Neuralgic amyotrophy

G6_NEURAMYO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G54.5
  • Hospital discharge: ICD-9 3535
  • Cause of death: ICD-10 G54.5
  • Cause of death: ICD-9 3535

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Amyotrophia neuralgica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 398 163 231
Only index persons 371 152 219
Unadjusted period prevalence (%)
Whole population 0.01 0.00 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 52.03 50.89 52.84
Only index persons 51.07 50.12 51.73

-FinnGen-

Key figures

All Female Male
Number of individuals 65 25 40
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 60.58 58.50 61.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
60
Matched controls
599
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.5
ICD-10 Finland
Neuralgic amyotrophy
+∞
83.3
59
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
16.1
8.9
14
11
TAB00
NOMESCO Finland
Lumbar puncture
18.0
8.7
13
9
R4120
NOMESCO Finland
Occupational therapy
12.4
7.5
13
13
N03AX16
ATC
pregabalin; oral
5.0
6.8
24
70
G56.0
ICD-10 Finland
Carpal tunnel syndrome
30.2
6.4
8
*
G54.9
ICD-10 Finland
Nerve root and plexus disorder, unspecified
+∞
6.4
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
13
6.84
3.62
1.3
1.1
—
—
—
0
0
32
175
2.63
3.56
4.8
5.9
—
—
—
0
0
9
18
5.62
3.51
1.3
1.2
343.4
198.6
e6/l
—
9
13
42
265
2.65
3.45
6.2
5.9
0.0
0.0
e9/l
0.74
37
230
6
7
9.28
3.33
1.3
1.1
—
—
—
0
0
6
7
9.28
3.33
1.3
1.1
—
—
—
0
0
42
270
2.57
3.24
6.4
5.9
2.7
2.0
e9/l
0.39
37
241
41
263
2.51
3.15
6.4
5.8
0.6
0.6
e9/l
0.24
36
229
33
198
2.35
2.86
1.8
2.0
96.8
88.0
pmol/l
0.41
19
105
7
15
5.09
2.67
1.0
1.1
—
—
—
0
0
19
91
2.54
2.66
1.3
1.3
22.8
24.0
iu/ml
—
6
29
26
146
2.30
2.57
5.7
4.8
—
—
—
0
0
5
8
6.65
2.41
1.2
1.3
—
—
—
0
0
49
377
2.22
2.02
3.9
4.0
12.9
11.6
mm/h
0.18
49
345
5
12
4.41
1.86
1.4
1.2
0.2
0.3
g/l
—
5
12
5
13
4.07
1.75
1.4
1.2
1.1
1.3
g/l
—
5
13
26
172
1.85
1.53
3.0
2.4
—
—
—
0
0
19
113
1.96
1.53
3.4
2.5
3.4
3.3
e6/l
0.03
19
104
31
220
1.78
1.44
5.2
8.9
1.2
1.3
inr
—
10
58
32
231
1.76
1.39
9.8
9.4
0.0
0.0
e9/l
0.62
27
188
9
44
2.21
1.33
5.3
2.9
8.1
10.1
g/l
—
9
39
22
146
1.77
1.25
9.9
6.3
—
—
—
0
0
5
19
2.76
1.24
1.4
1.4
—
—
—
0
0
5
19
2.76
1.24
1.0
1.3
—
—
—
0
0
47
388
1.76
1.20
4.0
3.8
—
—
—
0
0
13
206
0.54
1.15
2.1
2.6
—
—
—
0
0
8
41
2.08
1.13
2.3
16.3
—
—
—
0
0
9
50
1.93
1.02
1.2
1.3
—
—
—
0
0
12
70
1.88
1.01
1.3
1.3
—
—
—
0
0
23
164
1.62
0.99
4.9
2.6
—
—
—
0
0
59
539
2.02
0.94
23.1
14.8
25.9
23.9
mg/l
0.14
47
423
20
141
1.60
0.89
1.9
3.2
142.2
60.5
mg/l
0.29
13
97
0
24
0.00
0.81
0.0
1.6
—
—
—
0
0
0
25
0.00
0.81
0.0
1.1
—
—
—
0
0
13
84
1.68
0.79
2.5
2.5
—
—
—
0
0
16
110
1.60
0.78
1.8
2.0
0.6
1.1
mg/l
1.00
11
92
7
39
1.89
0.75
8.7
2.3
—
—
—
0
0
27
211
1.48
0.75
3.8
3.8
18.3
43.0
ng/l
0.96
18
150
5
25
2.08
0.74
4.2
4.2
—
—
—
0
0
18
131
1.52
0.69
2.8
3.5
—
—
—
0
0
21
159
1.47
0.67
2.2
3.8
19.7
7.1
mg/mmol
0.32
13
106
5
29
1.78
0.65
1.4
1.8
—
—
—
0
0
6
36
1.73
0.58
4.0
3.9
—
7.4
—
0
6
54
495
1.54
0.57
23.6
16.1
40.5
40.7
%
0.09
38
379
9
64
1.47
0.54
3.1
1.6
—
—
—
0
0
15
112
1.44
0.50
3.1
5.0
—
—
—
0
0
7
47
1.55
0.49
2.9
4.0
68.4
75.9
e9/l
—
7
41
7
47
1.55
0.49
8.9
3.0
65.7
66.5
g/l
—
7
42
41
364
1.34
0.48
3.5
4.3
—
—
—
0
0
27
227
1.32
0.45
1.8
2.0
—
—
—
0
0
31
266
1.32
0.45
3.2
4.5
0.0
0.0
estimate
—
6
52
5
32
1.61
0.43
5.8
27.3
—
—
—
0
0
8
59
1.41
0.43
3.0
3.9
1.8
2.0
%
—
8
52
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
4.2
—
—
—
0
0
5
35
1.46
0.40
1.2
1.2
—
—
—
0
0
20
164
1.32
0.39
3.9
4.1
—
—
—
0
0
6
42
1.47
0.37
2.0
4.0
—
—
—
0
0
6
43
1.43
0.36
1.3
1.4
—
—
—
0
0
31
272
1.27
0.36
2.5
3.5
0.0
0.0
estimate
—
6
48
6
86
0.67
0.36
2.2
2.2
10.7
14.3
umol/l
—
6
79
6
46
1.33
0.34
5.8
9.5
—
—
—
0
0
6
46
1.33
0.34
4.0
4.4
—
—
—
0
0
7
51
1.42
0.33
1.3
1.4
—
—
—
0
0
18
149
1.29
0.32
3.5
2.8
0.5
0.7
ug/l
0.80
13
104
11
140
0.74
0.32
2.0
3.1
—
—
—
0
0
23
197
1.26
0.32
2.6
3.3
—
—
—
0
0
17
144
1.24
0.25
4.2
2.9
—
—
—
0
0
5
39
1.31
0.23
1.2
1.6
—
—
—
0
0
5
41
1.24
0.22
2.4
2.8
3.8
4.7
kpa
—
5
41
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
5.7
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
17.2
—
0
6
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
6
48
1.27
0.21
4.5
3.5
—
—
—
0
0
6
50
1.22
0.20
3.0
3.9
5.9
5.7
kpa
—
6
50
0
14
0.00
0.20
0.0
3.1
—
1.5
—
0
14
0
14
0.00
0.20
0.0
3.9
—
66.0
—
0
14
0
14
0.00
0.20
0.0
3.1
—
7.0
—
0
14
7
57
1.26
0.19
1.3
1.2
—
—
—
0
0
6
75
0.78
0.16
2.0
2.3
21.8
23.7
%
—
6
67
15
131
1.19
0.16
1.2
1.3
—
—
—
0
0
5
43
1.18
0.10
1.0
1.3
—
—
—
0
0
13
144
0.88
0.09
3.5
4.0
0.0
0.0
estimate
—
6
49
6
54
1.12
0.09
3.0
4.4
—
—
—
0
0
10
113
0.86
0.09
4.2
4.0
—
1.0
—
0
13
47
456
1.11
0.08
27.9
17.9
13.6
14.1
%
1.53
47
448
8
76
1.06
0.08
1.1
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
24.8
—
0
6
0
6
0.00
0.00
0.0
1.0
—
268.5
—
0
6
5
56
0.88
0.00
1.2
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
106.9
—
0
9
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
65
0.92
0.00
6.5
1.7
174.2
151.2
ug/g
—
6
54
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
3.9
—
0
9
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
49
1.02
0.00
1.2
1.6
—
—
—
0
0
8
80
1.00
0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.5
—
0
5
0
9
0.00
0.00
0.0
3.0
—
1.5
—
0
9
6
59
1.02
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
17.3
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
12.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_NEURAMYO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_NEURAMYO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_NEURAMYO – Neuralgic amyotrophy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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