Erythema annulare centrifugum

L12_ERYTH_ANNULCENTRIFUG

erythema infectiosum: usually a benign childhood condition characterized by a classic slapped-cheek appearance (see the image below) and lacy exanthem.It results from infection with human parvovirus (PV) B19, an erythrovirus.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L53.1
  • Hospital discharge: ICD-9 6958B
  • Hospital discharge: ICD-8 69591
  • Cause of death: ICD-10 L53.1
  • Cause of death: ICD-9 6958B
  • Cause of death: ICD-8 69591

2 out of 7 registries used, show all original rules.

64

4. Check minimum number of events

None

64

5. Include endpoints

None

64

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L53
Name in latin
Erythema anulare centrifugum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 491 327 161
Only index persons 439 297 142
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.65 56.35 53.95
Only index persons 54.82 55.33 53.75

-FinnGen-

Key figures

All Female Male
Number of individuals 61 42 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 57.14 55.06 61.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
64
Matched controls
640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L53.1
ICD-10 Finland
Erythema annulare centrifugum
10962.3
84.7
62
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
8.3
16.0
31
65
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.1
12.6
24
30
D07AC01
ATC
betamethasone; topical
4.7
8.7
38
151
D07AC13
ATC
mometasone; topical
4.4
7.9
32
119
L50.8
ICD-10 Finland
Other urticaria
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14
24
7.15
5.94
1.4
1.3
—
—
—
0
0
34
186
2.77
3.87
3.3
4.2
20.79
21.26
ng/l
0.03
21
124
39
233
2.72
3.68
32.9
12.4
1.41
1.24
inr
0.44
11
78
36
215
2.54
3.29
4.2
3.4
—
5.74
—
0
17
39
242
2.57
3.28
11.2
6.1
—
—
—
0
0
28
162
2.29
2.60
2.3
2.9
—
—
—
0
0
25
138
2.33
2.58
5.6
4.2
0.00
0.00
estimate
—
7
50
6
12
5.39
2.46
2.8
5.3
—
—
—
0
0
11
41
3.03
2.35
8.4
3.4
0.20
0.20
%
—
5
10
38
260
2.14
2.24
7.2
5.3
0.00
0.00
estimate
—
9
52
38
260
2.14
2.24
5.4
3.9
0.00
0.00
estimate
—
9
51
7
19
4.00
2.22
2.0
1.3
1.13
1.26
g/l
—
7
19
38
261
2.12
2.21
5.5
3.8
0.00
0.02
estimate
—
10
56
11
44
2.81
2.14
8.5
3.3
1.30
0.69
%
—
5
13
15
71
2.45
2.13
1.0
1.4
—
—
—
0
0
22
124
2.18
2.11
4.9
4.5
—
—
—
0
0
5
11
4.83
1.98
2.0
1.5
—
—
—
0
0
12
53
2.56
1.95
3.8
2.8
1.75
1.59
%
0.21
12
48
6
18
3.56
1.79
5.8
10.4
95.58
95.14
%
—
6
18
6
18
3.56
1.79
2.2
1.3
0.20
0.26
g/l
—
6
18
20
117
2.03
1.71
3.8
3.6
—
—
—
0
0
8
33
2.62
1.60
1.3
1.3
—
—
—
0
0
5
15
3.52
1.55
2.8
2.9
—
—
—
0
0
6
21
3.04
1.54
1.2
1.0
—
—
—
0
0
25
164
1.86
1.52
4.7
3.7
7.42
7.39
ph
—
5
30
6
22
2.90
1.47
6.0
3.7
—
—
—
0
0
44
348
1.85
1.42
6.3
4.3
—
—
—
0
0
6
23
2.77
1.40
5.3
3.8
5.45
5.13
kpa
—
6
23
9
43
2.27
1.37
4.6
7.6
119.11
123.49
g/l
—
9
43
11
55
2.21
1.37
1.9
1.5
—
—
—
0
0
8
36
2.39
1.30
3.8
5.0
—
—
—
0
0
8
36
2.39
1.30
1.8
1.5
—
—
—
0
0
5
19
2.76
1.24
1.8
1.8
—
—
—
0
0
8
39
2.20
1.20
4.3
2.8
83.50
66.15
e9/l
—
8
30
8
40
2.14
1.17
1.9
1.3
—
—
—
0
0
8
41
2.08
1.13
3.8
3.0
—
—
—
0
0
12
68
1.94
1.09
1.8
1.6
—
—
—
0
0
13
78
1.84
1.01
1.9
1.7
—
—
—
0
0
13
78
1.84
1.01
1.5
1.3
192.00
760.00
titre
—
5
16
49
421
1.70
0.97
11.1
7.7
81.39
78.44
u/l
0.17
44
391
6
28
2.26
0.94
2.3
2.1
—
—
—
0
0
8
43
1.98
0.91
5.9
5.5
1.23
1.23
mmol/l
—
8
36
8
44
1.93
0.90
6.8
4.3
—
—
—
0
0
6
33
1.90
0.81
4.7
5.2
1.50
1.53
mmol/l
—
6
33
21
153
1.55
0.81
4.4
3.9
—
—
—
0
0
9
53
1.81
0.80
1.6
1.4
—
—
—
0
0
9
54
1.77
0.79
5.1
5.6
102.22
103.61
mmol/l
—
9
54
57
524
1.80
0.77
5.1
4.8
6.03
5.89
mmol/l
0.36
52
488
20
149
1.50
0.69
6.2
3.6
—
—
—
0
0
7
44
1.66
0.67
1.3
1.1
—
—
—
0
0
18
132
1.51
0.67
1.3
1.5
—
—
—
0
0
26
207
1.43
0.64
2.3
2.0
83.56
95.05
pmol/l
0.62
18
105
8
51
1.65
0.63
1.3
2.0
—
—
—
0
0
56
518
1.65
0.62
19.3
14.0
14.45
22.52
mg/l
1.66
46
399
6
34
1.84
0.60
1.0
1.2
—
—
—
0
0
55
508
1.59
0.60
4.7
4.0
1.37
1.28
mmol/l
0.51
49
470
43
381
1.39
0.54
3.1
3.8
—
—
—
0
0
7
46
1.58
0.50
1.1
1.3
—
—
—
0
0
20
158
1.39
0.50
4.8
3.1
9.08
52.76
mg/l
1.69
13
100
18
140
1.40
0.49
4.8
6.0
—
—
—
0
0
58
549
1.60
0.46
18.7
12.6
—
—
—
0
0
21
170
1.35
0.45
6.3
3.6
1.51
10.08
mg/mmol
1.61
13
103
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
20.35
—
0
17
5
35
1.46
0.40
8.0
5.4
—
—
—
0
0
8
66
1.24
0.28
1.6
1.5
—
—
—
0
0
9
74
1.25
0.27
1.3
1.2
—
—
—
0
0
13
107
1.27
0.24
1.1
1.3
1.66
11.82
u/ml
—
8
42
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
6
49
1.25
0.21
1.2
1.4
—
—
—
0
0
18
159
1.18
0.17
3.6
2.6
—
—
—
0
0
17
152
1.16
0.14
2.5
2.0
—
—
—
0
0
8
75
1.08
0.08
1.5
1.2
—
—
—
0
0
23
219
1.08
0.05
2.0
2.0
—
—
—
0
0
10
92
1.10
0.03
3.5
2.1
12.40
13.17
umol/l
—
10
84
19
188
1.02
0.00
4.4
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.95
-0.00
2.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
0.33
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
84
0.95
-0.00
3.9
2.3
2.41
2.42
g/l
—
8
74
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
37.80
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
0.88
—
0
7
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
6.78
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
16.18
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
1.56
—
0
5

Mortality – FinRegistry

Association

Association between endpoint L12_ERYTH_ANNULCENTRIFUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ERYTH_ANNULCENTRIFUG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ERYTH_ANNULCENTRIFUG – Erythema annulare centrifugum

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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