Radiodermatitis

L12_RADIODERMATITIS

acrodermatitis: An inflammatory skin condition affecting children. It is often associated with Epstein-Barr virus infection, hepatitis B infection or cytomegalovirus infection. It is characterized by the presence of cutaneous rashes and patches on the palms and soles. The trunk is not affected.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L58 Hospital discharge: ICD-8 — 6927 Cause of death: ICD-10 — L58 Cause of death: ICD-8 — 6927 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L55-L59
Name in latin: Radiodermatitis

NAME	L12_RADIODERMATITIS
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L58
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	6927
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L58
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	6927
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Radiodermatitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	430	304	124
Only index persons	380	272	108
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	61.07	62.40	57.84
Only index persons	60.71	62.23	56.88

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	62	19
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	58.54	58.72	57.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
718

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L58.9

ICD-10 Finland

Radiodermatitis, unspecified

+∞

51.3

L58.0

ICD-10 Finland

Acute radiodermatitis

+∞

23.2

115

Kela drug reimbursment

Breast cancer

12.7

15.3

HAB40

NOMESCO Finland

Wedge excision of mammary gland

14.1

11.7

L58.1

ICD-10 Finland

Chronic radiodermatitis

+∞

9.6

HA1AA

NOMESCO Finland

X-ray mammography

8.8

9.2

L57.0

ICD-10 Finland

Actinic keratosis

19.4

8.9

L02BA01

ATC

tamoxifen; oral

11.7

8.8

L02BG04

ATC

letrozole; oral

9.7

8.5

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

8.5

8.2

C50.40

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication

17.7

8.0

H02AB02

ATC

dexamethasone; systemic

6.6

7.9

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

9.0

7.7

PJA12

NOMESCO Finland

Sentinel node biopsy

6.0

7.1

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

7.1

7.0

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

10.3

6.9

WF003

NOMESCO Finland

Adjuvant radiotherapy

14.1

6.8

A03FA01

ATC

metoclopramide; systemic, rectal

4.1

6.8

112

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.0

6.3

8500/3-C50.4

ICD-O-3

Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast

12.7

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.06

6.78

2.3

1.3

—

(3023368) Bacteria identified in Blood by Culture

184

3.01

5.51

5.9

4.2

—

(40768443) Skin Pathology biopsy report

4.23

4.57

1.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

4.82

4.22

5.5

3.5

19.8

20.1

u/ml

—

(42870588) Differential panel, method unspecified - Blood

215

2.57

4.16

6.3

5.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.53

4.05

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

2.80

3.94

2.5

1.8

—

(3006315) Basophils [#/volume] in Blood

338

2.50

3.79

6.9

5.5

0.0

e9/l

0.07

300

(3013115) Eosinophils [#/volume] in Blood

348

2.51

3.77

7.2

5.6

0.2

e9/l

0.75

312

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.81

3.62

2.0

1.4

—

(3019198) Lymphocytes [#/volume] in Blood

343

2.44

3.59

6.9

5.5

1.7

1.8

e9/l

0.16

311

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.48

3.48

2.0

1.4

—

(3001604) Monocytes [#/volume] in Blood

337

2.39

3.46

7.0

5.5

0.6

e9/l

0.17

298

(3002256) Pathology report gross observation

2.69

3.26

1.4

1.1

—

(3032080) INR in Blood by Coagulation assay

254

2.24

3.15

9.6

7.9

1.1

1.2

inr

—

(40768804) Tissue Pathology biopsy report

281

2.24

3.14

2.9

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

381

2.25

2.94

3.1

2.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.78

2.93

2.4

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.81

2.87

2.6

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

316

2.16

2.86

5.4

4.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

336

2.16

2.83

10.9

5.5

1.2

mmol/l

0.64

281

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

147

2.26

2.77

3.5

1.9

—

(4035726)

2.69

2.77

1.6

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.55

2.76

4.1

2.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

2.60

2.74

4.3

4.9

5.8

6.2

ug/l

0.04

(3044640) Blood type and Crossmatch panel - Blood

213

2.13

2.73

3.2

2.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.79

2.59

1.2

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.41

2.27

1.4

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.83

2.24

1.2

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.52

2.22

4.7

4.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

4.54

2.19

6.2

3.6

82.0

31.6

u/ml

—

(3017181) Myelocytes/100 leukocytes in Blood

2.57

2.18

4.6

3.2

1.3

0.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.14

2.15

15.7

4.4

26.7

25.6

mmol/l

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

5.25

2.10

1.2

1.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.86

2.10

15.7

5.9

94.8

94.5

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.59

2.06

4.9

3.3

0.2

—

(3013512) EKG study

198

1.92

2.01

5.0

3.7

—

(40768793) Breast Pathology biopsy report

2.94

2.00

1.6

1.2

—

(1616796) Gas panel - Central venous blood

4.76

1.97

4.8

4.0

—

(3010421) pH of Blood

4.36

1.85

3.2

4.6

7.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

4.36

1.85

3.2

4.3

5.3

4.7

kpa

—

(3012501) Base excess in Blood by calculation

4.36

1.85

3.2

4.3

3.6

2.8

mmol/l

—

(3027315) Oxygen [Partial pressure] in Blood

4.36

1.85

3.2

4.3

7.5

9.0

kpa

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.51

1.78

1.0

1.4

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.44

1.72

4.2

3.1

1.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.32

1.69

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.13

1.67

1.4

1.8

—

(3022313) Gas panel - Capillary blood

3.15

1.61

7.2

2.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

2.07

1.57

12.1

5.0

15.3

12.7

kpa

0.77

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.07

1.57

12.1

5.0

5.1

5.3

kpa

0.27

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.48

1.54

6.4

1.4

4.0

5.5

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.48

1.54

7.2

1.5

58.0

59.9

—

(3037756) Immunofixation for Serum or Plasma

3.48

1.54

3.6

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

688

2.69

1.53

26.4

13.7

26.8

22.5

mg/l

0.57

532

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.00

1.53

1.5

2.0

—

(3000991) Gas panel - Venous blood

2.39

1.53

14.9

3.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

114

1.87

1.44

3.2

2.7

0.9

0.8

e6/l

0.02

(3003396) Base excess in Arterial blood by calculation

1.99

1.43

12.1

5.0

0.3

1.8

mmol/l

0.81

(40758558) Short blood count panel - Blood

192

1.70

1.37

11.9

7.4

—

(3019060) Gas panel - Arterial blood

2.23

1.35

3.9

4.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.29

1.25

2.3

2.4

123.9

130.2

g/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

233

1.62

1.23

4.4

3.6

26.9

28.7

u/l

0.30

222

(3025159) Blasts/100 leukocytes in Blood

2.14

1.22

5.4

3.3

0.2

0.0

—

(3000330) Specific gravity of Urine by Test strip

2.16

1.19

2.0

2.8

—

(3019225) pH of Specimen

2.04

1.18

4.9

3.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.59

1.17

2.2

3.8

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.37

1.13

2.6

2.7

24.5

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

108

1.73

1.07

3.3

3.0

3.3

3.4

e6/l

0.02

(3045414) Leukocytes [Presence] in Urine

2.16

1.06

1.4

1.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.16

1.06

1.7

2.2

0.7

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.16

1.06

1.7

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.98

1.04

5.3

7.5

25.8

25.4

mmol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

215

1.54

1.01

4.3

2.6

836.2

1024.5

ng/l

0.34

180

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

521

1.58

0.99

5.4

4.3

14.4

14.9

pmol/l

1.05

473

(3018095) Leukocytes [#/volume] in Urine

253

1.51

0.98

4.2

3.8

48.5

44.5

e6/l

0.07

178

(3015736) pH of Urine

263

1.50

0.97

4.6

3.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.97

0.96

1.9

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.97

0.96

20.6

6.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

163

1.57

0.96

7.0

4.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

120

1.64

0.96

1.3

76.5

34.8

iu/ml

—

(3012516) Albumin [Mass/volume] in Urine

181

1.55

0.96

2.9

48.9

47.5

mg/l

0.01

110

(3002582) Erythrocytes [#/volume] in Urine

219

1.51

0.92

3.4

3.2

14.9

26.5

e6/l

0.89

167

(3026008) Bacteria identified in Urine by Culture

221

1.49

0.87

3.4

2.9

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.86

0.87

2.3

2.4

5.0

4.2

kpa

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

240

1.47

0.86

4.0

3.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.82

0.85

5.4

3.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.70

0.84

13.2

7.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.94

0.83

3.0

52.0

48.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

299

1.44

0.82

2.6

2.3

73.7

78.3

nmol/l

0.42

265

(36304419) Bacteria [Presence] in Urine

187

1.49

0.82

3.6

2.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.88

0.81

1.2

2.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.88

0.81

1.0

—

(3008898) HLA-B27 [Presence]

0.00

0.80

0.0

1.2

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.75

0.78

2.2

2.4

5.6

6.0

kpa

—

(3002385) Erythrocyte distribution width [Ratio]

576

1.53

0.77

25.8

17.5

13.9

0.00

565

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

145

1.50

0.75

2.2

1.9

1.2

1.1

mg/l

0.03

122

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.65

0.74

2.9

2.3

11.3

5.5

ug/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

646

1.62

0.71

23.2

13.4

79.9

79.1

ml/min/173m2

0.12

517

(3020891) Body temperature

1.91

0.69

4.0

5.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.70

0.69

1.9

2.5

23.5

32.9

u/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

212

1.41

0.68

2.4

2.1

106.3

130.2

u/l

0.29

201

(3011397) Hemoglobin [Presence] in Urine by Test strip

158

1.44

0.66

5.7

3.6

—

(3018418) pH of Serum or Plasma

223

1.39

0.65

7.2

3.8

7.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.77

0.65

1.0

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

458

1.38

0.65

6.4

4.0

—

(40761535) Cells panel - Urine sediment

1.66

0.63

5.4

3.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

254

1.36

0.60

6.4

3.6

15.6

40.0

ng/l

0.92

176

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.53

0.59

3.5

2.9

15.6

34.3

u/ml

—

(3012544) pH of Venous blood

1.53

0.56

2.2

2.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

118

1.44

0.55

1.2

1.3

45.9

14.5

u/ml

—

(3035350) Ketones [Presence] in Urine by Test strip

336

1.31

0.53

4.8

3.8

0.0

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

111

1.43

0.51

1.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

129

1.40

0.51

4.1

3.6

44.2

173.7

ng/l

—

100

(3020682) Albumin/Creatinine [Ratio] in Urine

194

1.34

0.50

3.8

3.7

5.6

8.6

mg/mmol

0.24

109

(3042936) Bacteria identified in Isolate by Culture

1.46

0.49

2.1

2.0

—

(3009261) Glucose [Presence] in Urine by Test strip

340

1.28

0.47

4.8

3.8

0.0

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

178

1.32

0.45

5.8

4.0

0.0

estimate

—

(40761511) CBC panel - Blood by Automated count

716

1.64

0.45

22.2

12.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.47

0.44

2.3

1.9

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.45

0.44

1.3

3.2

115.6

200.4

ng/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

652

1.39

0.42

6.4

4.9

2.1

1.9

mu/l

0.50

586

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

3.2

—

(3000494) Fungus identified in Specimen by Culture

1.41

0.40

1.8

1.4

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.39

0.0

1.3

—

274.0

—

(3000492) Spirometry study

1.36

0.39

1.0

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

337

1.24

0.38

6.2

5.1

0.0

estimate

—

(3009542) Hematocrit [Volume Fraction] of Blood

625

1.30

0.34

22.7

14.6

40.0

39.4

0.21

456

(3037522) Nuclear Ab [Titer] in Serum

1.29

0.26

1.3

608.0

584.3

titre

—

(3044889) 12 lead EKG panel

508

1.19

0.25

4.6

3.8

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.37

0.24

1.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.30

0.23

1.8

1.6

—

(1761868) Lipid panel - Serum or Plasma

249

0.84

0.23

3.9

3.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.2

—

31.7

—

(4306422)

0.00

0.21

0.0

1.1

—

(4268621)

0.00

0.21

0.0

1.8

—

(4062490)

0.00

0.21

0.0

1.3

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.21

0.0

1.0

—

95.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.6

—

3.2

—

(3021589) Normoblasts [#/volume] in Blood

302

1.16

0.21

18.1

9.8

0.0

e9/l

0.00

243

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.7

—

48.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

1.17

0.19

1.5

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

194

0.84

0.19

3.6

3.4

—

(3022621) pH of Urine by Test strip

1.18

0.18

2.4

3.0

—

(3003694) ABO and Rh group [Type] in Blood

187

1.17

0.18

1.6

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

690

1.23

0.18

5.1

4.6

6.1

5.9

mmol/l

0.28

629

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.14

0.18

1.4

1.6

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.17

0.16

5.0

4.1

268.0

237.8

u/l

—

(3022145) Colonoscopy Study observation

0.77

0.15

1.0

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

133

1.16

0.13

1.4

1.3

2.3

2.4

g/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

281

1.11

0.12

2.4

1.9

90.3

101.6

pmol/l

0.72

127

(4010399)

1.14

0.09

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.09

4.8

3.6

—

(21494755) Public health laboratory ask at order entry panel

0.79

0.08

1.2

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.08

0.08

1.6

1.4

—

(40768797) Stomach Pathology biopsy report

102

0.87

0.07

1.1

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

686

0.95

0.01

4.4

4.5

1.6

mmol/l

0.19

628

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

664

1.05

0.00

3.9

4.0

1.4

1.3

mmol/l

0.45

605

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

119

1.01

0.00

1.4

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

691

0.99

0.00

4.4

4.6

4.9

4.7

mmol/l

0.84

639

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

264

0.98

0.00

5.5

3.8

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.7

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

33.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.91

0.00

1.8

1.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

3.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.6

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

700

1.00

0.00

5.0

5.1

2.8

2.7

mmol/l

0.45

644

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.0

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

23.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_RADIODERMATITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_RADIODERMATITIS	1.892 [1.32, 2.71]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.171

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 262 females with L12_RADIODERMATITIS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_RADIODERMATITIS.

N-year risk	Females	Males
1	0.18%	No data
5	1.015%	No data
10	2.571%	No data
15	5.165%	No data
20	9.201%	No data

Relationships between endpoints

↥

Index endpoint: L12_RADIODERMATITIS – Radiodermatitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Radiodermatitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints