obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
228 |
6. Filter based on genotype QC (FinnGen only) |
223 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80-D89
- Name in latin
- Deficientia immunalis variabilis communis
Similar endpoints
↥List of similar endpoints to
Common variable immunodeficiency
based on the number of shared cases.
Similar with more cases:
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
- Other or unspecified common variable immunodeficiency
- Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
- Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function
- Common variable immunodeficiency with autoantibodies to B- or T-cells
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 938 | 523 | 407 |
| Only index persons | 837 | 484 | 353 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 50.88 | 51.24 | 50.30 |
| Only index persons | 49.07 | 50.37 | 47.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 223 | 139 | 84 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 48.97 | 50.38 | 46.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 228
- Matched controls
- 2280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
124.8
108
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
119.6
104
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
110.7
97
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
101.9
90
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
100.7
89
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
28.3
91.6
67
33
J47
ICD-10 Finland
Bronchiectasis
42.0
75.4
47
14
ZX120
NOMESCO Finland
Intravenous
11.5
65.0
84
110
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
51.0
47
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
19.8
49.9
41
25
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
47.6
44
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.0
46.1
79
141
6BA02, ,
NOMESCO Finland
537.3
46.0
44
*
J01MA14
ATC
moxifloxacin; systemic
8.8
45.0
68
105
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
44.2
41
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
11.9
42.8
48
50
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.5
42.5
53
64
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.4
40.9
44
43
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
39.8
37
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
8.0
39.0
63
104
J01MA12
ATC
levofloxacin; systemic
6.2
38.6
93
229
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.8
37.8
103
283
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.8
36.9
53
76
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
34.2
32
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.4
33.3
49
72
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
8.8
32.2
45
62
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
31.4
113
381
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
30.1
150
644
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.3
29.0
48
80
C01CA24
ATC
epinephrine; parenteral
6.9
27.3
48
85
TPH04
NOMESCO Finland
Cathetrisation of vein
4.6
27.0
93
298
H02AB06
ATC
prednisolone; systemic
4.6
26.5
159
760
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.2
26.1
52
104
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
25.5
24
*
GD1AD
NOMESCO Finland
Thorax CT examination
8.4
25.4
36
50
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
8.4
24.9
35
48
WW200
NOMESCO Finland
Immunization
24.1
24.8
35
17
Z01.8
ICD-10 Finland
Other specified special examinations
4.3
24.2
86
279
R50.9
ICD-10 Finland
Fever, unspecified
4.8
23.8
68
186
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
23.9
23.4
33
16
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.5
23.1
32
43
H02AB07
ATC
prednisone; oral
4.6
21.5
62
170
J01FA15
ATC
telithromycin; oral
5.0
20.1
50
121
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.5
19.1
41
87
M05BA04
ATC
alendronic acid; oral
5.4
18.9
42
92
J01FA06
ATC
roxithromycin; oral
3.4
18.5
132
655
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.4
18.2
102
436
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
17.9
17
*
J45.1
ICD-10 Finland
Nonallergic asthma
5.4
17.3
38
82
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.2
17.0
31
56
Z3231
NOMESCO Finland
Registered nurse
3.3
16.8
94
398
UJF30
NOMESCO Finland
Ileoscopy through colon
4.4
16.1
47
128
J45.9
ICD-10 Finland
Asthma, unspecified
3.6
15.9
68
243
A07EA06
ATC
budesonide; oral, local oral
6.9
15.8
26
42
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
15.8
15
*
J01FF01
ATC
clindamycin; systemic
3.2
15.7
95
419
J01MA02
ATC
ciprofloxacin; systemic
3.1
15.6
111
536
Z2221
NOMESCO Finland
Medical doctor
3.1
15.5
95
422
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
6.5
15.2
26
44
SPAT1262
SPAT
Handing over of treatment supplies
3.6
14.8
59
200
TGC00
NOMESCO Finland
Bronchial lavation
13.9
14.8
25
20
XW000
NOMESCO Finland
Bone marrow biopsy
7.2
14.8
23
35
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
14.7
14
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
14.7
14
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.0
14.4
23
36
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
32.4
14.1
18
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.7
14.1
36
88
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
14.0
102
493
R03BB04
ATC
tiotropium bromide; inhalant
4.7
14.0
35
84
A07AA02
ATC
nystatin; oral
5.6
13.8
28
56
J32.4
ICD-10 Finland
Chronic pansinusitis
17.6
13.7
21
13
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.2
13.5
69
272
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.3
13.5
39
105
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.2
13.2
67
263
H02AB04
ATC
methylprednisolone; systemic
3.5
13.1
55
192
UJF32
NOMESCO Finland
Coloscopy
3.0
13.0
79
344
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.1
13.0
40
113
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.4
12.8
35
90
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
12.6
12
*
Z3226
NOMESCO Finland
Physiotherapist
3.1
12.6
65
257
R03DA04
ATC
theophylline; systemic, rectal
6.3
12.5
22
38
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
28.5
12.2
16
6
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.3
11.6
52
188
132
Kela drug reimbursment
Sarcoidosis
+∞
11.6
11
*
WX892
NOMESCO Finland
Monitored bed care
4.9
11.5
27
61
UJF92
NOMESCO Finland
Capsular endoscopy
11.4
11.5
21
20
J45.8
ICD-10 Finland
Mixed asthma
9.3
11.3
23
27
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
11.2
50
180
J05AB11
ATC
valaciclovir; oral
3.1
11.2
57
222
R01AD09
ATC
mometasone; nasal
2.6
11.2
135
817
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
11.0
49
176
R01AD05
ATC
budesonide; nasal
4.2
11.0
32
86
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
29.7
10.9
14
5
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.6
10.6
150
970
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.3
10.5
22
45
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
10.5
10
*
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
10.5
10
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
10.5
10
*
SPAT1255
SPAT
Intravenous administration of medicine
4.6
10.4
26
62
A02BC01
ATC
omeprazole; systemic
2.6
10.3
79
381
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.1
10.3
50
189
S01AA01
ATC
chloramphenicol; ophthalmic
5.0
10.3
23
50
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
9.8
10.3
20
22
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.8
10.1
63
274
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
9.4
10.0
20
23
H02AB09
ATC
hydrocortisone; systemic
11.4
10.0
18
17
R03BA02
ATC
budesonide; inhalant
2.8
9.8
63
277
C03CA01
ATC
furosemide; systemic
2.6
9.5
70
330
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
104.2
9.5
10
*
J46
ICD-10 Finland
Status asthmaticus
10.2
9.5
18
19
D83.2
ICD-10 Finland
Common variable immunodeficiency with autoantibodies to B- or T-cells
+∞
9.4
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.0
9.4
47
180
J02AC01
ATC
fluconazole; systemic
2.4
9.4
112
658
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.4
9.3
19
38
WW500
NOMESCO Finland
Blood transfusion
5.4
9.3
19
38
Z31.5
ICD-10 Finland
Genetic counselling
4.1
9.2
27
73
J01DA08
ATC
[U] cefaclor
3.1
9.1
42
154
R03DC03
ATC
montelukast; oral
2.8
9.0
52
216
OAB50, ,
SPAT
4.9
8.8
20
44
B99
ICPC
Blood/lymph/spleen disease other
52.0
8.7
10
*
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
52.0
8.7
10
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.3
8.7
100
573
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.3
8.7
139
916
J01AA02
ATC
doxycycline; systemic
2.9
8.6
189
1432
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.4
8.6
84
448
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
8.6
32
102
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
28.7
8.6
11
*
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
93.4
8.5
9
*
J01FA09
ATC
clarithromycin; systemic
2.3
8.5
91
506
J01DA06
ATC
[U] cefuroxime
2.8
8.5
51
216
ZXD05
NOMESCO Finland
Urgent procedure
2.4
8.4
85
460
D73.1
ICD-10 Finland
Hypersplenism
+∞
8.4
8
*
R03AC02
ATC
salbutamol; inhalant
2.3
8.4
144
972
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
8.3
74
379
XQ800
NOMESCO Finland
Prick test
3.7
8.2
28
84
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.7
8.2
20
32
R03AC12
ATC
salmeterol; inhalant
4.4
8.2
21
51
B29
ICPC
Lymph/immune mech sympt/complt other
23.0
8.1
11
5
A07AA09
ATC
vancomycin; oral
23.0
8.1
11
5
JN4BD
NOMESCO Finland
Extensive body CT
3.3
8.0
33
112
WZC30
NOMESCO Finland
Teaching
2.7
8.0
50
215
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
13.7
8.0
13
10
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.0
7.8
23
62
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
7.8
27
82
XG410
NOMESCO Finland
Flow-volume spirometry
7.1
7.8
18
27
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
7.8
100
595
ZXA00
NOMESCO Finland
Right side
2.4
7.8
71
366
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
7.8
96
562
J01FA10
ATC
azithromycin; systemic
2.3
7.7
157
1119
A10AB05
ATC
insulin aspart; parenteral
3.4
7.7
29
93
R4110
NOMESCO Finland
Physiotherapy
2.3
7.7
77
412
J01DA01
ATC
[U] cefalexin
2.3
7.7
155
1100
D70.89
ICD-10 Finland
Neutropenic splenomegaly
12.4
7.7
13
11
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
26.0
7.6
10
*
C10AC01
ATC
colestyramine; oral
6.9
7.6
18
28
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
7.5
44
183
ZXE00
NOMESCO Finland
One hour or less
2.2
7.4
102
621
ZXA05
NOMESCO Finland
Left side
2.4
7.4
66
336
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
7.3
31
107
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
7.3
7
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6.4
7.2
18
30
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.3
7.2
19
47
P01AB01
ATC
metronidazole; oral, rectal
2.1
7.2
105
651
1XC02, ,
NOMESCO Finland
31.1
7.2
9
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
9.2
7.2
14
16
R03AK07
ATC
formoterol and budesonide; inhalant
2.4
7.0
58
284
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
7.0
43
183
N02AX02
ATC
tramadol; systemic, rectal
2.1
7.0
108
683
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
7.0
18
44
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
11.4
6.9
12
11
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.7
6.9
41
172
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
17.3
6.8
10
6
E83.1
ICD-10 Finland
Disorders of iron metabolism
41.3
6.8
8
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
41.3
6.8
8
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
6.8
6.8
16
25
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.2
6.8
17
29
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
23.3
6.7
9
*
R05
ICD-10 Finland
Cough
2.4
6.7
57
283
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
6.7
40
168
J01DC02
ATC
cefuroxime; systemic
3.8
6.6
21
60
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
6.5
82
478
JN4AD
NOMESCO Finland
Body CT examination
3.1
6.5
28
98
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
71.8
6.5
7
*
ZXA10
NOMESCO Finland
Bilateral
2.4
6.4
52
252
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
6.4
34
134
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.7
6.3
9
5
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
18.7
6.3
9
5
C03DA01
ATC
spironolactone; oral
3.0
6.3
30
111
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
6.3
6
*
D81.0
ICD-10 Finland
Severe combined immunodeficiency [SCID] with reticular dysgenesis
+∞
6.3
6
*
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
6.3
6
*
K90.8
ICD-10 Finland
Other intestinal malabsorption
+∞
6.3
6
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.1
6.3
16
28
R03AC13
ATC
formoterol; inhalant
3.8
6.2
19
53
R03BA01
ATC
beclometasone; inhalant
2.6
6.1
38
162
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
6.1
60
315
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.9
6.1
16
29
K59.1
ICD-10 Finland
Functional diarrhoea
3.6
6.0
20
59
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
116
25.65
141.07
5.0
1.8
0.93
1.52
g/l
0.84
107
111
74
12
90.82
137.98
2.1
1.4
—
—
—
0
0
59
18
43.87
94.79
2.2
1.2
0.17
0.18
e9/l
0.06
48
13
58
18
42.87
92.66
2.2
1.2
451.83
802.85
e6/l
0.90
47
13
70
8
125.16
67.49
5.7
1.3
816.46
1250.75
u/ml
—
70
8
61
5
165.47
60.25
3.0
1.2
16.11
12.80
u/l
—
61
5
40
19
25.32
54.44
1.7
1.4
563.98
619.05
e6/l
0.21
40
19
140
423
6.98
48.21
5.0
1.4
1.21
2.32
g/l
11.13
86
270
70
121
7.91
41.71
2.1
1.2
98.06
308.20
u/ml
0.52
43
108
44
45
11.88
39.60
1.8
1.2
—
—
—
0
0
35
32
12.74
33.71
4.8
5.2
228.00
176.00
iu/ml
—
5
5
41
48
10.20
33.34
3.0
3.2
—
—
—
0
0
60
121
6.37
30.15
2.6
1.5
—
—
—
0
0
191
1083
5.71
24.50
25.3
9.3
3.47
3.97
e9/l
3.21
183
958
82
255
4.46
24.42
2.8
1.8
—
—
—
0
0
42
73
6.83
24.19
3.0
1.5
—
—
—
0
0
32
41
8.92
24.03
1.7
1.7
—
—
—
0
0
72
205
4.67
23.99
4.7
2.4
20.16
22.47
%
0.73
65
176
31
39
9.04
23.60
1.7
1.7
—
—
—
0
0
64
175
4.69
22.30
2.4
1.6
—
—
—
0
0
145
735
3.67
20.21
9.2
4.5
34.47
36.14
g/l
2.61
140
688
19
0
+∞
20.09
2.2
0.0
0.59
—
mg/l
—
11
0
19
0
+∞
20.09
2.2
0.0
1.40
—
mg/l
—
12
0
19
0
+∞
20.09
2.2
0.0
1.67
—
mg/l
—
10
0
19
0
+∞
20.09
2.2
0.0
0.43
—
mg/l
—
12
0
19
0
+∞
20.09
2.2
0.0
0.64
—
mg/l
—
9
0
19
0
+∞
20.09
2.2
0.0
3.26
—
mg/l
—
11
0
19
0
+∞
20.09
2.2
0.0
0.46
—
mg/l
—
12
0
19
0
+∞
20.09
2.2
0.0
0.61
—
mg/l
—
11
0
19
0
+∞
20.09
2.2
0.0
3.41
—
mg/l
—
12
0
19
0
+∞
20.09
2.2
0.0
1.41
—
mg/l
—
13
0
26
32
9.04
20.05
1.5
1.3
—
—
—
0
0
74
251
3.88
19.01
2.9
2.4
125.18
122.14
ug/g
0.03
64
201
33
59
6.37
18.32
1.6
2.5
1.35
1.41
g/l
0.13
27
51
26
14
20.77
17.79
2.2
2.1
47.65
46.50
%
—
20
6
96
402
3.40
17.65
3.9
2.0
2.99
3.29
mg/l
0.63
90
355
59
179
4.10
17.62
2.6
1.7
—
—
—
0
0
147
822
3.22
16.10
10.3
7.2
1.21
1.22
mmol/l
1.00
133
695
137
741
3.13
15.81
4.7
2.4
77.97
75.88
nmol/l
0.40
130
668
201
1382
4.84
15.43
13.2
3.9
12.02
10.46
mm/h
0.73
196
1274
117
587
3.04
15.32
5.2
3.1
—
—
—
0
0
18
5
38.85
14.67
1.2
1.0
82.06
102.60
%
—
18
5
95
459
2.83
12.83
4.7
3.0
0.43
0.40
e6/l
0.05
78
344
25
28
9.89
12.62
1.5
1.6
—
—
—
0
0
25
50
5.49
12.25
1.3
1.3
399.45
325.23
ug/g
1.15
20
23
24
27
9.80
12.10
1.7
1.7
—
—
—
0
0
24
27
9.80
12.10
1.7
1.7
—
—
—
0
0
22
21
11.46
12.06
1.6
1.3
—
—
—
0
0
20
17
12.77
11.58
3.0
1.0
—
—
—
0
0
20
17
12.77
11.58
3.0
1.0
—
—
—
0
0
18
15
12.91
10.54
1.7
1.6
—
—
—
0
0
18
15
12.91
10.54
1.7
1.6
—
—
—
0
0
20
21
10.32
10.50
1.8
1.7
—
—
—
0
0
19
18
11.40
10.50
1.3
1.4
—
—
—
0
0
20
38
5.67
10.31
1.5
1.4
—
—
—
0
0
18
16
12.10
10.25
3.3
2.0
—
—
—
0
0
22
29
8.28
10.17
1.8
1.8
—
—
—
0
0
123
746
2.41
9.67
14.5
10.4
1.05
1.18
inr
3.14
31
235
20
41
5.25
9.50
2.0
2.1
—
—
—
0
0
28
77
4.01
9.32
2.3
1.3
—
—
—
0
0
18
20
9.67
9.22
1.5
1.7
—
—
—
0
0
18
20
9.67
9.22
1.4
1.8
—
—
—
0
0
17
17
10.70
9.19
3.5
1.9
—
—
—
0
0
21
32
7.12
8.90
10.6
3.2
52.05
55.09
%
0.30
21
32
20
30
7.20
8.58
10.4
3.1
3.51
4.41
e9/l
0.78
20
30
18
24
8.04
8.34
1.5
1.7
—
—
—
0
0
20
49
4.38
7.71
3.5
1.4
—
—
—
0
0
148
1034
2.23
7.60
7.0
4.7
6.71
6.51
mmol/l
0.48
143
956
43
176
2.78
7.56
9.7
7.2
104.19
104.07
mmol/l
0.05
43
176
23
64
3.88
7.52
1.4
1.5
—
—
—
0
0
23
66
3.76
7.20
1.3
2.5
—
—
—
0
0
132
894
2.13
7.18
6.4
4.7
0.00
0.00
estimate
-0.00
33
178
13
14
9.77
6.88
4.5
3.7
—
—
—
0
0
131
896
2.09
6.81
5.0
3.4
0.00
0.00
estimate
-0.00
34
190
20
54
3.96
6.80
1.5
1.4
0.02
0.01
iu/ml
—
6
8
132
906
2.09
6.79
4.8
3.5
0.00
0.00
estimate
-0.00
33
170
14
18
8.21
6.72
1.6
1.7
—
—
—
0
0
11
9
12.76
6.65
1.3
1.0
—
—
—
0
0
102
641
2.07
6.62
2.5
1.9
90.20
98.88
pmol/l
0.88
63
315
17
30
6.03
6.60
1.4
1.4
—
—
—
0
0
26
88
3.21
6.35
2.4
1.7
—
—
—
0
0
21
63
3.57
6.17
4.1
2.0
—
—
—
0
0
22
69
3.42
6.05
3.2
3.5
24.84
25.08
mmol/l
0.13
22
69
15
27
5.87
5.79
4.3
1.5
—
—
—
0
0
15
27
5.87
5.79
4.3
1.5
—
—
—
0
0
12
16
7.85
5.71
2.8
1.3
0.69
0.07
u/ml
—
7
7
15
28
5.66
5.64
4.3
1.5
—
—
—
0
0
15
28
5.66
5.64
4.3
1.5
—
—
—
0
0
15
28
5.66
5.64
4.3
1.5
—
—
—
0
0
15
28
5.66
5.64
4.3
1.5
—
—
—
0
0
11
13
8.82
5.62
1.4
1.1
—
—
—
0
0
68
387
2.08
5.61
2.2
1.5
18.83
22.63
nmol/l
1.92
62
330
37
164
2.50
5.51
8.1
10.8
0.54
1.43
mmol/l
0.57
26
131
16
43
3.93
5.47
1.3
1.2
—
—
—
0
0
20
63
3.38
5.46
4.2
3.4
53.68
50.73
%
0.17
20
63
11
14
8.19
5.41
1.1
1.8
—
—
—
0
0
71
419
2.01
5.26
3.2
2.1
—
—
—
0
0
20
65
3.28
5.21
3.2
2.2
—
—
—
0
0
120
848
1.88
5.16
3.1
2.5
—
—
—
0
0
13
23
5.93
5.14
2.1
1.3
—
—
—
0
0
8
6
13.75
5.11
1.5
1.0
—
—
—
0
0
8
6
13.75
5.11
4.5
6.7
—
—
—
0
0
8
6
13.75
5.11
1.5
1.0
—
—
—
0
0
20
66
3.23
5.08
4.3
5.3
24.46
24.04
mmol/l
0.26
20
66
214
1882
3.23
4.77
40.0
12.4
18.83
21.16
mg/l
0.66
199
1436
19
64
3.15
4.68
3.0
3.0
0.62
0.64
%
0.06
19
64
11
18
6.36
4.66
1.9
1.8
—
—
—
0
0
11
18
6.36
4.66
1.9
1.8
—
—
—
0
0
11
18
6.36
4.66
1.9
1.8
—
—
—
0
0
49
263
2.10
4.65
3.2
3.1
1.64
2.95
e6/l
1.01
27
139
14
31
4.74
4.64
1.6
1.5
—
—
—
0
0
14
31
4.74
4.64
1.6
1.5
—
—
—
0
0
18
59
3.23
4.63
1.7
1.2
—
—
—
0
0
7
5
14.38
4.60
1.1
1.0
—
—
—
0
0
7
5
14.38
4.60
3.4
1.2
72.63
79.80
ug/l
—
7
5
50
273
2.07
4.53
3.0
2.9
1.28
0.78
e6/l
0.45
28
149
18
60
3.17
4.51
1.7
1.2
—
—
—
0
0
50
275
2.05
4.43
1.9
1.7
1437.05
1161.64
nmol/l
0.86
44
213
19
67
3.00
4.34
3.0
2.9
2.25
1.23
%
1.09
19
67
22
88
2.66
4.02
5.3
3.7
1.79
1.82
mmol/l
0.01
14
64
67
422
1.83
3.95
3.0
2.6
1363.53
1152.57
ng/l
0.10
58
348
71
460
1.79
3.80
1.4
1.3
2.42
1.60
u/ml
0.15
13
127
73
480
1.77
3.71
5.7
3.6
0.00
0.01
estimate
0.50
31
173
194
1679
2.04
3.68
40.2
14.8
15.15
14.57
%
0.80
194
1658
14
46
3.18
3.59
1.6
3.2
33.30
63.61
mg/l
—
9
38
6
6
10.22
3.51
1.2
1.0
—
—
—
0
0
7
10
7.18
3.39
1.9
2.6
—
—
—
0
0
7
10
7.18
3.39
1.9
2.6
—
—
—
0
0
8
14
5.88
3.37
1.8
1.7
—
—
—
0
0
160
1321
1.71
3.35
3.7
3.3
—
—
—
0
0
86
608
1.67
3.30
3.8
3.2
2.30
2.36
mmol/l
4.65
79
539
26
124
2.24
3.29
4.7
3.4
1.22
1.23
mmol/l
0.03
26
106
6
7
8.76
3.28
1.5
1.1
66.33
17.24
u/l
—
6
7
6
7
8.76
3.28
1.5
1.1
197.33
50.16
u/l
—
6
7
6
7
8.76
3.28
1.7
2.3
—
—
—
0
0
6
7
8.76
3.28
1.2
1.4
—
—
—
0
0
197
1738
1.98
3.18
29.4
11.3
87.94
85.93
ml/min/173m2
0.59
178
1426
6
8
7.66
3.07
1.7
2.1
—
—
—
0
0
6
8
7.66
3.07
1.2
1.1
—
—
—
0
0
6
8
7.66
3.07
1.7
2.1
—
—
—
0
0
5
5
10.18
2.99
1.0
1.0
—
—
—
0
0
5
5
10.18
2.99
1.0
1.4
—
—
—
0
0
5
5
10.18
2.99
1.0
1.2
—
—
—
0
0
5
5
10.18
2.99
1.0
1.0
—
—
—
0
0
5
5
10.18
2.99
1.0
1.2
—
—
—
0
0
95
705
1.60
2.93
5.4
3.4
—
—
—
0
0
6
9
6.81
2.88
2.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
9
6.81
2.88
1.0
1.2
—
—
—
0
0
85
620
1.59
2.79
4.2
3.1
27.79
36.11
ng/l
0.34
62
380
22
107
2.17
2.67
1.5
1.2
—
—
—
0
0
24
122
2.08
2.62
2.4
2.6
70.82
69.62
ml/min/173m2
0.03
11
53
5
7
7.27
2.56
1.0
1.7
—
—
—
0
0
5
7
7.27
2.56
1.0
1.1
—
—
—
0
0
9
26
3.56
2.51
1.2
1.1
—
—
—
0
0
61
421
1.61
2.48
1.9
1.8
1.01
0.97
mg/l
0.06
46
320
9
27
3.43
2.42
1.2
1.1
—
—
—
0
0
6
12
5.10
2.41
1.8
1.8
—
—
—
0
0
6
12
5.10
2.41
1.8
1.8
—
—
—
0
0
11
40
2.84
2.31
1.4
1.5
—
—
—
0
0
8
23
3.57
2.29
1.4
1.2
—
—
—
0
0
8
23
3.57
2.29
1.8
1.2
—
—
—
0
0
5
9
5.65
2.22
1.8
2.0
—
—
—
0
0
5
9
5.65
2.22
2.0
1.6
—
—
—
0
0
5
9
5.65
2.22
2.0
1.6
—
—
—
0
0
5
9
5.65
2.22
1.8
2.0
—
—
—
0
0
7
19
3.77
2.17
1.1
1.3
—
—
—
0
0
66
479
1.53
2.14
4.5
3.9
5.81
12.28
mg/mmol
1.12
46
289
46
307
1.62
2.13
2.4
2.8
2.41
2.45
mmol/l
1.52
39
261
5
10
5.08
2.08
1.2
1.0
—
—
—
0
0
5
10
5.08
2.08
2.0
1.6
—
—
—
0
0
5
10
5.08
2.08
2.0
1.6
—
—
—
0
0
5
10
5.08
2.08
3.0
1.1
—
—
—
0
0
5
10
5.08
2.08
1.8
1.9
—
—
—
0
0
50
344
1.58
2.05
1.4
1.3
14.16
11.92
u/ml
0.06
19
138
10
38
2.70
2.03
1.2
1.2
—
—
—
0
0
151
1303
1.47
2.00
4.9
2.9
58.45
45.15
u/l
0.99
146
1236
14
64
2.27
1.99
1.4
1.2
—
—
—
0
0
9
199
0.43
1.95
1.6
1.6
—
—
—
0
0
6
16
3.82
1.94
1.2
1.2
—
—
—
0
0
27
161
1.77
1.88
3.8
3.0
—
—
—
0
0
25
146
1.80
1.87
1.6
1.2
20.69
145.78
iu/ml
—
10
59
5
12
4.23
1.83
1.2
1.3
—
—
—
0
0
7
23
3.11
1.81
1.1
1.1
—
—
—
0
0
7
23
3.11
1.81
1.3
1.1
—
—
—
0
0
164
1453
1.46
1.78
4.5
4.0
15.07
14.65
pmol/l
1.33
153
1329
5
13
3.91
1.72
2.4
1.8
—
—
—
0
0
46
325
1.52
1.67
4.7
3.2
18.75
113.51
ng/l
1.92
29
223
5
14
3.63
1.62
2.0
2.1
—
—
—
0
0
5
14
3.63
1.62
1.0
1.3
—
—
—
0
0
169
1836
0.69
1.57
4.0
4.2
4.43
4.74
mmol/l
3.30
164
1715
168
1826
0.70
1.55
3.9
4.1
1.38
1.49
mmol/l
2.61
159
1702
20
116
1.79
1.54
2.4
2.9
4.50
4.66
pmol/l
0.44
20
102
47
344
1.46
1.44
1.4
1.3
18.27
41.77
iu/ml
—
10
115
187
1726
1.46
1.40
5.5
4.7
1.86
1.84
mu/l
0.08
179
1594
5
18
2.82
1.29
1.8
1.2
—
—
—
0
0
5
18
2.82
1.29
1.0
1.1
—
—
—
0
0
163
1756
0.75
1.14
3.7
3.8
1.36
1.26
mmol/l
0.99
154
1628
12
66
1.86
1.11
3.8
3.2
7.92
2245.75
u/ml
0.54
12
56
11
59
1.91
1.09
1.5
1.6
—
—
—
0
0
6
121
0.48
1.09
1.7
1.5
—
—
—
0
0
175
1862
0.74
1.07
4.5
4.6
2.62
2.82
mmol/l
1.92
164
1733
6
33
1.84
0.79
1.0
1.1
—
—
—
0
0
217
2107
1.62
0.79
54.6
18.4
39.89
40.47
%
0.93
206
1981
9
53
1.73
0.76
1.1
1.1
—
—
—
0
0
20
143
1.44
0.73
2.2
2.5
—
27.73
—
0
6
18
128
1.44
0.68
1.3
1.3
—
40.22
—
0
8
50
423
1.23
0.60
1.5
1.5
—
—
—
0
0
25
197
1.30
0.54
14.4
6.0
—
—
—
0
0
9
62
1.47
0.54
1.2
1.6
—
—
—
0
0
17
126
1.38
0.53
2.2
1.9
—
—
—
0
0
7
50
1.41
0.45
1.3
1.3
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
4.66
7.97
mmol/l
—
5
24
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
199.87
—
0
18
5
36
1.40
0.38
2.4
1.9
7.38
9.84
umol/l
—
5
25
19
153
1.26
0.37
2.5
2.0
—
—
—
0
0
38
343
1.13
0.24
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
5
43
1.17
0.21
1.6
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
28
253
1.12
0.18
2.6
2.7
0.57
0.73
ug/l
0.86
20
143
176
1787
0.93
0.13
4.6
4.1
5.91
5.82
mmol/l
0.37
168
1654
5
61
0.82
0.08
1.4
1.6
83.00
70.06
pmol/l
—
5
61
7
81
0.86
0.07
1.6
1.6
—
—
—
0
0
35
335
1.05
0.06
3.3
4.0
22.25
21.95
%
0.04
18
132
167
1656
1.03
0.04
6.3
5.2
39.53
38.98
mmol/mol
0.24
158
1558
29
291
1.00
0.00
2.6
2.1
—
—
—
0
0
11
107
1.03
0.00
1.1
1.0
—
—
—
0
0
27
268
1.01
0.00
2.6
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
1.17
—
0
7
0
5
0.00
-0.00
0.0
3.0
—
37.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
8.35
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
8.99
—
0
8
7
70
1.00
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_CVID | 3.228 [2.32, 4.48] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.337 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 476 females with D3_CVID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_CVID | 3.026 [2.02, 4.54] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 347 males with D3_CVID died.
Mortality risk
Mortality risk for people of age
years, who have D3_CVID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 0.681% |
| 5 | 2.034% | 3.255% |
| 10 | 5.02% | 7.718% |
| 15 | 8.881% | 14.648% |
| 20 | 15.33% | 23.297% |
Relationships between endpoints
↥Index endpoint: D3_CVID – Common variable immunodeficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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