Mucocutaneous lymph node syndrome [Kawasaki]

M13_KAWASAKI

mucocutaneous lymph node syndrome: Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M30.3 Hospital discharge: ICD-9 — 4461 Cause of death: ICD-10 — M30.3 Cause of death: ICD-9 — 4461 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	79

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M30
Name in latin: Syndroma mucocutaneum lymphonodorum (Kawasaki)

NAME	M13_KAWASAKI
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M303
HD_ICD_9	4461
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M303
COD_ICD_9	4461
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Mucocutaneous lymph node syndrome [Kawasaki] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1816	687	1129
Only index persons	1386	500	886
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	-	4.24	3.84
Only index persons	4.78	5.46	4.39

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	79	42	37
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	7.88	6.63	9.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
82: Matched controls
820

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M30.3

ICD-10 Finland

Mucocutaneous lymph node syndrome [Kawasaki]

+∞

70.2

4461A

ICD-9 Finland

Polyarteritis nodosa and allied conditions, Acute febrile mucocutaneous lymph node syndrome [MCLS]

+∞

32.5

M30.0

ICD-10 Finland

Polyarteritis nodosa

+∞

11.7

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.9

6.8

L04AX01

ATC

azathioprine; systemic

10.6

6.5

H02AB06

ATC

prednisolone; systemic

3.2

6.1

182

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

116

2.66

3.71

3.0

3.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

249

1.98

2.34

10.1

10.7

1.21

1.22

mmol/l

0.47

219

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.93

2.16

2.8

2.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

5.24

2.10

1.0

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.23

2.08

1.2

3.3

—

(3030467) Casts [#/volume] in Urine by Automated count

171

1.97

2.07

2.8

3.5

0.33

0.36

e6/l

0.03

129

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.53

1.98

2.2

1.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.76

1.97

1.2

1.1

—

(36304419) Bacteria [Presence] in Urine

174

1.93

1.95

2.9

3.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.84

1.77

1.6

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

157

1.85

1.66

2.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

209

1.78

1.64

2.8

3.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.73

1.64

3.2

4.5

54.60

53.93

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.73

1.64

3.2

4.4

3.54

3.35

e9/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.57

0.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

203

1.75

1.56

3.3

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

195

1.75

1.54

2.8

3.3

8.94

365.48

e6/l

0.57

153

(1761868) Lipid panel - Serum or Plasma

175

0.45

1.52

1.6

2.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.17

1.47

6.2

5.6

24.83

23.50

mmol/l

1.42

(3022145) Colonoscopy Study observation

2.28

1.39

1.6

—

(3044889) 12 lead EKG panel

331

1.63

1.34

3.1

2.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

193

1.68

1.34

8.0

8.1

1.06

1.20

inr

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.89

1.30

2.8

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

195

1.66

1.28

9.5

6.6

34.60

37.46

g/l

1.23

189

(3029937) Albumin [Presence] in Urine by Test strip

156

1.66

1.15

3.0

3.4

0.00

estimate

-0.00

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

140

1.67

1.12

5.3

2.7

59.89

25.14

ng/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.30

1.11

1.0

—

(3000991) Gas panel - Venous blood

1.82

1.02

5.8

9.9

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.99

0.0

2.1

—

10.95

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.84

0.99

8.0

8.3

25.42

24.82

mmol/l

0.46

(3021589) Normoblasts [#/volume] in Blood

330

1.48

0.96

8.9

6.9

0.00

e9/l

0.50

264

(3012544) pH of Venous blood

1.77

0.95

5.8

6.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.23

0.93

1.5

1.3

—

(3027008) Opiates [Presence] in Urine

1.71

0.91

1.1

1.6

—

(3027944) Amphetamines [Presence] in Urine

1.71

0.91

1.1

1.7

—

(3028300) Cannabinoids [Presence] in Urine

1.71

0.91

1.1

1.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.15

0.91

1.2

1.9

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

286

1.46

0.88

3.3

2.9

156.58

71.34

ug/l

0.85

269

(3028626) Oxygen [Partial pressure] in Capillary blood

1.82

0.84

7.6

5.5

8.92

9.78

kpa

—

(3018095) Leukocytes [#/volume] in Urine

234

1.44

0.79

3.0

3.8

35.64

44.89

e6/l

0.13

158

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.82

0.78

1.3

4.1

99.33

85.71

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

118

1.56

0.77

1.6

2.3

1.66

1.44

mg/l

0.09

(3022313) Gas panel - Capillary blood

1.68

0.76

7.3

4.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

154

0.60

0.73

4.0

2.1

—

(3000764) Benzodiazepines [Presence] in Urine

1.59

0.68

1.2

1.7

—

(3037121) Protein [Mass/volume] in Urine

1.84

0.67

6.2

6.0

0.34

0.17

g/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

308

1.37

0.66

10.0

7.0

—

(3042936) Bacteria identified in Isolate by Culture

1.67

0.65

4.2

2.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

147

0.64

0.60

3.0

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

162

1.40

0.58

1.5

1.7

97.98

96.14

pmol/l

0.05

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.62

0.55

3.8

2.1

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.52

0.55

8.6

5.0

5.01

5.07

kpa

0.14

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.52

0.55

8.6

4.9

1.83

1.25

mmol/l

0.61

(3002385) Erythrocyte distribution width [Ratio]

622

1.42

0.53

18.6

13.1

14.08

13.82

0.18

612

(3016879) Cocaine [Presence] in Urine

1.50

0.53

1.2

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

469

1.30

0.48

3.1

3.7

14.65

14.53

pmol/l

0.13

421

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

128

0.67

0.48

1.3

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.47

0.44

2.9

3.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.49

0.44

1.1

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

142

1.34

0.43

2.0

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

294

1.27

0.43

3.7

4.4

0.00

estimate

-0.00

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.0

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.41

0.0

2.3

—

3.57

—

(3035350) Ketones [Presence] in Urine by Test strip

295

1.26

0.41

2.9

3.2

0.00

estimate

-0.00

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

1.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.41

0.0

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

1.6

—

32.56

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.34

0.39

2.1

1.6

—

(3003694) ABO and Rh group [Type] in Blood

251

0.78

0.38

1.5

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

109

1.34

0.36

4.9

3.6

65.24

21.52

mg/mmol

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

260

1.24

0.36

5.1

6.0

21.92

12.05

umol/l

0.42

245

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

238

0.79

0.35

2.4

1.7

—

(3000492) Spirometry study

1.32

0.31

1.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

107

0.72

0.31

10.6

9.4

1.06

1.19

mmol/l

—

102

(3044640) Blood type and Crossmatch panel - Blood

193

0.79

0.31

3.8

2.2

—

(3002256) Pathology report gross observation

1.27

0.30

1.1

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

617

1.26

0.30

3.7

3.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

443

1.20

0.30

5.5

3.9

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

141

1.26

0.29

1.9

2.5

2.43

2.42

mg/l

0.01

126

(3026008) Bacteria identified in Urine by Culture

180

0.80

0.28

3.5

2.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.26

0.26

3.4

1.5

—

(3013512) EKG study

1.28

0.24

4.9

3.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

291

0.84

0.24

3.8

2.7

—

(3009261) Glucose [Presence] in Urine by Test strip

299

1.17

0.24

3.0

3.3

0.00

estimate

-0.00

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

112

0.78

0.21

1.7

1.5

—

(4034850) Laboratory test

0.00

0.21

0.0

19.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.30

0.21

1.0

1.4

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.2

—

377.31

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

9.19

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.21

0.0

1.4

—

281.46

—

(3007164) IgA [Mass/volume] in Serum or Plasma

195

0.84

0.20

1.4

1.6

1.97

1.95

g/l

—

109

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.20

0.0

1.4

—

(40768797) Stomach Pathology biopsy report

1.23

0.19

1.9

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.23

0.19

7.9

10.3

103.57

104.67

mmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

216

1.16

0.18

2.0

1.8

—

(40758558) Short blood count panel - Blood

187

1.17

0.18

6.5

6.8

—

(3011288) Drugs identified in Urine by Screen method

1.16

0.18

1.3

1.9

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.75

0.17

1.4

2.7

—

3554.05

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.75

0.17

1.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.72

0.17

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

0.71

0.17

3.8

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.23

0.17

1.8

2.0

—

(40761511) CBC panel - Blood by Automated count

680

1.20

0.17

15.4

9.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.14

0.17

3.3

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.14

0.17

1.9

1.6

360.50

469.42

pmol/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

444

0.89

0.16

4.0

3.9

36.80

37.11

mmol/mol

0.07

416

(36660697) Celiac disease serology panel - Serum

1.14

0.16

1.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

104

1.18

0.13

2.3

3.0

0.13

0.33

e6/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

187

0.89

0.11

1.5

1.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

664

1.14

0.11

10.6

8.1

31.56

26.64

u/l

0.51

633

(40768804) Tissue Pathology biopsy report

194

1.11

0.10

2.2

1.9

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.04

0.09

1.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

1.04

0.09

1.0

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

205

0.90

0.09

2.7

—

(3035941) MCH [Entitic mass]

759

1.24

0.08

21.4

15.4

29.51

29.67

0.33

748

(3024731) MCV [Entitic volume]

759

1.24

0.08

21.4

15.5

87.98

88.48

0.37

749

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.81

0.08

1.4

1.5

—

(3000963) Hemoglobin [Mass/volume] in Blood

759

1.24

0.08

21.7

15.6

133.74

135.88

g/l

0.55

749

(3026361) Erythrocytes [#/volume] in Blood

759

1.24

0.08

21.5

15.5

4.55

4.60

e12/l

0.32

732

(3010813) Leukocytes [#/volume] in Blood

760

1.22

0.08

21.8

15.5

7.11

6.87

e9/l

0.47

732

(3007461) Platelets [#/volume] in Blood

758

1.26

0.08

21.6

15.6

272.71

258.69

e9/l

1.15

734

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.77

0.08

1.4

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.14

0.08

3.3

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.80

0.08

1.7

2.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.06

0.07

4.9

1.6

—

(21494755) Public health laboratory ask at order entry panel

1.08

0.07

1.2

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

192

0.92

0.06

2.3

2.5

—

(3003338) MCHC [Mass/volume]

619

1.08

0.05

18.4

14.5

334.76

334.61

g/l

0.04

614

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

490

1.05

0.03

13.2

8.6

94.24

97.58

ml/min/173m2

0.34

374

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

651

1.07

0.03

17.6

10.5

28.81

22.59

mg/l

0.58

469

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

103

1.08

0.02

2.5

3.0

0.50

1.46

e6/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

265

1.03

0.00

2.4

2.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

119

1.01

0.00

1.9

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

0.99

0.00

2.3

1.5

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.0

—

3.92

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

9.0

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.8

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

54.13

—

(3018133) Calcium [Moles/volume] in Urine

0.00

0.0

4.0

—

2.44

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.1

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.3

—

13.73

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.7

—

12.70

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.87

-0.00

1.2

1.5

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.87

-0.00

1.2

1.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

4.10

—

(3010503) CD19 cells [#/volume] in Blood

0.00

-0.00

0.0

2.6

—

0.14

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

8.67

—

(3011841) English Walnut IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

2.18

—

(3013336) Amino acids [Identifier] in Serum or Plasma

0.00

-0.00

0.0

4.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.02

-0.00

1.0

1.6

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

109.17

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

21.38

—

(3036180) Methadone [Presence] in Urine

0.00

-0.00

0.0

2.0

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

36180.00

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.7

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3044941) Cell count panel - Synovial fluid

0.00

-0.00

0.0

1.4

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

2.0

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

-0.00

0.0

1.0

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.4

—

1.34

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

31.23

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3033882) Carnitine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

28.80

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.87

-0.00

1.2

1.5

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.6

—

6.09

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

0.89

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

1.50

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

22.60

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

14.7

—

859.11

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.87

-0.00

1.2

1.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

3.9

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

26.3

—

1687.56

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.7

—

2.22

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

2.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_KAWASAKI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_KAWASAKI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_KAWASAKI – Mucocutaneous lymph node syndrome [Kawasaki]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Mucocutaneous lymph node syndrome [Kawasaki]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints