No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
69 |
4. Check minimum number of eventsNone |
69 |
5. Include endpointsNone |
69 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
Similar endpoints
↥List of similar endpoints to
Kissing spine
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Paracetamol of NSAID medication
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 565 | 301 | 263 |
| Only index persons | 543 | 292 | 251 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.11 | 69.76 | 61.96 |
| Only index persons | 65.89 | 69.34 | 61.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 30 | 39 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 56.89 | 56.29 | 57.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 63
- Matched controls
- 630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.2
ICD-10 Finland
Kissing spine
+∞
74.5
56
*
M48.0
ICD-10 Finland
Spinal stenosis
630.2
35.7
32
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
24.6
22
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
353.5
24.4
23
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
51.1
18.1
21
6
N03AX16
ATC
pregabalin; oral
12.7
17.0
35
56
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
14.1
13
*
N03AX12
ATC
gabapentin; oral
13.8
13.0
23
25
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
145.5
11.9
12
*
N02AX02
ATC
tramadol; systemic, rectal
6.8
11.5
43
151
M54.4
ICD-10 Finland
Lumbago with sciatica
13.4
11.3
20
21
M54.5
ICD-10 Finland
Low back pain
7.1
10.9
32
80
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
48.4
10.4
12
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.6
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
11.5
8.7
16
18
M54.3
ICD-10 Finland
Sciatica
103.3
8.6
9
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
103.3
8.6
9
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
+∞
8.5
8
*
N06AX21
ATC
duloxetine; oral
12.5
8.0
14
14
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
90.3
7.6
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
4.7
7.6
33
120
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
+∞
7.4
7
*
M43.1
ICD-10 Finland
Spondylolisthesis
+∞
7.4
7
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
34.4
7.4
9
*
A02BC02
ATC
pantoprazole; systemic
4.6
6.9
49
272
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
25.8
6.9
9
*
UJF32
NOMESCO Finland
Coloscopy
4.7
6.8
26
81
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
77.4
6.6
7
*
M54.1
ICD-10 Finland
Radiculopathy
30.0
6.4
8
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
6.3
6
*
L02
ICPC
Back symptom/complaint
8.8
6.3
13
18
M53.1
ICD-10 Finland
Cervicobrachial syndrome
9.6
6.2
12
15
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.8
6.1
37
170
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
213
3.48
6.01
2.5
1.8
97.0
99.6
pmol/l
0.09
22
104
44
239
3.32
5.46
5.8
3.8
—
—
—
0
0
16
49
3.95
4.82
2.7
1.8
—
—
—
0
0
36
200
2.67
3.89
3.7
2.5
82.3
136.5
ug/l
2.33
36
184
19
76
3.07
3.78
2.5
1.8
—
—
—
0
0
14
48
3.40
3.54
2.6
1.7
—
—
—
0
0
39
237
2.48
3.36
4.5
3.6
0.0
0.0
estimate
—
9
49
39
238
2.47
3.32
5.5
4.9
0.0
0.0
estimate
—
9
53
38
230
2.45
3.28
4.6
3.7
0.0
0.0
estimate
—
9
52
21
105
2.44
2.67
1.2
1.2
0.3
1.0
u/ml
—
5
28
10
33
3.37
2.65
6.2
5.0
0.9
0.7
%
—
10
33
10
33
3.37
2.65
6.2
5.0
1.2
1.5
%
—
10
33
40
266
2.20
2.58
7.0
6.3
1.2
1.2
mmol/l
1.21
35
217
34
215
2.15
2.46
5.7
3.6
50.2
33.9
ng/l
0.24
25
155
8
22
3.97
2.45
1.3
2.4
—
—
—
0
0
15
67
2.58
2.38
2.0
2.2
2.4
2.3
g/l
0.15
15
61
15
68
2.54
2.31
1.3
1.2
22.4
8.4
u/ml
—
8
24
5
9
5.89
2.25
1.2
1.4
—
—
—
0
0
64
547
3.34
2.21
22.2
12.6
18.3
24.4
mg/l
1.09
52
418
41
287
2.06
2.19
3.2
2.8
—
—
—
0
0
22
124
2.14
2.08
6.0
3.9
0.0
0.0
estimate
—
7
53
8
27
3.21
2.01
1.4
1.7
—
—
—
0
0
18
95
2.21
1.98
5.8
2.9
116.4
135.1
ng/l
0.07
18
74
13
60
2.44
1.92
2.7
1.7
1.6
1.7
%
0.10
13
53
7
23
3.27
1.85
1.7
2.8
1.1
1.4
%
—
7
23
7
23
3.27
1.85
1.0
1.0
—
—
—
0
0
22
132
1.98
1.73
2.4
2.3
—
—
—
0
0
28
188
1.82
1.56
5.3
3.8
—
—
—
0
0
5
15
3.51
1.55
2.2
1.7
—
—
—
0
0
5
15
3.51
1.55
1.2
1.3
—
—
—
0
0
5
16
3.28
1.46
1.2
1.3
—
—
—
0
0
7
29
2.57
1.43
1.1
1.1
—
—
—
0
0
29
202
1.75
1.40
3.8
2.8
—
—
—
0
0
5
17
3.09
1.38
1.6
1.5
—
—
—
0
0
10
48
2.27
1.35
1.6
1.9
38.7
27.6
u/l
—
10
37
5
18
2.91
1.31
1.8
1.3
—
—
—
0
0
27
188
1.72
1.29
4.4
3.0
31.1
32.7
u/l
0.13
27
179
16
95
1.89
1.27
3.5
3.8
0.8
0.8
mmol/l
0.22
16
88
11
57
2.11
1.25
1.8
1.2
—
—
—
0
0
15
88
1.90
1.23
2.7
2.4
1.6
1.6
e6/l
—
9
47
5
20
2.61
1.17
2.0
4.4
57.5
49.2
%
—
5
20
5
21
2.48
1.11
1.0
1.5
—
—
—
0
0
60
537
1.90
1.05
16.8
12.5
74.6
79.3
ml/min/173m2
0.91
51
429
5
24
2.17
0.76
1.2
1.4
—
—
—
0
0
13
87
1.61
0.69
2.7
2.5
1.7
4.5
e6/l
—
7
46
11
71
1.65
0.67
15.5
7.5
—
—
—
0
0
8
53
1.58
0.61
3.8
2.6
4.8
5.9
ug/l
—
8
48
7
48
1.51
0.48
1.7
1.7
—
—
—
0
0
8
58
1.43
0.43
2.3
3.1
—
—
—
0
0
25
209
1.31
0.42
3.8
3.8
20.5
21.7
%
0.22
14
107
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
9
68
1.37
0.40
2.0
1.3
—
—
—
0
0
6
45
1.36
0.35
3.0
3.0
1.3
1.2
mmol/l
—
6
39
5
41
1.24
0.22
1.2
4.0
4.0
4.7
pmol/l
—
5
35
5
69
0.70
0.17
4.0
4.9
1.6
65.7
ug/l
—
5
59
16
146
1.12
0.09
1.9
1.6
1.3
1.4
mmol/l
0.43
16
119
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.1
—
0
5
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_KISSING and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_KISSING.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_KISSING – Kissing spine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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