No definition available.
Physiological and behavioural disorders associated with sexual development and orientation
F5_SEXUAL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
62 |
4. Check minimum number of eventsNone |
62 |
5. Include endpointsNone |
62 |
6. Filter based on genotype QC (FinnGen only) |
62 |
Control definitions (FinnGen only)
- Control exclude
- F5_PERSOBEH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F63-F69
- Name in latin
- Perturbationes psychologicae et modi se gerendi ad formationem et orientationem sexualem adjunctae
Similar endpoints
↥List of similar endpoints to
Physiological and behavioural disorders associated with sexual development and orientation
based on the number of shared cases.
Similar with more cases:
- Disorders of adult personality and behaviour
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 587 | 240 | 347 |
| Only index persons | 527 | 218 | 309 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 35.04 | 23.08 |
| Only index persons | 26.20 | 32.73 | 21.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 62 | 38 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 33.13 | 35.76 | 28.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 57
- Matched controls
- 570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
18.9
21.0
38
54
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
23.3
19.3
29
24
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
46.1
17.7
21
7
E66.01
ICD-10 Finland
Obesity due to excess calories
18.4
15.6
25
23
E66.9
ICD-10 Finland
Obesity, unspecified
51.2
15.6
18
5
F66.9
ICD-10 Finland
Psychosexual development disorder, unspecified
+∞
14.1
13
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
16.7
13.9
23
22
E66.8
ICD-10 Finland
Other obesity
18.8
13.5
21
17
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
11.9
11
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
11.9
11
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
21.3
11.7
17
11
N06AB04
ATC
citalopram; systemic
7.8
10.9
30
71
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
41.1
10.9
13
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
30.2
10.9
14
6
N05AA02
ATC
levomepromazine; systemic
19.6
10.8
16
11
N05AX12
ATC
aripiprazole; systemic
18.0
10.4
16
12
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
49.6
10.4
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
9.0
9.8
22
37
F32.9
ICD-10 Finland
Depressive episode, unspecified
8.0
9.7
24
47
F66.01
ICD-10 Finland
Disorder in sexual maturity homosexual
+∞
9.6
9
*
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
9.6
9
*
E66.00
ICD-10 Finland
Metabolic syndrome
23.5
9.4
13
7
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
29.7
9.4
12
5
N06AB03
ATC
fluoxetine; oral
8.6
9.2
21
36
N05AF03
ATC
chlorprothixene; systemic
20.5
9.1
13
8
N05BA04
ATC
oxazepam; oral
6.1
8.7
29
83
N05AH03
ATC
olanzapine; systemic
9.6
8.7
18
26
F31.8
ICD-10 Finland
Other bipolar affective disorders
21.2
8.5
12
7
N05AX08
ATC
risperidone; systemic
10.0
8.5
17
23
F34.1
ICD-10 Finland
Dysthymia
39.6
8.4
10
*
N05AH02
ATC
clozapine; systemic
26.7
8.4
11
5
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
26.7
8.4
11
5
F29
ICD-10 Finland
Unspecified nonorganic psychosis
22.2
8.0
11
6
N05BE01
ATC
buspirone; oral
22.2
8.0
11
6
N06AX12
ATC
bupropion; oral
10.3
7.7
15
19
IGY02
NOMESCO Finland
Psychiatric monitoring contact
91.5
7.6
8
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
14.8
7.5
12
10
F66.80
ICD-10 Finland
Other specified disorder of psychosexual development heterosexual
+∞
7.4
7
*
F66.00
ICD-10 Finland
Disorder in sexual maturity heterosexual
+∞
7.4
7
*
3020A
ICD-9 Finland
Sexual deviations and disorders, Ego-dystonic homosexuality
+∞
7.4
7
*
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
+∞
7.4
7
*
A10BA02
ATC
metformin; oral
6.1
7.4
22
53
IGY99
NOMESCO Finland
Other psychiatric treatment contact
34.9
7.4
9
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
7.9
7.3
17
29
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
16.6
7.2
11
8
N06AX16
ATC
venlafaxine; oral
6.3
7.1
20
45
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
45.6
6.9
8
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
26.2
6.9
9
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
16.9
6.7
10
7
N06AX03
ATC
mianserin; oral
13.3
6.6
11
10
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
30.4
6.4
8
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.0
6.4
11
11
F66.09
ICD-10 Finland
Disorder of sexual maturity other or indefinite
+∞
6.4
6
*
N06AB06
ATC
sertraline; oral
6.7
6.3
16
31
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.8
6.2
12
15
N05CF01
ATC
zopiclone; oral
4.6
6.2
24
77
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
17.4
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
6
15.02
5.23
20.8
9.5
919.5
1249.0
nmol/l
—
8
6
35
174
3.32
5.12
15.0
5.5
1.2
1.2
mmol/l
0.29
30
150
29
137
3.10
4.50
3.0
1.6
91.3
98.5
pmol/l
0.38
19
75
33
169
3.04
4.43
8.5
4.1
34.8
37.7
g/l
2.93
33
164
11
27
4.74
4.37
1.5
1.4
—
—
—
0
0
28
143
2.75
3.62
4.8
2.6
—
—
—
0
0
8
23
3.83
2.36
1.9
2.0
2.0
1.8
mg/l
—
8
13
15
75
2.32
1.89
5.7
3.5
830.0
99.3
ng/l
—
10
49
6
17
3.79
1.88
1.8
1.2
—
—
—
0
0
10
45
2.46
1.56
6.4
1.9
—
—
—
0
0
5
15
3.53
1.55
1.2
1.3
—
—
—
0
0
44
352
1.86
1.37
12.2
6.8
84.1
73.9
u/l
1.00
44
322
11
56
2.17
1.31
6.3
2.1
—
—
—
0
0
54
472
2.11
1.25
21.1
8.6
91.0
92.2
ml/min/173m2
0.12
47
373
16
99
1.83
1.14
3.9
2.3
—
—
—
0
0
30
232
1.57
0.92
6.3
4.5
0.0
0.0
estimate
—
5
40
8
46
1.85
0.86
3.1
1.3
—
—
—
0
0
30
237
1.52
0.81
5.0
3.3
0.0
0.0
estimate
—
5
39
18
132
1.51
0.67
1.6
1.3
0.6
0.8
u/ml
—
7
27
5
30
1.72
0.63
11.0
3.1
—
—
—
0
0
16
116
1.51
0.62
4.3
2.4
—
—
—
0
0
0
21
0.00
0.61
0.0
1.3
—
—
—
0
0
6
96
0.59
0.58
1.3
1.4
—
—
—
0
0
6
39
1.59
0.54
1.2
1.0
—
—
—
0
0
5
81
0.58
0.50
3.2
4.0
—
20.1
—
0
28
7
47
1.55
0.49
3.7
1.4
—
—
—
0
0
10
69
1.54
0.48
3.2
1.6
—
—
—
0
0
26
217
1.34
0.46
6.1
2.6
144.4
81.6
ug/l
0.52
26
209
55
518
1.55
0.44
28.5
10.5
22.1
20.5
mg/l
0.16
47
389
23
191
1.32
0.42
4.5
3.3
—
—
—
0
0
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
1.8
—
0
8
0
18
0.00
0.40
0.0
2.5
—
—
—
0
0
19
154
1.34
0.40
3.9
3.4
35.3
21.8
ng/l
0.31
12
82
12
91
1.40
0.37
2.8
3.1
533.8
768.9
ng/l
0.32
12
73
39
425
0.78
0.35
3.9
3.9
—
—
—
0
0
14
113
1.31
0.30
2.6
1.8
—
—
—
0
0
26
234
1.19
0.22
5.4
3.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
1.8
—
0
6
15
129
1.21
0.19
3.1
3.8
0.0
0.0
estimate
—
5
38
14
149
0.92
0.04
1.6
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
13.2
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_SEXUAL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have F5_SEXUAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: F5_SEXUAL – Physiological and behavioural disorders associated with sexual development and orientation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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