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Other and unspecified erythematous conditions

L12_ERYTH_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L53.8, L53.9
  • Hospital discharge: ICD-9 6958X|6959
  • Hospital discharge: ICD-8 6959
  • Hospital discharge: excluded ICD-8 69591
  • Cause of death: ICD-10 L53.8, L53.9
  • Cause of death: ICD-9 6958X|6959
  • Cause of death: ICD-8 6959
  • Cause of death: excluded ICD-8 69591
  • KELA reimbursements: KELA codes ANY
  • KELA reimbursements: ICD-10 L53

3 out of 7 registries used, show all original rules.

1133

4. Check minimum number of events

None

1133

5. Include endpoints

None

1133

6. Filter based on genotype QC (FinnGen only)

1133

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1133 728 405
Unadjusted period prevalence (%) 0.22 0.25 0.18
Median age at first event (years) 53.94 53.73 54.31

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1015
Matched controls
10148
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L53.9
ICD-10 Finland
Erythematous condition, unspecified
894.0
323.0
694
24
L53.8
ICD-10 Finland
Other specified erythematous conditions
322.1
140.2
139
5
69598
ICD-8 Finland
Erythematous condition, Alii definiti
+∞
106.1
100
*
69599
ICD-8 Finland
Erythematous condition, Other and unspecified
+∞
52.5
50
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
51.1
195
494
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
36.5
254
1026
E0000UV
ATC
NA
2.3
33.3
478
2852
L50.9
ICD-10 Finland
Urticaria, unspecified
13.1
31.6
56
45
A46
ICD-10 Finland
Erysipelas
2.9
26.7
183
719
H02AB06
ATC
prednisolone; systemic
2.1
26.4
506
3307
R06AE07
ATC
cetirizine; oral
2.0
22.5
472
3125
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
20.4
147
587
XQ800
NOMESCO Finland
Prick test
3.4
20.2
103
327
D07AC01
ATC
betamethasone; topical
1.9
20.1
373
2331
L50.3
ICD-10 Finland
Dermatographic urticaria
75.0
19.8
22
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
18.9
124
466
J01FF01
ATC
clindamycin; systemic
2.0
18.6
294
1719
E000001
ATC
NA
2.1
18.4
241
1302
J01DB01
ATC
cefalexin; oral
2.0
16.7
832
7076
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
16.7
304
1859
L50.8
ICD-10 Finland
Other urticaria
23.5
16.5
23
10
D07AC13
ATC
mometasone; topical
1.9
16.2
311
1932
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
16.0
433
3009
L52
ICD-10 Finland
Erythema nodosum
33.9
15.8
20
6
R60.0
ICD-10 Finland
Localized oedema
2.4
15.7
137
609
H02AB07
ATC
prednisone; oral
2.2
15.4
164
803
R06.0
ICD-10 Finland
Dyspnoea
1.9
15.1
260
1550
R03AC02
ATC
salbutamol; inhalant
1.7
14.7
524
3926
134
Kela drug reimbursment
General erythroderma
+∞
14.6
14
*
R06AX27
ATC
desloratadine; oral
1.9
14.6
273
1673
R50.9
ICD-10 Finland
Fever, unspecified
2.2
14.2
160
801
XQ802
NOMESCO Finland
Epicutan test
3.8
13.5
58
161
R06AE09
ATC
levocetirizine; oral
2.1
13.3
158
811
D07AA02
ATC
hydrocortisone; topical
2.2
13.2
149
745
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
12.8
359
2480
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.5
12.7
60
180
Y0999
ICD-8 Finland
Other specific examinations and investigations
32.5
12.6
16
5
6959X
ICD-9 Finland
Erythematous conditions, Unspecified erythematous condition
+∞
12.5
12
*
A02BC02
ATC
pantoprazole; systemic
1.6
12.4
631
5095
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
12.4
114
520
D07AB08
ATC
desonide; topical
2.3
11.9
119
564
L26
ICD-10 Finland
Exfoliative dermatitis
23.2
11.6
16
7
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
11.6
284
1877
E9399
ICD-8 Finland
Complications and failures arising in connection with medical procedures (excluding subsequent adverse effects).
11.3
11.6
21
19
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
11.5
320
2192
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
11.4
143
748
Z71.8
ICD-10 Finland
Other specified counselling
1.8
11.4
236
1479
L04AX01
ATC
azathioprine; systemic
3.2
11.3
59
192
T78.4
ICD-10 Finland
Allergy, unspecified
3.2
11.3
60
198
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
11.3
110
516
L50.0
ICD-10 Finland
Allergic urticaria
6.3
11.3
29
47
R51.80
ICD-10 Finland
Headache
2.0
11.1
154
837
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
11.1
179
1029
UJF32
NOMESCO Finland
Coloscopy
1.7
11.0
260
1696
N02BE01
ATC
paracetamol; systemic, rectal
1.8
10.8
846
7511
S21
ICPC
Skin texture symptom/complaint
2.1
10.7
130
670
Z3231
NOMESCO Finland
Registered nurse
1.7
10.7
269
1785
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
10.4
104
492
A92
ICPC
Allergy/allergic reaction NOS
4.5
10.4
36
83
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
10.3
93
419
D02AE01
ATC
carbamide; topical
2.5
10.2
79
329
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
10.2
120
610
C01CA24
ATC
epinephrine; parenteral
2.8
10.0
66
249
J02AC01
ATC
fluconazole; systemic
1.6
9.9
385
2848
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
9.9
224
1434
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
9.8
104
505
D06BX01
ATC
metronidazole; topical
2.1
9.7
112
566
S18
ICPC
Laceration/cut
1.5
9.6
397
2975
D07AD01
ATC
clobetasol; topical
1.9
9.5
158
915
E000006
ATC
NA
2.4
9.5
80
350
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.4
205
1300
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
9.4
165
977
P01BA02
ATC
hydroxychloroquine; oral
2.3
9.2
88
406
XQ848
NOMESCO Finland
Dermatological photography
4.0
9.1
35
90
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
9.0
96
466
R60.9
ICD-10 Finland
Oedema, unspecified
2.8
8.9
56
206
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.9
198
1259
M79.6
ICD-10 Finland
Pain in limb
1.5
8.9
349
2571
A02BC05
ATC
esomeprazole; systemic
1.5
8.9
380
2857
L17
ICPC
Foot/toe symptom/complaint
1.6
8.9
241
1621
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
8.8
93
452
R06AX22
ATC
ebastine; oral
1.8
8.8
167
1012
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
8.8
202
1295
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.7
357
2655
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.4
8.6
74
325
A02BC03
ATC
lansoprazole; oral
1.6
8.4
278
1960
M54.5
ICD-10 Finland
Low back pain
1.6
8.3
301
2169
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
8.3
104
543
A02BA02
ATC
ranitidine; systemic
1.7
8.3
193
1240
N02AX02
ATC
tramadol; systemic, rectal
1.5
8.2
391
2994
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
6.6
8.2
20
31
N05BA01
ATC
diazepam; systemic, rectal
1.9
8.2
131
748
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.7
8.2
22
39
H02AB04
ATC
methylprednisolone; systemic
1.8
8.1
143
846
S29
ICPC
Skin symptom/complaint other
1.8
8.1
156
948
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
8.1
52
196
N06AX11
ATC
mirtazapine; oral
1.6
8.1
287
2057
Z3226
NOMESCO Finland
Physiotherapist
1.7
8.0
180
1146
R02
ICPC
Shortness of breath/dyspnoea
1.9
7.9
116
643
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
7.8
107
579
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
7.8
77
364
N05BA04
ATC
oxazepam; oral
1.6
7.8
227
1549
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.8
169
1065
J01MA12
ATC
levofloxacin; systemic
1.7
7.7
171
1084
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
18.5
7.6
11
6
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.8
7.6
48
179
N03AX12
ATC
gabapentin; oral
1.7
7.6
151
926
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.5
190
1252
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.2
7.4
37
119
A07AA02
ATC
nystatin; oral
2.3
7.4
66
298
C07AB07
ATC
bisoprolol; oral
1.5
7.4
414
3262
R03DC03
ATC
montelukast; oral
1.7
7.4
151
936
WX002
NOMESCO Finland
Sedation and analgesia
1.6
7.3
187
1232
A04
ICPC
Weakness/tiredness general
1.8
7.3
119
684
L71.9
ICD-10 Finland
Rosacea, unspecified
4.0
7.3
27
68
C03CA01
ATC
furosemide; systemic
1.5
7.3
250
1771
J01DA01
ATC
[U] cefalexin; systemic
1.4
7.3
600
5087
L20.0
ICD-10 Finland
Besnier prurigo
2.3
7.2
63
283
J01FA10
ATC
azithromycin; systemic
1.4
7.2
537
4464
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
7.2
125
736
J01MA14
ATC
moxifloxacin; systemic
2.0
7.1
92
488
L50.1
ICD-10 Finland
Idiopathic urticaria
20.2
7.1
10
5
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.2
7.0
69
326
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
7.0
201
1360
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
7.0
7.0
16
23
R07.3
ICD-10 Finland
Other chest pain
1.9
7.0
98
534
N05BB01
ATC
hydroxyzine; systemic
2.2
7.0
66
307
S97
ICPC
Chronic ulcer skin
2.4
6.9
55
234
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.9
196
1325
L28
ICPC
Limited function/disability (L)
1.7
6.9
139
857
K30
ICD-10 Finland
Functional dyspepsia
1.9
6.9
105
593
R01AD09
ATC
mometasone; nasal
1.4
6.9
411
3267
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.8
388
3052
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.8
203
1387
M25.5
ICD-10 Finland
Pain in joint
1.5
6.8
259
1876
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
6.2
6.8
17
28
P29
ICPC
Psychological sympt/compl other
2.4
6.7
53
224
D01
ICPC
Abdominal pain/cramps general
1.9
6.7
103
582
D02AX
ATC
Other emollients and protectives
2.9
6.6
38
134
Z2221
NOMESCO Finland
Medical doctor
1.5
6.6
259
1885
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
6.5
154
994
E000002
ATC
NA
1.8
6.5
107
620
J01FA06
ATC
roxithromycin; oral
1.4
6.5
372
2926
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
6.4
159
1034
KMAK
NOMESCO Finland
NA
1.4
6.4
464
3810
R4110
NOMESCO Finland
Physiotherapy
1.5
6.3
242
1751
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.0
6.3
73
371
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.7
6.3
25
68
69590
ICD-8 Finland
Erythematous condition, Erythema chronicum migrans
+∞
6.3
6
*
6958X
ICD-9 Finland
Erythematous conditions, Other specified erythematous conditions[CASUS ERYTHEMATODES ALIA DEFINITA]
+∞
6.3
6
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.9
6.2
36
129
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.9
6.2
90
500
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
6.2
78
411
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.2
114
682
E000007
ATC
NA
2.2
6.1
58
271
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.8
6.1
36
131
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
6.1
73
376
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.0
401
3228

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: L12_ERYTH_NAS – Other and unspecified erythematous conditions

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).