obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D3_CVID_BCELL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
84 |
4. Check minimum number of eventsNone |
84 |
5. Include endpointsNone |
84 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D83
- Name in latin
- Deficientia immunalis variabilis communis praecipue cum abnormalitatibus numeri et functionis cellularum B
Similar endpoints
↥List of similar endpoints to
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
based on the number of shared cases.
Similar with more cases:
- Common variable immunodeficiency
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 312 | 164 | 146 |
| Only index persons | 287 | 154 | 133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.79 | 49.97 | 49.50 |
| Only index persons | 47.93 | 48.90 | 46.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 51 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 45.94 | 46.37 | 45.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 787
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
113.6
79
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
66.2
54
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
57.4
48
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
45.2
39
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
67.8
31.4
35
9
ZX120
NOMESCO Finland
Intravenous
16.4
21.4
37
40
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
20.7
19
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
18.8
19.6
31
26
6BA02
NOMESCO Finland
NA
245.7
19.4
19
*
J47
ICD-10 Finland
Bronchiectasis
70.2
19.0
21
*
C01CA24
ATC
epinephrine; parenteral
20.0
18.9
29
22
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
17.3
16
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
17.3
16
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
17.3
16
*
WW200
NOMESCO Finland
Immunization
37.4
16.1
20
7
J01MA12
ATC
levofloxacin; systemic
9.9
16.0
36
61
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.9
15.5
38
74
TDM10
NOMESCO Finland
Puncture of maxillary antrum
18.5
14.9
23
17
J01MA14
ATC
moxifloxacin; systemic
10.8
13.0
26
34
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
11.7
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.5
11.7
52
203
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
33.4
11.2
14
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.4
11.0
42
136
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
38.2
10.7
13
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
10.6
10
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
10.6
10
*
H02AB06
ATC
prednisolone; systemic
4.9
10.1
54
242
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
11.0
10.0
19
22
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.2
9.9
17
16
J01.0
ICD-10 Finland
Acute maxillary sinusitis
5.0
9.5
37
118
H02AB07
ATC
prednisone; oral
6.5
9.1
25
52
UGC12
NOMESCO Finland
Flexible bronchoscopy
8.5
9.1
20
30
Z01.8
ICD-10 Finland
Other specified special examinations
5.2
9.0
32
91
TPH04
NOMESCO Finland
Cathetrisation of vein
5.2
8.8
31
87
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
6.8
8.8
23
45
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
100.2
8.6
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.0
8.6
18
25
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.0
8.6
18
25
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.5
8
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
8.3
8.2
18
27
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
8.1
39
147
J01MA02
ATC
ciprofloxacin; systemic
4.0
7.9
44
188
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.3
7.8
17
25
J01FA06
ATC
roxithromycin; oral
3.9
7.8
48
224
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.6
7.6
23
54
SPAT1262
SPAT
Handing over of treatment supplies
4.9
7.6
27
76
M05BA04
ATC
alendronic acid; oral
8.4
7.5
16
23
J01FF01
ATC
clindamycin; systemic
4.1
7.4
36
134
R01AD09
ATC
mometasone; nasal
3.8
7.3
53
277
J32.4
ICD-10 Finland
Chronic pansinusitis
33.3
7.3
9
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
33.3
7.3
9
*
J01FA15
ATC
telithromycin; oral
5.6
7.3
22
51
R50.9
ICD-10 Finland
Fever, unspecified
4.7
6.7
24
67
A02BC01
ATC
omeprazole; systemic
4.0
6.6
30
105
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
16.1
6.6
10
7
J01FA09
ATC
clarithromycin; systemic
3.5
6.5
39
170
TGC00
NOMESCO Finland
Bronchial lavation
12.5
6.5
11
10
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
20.0
6.4
9
5
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.6
6.4
16
29
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
6.3
6
*
132
Kela drug reimbursment
Sarcoidosis
+∞
6.3
6
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
6.3
6
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
6.3
6
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
6.3
6
*
C03CA01
ATC
furosemide; systemic
4.3
6.2
24
72
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
0
+∞
44.87
3.1
0.0
18.0
—
u/l
—
39
0
21
15
18.33
23.65
1.6
1.1
—
—
—
0
0
20
14
18.44
22.70
2.6
2.2
—
—
—
0
0
15
10
18.04
17.19
1.6
1.5
—
—
—
0
0
26
47
7.56
14.91
2.2
1.3
—
—
—
0
0
11
0
+∞
11.73
1.8
0.0
0.1
—
mg/l
—
6
0
11
0
+∞
11.73
1.8
0.0
1.0
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
2.2
—
mg/l
—
6
0
11
0
+∞
11.73
1.8
0.0
0.2
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
0.3
—
mg/l
—
6
0
11
0
+∞
11.73
1.8
0.0
1.6
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
0.4
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
0.2
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
0.1
—
mg/l
—
5
0
11
0
+∞
11.73
1.8
0.0
0.7
—
mg/l
—
6
0
28
71
5.42
11.12
3.8
2.0
2.5
2.5
g/l
0.09
28
65
32
94
4.88
10.63
2.9
1.5
—
—
—
0
0
26
71
4.86
9.33
2.8
1.4
—
—
—
0
0
15
26
6.81
8.67
3.1
1.4
—
—
—
0
0
26
76
4.51
8.51
2.8
1.4
—
—
—
0
0
16
33
5.75
7.77
2.2
1.2
—
—
—
0
0
12
9
15.29
7.65
1.5
1.2
—
—
—
0
0
56
294
3.71
7.64
9.1
8.9
1.2
1.2
mmol/l
0.38
48
252
10
13
8.60
7.28
1.7
1.2
—
—
—
0
0
19
49
4.72
7.17
4.4
2.7
5.7
5.8
kpa
0.21
19
49
10
6
18.65
6.93
1.4
1.5
—
—
—
0
0
10
14
7.97
6.85
1.7
1.1
—
—
—
0
0
38
182
2.99
5.59
4.4
2.6
0.2
0.4
e6/l
0.41
32
138
5
0
+∞
5.25
1.6
0.0
—
—
—
0
0
12
28
4.83
5.01
1.3
1.1
—
—
—
0
0
8
7
12.45
4.89
1.5
1.1
—
—
—
0
0
8
7
12.45
4.89
1.1
1.7
—
—
—
0
0
8
7
12.45
4.89
1.5
1.3
—
—
—
0
0
42
229
2.67
4.65
4.8
3.0
—
—
—
0
0
11
26
4.72
4.51
2.9
1.5
—
—
—
0
0
12
31
4.35
4.43
9.3
6.3
24.1
25.1
mmol/l
0.28
12
31
8
9
9.67
4.38
1.6
1.1
—
—
—
0
0
7
8
9.41
3.85
3.9
3.1
—
—
—
0
0
7
8
9.41
3.85
1.7
1.1
—
—
—
0
0
9
16
6.16
3.77
1.7
1.4
—
—
—
0
0
9
17
5.79
3.62
1.4
2.1
—
—
—
0
0
23
104
2.67
3.57
3.0
2.5
0.8
0.7
e6/l
0.09
14
63
36
202
2.37
3.54
2.8
1.9
89.0
99.2
pmol/l
0.61
24
99
28
142
2.46
3.43
3.4
2.2
—
—
—
0
0
7
11
6.82
3.25
1.3
1.6
—
—
—
0
0
10
29
3.78
3.15
2.5
2.8
24.7
24.4
mmol/l
—
10
29
5
5
10.51
3.01
1.2
1.2
—
—
—
0
0
8
17
5.08
3.00
2.0
1.4
—
—
—
0
0
8
17
5.08
3.00
2.0
1.4
—
—
—
0
0
47
311
2.16
2.98
4.9
4.3
—
—
—
0
0
21
102
2.41
2.77
3.0
2.5
1.8
2.6
e6/l
0.30
12
61
6
10
6.36
2.74
1.8
1.1
—
—
—
0
0
8
20
4.30
2.64
1.8
1.7
—
—
—
0
0
5
7
7.50
2.58
1.6
1.0
—
—
—
0
0
5
7
7.50
2.58
1.6
1.0
—
—
—
0
0
5
7
7.50
2.58
2.0
1.3
—
—
—
0
0
8
21
4.10
2.53
1.9
1.2
—
—
—
0
0
8
22
3.90
2.43
1.9
1.2
—
—
—
0
0
15
66
2.55
2.41
7.7
17.3
-1.5
1.4
mmol/l
—
10
50
7
18
4.14
2.30
1.3
1.3
—
—
—
0
0
5
9
5.82
2.24
1.2
1.6
—
—
—
0
0
5
9
5.82
2.24
1.0
1.7
—
—
—
0
0
9
30
3.23
2.22
1.3
1.3
—
—
—
0
0
42
290
1.90
2.16
4.6
2.4
108.0
93.0
ug/l
0.22
42
274
7
20
3.72
2.10
1.1
1.2
—
—
—
0
0
9
32
3.02
2.07
3.8
2.9
50.3
56.4
%
—
9
32
8
27
3.16
1.99
2.3
2.0
3.1
1.5
%
—
8
27
65
532
1.98
1.84
3.5
3.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
5
13
4.02
1.74
6.6
2.4
0.3
0.3
u/ml
—
5
7
5
14
3.73
1.64
1.8
1.2
—
—
—
0
0
45
343
1.67
1.49
5.6
4.8
0.0
0.0
estimate
—
9
62
45
345
1.66
1.44
4.2
3.5
0.0
0.0
estimate
—
8
63
7
29
2.54
1.42
1.3
2.1
—
—
—
0
0
9
41
2.34
1.42
1.8
1.3
—
—
—
0
0
45
346
1.65
1.42
4.6
3.5
0.0
0.0
estimate
—
9
65
5
17
3.06
1.38
2.0
1.1
5.8
162.1
e6/l
—
5
12
5
17
3.06
1.38
2.0
1.2
3.3
3.8
mmol/l
—
5
17
8
34
2.49
1.33
12.3
13.6
0.6
0.7
%
—
8
34
8
35
2.42
1.31
12.3
12.5
1.6
2.0
%
—
8
35
5
18
2.89
1.30
2.0
1.3
368.2
397.7
mg/l
—
5
18
11
58
2.03
1.18
3.0
2.6
—
—
—
0
0
5
20
2.59
1.17
1.2
1.1
—
7.5
—
0
5
9
45
2.12
1.09
4.3
3.4
1.2
1.2
mmol/l
—
9
39
18
118
1.67
1.01
4.5
3.2
17.9
86.2
ng/l
0.73
12
76
8
132
0.56
0.82
1.5
2.0
—
—
—
0
0
5
23
2.25
0.77
1.0
1.2
—
—
—
0
0
22
166
1.44
0.68
2.2
1.7
1.5
0.8
mg/l
0.83
17
128
18
132
1.46
0.64
1.5
1.4
—
—
—
0
0
13
89
1.55
0.62
2.8
2.4
0.6
0.6
ug/l
—
8
44
8
121
0.63
0.60
1.5
1.8
—
—
—
0
0
6
37
1.67
0.57
1.3
2.1
—
4802.7
—
0
12
13
178
0.68
0.56
1.2
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
9
70
1.32
0.38
1.8
2.2
—
—
—
0
0
6
43
1.43
0.36
1.2
1.0
—
—
—
0
0
8
108
0.71
0.31
1.8
2.0
1.8
1.4
%
—
8
100
14
119
1.21
0.19
3.6
3.7
18.1
21.2
%
—
8
44
7
59
1.20
0.18
1.9
1.9
—
—
—
0
0
56
534
1.15
0.18
4.8
4.0
15.0
14.8
pmol/l
0.22
51
494
5
69
0.71
0.17
21.6
6.7
—
—
—
0
0
61
627
0.90
0.11
6.2
5.1
38.1
39.4
mmol/mol
0.33
56
592
5
47
1.07
0.09
1.6
2.6
3.7
4.1
ug/l
—
5
40
15
136
1.13
0.09
1.5
1.3
—
43.8
iu/ml
—
0
44
29
274
1.09
0.09
5.1
3.5
—
—
—
0
0
20
189
1.08
0.05
5.5
3.7
0.0
0.0
estimate
—
7
59
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
64.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
6.7
—
0
5
0
6
0.00
0.00
0.0
1.0
—
9.7
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVID_BCELL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CVID_BCELL.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CVID_BCELL – Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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