Burkitt lymphoma, excluding all cancers (controls excluding all cancers)

C3_BURKITT_EXALLC

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions HLP_C3_BURKITT	27
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — C83.70, C83.71 Hospital discharge: ICD-9 — 2002A Cause of death: ICD-10 — C83.70, C83.71 Cause of death: ICD-9 — 2002A Cancer registry: Topography ICD-O-3 — C42\|C77 Cancer registry: Morphology ICD-O-3 — 9687\|9826 Cancer registry: Behaviour codes — 3 3 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints HLP_C3_BURKITT	27
6. Filter based on genotype QC (FinnGen only)	27

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE_EXALLC
Control conditions: not HLP_C3_BURKITT

Extra metadata

First used in FinnGen datafreeze: DF12
Parent code in ICD-10: C81-C96
Name in latin: Lymphoma non-Hodgkin diffusum

NAME	C3_BURKITT_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE_EXALLC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS	!HLP_C3_BURKITT
SEX
INCLUDE	HLP_C3_BURKITT
PRE_CONDITIONS
CONDITIONS	HLP_C3_BURKITT
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	C837
HD_ICD_9	2002A
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C837
COD_ICD_9	2002A
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C42\|C77
CANC_TOPO_EXCL
CANC_MORPH	9687\|9826
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Burkitt lymphoma, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	8	19
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	42.46	32.14	46.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3028026) IgM [Mass/volume] in Serum or Plasma

16.19

10.24

3.1

1.2

1.11

1.21

g/l

0.11

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

10.45

8.72

1.9

1.5

—

(4035726)

30.21

7.82

1.4

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

9.31

7.69

1.4

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

10.00

7.65

1.5

—

(3045142) Bone marrow Pathology biopsy report

+∞

7.63

1.7

0.0

—

(3023368) Bacteria identified in Blood by Culture

8.97

7.55

10.0

5.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

8.12

6.91

1.7

2.2

—

(3023520) Reticulocytes [#/volume] in Blood

10.00

6.83

4.3

1.6

65.19

63.11

e9/l

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

+∞

6.49

3.2

0.0

—

(21494434) Karyotype in Bone marrow

+∞

6.49

1.0

0.0

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

+∞

6.49

12.7

0.0

0.22

—

umol/l

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

+∞

5.36

1.2

0.0

—

(3044290) Cell count panel - Cerebral spinal fluid

18.11

4.86

4.3

1.2

—

(3026008) Bacteria identified in Urine by Culture

5.69

4.70

1.8

2.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

6.32

4.53

2.6

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

10.76

4.41

3.0

1.6

—

(3042936) Bacteria identified in Isolate by Culture

6.03

4.31

2.4

4.7

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

12.90

4.28

4.0

1.1

4.13

3.64

mmol/l

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

12.90

4.28

1.6

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

5.09

4.15

12.7

2.0

307.25

13930.28

umol/l

0.79

(42870588) Differential panel, method unspecified - Blood

5.46

4.10

26.4

4.7

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

11.26

4.04

4.3

1.3

222.43

544.87

mg/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

5.04

4.01

8.2

2.3

—

(3044640) Blood type and Crossmatch panel - Blood

4.47

3.54

8.7

2.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

10.55

3.45

2.0

1.9

3.52

4.40

g/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

10.55

3.45

1.2

1.7

—

(3035350) Ketones [Presence] in Urine by Test strip

111

4.99

3.43

4.6

2.9

0.00

estimate

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

8.13

3.43

1.6

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

5.83

3.08

2.6

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

5.83

3.08

2.9

1.3

—

(3025941) Bacteria identified in Stool by Culture

6.33

2.95

1.4

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

4.05

2.94

8.3

5.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

9.84

2.87

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

111

4.07

2.75

6.8

4.3

0.00

estimate

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.71

2.74

5.8

2.5

—

(3021589) Normoblasts [#/volume] in Blood

115

3.83

2.68

35.5

7.8

0.01

0.00

e9/l

0.60

(40760892) CBC W Ordered Manual Differential panel - Blood

3.84

2.66

9.3

3.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

8.41

2.66

1.2

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

3.58

2.59

1.8

2.6

55.81

71.68

nmol/l

1.85

(36304419) Bacteria [Presence] in Urine

3.47

2.48

5.6

2.3

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

7.35

2.48

5.8

1.3

4.82

1.90

ug/l

—

(3015736) pH of Urine

3.52

2.48

4.0

2.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

6.51

2.32

2.2

1.4

90.00

90.78

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.38

2.12

4.8

2.6

0.00

1.22

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

3.13

2.05

4.6

2.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.84

1.91

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

3.11

1.87

4.8

2.6

0.20

0.64

e6/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

3.11

1.87

1.9

3.4

3.89

2.24

mg/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

142

3.14

1.85

5.9

3.5

—

(40758558) Short blood count panel - Blood

2.80

1.71

34.2

5.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.13

1.65

18.6

6.9

23.90

26.05

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.67

1.63

4.3

2.9

—

(3000991) Gas panel - Venous blood

3.01

1.58

17.4

13.1

—

(3026782) Osmolality of Urine

2.78

1.56

3.9

2.3

586.11

554.68

mosm/kgh2o

—

(40768804) Tissue Pathology biopsy report

2.69

1.54

1.9

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

165

2.79

1.42

6.5

3.6

13.82

10.26

mm/h

0.63

152

(3019832) Treponema pallidum Ab [Presence] in Serum

3.16

1.35

1.4

2.6

—

(3033658) Prothrombin time (PT) actual/Normal

2.53

1.32

12.7

3.4

83.00

86.82

—

(3003694) ABO and Rh group [Type] in Blood

2.46

1.31

2.2

1.4

—

(3002032) Base excess in Venous blood by calculation

2.20

1.03

18.1

3.9

5.56

1.59

mmol/l

—

(3012544) pH of Venous blood

2.20

1.03

18.0

4.5

—

(3000494) Fungus identified in Specimen by Culture

2.56

1.01

3.2

2.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

121

2.09

0.96

11.8

9.1

6.45

6.83

mmol/l

0.32

111

(3041096) Erythrocytes [Presence] in Urine by Automated

2.02

0.83

4.1

2.9

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.43

0.81

24.6

4.4

26.80

24.39

mmol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.32

0.79

28.8

3.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.32

0.79

14.2

16.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

155

1.76

0.65

3.9

3.8

14.72

pmol/l

0.00

142

(3007853) Bacteria identified in Skin by Aerobe culture

1.69

0.57

2.3

2.0

—

(1761868) Lipid panel - Serum or Plasma

0.55

0.57

2.2

2.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

221

0.63

0.51

4.3

4.0

2.74

2.73

mmol/l

0.01

203

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

152

1.55

0.50

2.8

3.8

131.06

50.10

u/l

0.92

146

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

216

0.59

0.50

4.1

3.7

1.22

1.35

mmol/l

1.15

196

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

9.62

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

6.02

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

4.91

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.48

0.40

1.4

1.7

1246.20

1259.80

nmol/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

219

0.67

0.35

4.0

3.7

4.41

4.51

mmol/l

0.17

200

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

188

1.52

0.29

4.3

4.2

2.23

1.94

mu/l

0.43

168

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.43

0.25

1.4

2.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.27

0.23

1.8

2.3

—

(3013512) EKG study

1.39

0.23

5.0

3.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.22

0.0

1.7

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.22

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

4.6

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.5

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

0.05

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

204

0.77

0.19

3.9

3.6

1.37

1.28

mmol/l

0.26

183

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

187

1.27

0.18

30.7

10.5

98.25

85.17

ml/min/173m2

2.03

147

(3009542) Hematocrit [Volume Fraction] of Blood

216

0.88

0.10

42.3

14.6

37.48

40.22

1.08

172

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.12

0.09

1.0

2.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.80

0.09

1.0

1.8

1.63

1.31

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

169

1.19

0.08

3.6

—

(3044889) 12 lead EKG panel

139

1.18

0.08

5.2

3.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.14

0.03

3.6

3.9

1.64

2.05

ug/l

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

1.30

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

2.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.26

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(4034850)

0.00

0.0

6.3

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.2

—

(3002385) Erythrocyte distribution width [Ratio]

198

1.04

0.00

62.1

15.3

14.69

13.41

2.08

193

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

2.7

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_BURKITT_EXALLC – Burkitt lymphoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Burkitt lymphoma, excluding all cancers (controls excluding all cancers)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Burkitt lymphoma, excluding all cancers (controls excluding all cancers) (C3_BURKITT_EXALLC)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints