Radiodermatitis

L12_RADIODERMATITIS

A significant side effect of ionizing radiation delivered to the skin during cancer treatment as well as a result of nuclear attacks and disasters.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L58 Hospital discharge: ICD-8 — 6927 Cause of death: ICD-10 — L58 Cause of death: ICD-8 — 6927 2 out of 7 registries used, show all original rules.	86
4. Check minimum number of events None	86
5. Include endpoints None	86
6. Filter based on genotype QC (FinnGen only)	83

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L55-L59
Name in latin: Radiodermatitis

NAME	L12_RADIODERMATITIS
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L58
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	6927
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L58
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	6927
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Radiodermatitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	430	304	124
Only index persons	380	272	108
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	61.07	62.40	57.84
Only index persons	60.71	62.23	56.88

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	83	63	20
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	58.76	58.82	58.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
86: Matched controls
860

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L58.9

ICD-10 Finland

Radiodermatitis, unspecified

+∞

63.6

L58.0

ICD-10 Finland

Acute radiodermatitis

+∞

26.4

115

Kela drug reimbursment

Breast cancer

6.7

16.1

HAB40

NOMESCO Finland

Wedge excision of mammary gland

7.2

13.5

H02AB02

ATC

dexamethasone; systemic

5.6

12.2

L58.1

ICD-10 Finland

Chronic radiodermatitis

+∞

10.6

HA1AA

NOMESCO Finland

X-ray mammography

5.7

10.6

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

6.2

10.1

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

6.1

9.6

L02BG04

ATC

letrozole; oral

5.0

9.0

WF003

NOMESCO Finland

Adjuvant radiotherapy

12.0

9.0

A03FA01

ATC

metoclopramide; systemic, rectal

3.9

8.9

162

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.1

8.1

C50.40

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication

10.9

7.6

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.6

7.4

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

4.4

7.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.3

6.6

292

PJA12

NOMESCO Finland

Sentinel node biopsy

3.9

6.5

XX3DW

NOMESCO Finland

Time consuming IT work

3.8

6.4

L57.0

ICD-10 Finland

Actinic keratosis

7.0

6.3

L02BA01

ATC

tamoxifen; oral

5.8

6.2

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.3

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

3.88

6.67

2.4

1.3

—

(3023368) Bacteria identified in Blood by Culture

197

3.21

6.58

5.4

4.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.83

5.06

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

334

2.66

4.56

7.7

5.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

5.63

4.51

4.8

3.4

19.50

19.92

u/ml

0.02

(3006315) Basophils [#/volume] in Blood

361

2.58

4.21

6.7

5.3

0.04

e9/l

0.00

319

(3013115) Eosinophils [#/volume] in Blood

371

2.59

4.19

6.9

5.5

0.21

0.18

e9/l

0.63

331

(40768443) Skin Pathology biopsy report

4.20

4.02

1.1

—

(3019198) Lymphocytes [#/volume] in Blood

367

2.51

3.98

6.7

5.3

1.65

1.77

e9/l

0.46

333

(3002256) Pathology report gross observation

2.84

3.88

1.5

1.1

—

(3001604) Monocytes [#/volume] in Blood

361

2.45

3.84

6.8

5.3

0.58

0.56

e9/l

0.20

321

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

114

2.68

3.82

2.4

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.78

3.62

2.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.45

3.47

2.0

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

335

2.28

3.41

3.4

2.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

2.76

3.35

3.9

4.8

5.74

5.98

ug/l

0.02

(40768804) Tissue Pathology biopsy report

296

2.19

3.16

3.0

1.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

365

2.18

3.02

10.8

5.5

1.21

1.22

mmol/l

0.61

308

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.75

2.93

2.4

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

7.06

2.91

2.3

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

7.06

2.91

2.3

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

224

2.14

2.91

3.2

2.0

—

(4035726) Immunohistochemistry procedure

2.62

2.80

1.6

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.53

2.75

2.6

2.1

—

(3013512) EKG study

203

2.12

2.74

5.1

3.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

155

2.20

2.73

3.5

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

406

2.09

2.65

3.0

2.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.30

2.64

4.1

2.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.77

2.59

1.2

1.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

342

2.01

2.53

12.0

11.9

1.13

1.17

inr

0.21

107

(3017181) Myelocytes/100 leukocytes in Blood

2.64

2.44

4.3

3.1

1.33

0.78

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.66

2.33

4.5

3.2

0.17

0.15

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.34

2.25

1.4

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.82

2.24

1.2

1.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

5.23

2.10

1.2

1.9

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

4.21

2.07

6.2

3.4

82.03

29.91

u/ml

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.92

2.00

15.7

5.3

26.70

26.09

mmol/l

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.52

1.98

3.9

3.0

1.17

0.57

—

(3023419) Bacteria identified in Sputum by Culture

4.75

1.97

1.6

2.3

—

(1616796) Gas panel - Central venous blood

4.75

1.97

4.8

4.0

—

(40768793) Breast Pathology biopsy report

2.83

1.93

1.6

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.30

1.88

4.7

3.9

—

(3037756) Immunofixation for Serum or Plasma

3.71

1.87

3.5

1.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

4.35

1.85

3.2

4.3

5.28

4.74

kpa

—

(3012501) Base excess in Blood by calculation

4.35

1.85

3.2

4.3

3.60

2.80

mmol/l

—

(3027315) Oxygen [Partial pressure] in Blood

4.35

1.85

3.2

4.3

7.50

8.96

kpa

—

(3010421) pH of Blood

4.35

1.85

3.2

4.6

7.45

7.43

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

730

2.88

1.82

25.9

13.8

26.09

22.24

mg/l

0.52

564

(3033705) Calcium.ionized [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

—

(3035285) Chloride [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

107.00

106.54

mmol/l

—

(3041354) Potassium [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

3.82

3.90

mmol/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.69

1.73

15.7

7.4

94.75

94.43

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.31

1.69

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.31

1.69

1.0

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.08

1.68

1.4

1.8

—

(3022313) Gas panel - Capillary blood

3.14

1.61

7.2

2.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.57

1.58

2.4

2.8

24.80

24.60

mmol/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

247

1.70

1.55

4.1

3.5

26.74

28.27

u/l

0.28

235

(3008037) Lactate [Moles/volume] in Venous blood

3.47

1.54

2.2

3.5

1.46

1.44

mmol/l

—

(3038515) Glucose [Moles/volume] in Venous blood

3.47

1.54

2.2

3.5

7.34

7.80

mmol/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.01

1.54

11.7

5.5

5.12

5.31

kpa

0.43

(3027801) Oxygen [Partial pressure] in Arterial blood

2.01

1.54

11.7

5.5

15.15

12.57

kpa

0.85

(40758558) Short blood count panel - Blood

203

1.73

1.54

11.8

7.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.99

1.53

2.2

4.9

—

(3019225) pH of Specimen

2.20

1.52

4.6

3.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.46

1.48

2.1

2.5

125.11

130.97

g/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.85

1.46

1.5

2.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.25

1.46

6.4

1.4

3.99

5.42

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.25

1.46

7.2

1.5

58.00

59.75

—

(3000330) Specific gravity of Urine by Test strip

2.33

1.42

2.0

3.3

—

(3019060) Gas panel - Arterial blood

2.28

1.40

4.1

4.7

—

(3026008) Bacteria identified in Urine by Culture

235

1.66

1.39

3.8

3.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.49

1.33

1.6

2.4

0.69

0.64

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.28

1.25

1.6

2.3

0.68

1.34

—

(3000991) Gas panel - Venous blood

2.13

1.22

14.9

5.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.13

1.22

5.0

3.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

129

1.72

1.19

1.3

76.50

39.70

iu/ml

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

319

1.55

1.15

2.5

2.3

73.44

77.44

nmol/l

0.38

283

(3002385) Erythrocyte distribution width [Ratio]

639

1.78

1.14

24.5

17.3

15.45

15.04

0.20

629

(3012516) Albumin [Mass/volume] in Urine

191

1.60

1.14

2.9

43.44

45.71

mg/l

0.02

116

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

228

1.56

1.11

5.0

2.6

943.51

1000.63

ng/l

0.09

190

(3025159) Blasts/100 leukocytes in Blood

2.00

1.06

5.4

3.2

0.20

0.08

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.15

1.05

2.7

3.1

54.71

49.72

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.80

1.05

12.4

7.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

125

1.67

1.05

3.2

2.8

0.87

0.82

e6/l

0.03

(3045414) Leukocytes [Presence] in Urine

2.09

1.02

1.4

1.8

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.93

1.02

2.1

2.6

4.99

4.24

kpa

—

(3037467) Urinalysis macro (dipstick) panel - Urine

487

1.51

0.97

6.5

4.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.97

0.96

1.7

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.97

0.96

1.9

2.6

—

(3018095) Leukocytes [#/volume] in Urine

273

1.48

0.93

4.1

3.8

47.85

58.42

e6/l

0.17

197

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.00

0.91

18.6

6.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

687

1.72

0.87

22.4

13.6

80.05

78.73

ml/min/173m2

0.25

546

(3002582) Erythrocytes [#/volume] in Urine

239

1.46

0.87

3.3

3.2

14.32

26.97

e6/l

1.15

186

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

259

1.44

0.84

3.9

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

269

1.44

0.83

6.2

3.8

17.02

39.43

ng/l

0.91

190

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

116

1.58

0.82

1.2

1.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.79

0.79

2.1

2.9

5.55

6.00

kpa

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.82

0.78

1.0

—

(40761535) Cells panel - Urine sediment

1.74

0.77

4.9

3.1

—

(3035350) Ketones [Presence] in Urine by Test strip

359

1.40

0.76

4.7

3.7

0.00

estimate

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

119

1.53

0.74

3.3

3.0

3.25

3.06

e6/l

0.03

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.65

0.74

3.3

2.9

15.00

33.68

u/ml

—

(3009261) Glucose [Presence] in Urine by Test strip

361

1.38

0.73

4.7

3.8

0.00

estimate

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.77

0.72

1.9

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

156

1.46

0.70

2.2

1.9

1.20

1.14

mg/l

0.06

130

(3000494) Fungus identified in Specimen by Culture

1.57

0.69

1.6

1.4

—

(36304419) Bacteria [Presence] in Urine

202

1.41

0.68

3.5

3.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

166

1.44

0.67

5.6

3.5

—

(3020891) Body temperature

1.83

0.67

4.0

5.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

203

1.40

0.66

3.3

3.6

5.12

8.22

mg/mmol

0.28

116

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

559

1.39

0.64

5.3

4.3

14.40

14.91

pmol/l

1.09

510

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

223

1.38

0.64

2.4

2.0

106.79

129.16

u/l

0.28

211

(3021601) Nitrite [Presence] in Urine by Test strip

358

1.34

0.62

6.1

5.1

0.00

estimate

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

142

1.43

0.61

4.2

3.5

41.91

158.87

ng/l

0.77

111

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.56

0.56

2.9

2.3

11.27

5.48

ug/l

—

(3042936) Bacteria identified in Isolate by Culture

100

1.48

0.56

2.0

—

(40761511) CBC panel - Blood by Automated count

763

1.69

0.56

21.8

12.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

128

1.41

0.53

1.2

1.3

39.44

13.85

u/ml

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

696

1.45

0.51

6.2

4.9

2.08

1.88

mu/l

0.47

629

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.53

0.49

1.9

2.4

23.50

32.19

u/l

—

(3018418) pH of Serum or Plasma

243

1.29

0.46

7.7

3.8

7.40

—

(1761868) Lipid panel - Serum or Plasma

267

0.76

0.45

3.9

3.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.65

0.44

1.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

188

1.30

0.43

5.7

4.0

0.00

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.42

0.43

14.1

5.4

105.00

103.77

mmol/l

0.43

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.41

0.40

1.3

1.5

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.39

0.0

1.3

—

274.00

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.34

0.39

1.4

—

(3021589) Normoblasts [#/volume] in Blood

319

1.22

0.35

16.8

9.6

0.00

e9/l

-0.00

256

(3003694) ABO and Rh group [Type] in Blood

194

1.25

0.34

1.6

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.40

0.32

1.4

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

730

1.35

0.32

5.0

4.5

6.07

5.91

mmol/l

0.32

667

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.30

0.29

2.3

1.9

—

(3022621) pH of Urine by Test strip

1.30

0.29

2.6

3.0

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.28

0.28

1.3

3.0

115.63

201.15

ng/l

—

(3000492) Spirometry study

1.26

0.26

1.0

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.27

0.23

1.2

1.6

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.23

0.22

1.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.20

0.22

1.2

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.21

0.0

1.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.2

—

31.73

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.21

0.0

2.6

—

50.60

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.21

0.0

1.0

—

95.20

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3037522) Nuclear Ab [Titer] in Serum

1.25

0.21

1.3

608.00

568.33

titre

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.6

—

3.20

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.7

—

48.29

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.1

—

10.51

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.0

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.27

0.20

4.7

4.0

263.50

236.96

u/l

—

(4200892) Spirometry reversibility

1.22

0.19

1.4

1.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.22

0.19

10.0

4.6

1.23

mmol/l

—

(21494755) Public health laboratory ask at order entry panel

0.76

0.17

1.2

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

141

1.17

0.15

1.4

1.3

2.18

2.39

g/l

—

(3022145) Colonoscopy Study observation

0.82

0.14

1.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

279

1.12

0.13

5.2

3.8

—

(3044889) 12 lead EKG panel

540

1.11

0.12

4.6

3.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

301

1.10

0.11

2.5

1.9

92.67

99.49

pmol/l

0.40

137

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.14

0.10

1.8

1.6

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.12

0.10

4.4

2.8

70.60

76.44

ng/l

—

(40761536) Microorganisms panel - Urine sediment

1.08

0.09

4.8

3.5

—

(40768797) Stomach Pathology biopsy report

101

0.88

0.07

1.1

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

131

1.08

0.04

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

743

1.07

0.02

4.8

5.1

2.86

2.76

mmol/l

0.44

684

(3041096) Erythrocytes [Presence] in Urine by Automated

207

0.96

0.01

3.5

3.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

728

1.02

0.00

4.3

4.5

1.59

1.55

mmol/l

0.27

668

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

704

0.97

0.00

3.9

4.0

1.35

1.27

mmol/l

0.43

642

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

734

0.96

0.00

4.4

4.5

4.93

4.76

mmol/l

0.75

680

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

1.7

—

33.83

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.99

0.00

1.7

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

33.80

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

0.33

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.9

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.6

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

23.40

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.9

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

5.95

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_RADIODERMATITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_RADIODERMATITIS	1.892 [1.32, 2.71]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.171

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 262 females with L12_RADIODERMATITIS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_RADIODERMATITIS.

N-year risk	Females	Males
1	0.18%	No data
5	1.015%	No data
10	2.571%	No data
15	5.165%	No data
20	9.201%	No data

Relationships between endpoints

↥

Index endpoint: L12_RADIODERMATITIS – Radiodermatitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Radiodermatitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints