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Physiological and behavioural disorders associated with sexual development and orientation

DOID Endpoint Browser PheWeb

F5_SEXUAL

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F66
  • Hospital discharge: ICD-9 — 3020
  • Cause of death: ICD-10 — F66
  • Cause of death: ICD-9 — 3020

2 out of 7 registries used, show all original rules.

62

4. Check minimum number of events

None

62

5. Include endpoints

None

62

6. Filter based on genotype QC (FinnGen only)

62

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F63-F69
Name in latin
Perturbationes psychologicae et modi se gerendi ad formationem et orientationem sexualem adjunctae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 587 240 347
Only index persons 527 218 309
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population - 35.04 23.08
Only index persons 26.20 32.73 21.59

-FinnGen-

Key figures

All Female Male
Number of individuals 62 38 24
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 33.13 35.76 28.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
18.9
21.0
38
54
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
23.3
19.3
29
24
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
46.1
17.7
21
7
E66.01
ICD-10 Finland
Obesity due to excess calories
18.4
15.6
25
23
E66.9
ICD-10 Finland
Obesity, unspecified
51.2
15.6
18
5
F66.9
ICD-10 Finland
Psychosexual development disorder, unspecified
+∞
14.1
13
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
16.7
13.9
23
22
E66.8
ICD-10 Finland
Other obesity
18.8
13.5
21
17
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
11.9
11
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
11.9
11
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
21.3
11.7
17
11
N06AB04
ATC
citalopram; systemic
7.8
10.9
30
71
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
41.1
10.9
13
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
30.2
10.9
14
6
N05AA02
ATC
levomepromazine; systemic
19.6
10.8
16
11
ZY010
NOMESCO Finland
Hospital outpatient
14.9
10.8
18
17
N05AX12
ATC
aripiprazole; systemic
18.0
10.4
16
12
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
49.6
10.4
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
9.0
9.8
22
37
F32.9
ICD-10 Finland
Depressive episode, unspecified
8.0
9.7
24
47
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
9.6
9
*
F66.01
ICD-10 Finland
Disorder in sexual maturity homosexual
+∞
9.6
9
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
14.3
9.5
16
15
E66.00
ICD-10 Finland
Metabolic syndrome
23.5
9.4
13
7
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
29.7
9.4
12
5
N06AB03
ATC
fluoxetine; oral
8.6
9.2
21
36
Z2446
NOMESCO Finland
Social worker
11.6
9.1
17
20
N05AF03
ATC
chlorprothixene; systemic
20.5
9.1
13
8
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
11.0
8.9
17
21
N05BA04
ATC
oxazepam; oral
6.1
8.7
29
83
N05AH03
ATC
olanzapine; systemic
9.6
8.7
18
26
F31.8
ICD-10 Finland
Other bipolar affective disorders
21.2
8.5
12
7
Z3226
NOMESCO Finland
Physiotherapist
7.3
8.5
22
45
N05AX08
ATC
risperidone; systemic
10.0
8.5
17
23
F34.1
ICD-10 Finland
Dysthymia
39.6
8.4
10
*
N05AH02
ATC
clozapine; systemic
26.7
8.4
11
5
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
26.7
8.4
11
5
Z2445
NOMESCO Finland
Psychologist
13.8
8.4
14
13
F29
ICD-10 Finland
Unspecified nonorganic psychosis
22.2
8.0
11
6
N05BE01
ATC
buspirone; oral
22.2
8.0
11
6
N06AX12
ATC
bupropion; oral
10.3
7.7
15
19
IGY02
NOMESCO Finland
Psychiatric monitoring contact
91.5
7.6
8
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
14.8
7.5
12
10
3020A
ICD-9 Finland
Sexual deviations and disorders, Ego-dystonic homosexuality
+∞
7.4
7
*
F66.00
ICD-10 Finland
Disorder in sexual maturity heterosexual
+∞
7.4
7
*
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
+∞
7.4
7
*
F66.80
ICD-10 Finland
Other specified disorder of psychosexual development heterosexual
+∞
7.4
7
*
A10BA02
ATC
metformin; oral
6.1
7.4
22
53
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
23.7
7.4
10
5
IGY99
NOMESCO Finland
Other psychiatric treatment contact
34.9
7.4
9
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
7.9
7.3
17
29
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
11.6
7.2
13
14
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
16.6
7.2
11
8
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
13.4
7.2
12
11
N06AX16
ATC
venlafaxine; oral
6.3
7.1
20
45
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
45.6
6.9
8
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
26.2
6.9
9
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
10.2
6.8
13
16
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
16.9
6.7
10
7
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
13.3
6.6
11
10
N06AX03
ATC
mianserin; oral
13.3
6.6
11
10
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
30.4
6.4
8
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.0
6.4
11
11
F66.09
ICD-10 Finland
Disorder of sexual maturity other or indefinite
+∞
6.4
6
*
N06AB06
ATC
sertraline; oral
6.7
6.3
16
31
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.8
6.2
12
15
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
9.8
6.2
12
15
N05CF01
ATC
zopiclone; oral
4.6
6.2
24
77
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
17.4
6.1
9
6

Mortality – FinRegistry

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Association

Association between endpoint F5_SEXUAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_SEXUAL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: F5_SEXUAL – Physiological and behavioural disorders associated with sexual development and orientation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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