Lens-induced iridocyclitis

H7_IRIDOLENS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H20.2
  • Cause of death: ICD-10 H20.2

2 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

60

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H20
Name in latin
Iridocyclitis phakogenes

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 330 171 157
Only index persons 311 165 146
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.04 53.69 52.23
Only index persons 53.04 53.29 52.76

-FinnGen-

Key figures

All Female Male
Number of individuals 60 33 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 57.46 54.93 60.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
55
Matched controls
551
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H20.2
ICD-10 Finland
Lens-induced iridocyclitis
+∞
78.8
55
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
39.4
33
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
16.5
15
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
61.2
12.6
14
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
10.8
11.2
23
34
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
75.1
11.1
12
*
S01ED01
ATC
timolol; ophthalmic
23.7
9.5
13
7
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
19.2
7.6
11
7
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
8.9
7.5
16
24
S01ED51
ATC
timolol, combinations; ophthalmic
8.9
7.1
15
22
S01FA04
ATC
cyclopentolate; ophthalmic
45.8
7.0
8
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
78.6
6.6
7
*
H26.2
ICD-10 Finland
Complicated cataract
78.6
6.6
7
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
+∞
6.4
6
*
S01EA03
ATC
apraclonidine; ophthalmic
+∞
6.4
6
*
WX140
NOMESCO Finland
Parabulbar anesthesy
9.2
6.0
12
16

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
286
3.02
3.59
11.8
9.9
4.3
4.4
e9/l
0.03
44
252
12
38
3.70
3.43
3.7
1.8
717.7
191.7
ng/l
0.40
12
30
30
163
2.68
3.43
12.2
4.8
—
—
—
0
0
22
102
2.83
3.41
6.8
6.5
—
—
—
0
0
29
157
2.64
3.31
5.1
4.0
7.4
7.4
ph
—
7
27
38
237
2.65
3.22
12.1
5.5
0.6
0.6
e9/l
0.19
38
208
38
238
2.63
3.18
12.0
5.4
0.0
0.0
e9/l
1.22
38
209
39
249
2.62
3.11
12.0
5.6
0.2
0.2
e9/l
0.13
39
223
35
222
2.38
2.70
13.0
5.2
0.7
0.6
%
0.17
35
208
8
21
4.23
2.56
3.0
4.5
—
—
—
0
0
35
226
2.32
2.54
13.1
5.4
2.9
2.8
%
0.18
35
214
35
226
2.32
2.54
12.4
5.7
56.9
58.5
%
0.44
35
213
25
141
2.33
2.48
3.4
2.9
—
—
—
0
0
35
228
2.28
2.47
13.6
5.9
8.4
8.4
%
0.03
35
217
5
8
6.69
2.42
9.6
7.5
—
—
—
0
0
25
144
2.26
2.34
3.6
3.0
0.3
0.4
e6/l
0.13
19
111
35
233
2.21
2.28
13.5
5.8
28.1
27.0
%
0.31
35
219
7
19
4.03
2.22
1.0
1.1
—
—
—
0
0
36
247
2.14
2.12
6.4
5.2
0.0
0.0
estimate
—
8
49
36
247
2.14
2.12
5.1
3.8
0.0
0.0
estimate
—
8
46
5
10
5.34
2.11
1.0
1.1
—
—
—
0
0
35
245
2.03
1.88
5.1
3.8
0.0
0.0
estimate
—
8
48
5
12
4.44
1.86
12.2
3.5
—
—
—
0
0
31
212
1.96
1.74
13.1
6.0
1.2
1.3
inr
—
9
64
17
94
2.13
1.69
1.4
1.6
1301.8
1218.8
nmol/l
0.12
17
73
11
50
2.47
1.69
1.5
1.4
—
—
—
0
0
22
138
1.94
1.55
6.2
4.1
0.0
0.0
estimate
—
7
44
29
200
1.87
1.54
3.2
3.5
20.5
40.3
ng/l
0.68
22
141
13
67
2.20
1.52
1.5
1.7
—
—
—
0
0
28
192
1.86
1.51
4.1
3.6
827.1
69.3
e6/l
0.45
22
137
43
340
1.93
1.46
6.4
4.0
—
—
—
0
0
9
41
2.40
1.44
2.7
4.2
—
—
—
0
0
9
44
2.23
1.34
5.6
3.6
—
—
—
0
0
20
130
1.81
1.24
7.8
7.5
—
—
—
0
0
8
39
2.21
1.20
2.9
3.6
1.2
1.2
mmol/l
—
8
34
22
149
1.75
1.18
5.1
4.1
3.1
7.4
mg/mmol
0.98
15
97
10
52
2.11
1.14
3.2
2.5
17.5
8.8
umol/l
—
10
44
11
60
2.02
1.11
1.6
1.5
—
—
—
0
0
9
45
2.17
1.11
6.7
3.2
—
—
—
0
0
14
84
1.87
1.09
1.3
3.1
0.8
0.8
mmol/l
0.09
14
79
7
34
2.20
1.07
1.1
1.3
—
—
—
0
0
23
163
1.67
1.03
1.9
2.4
—
—
—
0
0
7
37
2.01
0.97
3.1
9.8
1.5
1.6
%
—
7
37
22
158
1.62
0.93
3.5
3.0
—
—
—
0
0
6
29
2.18
0.92
9.0
6.5
26.4
26.0
mmol/l
—
6
29
20
142
1.61
0.88
4.1
3.3
26.8
49.2
mg/l
0.76
15
96
6
32
1.97
0.84
1.5
1.3
—
—
—
0
0
17
118
1.61
0.81
5.9
3.5
—
—
—
0
0
9
53
1.82
0.80
5.8
3.5
74.7
70.1
e9/l
—
9
44
19
136
1.58
0.80
4.3
3.7
—
—
—
0
0
12
76
1.72
0.79
1.1
1.3
1.0
10.3
u/ml
—
7
29
39
330
1.52
0.75
6.5
4.2
—
40.0
—
0
8
7
40
1.85
0.74
1.0
1.4
—
—
—
0
0
7
43
1.71
0.69
3.6
9.5
—
—
—
0
0
47
421
1.54
0.62
27.4
17.9
13.8
13.9
%
0.11
47
412
0
21
0.00
0.61
0.0
4.1
—
0.2
—
0
9
6
34
1.85
0.61
1.3
1.3
—
—
—
0
0
0
23
0.00
0.59
0.0
1.0
—
—
—
0
0
19
146
1.44
0.56
3.9
3.9
—
—
—
0
0
7
47
1.55
0.50
5.3
1.9
408.1
403.0
nmol/l
—
7
41
11
78
1.50
0.47
1.5
1.6
—
—
—
0
0
5
32
1.61
0.43
1.4
2.7
5.1
3.2
e9/l
—
5
24
40
359
1.34
0.43
5.2
3.9
—
—
—
0
0
17
135
1.36
0.41
3.9
4.4
—
—
—
0
0
6
44
1.40
0.35
2.3
2.5
0.3
0.2
g/l
—
6
39
9
75
1.23
0.26
1.3
1.2
—
—
—
0
0
53
509
1.35
0.24
23.2
17.1
139.5
139.7
mmol/l
0.19
53
497
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
18
205
0.83
0.21
1.8
2.3
—
—
—
0
0
6
47
1.31
0.21
4.7
2.9
2.3
3.1
mmol/l
—
6
38
6
48
1.28
0.21
2.5
8.1
1.1
1.3
mmol/l
—
6
42
6
48
1.28
0.21
3.5
3.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
258.6
—
0
7
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
52
1.17
0.20
1.2
1.2
—
—
—
0
0
5
66
0.74
0.18
1.2
1.3
—
—
—
0
0
53
513
1.28
0.16
24.1
17.0
4.0
4.0
mmol/l
0.14
53
501
53
513
1.28
0.16
23.2
13.7
—
—
—
0
0
15
132
1.18
0.15
1.4
1.4
—
—
—
0
0
12
104
1.19
0.13
2.0
1.7
0.9
1.1
mg/l
—
7
88
15
166
0.87
0.11
3.9
3.1
—
—
—
0
0
5
43
1.18
0.10
1.8
1.5
—
—
—
0
0
7
65
1.09
0.08
1.4
1.4
—
—
—
0
0
45
449
1.01
0.00
27.4
15.1
37.2
39.7
%
0.74
32
314
21
205
1.04
0.00
2.4
2.0
96.0
97.2
pmol/l
0.03
14
101
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
62.9
—
0
8
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
7.8
—
13.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
0.9
—
0
5
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
12.1
—
0
5
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.4
—
18.7
—
0
9

Mortality – FinRegistry

Association

Association between endpoint H7_IRIDOLENS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOLENS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_IRIDOLENS – Lens-induced iridocyclitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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