cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
58 |
4. Check minimum number of eventsNone |
58 |
5. Include endpointsNone |
58 |
6. Filter based on genotype QC (FinnGen only) |
55 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D89
- Name in latin
- Cryoglobulinaemia
Similar endpoints
↥List of similar endpoints to
Cryoglobulinemia
based on the number of shared cases.
Similar with more cases:
- Other disorders involving the immune mechanism, not elsewhere classified
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 308 | 146 | 161 |
| Only index persons | 253 | 121 | 132 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.79 | 59.34 | 58.14 |
| Only index persons | 56.02 | 55.87 | 56.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55 | 27 | 28 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 54.85 | 50.01 | 59.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 58
- Matched controls
- 580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D89.1
ICD-10 Finland
Cryoglobulinaemia
+∞
37.6
32
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
17.3
27.2
31
36
N08.2*D89.1
ICD-10 Finland
Glomerular disorders in cryoglobulinaemia
+∞
27.2
24
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
23.5
21
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
68.9
20.0
22
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
99.2
19.1
20
*
H02AB04
ATC
methylprednisolone; systemic
11.1
19.0
29
48
A11CC03
ATC
alfacalcidol; systemic
137.8
18.8
19
*
R50.9
ICD-10 Finland
Fever, unspecified
9.9
17.3
29
53
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
34.3
17.2
22
10
A12AA04
ATC
calcium carbonate; oral
117.4
16.6
17
*
L04AA06
ATC
mycophenolic acid; systemic
215.9
16.4
16
*
Z94.0
ICD-10 Finland
Kidney transplant status
180.6
14.1
14
*
127
Kela drug reimbursment
Transplant complication
90.3
13.2
14
*
B05DA
ATC
Isotonic solutions
+∞
13.0
12
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
13.0
12
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
13.0
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.8
12.8
24
30
C03CA01
ATC
furosemide; systemic
6.8
11.9
37
120
TPH04
NOMESCO Finland
Cathetrisation of vein
6.8
11.6
26
62
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.9
11.3
24
54
TK800
NOMESCO Finland
Hemodialysis
30.0
10.8
14
6
J01MA12
ATC
levofloxacin; systemic
6.4
10.8
25
61
V03AE01
ATC
polystyrene sulfonate; oral
+∞
10.7
10
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
10.7
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.4
10.5
19
36
B03XA02
ATC
darbepoetin alfa; parenteral
49.3
10.4
12
*
N18.8
ICD-10 Finland
Other chronic renal failure
25.7
10.4
14
7
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
16.4
10.1
16
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.3
10.0
42
171
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
118.6
9.7
10
*
L04AA01
ATC
[U] ciclosporin
118.6
9.7
10
*
N18.0
ICD-10 Finland
End-stage renal disease
118.6
9.7
10
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
9.6
9
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
9.6
9
*
L04AX01
ATC
azathioprine; systemic
20.0
9.6
14
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.4
9.4
20
44
ZX120
NOMESCO Finland
Intravenous
10.3
9.4
19
26
Z49.1
ICD-10 Finland
Extracorporeal dialysis
44.3
9.4
11
*
B03XA01
ATC
erythropoietin; parenteral
104.6
8.7
9
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
8.5
8
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
8.5
8
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
8.5
8
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
+∞
8.5
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
39.5
8.4
10
*
L04AD01
ATC
ciclosporin; systemic
39.5
8.4
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.8
8.0
33
126
KA1AE
NOMESCO Finland
Kidney ultrasound examination
52.3
8.0
9
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.9
7.8
14
15
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
91.3
7.6
8
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
91.3
7.6
8
*
R31
ICD-10 Finland
Unspecified haematuria
8.1
7.5
17
28
M05BA04
ATC
alendronic acid; oral
12.5
7.5
13
13
B05DB
ATC
Hypertonic solutions
+∞
7.4
7
*
B01AB10
ATC
tinzaparin; parenteral
8.8
7.1
15
22
M04AA01
ATC
allopurinol; systemic
5.1
7.1
19
51
N17.9
ICD-10 Finland
Acute renal failure, unspecified
16.9
6.7
10
7
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
78.1
6.6
7
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.5
6.4
12
14
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
6.4
6
*
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
6.4
6
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
6.2
31
131
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.8
6.2
12
15
B07.9
ICD-10 Finland
Verruca simplex
17.4
6.1
9
6
R4190
NOMESCO Finland
Nutritional therapy
17.4
6.1
9
6
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.0
6.1
11
12
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
191
12.67
14.72
27.6
10.5
1.21
1.21
mmol/l
0.26
42
161
45
152
9.75
14.65
10.2
3.0
—
—
—
0
0
16
11
19.48
10.77
3.2
1.4
0.23
0.26
g/l
0.47
16
11
27
72
6.15
10.55
3.5
5.2
0.80
0.84
mmol/l
0.94
27
67
16
12
17.84
10.43
3.1
1.4
1.16
1.19
g/l
0.09
16
12
27
74
5.96
10.19
9.5
1.9
10.73
12.56
umol/l
0.84
27
66
25
70
5.52
9.07
10.1
1.9
2.02
2.42
g/l
2.97
25
61
15
14
13.97
8.93
4.3
1.3
3.68
3.51
g/l
0.10
15
14
15
14
13.97
8.93
4.3
1.3
—
—
—
0
0
15
14
13.97
8.93
4.3
1.3
7.62
8.76
g/l
1.53
15
14
13
10
16.30
8.36
1.5
1.5
—
—
—
0
0
13
10
16.30
8.36
4.7
1.0
0.00
0.00
g/l
—
13
10
13
10
16.30
8.36
1.4
1.4
—
—
—
0
0
14
13
13.75
8.34
4.2
1.0
9.63
9.18
g/l
0.10
14
13
14
13
13.75
8.34
4.5
1.3
3.01
3.15
g/l
0.11
14
13
36
145
4.91
8.23
9.0
4.1
41.52
13.01
mg/mmol
2.11
31
94
23
65
5.21
8.15
3.1
2.4
29.97
29.54
s
0.15
23
65
14
16
11.12
7.57
15.4
2.0
21.80
24.85
mmol/l
2.97
14
16
12
11
13.37
7.19
4.6
1.0
38.18
37.08
g/l
0.21
12
11
12
11
13.37
7.19
2.7
1.7
—
—
—
0
0
14
18
9.86
7.12
8.4
4.6
23.01
25.64
mmol/l
1.48
14
18
18
35
6.97
7.09
14.8
3.2
5.63
5.61
kpa
0.03
18
35
22
67
4.68
7.01
2.6
1.7
—
—
—
0
0
13
15
10.79
7.00
2.3
1.2
—
—
—
0
0
11
10
13.22
6.62
2.8
1.4
—
—
—
0
0
18
49
4.88
6.53
5.6
4.1
—
—
—
0
0
48
270
5.51
6.52
22.0
11.5
5.09
4.01
e9/l
2.05
48
241
10
9
13.10
6.06
5.1
1.0
0.00
0.00
g/l
—
10
9
10
9
13.10
6.06
5.1
1.0
0.00
0.00
g/l
—
10
9
13
21
7.64
5.79
4.2
2.4
0.67
0.69
%
0.04
13
21
8
5
18.20
5.58
1.3
1.2
—
—
—
0
0
17
50
4.40
5.53
2.6
1.5
—
—
—
0
0
40
214
3.80
5.41
44.7
11.7
1.16
1.20
inr
0.10
14
58
19
62
4.07
5.39
6.9
2.8
0.92
1.98
e6/l
0.34
14
39
14
28
6.24
5.38
7.7
3.6
6.01
4.53
kpa
1.19
14
28
17
52
4.21
5.24
2.6
1.5
—
—
—
0
0
42
235
3.85
5.24
8.6
3.5
0.00
0.00
estimate
-0.00
15
45
9
10
10.39
4.98
1.1
1.9
—
—
—
0
0
12
22
6.58
4.92
4.4
2.4
1.07
1.21
%
0.20
12
22
11
18
7.26
4.88
3.0
1.4
—
—
—
0
0
41
235
3.54
4.73
11.4
4.9
0.00
0.00
estimate
-0.00
15
42
41
236
3.52
4.68
8.8
3.5
0.00
0.00
estimate
-0.00
15
40
15
46
4.05
4.56
12.3
10.0
103.47
104.09
mmol/l
0.18
15
46
24
102
3.31
4.51
3.4
3.1
—
—
—
0
0
20
76
3.49
4.48
1.5
1.3
81.09
49.32
iu/ml
0.43
11
24
12
26
5.53
4.35
6.7
4.1
112.83
128.46
g/l
1.86
12
26
12
26
5.53
4.35
10.8
8.0
1.30
1.45
mmol/l
0.12
12
26
24
105
3.19
4.27
3.0
2.1
3.16
3.24
mg/l
0.06
24
98
14
37
4.65
4.26
1.9
1.6
—
—
—
0
0
14
43
3.97
4.23
2.3
1.6
338.00
409.08
nmol/l
0.66
14
36
37
210
3.10
4.15
3.7
3.2
—
—
—
0
0
6
5
13.15
3.85
1.0
1.4
—
—
—
0
0
8
14
6.43
3.47
1.4
1.9
—
—
—
0
0
9
19
5.40
3.40
2.0
1.7
—
—
—
0
0
10
24
4.81
3.38
4.1
3.1
0.42
0.02
e6/l
—
10
24
8
15
6.00
3.32
1.4
1.8
98.63
83.93
%
—
8
15
28
150
2.68
3.29
6.3
3.4
2.30
2.35
mmol/l
0.86
28
129
8
16
5.61
3.17
2.5
2.5
—
—
—
0
0
6
8
8.19
3.13
1.5
1.3
—
—
—
0
0
26
137
2.63
3.13
9.1
3.4
0.00
0.00
estimate
-0.00
14
38
7
13
5.96
2.96
1.4
1.8
—
—
—
0
0
7
14
5.52
2.82
13.3
13.4
23.43
25.30
mmol/l
—
7
14
7
15
5.15
2.69
1.4
1.8
—
—
—
0
0
5
7
7.67
2.60
1.6
1.4
—
—
—
0
0
6
12
5.44
2.47
1.5
1.7
—
—
—
0
0
5
9
5.95
2.26
1.4
1.1
—
—
—
0
0
7
21
3.64
2.03
7.4
4.3
23.67
24.64
mmol/l
—
7
21
30
200
2.04
1.86
8.9
3.5
—
—
—
0
0
6
18
3.59
1.79
1.3
1.3
—
—
—
0
0
6
19
3.40
1.71
8.3
4.8
60.17
55.39
%
—
6
19
5
16
3.32
1.47
2.6
1.7
—
—
—
0
0
13
74
1.98
1.18
4.5
3.6
2.47
2.45
mmol/l
0.19
13
62
36
288
1.66
1.02
4.8
3.1
—
—
—
0
0
23
169
1.60
0.89
3.0
1.9
97.25
97.51
pmol/l
0.01
12
87
0
21
0.00
0.61
0.0
1.5
—
2.11
—
0
16
49
445
1.65
0.61
54.9
13.0
61.31
82.55
ml/min/173m2
4.17
49
356
11
74
1.60
0.58
2.0
1.6
—
—
—
0
0
5
36
1.42
0.39
1.0
2.5
—
—
—
0
0
45
480
0.72
0.37
7.1
4.9
2.42
2.75
mmol/l
1.39
45
450
6
45
1.37
0.35
2.0
2.2
1.90
1.41
%
—
6
40
7
53
1.36
0.32
19.1
7.6
—
—
—
0
0
5
42
1.21
0.22
1.0
2.6
—
—
—
0
0
6
57
1.06
0.09
2.3
1.5
—
—
—
0
0
12
108
1.14
0.08
1.6
1.9
433.00
478.32
pmol/l
0.26
12
94
14
148
0.93
0.03
4.1
4.6
29.14
20.92
%
—
8
72
18
181
0.99
0.00
4.1
5.2
2.30
3.79
ug/l
0.39
18
162
32
323
0.98
0.00
5.0
3.1
61.31
48.55
u/l
0.39
32
302
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
4.5
—
17.62
—
0
6
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
7.34
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
6.88
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint D3_CRYOGLOBU and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CRYOGLOBU.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CRYOGLOBU – Cryoglobulinemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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