Toxic erythema

L12_ERTYTH_TOXIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L53.0
  • Hospital discharge: ICD-9 6950A|6951D
  • Hospital discharge: ICD-8 69500
  • Cause of death: ICD-10 L53.0
  • Cause of death: ICD-9 6950A|6951D
  • Cause of death: ICD-8 69500

2 out of 7 registries used, show all original rules.

68

4. Check minimum number of events

None

68

5. Include endpoints

None

68

6. Filter based on genotype QC (FinnGen only)

68

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L53
Name in latin
Erythema toxicum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 643 346 293
Only index persons 480 272 208
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 41.77 45.18 37.64
Only index persons 35.89 39.71 30.89

-FinnGen-

Key figures

All Female Male
Number of individuals 68 47 21
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 38.96 39.83 37.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
63
Matched controls
631
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L53.0
ICD-10 Finland
Toxic erythema
+∞
44.0
37
*
6951D
ICD-9 Finland
Erythematous conditions, Erythema multiforme[ERYTHEMA FIXUM]
+∞
14.1
13
*
69500
ICD-8 Finland
Erythematous condition, Toxic erythema
+∞
8.5
8
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
152
2.58
3.46
3.2
2.6
—
—
—
0
0
28
149
2.49
3.19
2.7
2.1
132.6
137.9
u/l
0.06
28
140
10
29
3.87
3.18
2.0
1.2
—
—
—
0
0
20
103
2.33
2.37
1.7
1.6
0.6
0.9
mg/l
0.77
13
85
48
354
2.21
2.28
3.0
3.5
—
—
—
0
0
14
62
2.58
2.26
1.1
1.4
—
—
—
0
0
7
21
3.59
2.02
1.4
1.2
—
—
—
0
0
6
16
4.00
1.98
1.3
1.9
—
—
—
0
0
10
41
2.69
1.85
1.7
1.7
—
—
—
0
0
51
403
2.06
1.79
4.0
4.2
9.8
11.1
mm/h
0.36
45
374
6
19
3.36
1.70
1.8
4.0
—
—
—
0
0
5
14
3.76
1.64
1.2
1.1
—
—
—
0
0
6
21
3.03
1.54
2.0
2.1
1.0
1.6
%
—
6
21
9
39
2.50
1.50
4.0
3.6
—
—
—
0
0
6
22
2.89
1.47
2.0
3.6
24.6
24.8
mmol/l
—
6
22
61
538
2.30
1.42
17.4
13.3
22.2
20.1
mg/l
0.23
49
412
22
141
1.83
1.40
2.6
2.8
6.8
7.6
mmol/l
0.24
15
110
5
17
3.09
1.38
1.2
1.2
—
—
—
0
0
5
17
3.09
1.38
1.0
1.4
—
—
—
0
0
5
17
3.09
1.38
2.0
4.3
23.9
24.8
mmol/l
—
5
17
25
168
1.77
1.36
3.9
5.4
—
—
—
0
0
5
19
2.76
1.24
1.2
1.3
—
—
—
0
0
5
19
2.76
1.24
1.2
1.3
—
—
—
0
0
5
19
2.76
1.24
1.2
1.3
—
—
—
0
0
18
113
1.81
1.21
3.5
5.0
—
—
—
0
0
36
275
1.66
1.21
4.1
6.5
10.9
11.1
umol/l
0.04
31
263
15
89
1.88
1.20
2.1
1.8
1650.3
1306.2
nmol/l
—
9
70
20
131
1.75
1.17
2.9
2.7
0.0
0.5
e6/l
2.44
15
99
5
20
2.61
1.17
1.2
1.3
—
—
—
0
0
8
40
2.13
1.16
1.3
1.5
—
—
—
0
0
34
258
1.64
1.16
5.8
5.1
0.0
0.0
estimate
—
5
45
9
49
1.96
1.03
3.9
5.4
—
—
—
0
0
34
266
1.56
0.97
4.6
3.8
0.0
0.0
estimate
—
7
44
7
37
1.99
0.97
3.4
2.0
—
—
—
0
0
8
42
2.02
0.92
2.8
3.9
—
—
—
0
0
8
43
1.97
0.91
1.6
2.2
9.4
9.9
g/l
—
8
38
26
194
1.55
0.90
7.3
8.4
1.2
1.2
inr
0.04
11
59
8
44
1.93
0.89
1.9
1.3
—
—
—
0
0
24
178
1.54
0.85
2.6
3.5
2.4
2.4
mmol/l
0.00
18
153
27
206
1.52
0.84
4.0
3.7
—
—
—
0
0
6
33
1.90
0.81
1.7
1.5
—
—
—
0
0
19
135
1.57
0.80
2.9
2.5
—
—
—
0
0
23
172
1.51
0.78
3.4
3.7
82.9
79.6
e6/l
0.02
17
129
5
23
2.26
0.78
2.4
4.1
118.6
127.8
g/l
—
5
23
42
355
1.48
0.77
5.5
3.9
—
—
—
0
0
11
68
1.74
0.77
1.1
1.2
—
—
—
0
0
17
120
1.56
0.74
4.2
3.9
—
—
—
0
0
26
203
1.45
0.71
2.2
1.9
115.2
101.9
pmol/l
0.43
15
96
32
260
1.44
0.71
4.6
3.7
0.0
0.0
estimate
—
6
46
60
556
1.67
0.62
18.5
15.4
72.5
74.7
umol/l
0.35
60
556
19
144
1.44
0.59
3.6
3.7
40.6
2.6
mg/mmol
0.99
11
82
20
154
1.42
0.57
5.2
3.1
—
—
—
0
0
26
211
1.38
0.55
2.1
2.2
—
—
—
0
0
6
39
1.59
0.54
1.3
1.2
—
—
—
0
0
47
514
0.72
0.52
4.3
3.8
1.4
1.3
mmol/l
0.34
42
470
60
560
1.61
0.51
16.6
12.1
—
—
—
0
0
19
150
1.37
0.47
3.1
2.9
18.4
429.7
e6/l
0.51
14
122
17
133
1.37
0.44
2.8
3.0
125.4
16.4
mg/l
—
9
80
16
124
1.38
0.44
2.3
5.8
—
—
—
0
0
13
97
1.42
0.43
2.2
1.7
—
—
—
0
0
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
14
107
1.39
0.41
1.8
1.6
2.5
2.9
g/l
—
8
63
23
191
1.31
0.41
5.9
3.3
62.5
23.7
ng/l
0.51
17
122
9
66
1.42
0.40
1.6
1.5
—
—
—
0
0
5
35
1.46
0.40
2.6
9.5
—
—
—
0
0
45
409
1.30
0.40
6.0
4.1
14.9
14.6
pmol/l
0.43
39
371
49
526
0.76
0.39
4.8
4.3
5.6
5.8
mmol/l
1.91
44
485
7
52
1.39
0.32
1.4
1.4
—
—
—
0
0
18
149
1.28
0.32
5.9
3.8
0.0
0.0
estimate
—
6
43
53
500
1.27
0.29
6.7
4.7
1.7
1.8
mu/l
0.29
47
451
52
490
1.26
0.28
6.3
5.1
39.1
39.5
mmol/mol
0.11
46
462
17
200
0.80
0.27
1.9
2.8
—
—
—
0
0
13
105
1.29
0.27
1.5
1.2
32.4
3.6
u/ml
—
6
39
15
124
1.27
0.27
1.3
1.3
1.2
0.7
u/ml
—
5
38
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.25
0.20
2.5
2.1
327.2
407.8
nmol/l
—
6
43
0
14
0.00
0.20
0.0
2.6
—
16.3
—
0
14
6
50
1.22
0.20
1.5
1.4
—
—
—
0
0
7
59
1.21
0.19
1.3
1.3
—
—
—
0
0
51
490
1.16
0.15
16.9
13.4
37.3
40.4
%
0.92
30
376
55
533
1.17
0.13
4.3
4.3
4.7
4.8
mmol/l
0.12
48
496
15
134
1.15
0.12
1.4
1.4
—
—
—
0
0
55
536
1.14
0.09
4.4
4.8
2.9
2.8
mmol/l
0.21
46
494
6
70
0.84
0.08
1.7
1.7
—
—
—
0
0
8
77
1.04
0.07
1.6
1.6
—
—
—
0
0
15
138
1.11
0.07
5.5
6.8
—
—
—
0
0
16
166
0.95
0.00
1.9
2.1
—
—
—
0
0
15
147
1.03
0.00
4.6
3.2
—
—
—
0
0
53
531
0.99
0.00
4.3
4.3
1.5
1.5
mmol/l
0.01
45
490
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
5.5
—
4.8
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
13.2
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.7
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
2.0
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
29.8
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
1976.6
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
84.0
—
0
5
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
13.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
31.6
—
0
5

Mortality – FinRegistry

Association

Association between endpoint L12_ERTYTH_TOXIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ERTYTH_TOXIC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ERTYTH_TOXIC – Toxic erythema

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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