Risteys · C3_KAPOSI_SARCOMA

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — C46 Cause of death: ICD-10 — C46 2 out of 7 registries used, show all original rules.	61
4. Check minimum number of events None	61
5. Include endpoints None	61
6. Filter based on genotype QC (FinnGen only)	54

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	14	40
Unadjusted period prevalence (%)	0.01	0.00	0.02
Median age at first event (years)	73.11	68.35	74.77

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
61: Matched controls
610

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

C46.0

ICD-10 Finland

Kaposi sarcoma of skin

+∞

47.1

9140/3-C44.7

ICD-O-3

Kaposi sarcoma of skin of lower limb and hip

+∞

23.4

C46.9

ICD-10 Finland

Kaposi sarcoma, unspecified

+∞

13.0

WF004

NOMESCO Finland

Palliative radiotherapy

+∞

10.7

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

14.2

10.1

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

29.2

9.3

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

+∞

8.5

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

39.1

8.4

D48.5

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Skin

26.3

8.4

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

+∞

7.4

C61

ICD-10 Finland

Malignant neoplasm of prostate

+∞

7.4

B23.1

ICD-10 Finland

HIV disease resulting in (persistent) generalized lymphadenopathy

77.6

6.6

YN1BD

NOMESCO Finland

Extensive CT examination of extremities for dose design of radiotherapy

+∞

6.3

C46.3

ICD-10 Finland

Kaposi sarcoma of lymph nodes

+∞

6.3

C46.7

ICD-10 Finland

Kaposi sarcoma of other sites

+∞

6.3

WF002

NOMESCO Finland

Radical radiotherapy

+∞

6.3

A04AA02

ATC

granisetron; systemic, transdermal

+∞

6.3

9140/3-C44.9

ICD-O-3

Kaposi sarcoma of skin, NOS

+∞

6.3

J01MA12

ATC

levofloxacin; systemic

4.2

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4035726) Immunohistochemistry procedure

23.47

11.47

2.1

1.2

—

(40768804) Tissue Pathology biopsy report

100

4.62

7.96

3.9

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

7.28

7.35

1.7

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.57

5.64

1.8

1.9

—

(3002256) Pathology report gross observation

6.40

5.50

2.4

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

7.57

5.40

4.6

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

8.29

4.87

4.7

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

187

2.85

3.89

12.4

3.1

9.91

13.39

umol/l

1.76

176

(3019832) Treponema pallidum Ab [Presence] in Serum

9.68

3.88

1.6

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

107

2.85

3.55

5.1

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

153

2.71

3.52

14.8

5.2

—

(3037121) Protein [Mass/volume] in Urine

5.96

3.31

9.1

2.2

0.36

0.24

g/l

—

(3000494) Fungus identified in Specimen by Culture

3.68

3.07

2.4

1.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

5.24

3.03

3.8

1.6

—

(40768443) Skin Pathology biopsy report

4.94

2.90

1.6

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

8.93

2.80

4.2

5.8

—

(3018010) Neutrophils/100 leukocytes in Blood

167

2.40

2.79

14.4

5.1

57.96

59.69

0.33

151

(3042936) Bacteria identified in Isolate by Culture

3.03

2.74

2.4

1.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

130

2.40

2.62

3.8

3.0

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.93

2.44

2.8

2.3

2.27

2.21

g/l

0.10

(3015736) pH of Urine

143

2.27

2.37

4.8

3.3

—

6.00

—

(40758558) Short blood count panel - Blood

2.54

2.34

15.7

3.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

145

2.23

2.28

6.0

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

252

2.19

2.26

6.2

4.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.68

2.23

2.8

2.1

11.52

12.30

umol/l

0.12

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.63

2.21

1.7

1.4

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

4.63

2.21

5.7

1.6

0.51

0.62

ug/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.52

2.18

2.5

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.83

2.15

4.3

3.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

4.31

2.09

4.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

176

2.09

2.05

7.2

4.7

0.00

estimate

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.62

2.03

1.4

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.27

2.02

4.4

2.5

361.28

5324.55

umol/l

0.50

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.44

1.88

2.3

2.5

1.49

0.74

e6/l

—

(3009261) Glucose [Presence] in Urine by Test strip

181

2.01

1.86

5.3

3.5

0.00

estimate

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.30

1.86

1.6

1.7

60.59

65.19

g/l

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

3.30

1.86

5.6

3.7

0.06

0.21

e6/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.34

1.82

2.9

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

174

1.99

1.80

5.2

3.5

0.00

estimate

—

(3008037) Lactate [Moles/volume] in Venous blood

4.09

1.75

4.6

1.9

1.36

1.26

mmol/l

—

(3038515) Glucose [Moles/volume] in Venous blood

4.09

1.75

4.6

1.9

10.38

6.90

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.31

1.69

3.1

2.7

1.36

1.61

e6/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

200

1.86

1.53

33.7

18.9

1.70

1.43

inr

—

(40768797) Stomach Pathology biopsy report

2.40

1.49

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.91

1.47

1.0

1.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

3.31

1.47

5.8

3.6

—

(36304419) Bacteria [Presence] in Urine

1.99

1.46

2.3

2.7

—

(3021589) Normoblasts [#/volume] in Blood

158

1.86

1.45

17.8

8.5

0.00

e9/l

0.48

128

(3023368) Bacteria identified in Blood by Culture

116

1.93

1.43

5.5

4.1

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.78

1.40

3.2

4.0

71.50

81.67

ng/l

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.77

1.24

3.6

2.0

0.62

0.89

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.63

1.17

3.6

2.0

1.84

1.52

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.63

1.17

4.6

2.3

131.60

132.55

g/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.84

1.14

1.7

1.8

1.40

1.25

mmol/l

0.32

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.34

1.12

1.4

33.57

27.48

u/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

160

1.70

1.11

1.7

2.0

86.02

84.39

pmol/l

0.07

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.88

0.93

2.1

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

1.72

0.92

4.3

3.7

0.00

estimate

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

364

1.61

0.88

25.6

13.0

76.35

72.89

ml/min/173m2

0.37

289

(40761536) Microorganisms panel - Urine sediment

2.03

0.87

4.0

3.1

—

(3022145) Colonoscopy Study observation

2.03

0.87

1.5

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.97

0.84

1.8

6.7

108.00

124.75

g/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.91

0.81

5.3

2.9

1.22

2.21

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.81

0.0

1.6

—

(3022313) Gas panel - Capillary blood

2.18

0.76

6.0

2.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

111

1.60

0.76

6.1

3.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.09

0.74

1.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.80

0.73

1.4

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.70

0.71

3.6

3.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.71

0.69

1.1

1.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.85

0.68

12.2

4.9

0.40

0.00

—

(3022621) pH of Urine by Test strip

1.79

0.65

2.2

3.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.65

0.63

6.8

1.8

0.74

0.84

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

144

1.46

0.60

5.4

3.5

—

(3013512) EKG study

136

1.46

0.58

8.4

3.9

—

(3002032) Base excess in Venous blood by calculation

1.69

0.57

4.3

2.6

2.85

2.14

mmol/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

413

1.46

0.56

34.4

15.7

83.33

87.52

umol/l

0.52

413

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

395

1.41

0.51

32.4

13.3

23.89

25.08

mg/l

0.11

306

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

115

1.40

0.44

1.9

1.7

52.07

95.66

u/l

0.54

108

(1761868) Lipid panel - Serum or Plasma

126

1.37

0.40

3.2

3.3

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.42

0.39

2.8

1.4

1.38

1.73

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.33

0.39

1.1

1.2

—

0.97

—

(3026008) Bacteria identified in Urine by Culture

118

1.36

0.38

4.5

3.2

—

(3019225) pH of Specimen

1.51

0.37

7.8

3.0

—

(3003694) ABO and Rh group [Type] in Blood

1.42

0.37

1.3

1.2

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.34

0.34

1.8

6.1

4.75

5.15

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.34

0.34

1.8

6.1

10.38

9.32

kpa

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

196

1.28

0.34

2.1

2.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

439

1.31

0.31

43.4

18.7

131.57

137.33

g/l

1.25

423

(3019550) Sodium [Moles/volume] in Serum or Plasma

408

1.28

0.31

31.4

16.7

138.93

139.83

mmol/l

1.30

390

(3023103) Potassium [Moles/volume] in Serum or Plasma

411

1.25

0.27

31.5

16.6

4.02

4.03

mmol/l

0.05

393

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.31

0.21

3.8

4.9

101.67

104.89

mmol/l

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.1

—

(3003338) MCHC [Mass/volume]

327

1.17

0.18

39.2

16.0

332.02

332.89

g/l

0.16

322

(3035941) MCH [Entitic mass]

439

1.19

0.17

43.9

18.5

30.68

30.38

0.47

423

(3024731) MCV [Entitic volume]

439

1.19

0.17

44.0

18.5

92.23

91.18

0.76

423

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

169

1.18

0.17

5.9

3.5

18.00

25.09

—

(3044889) 12 lead EKG panel

278

1.16

0.16

4.8

4.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

122

1.19

0.15

3.1

2.7

0.69

0.77

ug/l

—

(3012516) Albumin [Mass/volume] in Urine

135

1.15

0.11

3.7

3.2

198.81

554.29

mg/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

385

1.11

0.09

13.6

4.9

6.13

6.16

mmol/l

0.07

339

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

268

1.08

0.06

4.1

3.2

15.71

14.86

pmol/l

0.72

230

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

139

1.10

0.06

2.3

2.2

150.53

215.93

u/l

0.58

129

(40761511) CBC panel - Blood by Automated count

408

0.94

0.02

27.8

12.6

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

3.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

2.8

—

79.36

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.2

—

(3011951) Aspergillus fumigatus IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

0.80

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

117.38

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.00

-0.00

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_KAPOSI_SARCOMA_WIDE – Kaposi sarcoma, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

NAME	C3_KAPOSI_SARCOMA_WIDE
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	C46
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C46
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Kaposi sarcoma, including Hilmo

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Kaposi sarcoma, including Hilmo (C3_KAPOSI_SARCOMA_WIDE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints