Risteys · PDMED_BENZATROPINE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Medicine purchases: ATC — N04AC01 1 out of 7 registries used, show all original rules.	27
4. Check minimum number of events Min. number of events 3	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	12	15
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	41.81	38.81	44.21

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

+∞

9.97

14.6

0.0

913.00

—

nmol/l

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

+∞

8.79

16.9

0.0

88254.38

—

nmol/l

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

12.90

4.28

3.7

5.7

0.90

0.77

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

8.41

2.66

3.6

3.4

5.02

5.16

kpa

—

(3026008) Bacteria identified in Urine by Culture

3.25

2.22

4.2

3.6

—

(3022621) pH of Urine by Test strip

4.81

2.17

2.5

1.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

248

0.26

2.04

13.6

11.5

22.15

27.32

u/l

1.12

238

(3007461) Platelets [#/volume] in Blood

253

0.24

1.96

62.0

22.0

267.29

244.48

e9/l

0.51

242

(3024731) MCV [Entitic volume]

253

0.24

1.96

66.6

21.9

90.82

91.36

0.20

245

(3000963) Hemoglobin [Mass/volume] in Blood

253

0.24

1.96

67.4

22.1

132.48

138.28

g/l

1.42

245

(3010813) Leukocytes [#/volume] in Blood

253

0.24

1.96

66.7

21.9

7.80

6.47

e9/l

2.56

241

(3035941) MCH [Entitic mass]

253

0.24

1.96

62.3

21.8

30.23

30.50

0.32

245

(3026361) Erythrocytes [#/volume] in Blood

253

0.24

1.96

66.8

22.0

4.41

4.56

e12/l

0.88

241

(3007853) Bacteria identified in Skin by Aerobe culture

3.73

1.95

1.1

1.4

—

(3042936) Bacteria identified in Isolate by Culture

3.01

1.58

1.7

2.3

—

(42870588) Differential panel, method unspecified - Blood

2.55

1.48

5.1

6.5

—

(3018010) Neutrophils/100 leukocytes in Blood

2.51

1.44

24.0

7.3

58.33

58.44

0.01

(3006504) Eosinophils/100 leukocytes in Blood

2.51

1.44

23.6

7.4

1.67

2.70

1.33

(3019069) Monocytes/100 leukocytes in Blood

2.51

1.44

27.8

7.9

7.08

8.56

0.88

(3023368) Bacteria identified in Blood by Culture

2.57

1.42

6.5

5.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

101

2.43

1.35

25.2

7.6

28.64

27.17

0.21

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.79

1.32

2.5

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.99

1.27

3.6

1.6

—

(3012544) pH of Venous blood

2.99

1.27

6.4

3.8

—

(3037522) Nuclear Ab [Titer] in Serum

0.00

1.26

0.0

1.7

—

515.56

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.83

1.20

5.0

6.6

131.80

125.40

g/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

217

0.42

1.20

23.1

13.5

80.44

80.60

ml/min/173m2

—

170

(40761511) CBC panel - Blood by Automated count

238

0.39

1.19

35.4

14.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.25

1.14

1.8

2.2

1.91

3.34

mg/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.27

1.06

2.9

1.8

—

(3022145) Colonoscopy Study observation

0.00

1.05

0.0

1.3

—

(40768797) Stomach Pathology biopsy report

0.00

1.03

0.0

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

242

0.41

0.99

33.0

17.2

74.05

80.76

umol/l

0.62

242

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

226

0.46

0.97

33.4

15.3

27.21

21.07

mg/l

0.46

177

(3015736) pH of Urine

1.98

0.88

6.1

3.3

—

(3022096) Basophils/100 leukocytes in Blood

1.95

0.84

22.6

7.4

0.44

0.65

1.30

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.84

0.0

1.6

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.83

0.0

4.0

—

(3002256) Pathology report gross observation

0.00

0.83

0.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.89

0.78

5.7

4.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.90

0.75

1.0

1.9

910.29

1428.28

nmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.13

0.75

2.8

1.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.80

0.69

1.3

1.5

21.26

20.50

nmol/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

236

0.51

0.64

32.4

15.3

4.07

3.99

mmol/l

0.88

226

(3019550) Sodium [Moles/volume] in Serum or Plasma

236

0.51

0.64

33.5

15.4

139.10

139.69

mmol/l

0.34

227

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.79

0.63

4.1

3.1

21.73

34.06

u/l

0.81

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.63

0.0

1.7

—

(3000492) Spirometry study

0.00

0.63

0.0

1.3

—

(4035726)

0.00

0.63

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.63

0.0

1.3

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.63

0.0

1.6

—

16.82

—

(3044640) Blood type and Crossmatch panel - Blood

1.64

0.61

2.0

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.54

0.55

2.5

2.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

100

0.60

0.53

3.1

4.6

1.27

2.28

ug/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.64

0.49

4.5

3.3

—

(3029937) Albumin [Presence] in Urine by Test strip

1.65

0.48

4.1

4.5

—

0.00

—

(3009542) Hematocrit [Volume Fraction] of Blood

206

0.62

0.46

59.6

14.1

33.13

40.63

0.79

145

(3035350) Ketones [Presence] in Urine by Test strip

120

1.56

0.44

5.7

3.9

—

0.00

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.42

0.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.00

0.42

0.0

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

3.8

—

1.30

—

(3002385) Erythrocyte distribution width [Ratio]

187

0.65

0.40

51.7

18.0

13.92

13.63

0.53

182

(3009261) Glucose [Presence] in Urine by Test strip

123

1.49

0.37

5.9

3.8

—

0.00

—

(3021601) Nitrite [Presence] in Urine by Test strip

123

1.49

0.37

8.6

5.0

—

0.00

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.37

0.30

5.1

3.8

—

(3044889) 12 lead EKG panel

170

0.74

0.23

5.1

3.7

—

(3013707) Erythrocyte sedimentation rate by Westergren method

160

0.74

0.23

3.4

5.5

12.07

12.31

mm/h

0.03

145

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.39

0.23

2.5

1.7

0.38

1.68

mg/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.22

0.0

1.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.22

0.0

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.22

0.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.1

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.20

0.0

6.1

—

93.55

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.25

0.20

27.9

6.4

—

(3018418) pH of Serum or Plasma

1.22

0.20

1.4

5.9

—

7.41

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

186

0.77

0.17

7.1

8.4

88.12

78.33

u/l

0.61

169

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

162

0.83

0.09

4.4

2.9

53.80

51.73

u/l

0.04

151

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.17

0.08

2.0

2.5

114.07

90.13

ug/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

101

0.84

0.08

4.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

121

1.14

0.05

3.8

2.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

128

0.89

0.03

5.4

7.0

6.42

10.34

umol/l

3.90

117

(3013826) Glucose [Moles/volume] in Serum or Plasma

131

0.99

0.00

10.2

4.2

6.75

6.78

mmol/l

0.02

126

(3037467) Urinalysis macro (dipstick) panel - Urine

151

0.99

0.00

7.0

4.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(40758558) Short blood count panel - Blood

0.93

0.00

6.8

8.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.0

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.0

6.4

—

26.29

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.2

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

2.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

47.86

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

2.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

8.85

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

3.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.25

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

3.6

—

4.69

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.4

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

5.3

—

26.50

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.4

—

22.75

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.4

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.5

—

(3013512) EKG study

1.00

0.00

10.0

4.1

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.0

5.2

—

128.20

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

6.6

—

(4094501)

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.1

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.4

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

338.83

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

4.0

—

61.40

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.00

0.00

1.3

1.4

1.39

1.29

mmol/l

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.0

—

291.60

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

1.22

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.88

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.0

1.6

—

1.87

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: PDMED_BENZATROPINE – Use of benzatropine

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	PDMED_BENZATROPINE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC	N04AC01
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Use of benzatropine

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Case counts by code for Use of benzatropine (PDMED_BENZATROPINE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints