Secondary sideroblastic anaemia due to drugs and toxins

SECONDA_SIDEROBLASTIC_ANAEM_DRUGS_TOXINS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D64.2# 1 out of 7 registries used, show all original rules.	24
4. Check minimum number of events None	24
5. Include endpoints None	24
6. Filter based on genotype QC (FinnGen only)	24

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	SECONDA_SIDEROBLASTIC_ANAEM_DRUGS_TOXINS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D642
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Secondary sideroblastic anaemia due to drugs and toxins based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	262	166	93
Only index persons	173	112	61
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	70.46	70.82	70.24
Only index persons	68.59	68.69	68.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	24	17	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	67.32	66.12	70.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4281824)

+∞

10.06

1.6

0.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

13.50

5.33

2.9

3.5

0.8

0.0

e6/l

—

(3013512) EKG study

6.91

4.78

3.6

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

4.96

3.32

5.3

2.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

5.11

2.95

2.9

3.2

7.2

2.9

e6/l

—

(3003694) ABO and Rh group [Type] in Blood

4.22

2.89

1.6

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

4.17

2.88

2.5

2.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

4.11

2.82

2.7

3.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

4.25

2.79

7.5

4.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

6.85

2.72

1.5

2.1

—

(3002582) Erythrocytes [#/volume] in Urine

3.88

2.62

2.8

3.4

26.9

1221.3

e6/l

0.52

(3021589) Normoblasts [#/volume] in Blood

3.20

1.96

33.6

10.5

0.0

e9/l

0.49

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

3.14

1.90

4.1

3.4

—

(3033658) Prothrombin time (PT) actual/Normal

3.18

1.83

2.5

3.2

96.9

93.6

—

(3018095) Leukocytes [#/volume] in Urine

3.05

1.83

5.8

4.3

40.8

48.4

e6/l

0.08

(4035726)

3.85

1.79

1.3

—

(3023368) Bacteria identified in Blood by Culture

3.06

1.78

6.5

4.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.98

1.63

1.7

2.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

2.62

1.53

9.3

5.5

1.2

mmol/l

0.50

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.00

1.50

0.0

1.2

—

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

0.00

1.50

0.0

1.2

—

16.7

—

(3032080) INR in Blood by Coagulation assay

2.70

1.49

1.9

9.6

1.1

1.3

inr

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.66

1.47

1.4

1.6

1.8

0.9

mg/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

105

2.56

1.29

24.7

11.2

4.3

4.1

e9/l

0.19

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.49

1.27

1.1

1.3

—

(3026008) Bacteria identified in Urine by Culture

2.38

1.14

3.1

2.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

106

0.42

1.07

1.7

2.9

—

(40758558) Short blood count panel - Blood

2.35

1.02

21.5

9.5

—

(3019150) Specific gravity of Urine by Refractometry

2.05

0.92

4.8

3.5

—

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.84

0.0

1.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

2.04

0.84

8.4

4.6

1.2

mmol/l

0.51

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.83

0.0

1.9

—

(3002256) Pathology report gross observation

2.36

0.80

1.2

1.1

—

(3042936) Bacteria identified in Isolate by Culture

2.07

0.73

1.0

1.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.63

0.0

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.82

0.61

3.7

4.8

—

(3015736) pH of Urine

0.53

0.59

7.0

3.4

—

(3002385) Erythrocyte distribution width [Ratio]

153

1.70

0.43

48.4

17.6

15.5

14.0

1.67

148

(3000492) Spirometry study

0.00

0.43

0.0

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.43

0.0

1.7

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.43

0.0

3.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.42

0.0

1.6

—

(3010813) Leukocytes [#/volume] in Blood

205

0.65

0.42

59.1

22.2

7.1

6.5

e9/l

0.55

200

(3026361) Erythrocytes [#/volume] in Blood

205

0.65

0.42

59.1

22.2

3.6

4.4

e12/l

5.21

200

(3030467) Casts [#/volume] in Urine by Automated count

1.56

0.36

1.7

3.2

0.2

e6/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.46

0.33

2.8

3.6

3333.4

2752.0

ng/l

—

(3013115) Eosinophils [#/volume] in Blood

1.45

0.29

5.9

5.1

0.2

e9/l

0.12

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.43

0.26

2.1

1.9

77.6

107.2

pmol/l

—

(3003338) MCHC [Mass/volume]

150

0.71

0.25

21.3

18.7

329.2

330.1

g/l

0.15

150

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

2.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.7

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.22

0.0

1.0

—

9.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

0.00

0.20

0.0

1.4

—

(4010399)

0.00

0.20

0.0

1.2

—

(3001604) Monocytes [#/volume] in Blood

1.34

0.19

6.4

5.2

0.8

0.6

e9/l

1.62

(40768804) Tissue Pathology biopsy report

1.22

0.18

3.6

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

135

1.30

0.18

4.4

4.9

—

(3006315) Basophils [#/volume] in Blood

1.31

0.17

6.4

5.1

0.0

e9/l

0.14

(3019198) Lymphocytes [#/volume] in Blood

1.27

0.13

6.7

5.5

1.7

1.8

e9/l

0.03

(3022096) Basophils/100 leukocytes in Blood

1.26

0.12

6.8

4.9

0.4

0.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

194

0.90

0.10

46.4

18.0

98.7

74.8

umol/l

0.57

194

(42870588) Differential panel, method unspecified - Blood

1.09

0.09

7.0

4.5

—

(3019069) Monocytes/100 leukocytes in Blood

1.21

0.08

6.8

5.2

12.6

8.3

—

(3006504) Eosinophils/100 leukocytes in Blood

1.21

0.08

6.8

5.0

2.1

2.7

—

(3044889) 12 lead EKG panel

130

1.18

0.07

3.8

4.0

—

(3018010) Neutrophils/100 leukocytes in Blood

1.17

0.05

6.9

5.2

58.6

57.4

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.15

0.04

7.0

5.3

22.5

27.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.8

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.7

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.8

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

499.7

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

192

0.95

0.00

48.9

16.9

4.0

mmol/l

0.42

184

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

189

1.03

0.00

26.2

15.3

40.3

19.4

mg/l

1.44

146

(40761511) CBC panel - Blood by Automated count

192

0.95

0.00

44.5

13.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

192

0.95

0.00

48.8

16.8

137.4

139.8

mmol/l

2.46

184

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

2.8

—

22.8

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

36.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.4

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

149.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

1.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

3.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.0

—

(3009508) Creatinine [Moles/volume] in Urine

1.03

0.00

4.2

2.7

6.3

6.8

mmol/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

6.6

—

25.9

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

16.8

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(3022313) Gas panel - Capillary blood

0.00

0.0

6.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.4

—

(1761868) Lipid panel - Serum or Plasma

0.98

0.00

4.0

2.5

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint SECONDA_SIDEROBLASTIC_ANAEM_DRUGS_TOXINS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have SECONDA_SIDEROBLASTIC_ANAEM_DRUGS_TOXINS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: SECONDA_SIDEROBLASTIC_ANAEM_DRUGS_TOXINS – Secondary sideroblastic anaemia due to drugs and toxins

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Secondary sideroblastic anaemia due to drugs and toxins

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints