erythematosquamous dermatosis: Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1277 |
6. Filter based on genotype QC (FinnGen only) |
1277 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other erythematous conditions
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10019 | 5986 | 3954 |
| Only index persons | 8013 | 5008 | 3005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.17 | 0.11 |
| Only index persons | 0.16 | 0.18 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 49.22 | 52.43 | 44.24 |
| Only index persons | 48.59 | 51.84 | 43.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1277 | 828 | 449 |
| Unadjusted period prevalence (%) | 0.25 | 0.28 | 0.20 |
| Median age at first event (years) | 53.70 | 53.33 | 54.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1145
- Matched controls
- 11451
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L53.9
ICD-10 Finland
Erythematous condition, unspecified
596.2
323.0
694
29
L53.8
ICD-10 Finland
Other specified erythematous conditions
225.6
137.1
139
7
69598
ICD-8 Finland
Erythematous condition, Alii definiti
+∞
105.9
100
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.0
66.3
236
561
L53.1
ICD-10 Finland
Erythema annulare centrifugum
542.0
52.9
52
*
69599
ICD-8 Finland
Erythematous condition, Other and unspecified
+∞
52.5
50
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.2
46.4
296
1137
L53.0
ICD-10 Finland
Toxic erythema
+∞
39.8
38
*
E0000UV
ATC
NA
2.3
39.6
534
3111
L50.9
ICD-10 Finland
Urticaria, unspecified
10.7
30.7
60
59
H02AB06
ATC
prednisolone; systemic
2.0
28.8
577
3815
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.2
26.3
148
504
D07AC01
ATC
betamethasone; topical
2.0
24.6
422
2574
XQ800
NOMESCO Finland
Prick test
3.4
24.3
125
398
R06AE07
ATC
cetirizine; oral
1.9
23.6
534
3602
J01DB01
ATC
cefalexin; oral
2.1
23.5
935
7747
A46
ICD-10 Finland
Erysipelas
2.6
23.5
196
854
D07AC13
ATC
mometasone; topical
2.0
22.7
362
2133
L50.8
ICD-10 Finland
Other urticaria
35.8
22.1
28
8
E000001
ATC
NA
2.2
22.0
270
1418
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
20.5
162
681
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
19.5
349
2124
L50.3
ICD-10 Finland
Dermatographic urticaria
28.3
18.8
25
9
D07AB08
ATC
desonide; topical
2.7
18.7
140
570
R50.9
ICD-10 Finland
Fever, unspecified
2.4
18.7
180
840
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
17.9
484
3360
J01FF01
ATC
clindamycin; systemic
1.9
17.3
325
1998
L52
ICD-10 Finland
Erythema nodosum
35.6
16.7
21
6
R60.0
ICD-10 Finland
Localized oedema
2.4
16.4
145
644
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.7
16.3
73
208
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
16.1
405
2726
R06.0
ICD-10 Finland
Dyspnoea
1.9
15.8
290
1756
134
Kela drug reimbursment
General erythroderma
+∞
15.7
15
*
H02AB07
ATC
prednisone; oral
2.2
15.6
177
887
R03AC02
ATC
salbutamol; inhalant
1.7
15.1
592
4502
XQ802
NOMESCO Finland
Epicutan test
3.6
14.8
67
193
A02BC02
ATC
pantoprazole; systemic
1.6
14.7
707
5665
R06AX27
ATC
desloratadine; oral
1.8
14.6
306
1933
R06AE09
ATC
levocetirizine; oral
2.1
14.1
179
938
T78.4
ICD-10 Finland
Allergy, unspecified
3.3
13.6
70
224
6951D
ICD-9 Finland
Erythematous conditions, Erythema multiforme[ERYTHEMA FIXUM]
+∞
13.6
13
*
L53.3
ICD-10 Finland
Other chronic figurate erythema
+∞
13.6
13
*
S21
ICPC
Skin texture symptom/complaint
2.2
13.6
146
714
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
13.4
323
2122
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
13.3
257
1571
L50.0
ICD-10 Finland
Allergic urticaria
6.5
13.3
34
54
UJF32
NOMESCO Finland
Coloscopy
1.8
13.2
287
1823
D07AD01
ATC
clobetasol; topical
2.0
13.0
186
1020
D07AA02
ATC
hydrocortisone; topical
2.1
13.0
165
867
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
12.8
125
585
R06AX22
ATC
ebastine; oral
1.9
12.8
190
1061
C01CA24
ATC
epinephrine; parenteral
2.9
12.6
77
276
L26
ICD-10 Finland
Exfoliative dermatitis
32.4
12.6
16
5
6959X
ICD-9 Finland
Erythematous conditions, Unspecified erythematous condition
+∞
12.5
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
12.5
104
447
N02BE01
ATC
paracetamol; systemic, rectal
1.7
12.3
946
8372
XQ848
NOMESCO Finland
Dermatological photography
4.3
11.7
43
104
M79.6
ICD-10 Finland
Pain in limb
1.6
11.5
393
2818
S18
ICPC
Laceration/cut
1.6
11.5
449
3330
L04AX01
ATC
azathioprine; systemic
3.1
11.1
63
214
D02AE01
ATC
carbamide; topical
2.5
11.1
89
375
E9399
ICD-8 Finland
Complications and failures arising in connection with medical procedures (excluding subsequent adverse effects).
10.2
11.0
21
21
A02BC05
ATC
esomeprazole; systemic
1.6
10.9
430
3184
R51.80
ICD-10 Finland
Headache
1.9
10.8
164
918
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
10.7
59
200
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
10.6
181
1057
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.5
441
3312
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
10.2
103
488
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.1
10.0
119
606
R07.3
ICD-10 Finland
Other chest pain
2.1
10.0
113
565
N03AX12
ATC
gabapentin; oral
1.8
9.9
172
1010
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
9.9
114
574
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.7
230
1484
Y0999
ICD-8 Finland
Other specific examinations and investigations
13.5
9.7
16
12
J02AC01
ATC
fluconazole; systemic
1.5
9.6
434
3290
P01BA02
ATC
hydroxychloroquine; oral
2.2
9.5
100
484
L92.0
ICD-10 Finland
Granuloma annulare
12.5
9.4
16
13
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
9.3
220
1420
A07AA02
ATC
nystatin; oral
2.4
9.2
75
322
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
9.1
354
2592
A02BC03
ATC
lansoprazole; oral
1.6
9.0
313
2229
Z71.8
ICD-10 Finland
Other specified counselling
1.6
9.0
259
1757
M54.5
ICD-10 Finland
Low back pain
1.5
9.0
338
2450
K30
ICD-10 Finland
Functional dyspepsia
2.0
9.0
123
661
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
8.9
199
1259
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.9
666
5582
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
8.8
443
3425
R01AD09
ATC
mometasone; nasal
1.5
8.8
468
3659
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
8.7
225
1484
C84.0
ICD-10 Finland
Mycosis fungoides
50.4
8.7
10
*
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
3.9
8.7
34
89
E000002
ATC
NA
1.9
8.6
128
709
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.8
8.6
23
40
D06BX01
ATC
metronidazole; topical
1.9
8.6
122
666
R03DC03
ATC
montelukast; oral
1.7
8.5
172
1057
M25.5
ICD-10 Finland
Pain in joint
1.5
8.5
296
2104
S29
ICPC
Skin symptom/complaint other
1.7
8.4
174
1076
L20.0
ICD-10 Finland
Besnier prurigo
2.3
8.4
73
323
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.4
396
3009
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.3
8.4
80
369
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.9
8.4
115
622
69500
ICD-8 Finland
Erythematous condition, Toxic erythema
+∞
8.3
8
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
8.3
133
758
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
8.2
130
738
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
8.2
149
887
E000006
ATC
NA
2.1
8.1
88
432
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
8.0
139
815
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.6
8.0
56
223
L50
ICD-10 Finland
Urticaria
6.1
7.9
20
33
N05BB01
ATC
hydroxyzine; systemic
2.3
7.8
72
328
N05BA01
ATC
diazepam; systemic, rectal
1.8
7.8
146
876
J01MA12
ATC
levofloxacin; systemic
1.6
7.8
193
1258
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.8
7.8
31
83
R02
ICPC
Shortness of breath/dyspnoea
1.8
7.8
125
715
J01MA14
ATC
moxifloxacin; systemic
2.0
7.7
98
512
A69.2
ICD-10 Finland
Lyme disease
2.5
7.7
58
240
C07AB07
ATC
bisoprolol; oral
1.4
7.7
465
3695
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.2
7.7
78
371
H02AB04
ATC
methylprednisolone; systemic
1.7
7.6
156
962
L17
ICPC
Foot/toe symptom/complaint
1.5
7.6
266
1886
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
11.9
7.6
13
11
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
7.5
114
639
J01AA02
ATC
doxycycline; systemic
1.5
7.5
827
7346
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.4
215
1455
D01
ICPC
Abdominal pain/cramps general
1.9
7.4
115
648
E000007
ATC
NA
2.3
7.4
67
306
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
7.4
45
166
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
7.3
120
691
A04
ICPC
Weakness/tiredness general
1.8
7.3
132
784
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.2
220
1508
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
7.2
104
574
D02AX
ATC
Other emollients and protectives
2.8
7.1
43
157
L50.1
ICD-10 Finland
Idiopathic urticaria
20.2
7.1
10
5
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.1
403
3150
C03CA01
ATC
furosemide; systemic
1.5
7.1
277
2013
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.1
184
1213
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
7.0
58
250
A02BA02
ATC
ranitidine; systemic
1.6
6.9
207
1410
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
6.9
270
1957
A92
ICPC
Allergy/allergic reaction NOS
3.1
6.9
36
120
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.9
208
1422
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.1
6.8
75
372
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.8
134
816
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
6.8
167
1084
A08
ICPC
Swelling
2.5
6.8
49
199
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.0
6.8
89
471
N06AX11
ATC
mirtazapine; oral
1.5
6.8
326
2465
J01FA06
ATC
roxithromycin; oral
1.4
6.7
414
3280
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
6.7
85
447
S97
ICPC
Chronic ulcer skin
2.3
6.7
59
264
R03BA08
ATC
ciclesonide; inhalant
2.0
6.7
86
452
L28
ICPC
Limited function/disability (L)
1.7
6.6
152
968
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.6
6.5
27
76
ZXA05
NOMESCO Finland
Left side
1.5
6.5
257
1867
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.2
6.5
16
26
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
6.5
129
789
J31.0
ICD-10 Finland
Chronic rhinitis
1.9
6.4
84
449
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
6.3
181
1222
N03AX16
ATC
pregabalin; oral
1.5
6.3
241
1736
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.3
225
1596
6958X
ICD-9 Finland
Erythematous conditions, Other specified erythematous conditions[CASUS ERYTHEMATODES ALIA DEFINITA]
+∞
6.3
6
*
69590
ICD-8 Finland
Erythematous condition, Erythema chronicum migrans
+∞
6.3
6
*
A01
ICPC
Pain general/multiple sites
2.0
6.2
81
430
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.2
131
816
R4110
NOMESCO Finland
Physiotherapy
1.5
6.1
262
1931
N06AX21
ATC
duloxetine; oral
1.7
6.1
113
677
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.7
6.1
40
154
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
6.1
114
687
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.7
6.0
37
138
A02BC01
ATC
omeprazole; systemic
1.4
6.0
276
2063
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.2
6.0
21
51
S06
ICPC
Rash localized
2.1
6.0
62
300
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
6.0
79
421
J01FA10
ATC
azithromycin; systemic
1.4
6.0
600
5128
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMATOUSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMATOUSOTH | 1.367 [1.2, 1.56] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.795 |
During the follow-up period (1.1.1998 — 31.12.2019), 596 out of 3698 females with L12_ERYTHEMATOUSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMATOUSOTH | 1.759 [1.44, 2.15] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 2261 males with L12_ERYTHEMATOUSOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMATOUSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.311% |
| 5 | 0.941% | 1.697% |
| 10 | 2.352% | 4.431% |
| 15 | 4.349% | 8.339% |
| 20 | 7.553% | 13.454% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMATOUSOTH – Other erythematous conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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