No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
70 |
4. Check minimum number of eventsNone |
70 |
5. Include endpointsNone |
70 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
Similar endpoints
↥List of similar endpoints to
Kissing spine
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Paracetamol or NSAID medication
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 565 | 301 | 263 |
| Only index persons | 543 | 292 | 251 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.11 | 69.76 | 61.96 |
| Only index persons | 65.89 | 69.34 | 61.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 31 | 38 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 56.56 | 55.04 | 57.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 70
- Matched controls
- 700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.2
ICD-10 Finland
Kissing spine
+∞
82.4
62
*
M48.0
ICD-10 Finland
Spinal stenosis
201.6
39.7
38
*
N03AX16
ATC
[U] pregabalin
17.0
33.1
40
51
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
28.0
25
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
80.9
24.1
26
5
M54.5
ICD-10 Finland
Low back pain
9.4
20.5
42
96
N03AX12
ATC
[U] gabapentin; oral
10.2
19.1
28
43
M54.4
ICD-10 Finland
Lumbago with sciatica
10.6
18.3
25
35
N02AX02
ATC
tramadol; systemic, rectal
9.2
18.2
51
158
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
31.2
16.9
22
10
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
16.3
15
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
14.0
13
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
50.8
13.8
16
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
157.0
12.9
13
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
142.5
11.8
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
11.5
11.1
21
25
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
+∞
10.7
10
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
+∞
10.7
10
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
10.7
10
*
M43.1
ICD-10 Finland
Spondylolisthesis
114.9
9.7
10
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.6
9
*
N06AX21
ATC
duloxetine; oral
11.8
8.9
16
17
ZXA05
NOMESCO Finland
Left side
4.6
8.7
30
98
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
101.8
8.6
9
*
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
12.4
8.5
15
15
M54.1
ICD-10 Finland
Radiculopathy
38.3
8.3
10
*
UJF32
NOMESCO Finland
Coloscopy
4.2
7.7
29
100
M54.2
ICD-10 Finland
Cervicalgia
13.0
7.7
13
12
N02AJ06
ATC
codeine and paracetamol; systemic
4.0
7.6
41
182
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.3
7.5
18
43
N02BF01
ATC
gabapentin; oral
12.0
7.4
13
13
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
7.4
27
91
N02BF02
ATC
pregabalin; oral
16.0
7.2
11
8
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
7.1
28
99
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.0
7.1
18
45
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.9
7.1
43
204
M54.3
ICD-10 Finland
Sciatica
12.9
7.1
12
11
J45.9
ICD-10 Finland
Asthma, unspecified
4.7
7.1
20
55
G56.0
ICD-10 Finland
Carpal tunnel syndrome
5.2
7.0
17
41
R03DC03
ATC
montelukast; oral
4.5
6.8
20
57
M53.1
ICD-10 Finland
Cervicobrachial syndrome
7.6
6.6
15
24
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
6.6
24
80
ZXD05
NOMESCO Finland
Urgent procedure
3.7
6.4
31
125
A02BC02
ATC
pantoprazole; systemic
4.8
6.4
58
353
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
29.6
6.4
8
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
+∞
6.3
6
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
6.3
6
*
7215A
ICD-9 Finland
Spondylosis and allied disorders, Kissing spine
+∞
6.3
6
*
L86
ICPC
Back syndrome with radiating pain
11.6
6.3
11
11
L02
ICPC
Back symptom/complaint
8.1
6.1
13
19
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.9
6.0
22
73
K59.1
ICD-10 Finland
Functional diarrhoea
12.7
6.0
10
9
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
214
3.62
6.44
2.6
1.8
96.85
99.30
pmol/l
0.09
23
106
44
245
3.14
5.09
3.4
2.4
—
—
—
0
0
16
51
3.77
4.54
2.7
1.7
—
—
—
0
0
37
204
2.73
4.10
3.8
2.5
81.66
135.60
ug/l
2.40
37
188
17
65
3.13
3.63
6.4
5.5
103.71
105.20
mmol/l
0.58
17
65
40
240
2.56
3.60
4.4
3.6
0.00
0.00
estimate
—
9
49
44
277
2.58
3.57
23.6
13.8
1.05
1.33
inr
—
8
86
40
241
2.54
3.55
5.4
4.9
0.00
0.00
estimate
—
9
54
19
79
2.93
3.51
2.5
1.8
—
—
—
0
0
39
236
2.47
3.38
4.5
3.6
0.00
0.00
estimate
—
9
56
14
50
3.25
3.31
2.6
1.7
—
—
—
0
0
11
30
4.15
3.26
6.0
6.7
93.10
92.95
%
0.05
11
30
16
66
2.85
2.97
1.5
1.2
19.96
8.71
u/ml
—
9
23
16
68
2.75
2.80
1.9
2.3
2.33
2.31
g/l
0.08
16
62
11
35
3.53
2.79
6.0
5.9
1.18
1.51
%
0.60
11
35
11
35
3.53
2.79
6.0
5.8
0.86
0.73
%
0.31
11
35
17
75
2.67
2.78
1.9
2.2
17.41
12.33
umol/l
1.56
17
69
21
106
2.40
2.60
1.2
1.2
0.30
1.83
u/ml
—
5
28
34
216
2.12
2.41
5.7
3.6
50.22
33.90
ng/l
0.24
25
156
65
553
3.45
2.38
22.5
12.8
18.17
24.51
mg/l
1.19
53
424
8
23
3.79
2.35
1.3
2.3
—
—
—
0
0
19
96
2.34
2.33
5.9
3.1
110.53
136.19
ng/l
0.10
19
75
9
29
3.41
2.32
1.3
1.7
—
—
—
0
0
42
294
2.07
2.25
4.0
2.8
—
—
—
0
0
5
11
4.80
1.97
1.2
1.5
—
—
—
0
0
6
17
3.76
1.88
1.2
1.2
—
—
—
0
0
6
17
3.76
1.88
1.5
1.5
—
—
—
0
0
6
17
3.76
1.88
1.2
1.2
—
—
—
0
0
7
23
3.26
1.85
1.7
2.8
1.06
0.97
%
—
7
23
22
129
2.03
1.85
6.0
3.9
0.00
0.00
estimate
—
7
54
11
48
2.53
1.81
1.7
1.9
37.18
28.11
u/l
0.61
11
37
5
13
4.05
1.74
1.4
1.0
0.23
0.27
g/l
—
5
13
13
63
2.31
1.73
2.7
1.7
1.64
1.71
%
0.07
13
55
7
25
2.99
1.70
1.0
1.0
—
—
—
0
0
5
14
3.76
1.64
2.2
3.4
109.70
765.77
ug/l
—
5
14
5
14
3.76
1.64
1.4
1.2
1.24
1.08
g/l
—
5
14
30
204
1.82
1.60
4.0
3.0
—
—
—
0
0
22
136
1.90
1.57
2.4
2.3
—
—
—
0
0
6
21
3.02
1.54
5.3
1.2
—
—
—
0
0
16
89
2.03
1.53
2.9
2.4
1.46
1.57
e6/l
—
10
48
28
189
1.80
1.52
4.3
3.0
30.43
32.83
u/l
0.22
28
180
28
190
1.79
1.49
5.2
3.8
—
—
—
0
0
6
23
2.75
1.40
6.8
1.4
—
—
—
0
0
5
17
3.08
1.38
2.2
1.6
—
—
—
0
0
6
25
2.53
1.27
1.2
1.4
—
—
—
0
0
16
97
1.84
1.19
3.5
3.8
0.80
0.81
mmol/l
0.17
16
90
5
20
2.61
1.17
2.0
4.4
57.52
50.09
%
—
5
20
7
30
2.48
1.16
1.1
1.3
—
—
—
0
0
5
21
2.48
1.11
2.8
3.8
26.72
24.44
mmol/l
—
5
21
56
486
1.76
1.06
25.0
16.3
15.61
14.87
%
0.30
56
479
11
61
1.95
1.05
1.8
1.2
—
—
—
0
0
61
545
1.93
1.04
17.2
12.6
75.06
79.62
ml/min/173m2
0.88
52
437
6
29
2.17
0.92
2.7
4.3
5.28
5.05
kpa
—
6
29
14
89
1.72
0.89
2.9
2.6
1.65
4.75
e6/l
—
8
48
24
180
1.51
0.80
3.8
4.2
6.22
4.51
mg/mmol
0.20
19
124
8
49
1.71
0.65
1.8
1.7
—
—
—
0
0
8
53
1.57
0.61
3.8
2.6
4.79
5.96
ug/l
—
8
48
11
74
1.58
0.57
15.5
7.6
—
—
—
0
0
8
57
1.45
0.44
2.3
3.0
—
—
—
0
0
25
208
1.31
0.44
3.8
3.8
20.49
21.87
%
0.26
14
106
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
10
72
1.45
0.39
3.6
1.3
—
—
—
0
0
6
45
1.36
0.35
3.0
3.0
1.27
1.22
mmol/l
—
6
39
5
72
0.67
0.27
4.0
5.0
1.62
64.79
ug/l
—
5
60
5
42
1.20
0.22
1.2
3.7
4.02
4.64
pmol/l
—
5
36
17
147
1.21
0.20
1.9
1.6
1.30
1.43
mmol/l
0.36
17
121
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
18.94
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.10
—
0
5
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_KISSING and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_KISSING.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_KISSING – Kissing spine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data