l
0.69
26
266
9
73
1.24
0.25
1.4
1.3
—
—
—
0
0
34
302
1.13
0.25
2.3
3.1
24.6
55.4
u/ml
1.36
34
294
12
148
0.81
0.25
1.3
1.4
—
—
—
0
0
23
200
1.16
0.22
3.0
3.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
163
1570
1.06
0.21
3.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
0.1
—
0
5
126
1205
1.06
0.20
1.3
1.5
—
—
—
0
0
6
48
1.25
0.20
1.2
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
2860.3
—
0
8
10
122
0.82
0.19
1.3
1.3
—
—
—
0
0
17
147
1.16
0.18
7.9
11.3
—
—
—
0
0
22
195
1.13
0.17
2.0
1.8
—
—
—
0
0
44
407
1.09
0.17
11.2
7.7
0.5
1.5
mmol/l
0.75
39
326
7
61
1.15
0.17
1.4
1.3
—
—
nmol/l
—
0
0
7
62
1.13
0.17
2.9
2.0
—
—
—
0
0
31
283
1.10
0.16
1.4
1.4
—
—
—
0
0
8
73
1.10
0.15
1.3
1.4
—
—
—
0
0
9
78
1.16
0.15
3.2
2.5
—
—
—
0
0
43
461
0.93
0.15
1.2
1.6
—
—
—
0
0
7
88
0.79
0.14
3.3
2.7
1.5
1.5
mmol/l
—
7
88
10
84
1.19
0.14
1.5
1.3
—
—
—
0
0
31
286
1.09
0.13
3.8
2.7
—
—
—
0
0
20
180
1.12
0.13
19.8
10.3
—
—
—
0
0
13
148
0.88
0.12
1.3
1.4
—
—
—
0
0
13
148
0.88
0.12
1.2
1.4
—
—
—
0
0
10
116
0.86
0.12
1.1
1.5
—
—
—
0
0
13
147
0.88
0.11
1.3
1.4
—
—
—
0
0
47
445
1.06
0.11
1.4
1.5
—
—
—
0
0
13
115
1.13
0.10
1.3
1.2
—
—
—
0
0
13
145
0.89
0.09
1.9
4.7
—
—
—
0
0
42
440
0.95
0.08
2.7
3.8
71.0
19.2
ug/l
0.34
34
360
10
113
0.88
0.08
1.1
1.4
—
—
—
0
0
10
112
0.89
0.07
1.1
1.4
—
—
—
0
0
7
81
0.86
0.07
3.3
2.8
8.3
7.3
mmol/l
—
7
81
11
99
1.11
0.06
2.2
2.2
—
—
—
0
0
18
193
0.93
0.06
1.1
1.1
—
—
—
0
0
17
182
0.93
0.05
19.5
7.5
23.4
24.6
mmol/l
0.68
17
171
11
100
1.10
0.05
1.7
1.6
—
—
—
0
0
10
109
0.92
0.04
1.5
1.2
479.1
486.1
mg/l
—
10
100
33
320
1.03
0.03
1.6
1.5
—
—
—
0
0
13
135
0.96
0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
1.1
1.3
403.0
181.8
e6/l
—
9
79
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
1.2
1.3
—
—
—
0
0
8
84
0.95
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
1.8
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LOCALSCLERODERMA and mortality.

Females

Parameter HR [95% CI] p-value
L12_LOCALSCLERODERMA 1.057 [0.89, 1.26] 0.536
Birth year 0.991 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 2016 females with L12_LOCALSCLERODERMA died.

Males

Parameter HR [95% CI] p-value
L12_LOCALSCLERODERMA 1.088 [0.8, 1.49] 0.599
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 560 males with L12_LOCALSCLERODERMA died.

Mortality risk

Mortality risk for people of age

years, who have L12_LOCALSCLERODERMA.

N-year risk Females Males
1 0.082% 0.212%
5 0.556% 1.342%
10 1.324% 3.33%
15 2.594% 6.147%
20 4.421% 10.464%

Relationships between endpoints

↥

Index endpoint: L12_LOCALSCLERODERMA – Localized scleroderma [morphea]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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