Mucocutaneous lymph node syndrome [Kawasaki]

M13_KAWASAKI

mucocutaneous lymph node syndrome: Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M30.3 Hospital discharge: ICD-9 — 4461 Cause of death: ICD-10 — M30.3 Cause of death: ICD-9 — 4461 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M30
Name in latin: Syndroma mucocutaneum lymphonodorum (Kawasaki)

NAME	M13_KAWASAKI
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M303
HD_ICD_9	4461
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M303
COD_ICD_9	4461
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Mucocutaneous lymph node syndrome [Kawasaki] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1816	687	1129
Only index persons	1386	500	886
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	-	4.24	3.84
Only index persons	4.78	5.46	4.39

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	43	38
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	7.47	6.38	8.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
74: Matched controls
738

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M30.3

ICD-10 Finland

Mucocutaneous lymph node syndrome [Kawasaki]

+∞

61.1

4461A

ICD-9 Finland

Polyarteritis nodosa and allied conditions, Acute febrile mucocutaneous lymph node syndrome [MCLS]

+∞

31.5

M30.0

ICD-10 Finland

Polyarteritis nodosa

+∞

10.7

L04AX01

ATC

azathioprine; systemic

15.9

7.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

116

2.67

3.72

3.0

3.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

245

2.04

2.49

10.1

10.8

1.2

mmol/l

0.42

216

(3030467) Casts [#/volume] in Urine by Automated count

166

2.05

2.27

2.8

3.5

0.3

0.4

e6/l

0.03

127

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.94

2.19

2.8

2.1

—

(36304419) Bacteria [Presence] in Urine

169

2.00

2.15

2.9

3.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.64

2.14

2.2

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

5.25

2.10

1.0

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.96

1.97

1.2

3.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.76

1.97

1.2

1.1

—

(3032080) INR in Blood by Coagulation assay

174

1.93

1.96

8.0

5.8

1.1

1.2

inr

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.95

1.85

1.6

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

198

1.82

1.72

3.3

3.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

156

1.87

1.70

2.6

2.7

—

(3002582) Erythrocytes [#/volume] in Urine

190

1.82

1.70

2.8

3.4

8.9

370.3

e6/l

0.57

151

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

208

1.79

1.68

2.8

3.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.73

1.64

3.2

4.5

54.6

53.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.73

1.64

3.2

4.4

3.5

3.4

e9/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.25

1.58

6.2

5.6

24.8

23.5

mmol/l

1.40

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.57

0.0

1.3

—

(1761868) Lipid panel - Serum or Plasma

175

0.45

1.53

1.6

2.1

—

(3044889) 12 lead EKG panel

329

1.65

1.40

3.1

2.9

—

(3022145) Colonoscopy Study observation

2.28

1.39

1.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.89

1.30

2.8

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

195

1.67

1.29

9.5

6.7

34.6

37.4

g/l

1.20

189

(3022217) INR in Platelet poor plasma by Coagulation assay

0.00

1.19

0.0

17.0

—

1.1

—

(3029937) Albumin [Presence] in Urine by Test strip

155

1.68

1.18

3.0

3.4

0.0

estimate

0.00

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.96

1.16

8.0

8.5

25.4

25.0

mmol/l

0.26

(3000991) Gas panel - Venous blood

1.90

1.15

5.8

10.2

—

(3021589) Normoblasts [#/volume] in Blood

322

1.55

1.12

8.9

6.9

0.0

e9/l

0.50

258

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

140

1.68

1.12

5.3

2.7

59.9

25.2

ng/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.30

1.11

1.0

—

(3012544) pH of Venous blood

1.82

1.02

5.8

6.9

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.99

0.0

2.1

—

10.9

—

(42870588) Differential panel, method unspecified - Blood

234

1.53

0.99

8.9

6.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

282

1.50

0.96

3.3

2.9

156.6

72.5

ug/l

0.84

266

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.32

0.95

1.5

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.71

0.91

1.1

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.71

0.91

1.1

1.7

—

(3027008) Opiates [Presence] in Urine

1.71

0.91

1.1

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.15

0.91

1.2

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

122

1.61

0.90

5.2

—

(3018095) Leukocytes [#/volume] in Urine

229

1.49

0.90

3.0

3.8

35.6

45.5

e6/l

0.14

156

(3022313) Gas panel - Capillary blood

1.73

0.83

7.2

4.5

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.88

0.81

1.3

4.2

99.3

86.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

117

1.57

0.80

1.6

2.3

1.7

0.7

mg/l

0.86

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

152

0.61

0.70

4.0

2.1

—

(3000764) Benzodiazepines [Presence] in Urine

1.59

0.68

1.2

1.7

—

(3037121) Protein [Mass/volume] in Urine

1.84

0.67

6.2

6.0

0.3

0.2

g/l

—

(3042936) Bacteria identified in Isolate by Culture

1.67

0.65

4.2

2.5

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.57

0.61

8.6

5.1

5.0

5.1

kpa

0.16

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.57

0.61

8.6

5.0

1.8

1.3

mmol/l

0.57

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

461

1.36

0.60

3.1

3.7

14.7

14.6

pmol/l

0.09

414

(3011397) Hemoglobin [Presence] in Urine by Test strip

146

0.64

0.59

3.0

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

162

1.40

0.58

1.5

1.8

98.0

95.8

pmol/l

0.06

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.62

0.55

3.8

2.1

—

(3016879) Cocaine [Presence] in Urine

1.50

0.53

1.2

1.7

—

(3002385) Erythrocyte distribution width [Ratio]

602

1.40

0.52

18.7

13.5

13.3

0.08

591

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

139

1.38

0.49

2.0

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

128

0.67

0.48

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

292

1.28

0.46

3.7

4.5

0.0

estimate

0.00

(3035350) Ketones [Presence] in Urine by Test strip

292

1.28

0.46

2.9

3.2

0.0

estimate

0.00

(40761536) Microorganisms panel - Urine sediment

1.50

0.45

2.9

3.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.49

0.44

1.1

1.8

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.41

0.0

2.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.41

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

1.8

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

1.6

—

32.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

258

1.26

0.39

5.1

6.1

21.9

12.1

umol/l

0.42

243

(3020682) Albumin/Creatinine [Ratio] in Urine

108

1.36

0.38

4.9

3.8

65.2

21.5

mg/mmol

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.32

0.38

2.1

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

437

1.24

0.37

5.5

4.0

—

(3003694) ABO and Rh group [Type] in Blood

249

0.79

0.36

1.5

1.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

138

1.29

0.34

1.9

2.3

2.4

mg/l

0.01

124

(3000492) Spirometry study

1.41

0.32

1.3

—

(3002256) Pathology report gross observation

1.27

0.30

1.1

1.2

—

(40761511) CBC panel - Blood by Automated count

671

1.32

0.30

15.4

9.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

608

1.25

0.29

3.7

3.8

—

(3044640) Blood type and Crossmatch panel - Blood

191

0.80

0.28

3.8

2.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.26

0.26

3.4

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

297

1.19

0.26

3.0

3.3

0.0

estimate

0.00

(3026008) Bacteria identified in Urine by Culture

179

0.80

0.26

3.5

2.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

231

0.82

0.26

2.3

1.7

—

(3013512) EKG study

1.29

0.26

4.9

3.3

—

(40758558) Short blood count panel - Blood

181

1.22

0.26

6.5

6.9

—

(36660697) Celiac disease serology panel - Serum

1.21

0.26

1.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

104

0.74

0.22

10.6

9.4

1.1

1.2

mmol/l

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

112

0.78

0.21

1.7

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(4034850)

0.00

0.21

0.0

19.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.4

—

(4306422)

0.00

0.21

0.0

1.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

656

1.23

0.21

10.6

8.1

31.6

26.5

u/l

0.52

626

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

288

0.86

0.21

6.1

4.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.30

0.21

1.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.21

0.0

1.4

—

281.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.2

—

377.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

100

1.23

0.19

2.3

3.1

0.1

0.3

e6/l

—

(40768797) Stomach Pathology biopsy report

1.25

0.19

1.9

1.3

—

(3011288) Drugs identified in Urine by Screen method

1.16

0.18

1.3

1.9

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.75

0.17

1.4

2.7

—

3554.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.72

0.17

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

0.71

0.17

3.8

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

217

1.15

0.17

2.0

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.23

0.17

1.8

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.14

0.17

3.3

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.14

0.17

1.9

1.6

360.5

469.4

pmol/l

—

(3015736) pH of Urine

237

1.14

0.16

2.5

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.78

0.16

1.7

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

651

1.17

0.14

18.3

12.9

40.1

40.4

0.22

560

(40768804) Tissue Pathology biopsy report

190

1.14

0.14

2.2

1.9

—

(3003338) MCHC [Mass/volume]

610

1.15

0.14

18.4

14.7

334.8

334.5

g/l

0.06

605

(3007164) IgA [Mass/volume] in Serum or Plasma

189

0.87

0.13

1.4

1.6

2.0

g/l

—

106

(3019832) Treponema pallidum Ab [Presence] in Serum

187

0.88

0.11

1.5

1.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

439

0.91

0.11

4.0

3.9

36.8

37.1

mmol/mol

0.08

411

(3005033) Fetal Nuchal fold Thickness US

1.04

0.09

1.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.04

0.09

1.0

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

205

0.90

0.09

2.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.81

0.08

1.4

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.78

0.08

1.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.77

0.08

1.4

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.14

0.08

3.3

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.09

0.08

4.9

1.5

—

(21494755) Public health laboratory ask at order entry panel

1.08

0.07

1.2

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

486

1.08

0.07

13.3

8.6

94.2

97.5

ml/min/173m2

0.34

369

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.13

0.07

2.5

3.1

0.5

1.5

e6/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

192

0.92

0.06

2.3

2.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

642

1.06

0.02

17.9

10.7

28.7

22.6

mg/l

0.56

465

(3017143) Hepatitis C virus Ab [Presence] in Serum

122

0.98

0.00

2.3

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

119

1.01

0.00

1.9

2.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

266

1.02

0.00

2.4

2.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.3

—

13.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3013336) Amino acids [Identifier] in Serum or Plasma

0.00

0.0

5.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.87

0.00

1.2

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.87

0.00

1.2

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

9.0

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.02

0.00

1.0

1.6

—

(4198724)

0.00

0.0

2.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.3

—

4.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.87

0.00

1.2

1.5

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

2.9

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.3

—

109.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

31.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.3

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

1.4

—

1.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

2.6

—

0.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.6

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

3.9

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.8

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.8

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

14.7

—

859.1

—

(3011841) English Walnut IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

2.2

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.7

—

2.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.87

0.00

1.2

1.5

—

(4062490)

0.00

0.0

1.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(4268621)

0.00

0.0

2.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.1

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.7

—

12.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.0

—

(3018133) Calcium [Moles/volume] in Urine

0.00

0.0

2.7

—

2.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

8.7

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

26.3

—

1687.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

54.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

21.4

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

1.6

—

6.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_KAWASAKI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_KAWASAKI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_KAWASAKI – Mucocutaneous lymph node syndrome [Kawasaki]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Mucocutaneous lymph node syndrome [Kawasaki]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints