Risteys · AB1_HELMINTHIASES

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B83 Hospital discharge: ICD-9 — 128 Hospital discharge: ICD-8 — 1289 Cause of death: ICD-10 — B83 Cause of death: ICD-9 — 128 Cause of death: ICD-8 — 1289 2 out of 7 registries used, show all original rules.	48
4. Check minimum number of events None	48
5. Include endpoints None	48
6. Filter based on genotype QC (FinnGen only)	48

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	419	211	208
Only index persons	309	162	147
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	-	41.18	38.38
Only index persons	34.17	35.74	32.44

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	48	29	19
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	50.70	47.80	55.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3003327) Ova and parasites identified in Stool by Light microscopy

17.56

14.91

3.9

1.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

13.36

4.98

1.3

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

16.02

4.73

1.3

1.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

3.52

4.15

2.2

1.3

g/l

2.1

2.4

0.58

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

3.23

3.63

1.5

1.2

u/ml

0.4

0.7

—

(3022145) Colonoscopy Study observation

3.54

3.44

1.2

1.3

—

(3021589) Normoblasts [#/volume] in Blood

170

2.55

2.53

14.9

9.7

e9/l

0.0

0.00

142

(40768797) Stomach Pathology biopsy report

2.81

2.29

1.2

1.3

—

(36660697) Celiac disease serology panel - Serum

3.12

2.06

1.0

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.88

1.90

1.0

—

(42870588) Differential panel, method unspecified - Blood

130

2.09

1.63

11.1

6.1

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.60

1.53

1.7

3.3

u/l

28.3

31.8

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.36

1.47

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.36

1.47

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.36

1.47

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.36

1.47

1.6

1.9

—

(3000492) Spirometry study

2.62

1.37

2.1

1.6

—

(40768443) Skin Pathology biopsy report

2.98

1.32

1.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.17

1.05

1.0

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.98

1.04

2.1

2.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.86

1.02

4.1

3.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.39

0.97

1.2

1.1

—

(3013512) EKG study

120

0.51

0.94

6.4

3.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.83

0.93

10.8

6.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.93

0.90

1.3

1.4

—

(40758558) Short blood count panel - Blood

108

1.72

0.88

17.0

7.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.88

0.88

1.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.83

0.84

2.4

1.5

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.00

0.81

0.0

1.8

—

131.9

—

(40761511) CBC panel - Blood by Automated count

412

0.56

0.80

16.0

11.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.75

0.78

1.9

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.69

0.78

2.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.98

0.78

1.4

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.73

0.70

3.1

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

1.63

0.69

5.7

4.0

estimate

0.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

280

1.57

0.67

6.4

4.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.64

0.65

1.9

1.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.74

0.63

1.4

1.5

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.62

0.0

2.6

—

0.0

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.62

0.0

2.6

—

10.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.61

0.0

2.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.81

0.60

1.7

2.7

1.8

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.66

0.57

2.0

1.7

—

(3042936) Bacteria identified in Isolate by Culture

1.53

0.56

2.2

1.5

—

(3044889) 12 lead EKG panel

255

1.47

0.56

3.7

3.5

—

(1761868) Lipid panel - Serum or Plasma

139

1.47

0.54

3.7

2.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

177

1.45

0.54

4.5

5.4

mmol/l

1.2

0.36

157

(40768804) Tissue Pathology biopsy report

168

1.44

0.53

2.4

2.1

—

(3026361) Erythrocytes [#/volume] in Blood

435

0.61

0.52

36.1

20.6

e12/l

4.4

4.5

0.37

422

(3007461) Platelets [#/volume] in Blood

435

0.61

0.52

36.1

20.6

e9/l

243.4

254.6

0.44

424

(3035941) MCH [Entitic mass]

435

0.61

0.52

36.0

20.4

30.4

30.3

0.09

428

(3010813) Leukocytes [#/volume] in Blood

435

0.61

0.52

36.2

20.6

e9/l

6.1

6.7

1.40

420

(3024731) MCV [Entitic volume]

435

0.61

0.52

36.0

20.5

91.4

91.1

0.16

428

(3000963) Hemoglobin [Mass/volume] in Blood

435

0.61

0.52

36.3

20.7

g/l

134.7

135.2

0.09

428

(3020682) Albumin/Creatinine [Ratio] in Urine

113

1.48

0.51

4.0

3.6

mg/mmol

3.8

12.6

—

(3025941) Bacteria identified in Stool by Culture

1.63

0.44

1.4

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.40

0.43

1.4

1.3

—

(1002224) Polysomnography panel

0.00

0.42

0.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.52

0.42

4.4

3.6

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.41

0.0

2.8

—

0.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.41

0.0

2.8

—

0.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.41

0.0

2.8

—

0.0

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.40

0.0

4.0

—

28.8

—

(36304419) Bacteria [Presence] in Urine

119

1.38

0.38

4.7

2.9

—

(3012516) Albumin [Mass/volume] in Urine

102

1.38

0.34

2.9

3.0

mg/l

21.6

80.0

—

(3044640) Blood type and Crossmatch panel - Blood

131

1.33

0.33

2.6

2.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

192

1.27

0.28

8.6

5.8

estimate

0.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

144

1.28

0.27

5.1

3.0

—

(3012544) pH of Venous blood

1.28

0.23

1.8

3.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.21

0.22

2.2

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

268

1.21

0.19

6.5

4.8

—

113.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.72

0.18

1.2

1.9

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

410

0.85

0.17

25.7

16.3

umol/l

71.3

75.5

0.82

410

(3023103) Potassium [Moles/volume] in Serum or Plasma

402

0.84

0.17

24.2

15.3

mmol/l

3.8

4.0

2.06

390

(3019550) Sodium [Moles/volume] in Serum or Plasma

401

0.85

0.16

23.5

15.1

mmol/l

139.7

139.9

0.27

389

(3019150) Specific gravity of Urine by Refractometry

1.17

0.16

5.2

4.1

—

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

142

1.19

0.15

6.9

4.1

—

(3023368) Bacteria identified in Blood by Culture

113

1.21

0.15

4.2

4.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

355

0.86

0.12

24.9

14.8

38.2

40.0

0.39

265

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

265

1.14

0.10

3.1

3.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

416

0.90

0.08

18.7

10.5

u/l

28.3

24.7

0.55

403

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

396

0.92

0.07

24.4

13.9

mg/l

18.6

22.7

0.39

321

(3003694) ABO and Rh group [Type] in Blood

109

1.13

0.07

1.9

1.4

—

(3026008) Bacteria identified in Urine by Culture

130

1.11

0.05

2.6

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

161

1.09

0.04

2.1

2.0

pmol/l

122.6

98.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

107

1.04

0.00

7.0

3.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

366

1.05

0.00

21.2

14.0

ml/min/173m2

85.5

81.5

0.51

296

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

188

1.02

0.00

4.8

3.7

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.4

—

3.9

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

4.0

—

(44806071)

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.4

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(4027681)

0.00

0.0

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.7

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(4281824)

0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.4

—

109.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.2

—

32.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.03

0.00

4.3

3.0

mmol/l

0.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

3.8

—

87.6

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.90

0.00

3.6

4.5

ug/l

1.6

2.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

12.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.8

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HELMINTHIASES_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_HELMINTHIASES_NOS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_HELMINTHIASES_NOS – Other helminthiases

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	AB1_HELMINTHIASES_NOS
CONTROL_EXCLUDE	AB1_HELMINTIASES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B83
HD_ICD_9	128
HD_ICD_8	1289
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B83
COD_ICD_9	128
COD_ICD_8	1289
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other helminthiases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints