No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpointsNone |
89 |
6. Filter based on genotype QC (FinnGen only) |
85 |
Control definitions (FinnGen only)
- Control exclude
- N14_GLOMERULAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N00-N08
- Name in latin
- Syndroma nephriticum cito progrediens
Similar endpoints
↥List of similar endpoints to
Rapidly progressive nephritic syndrome
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- All kidney diseases
- Genitourinary diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 618 | 323 | 291 |
| Only index persons | 464 | 246 | 218 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.72 | 58.87 | 58.31 |
| Only index persons | 52.82 | 52.51 | 53.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 85 | 41 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 54.53 | 45.46 | 62.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 89
- Matched controls
- 890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
28.2
45.3
35
20
N01.9
ICD-10 Finland
Rapidly progressive nephritic syndrome, unspecified
+∞
34.7
31
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
80.5
32.3
35
7
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
201.0
28.5
28
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
77.9
28.5
31
6
H02AB04
ATC
methylprednisolone; systemic
10.7
26.3
38
58
L04AX01
ATC
azathioprine; systemic
32.3
22.2
29
13
A11CC03
ATC
alfacalcidol; systemic
64.7
21.4
24
5
TK800
NOMESCO Finland
Hemodialysis
40.3
19.6
24
8
L04AA06
ATC
mycophenolic acid; systemic
67.7
18.9
21
*
A12AA04
ATC
calcium carbonate; oral
67.7
18.9
21
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
54.0
18.2
21
5
N18.8
ICD-10 Finland
Other chronic renal failure
33.8
18.0
23
9
127
Kela drug reimbursment
Transplant complication
63.5
17.8
20
*
C03CA01
ATC
furosemide; systemic
6.4
17.1
56
187
Z94.0
ICD-10 Finland
Kidney transplant status
59.5
16.8
19
*
B03XA02
ATC
darbepoetin alfa; parenteral
47.5
16.1
19
5
N18.0
ICD-10 Finland
End-stage renal disease
192.4
16.0
16
*
137
Kela drug reimbursment
Uraemia requiring dialysis
95.9
15.1
16
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
14.2
15.0
26
25
N01.7
ICD-10 Finland
Rapidly progressive nephritic syndrome, diffuse crescentic glomerulonephritis
+∞
15.0
14
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
20.4
14.9
22
14
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
51.7
14.7
17
*
V03AE01
ATC
polystyrene sulfonate; oral
64.1
14.3
16
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
38.4
13.1
16
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
13.0
28
62
N19
ICD-10 Finland
Unspecified kidney failure
16.8
12.7
20
15
L04AD01
ATC
ciclosporin; systemic
44.5
12.7
15
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.1
12.4
26
56
205
Kela drug reimbursment
Chronic hypertension
4.7
11.9
43
147
N01.1
ICD-10 Finland
Rapidly progressive nephritic syndrome, focal and segmental glomerular lesions
+∞
11.7
11
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
11.3
11.6
22
25
KA1AE
NOMESCO Finland
Kidney ultrasound examination
25.4
11.1
15
7
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
68.5
10.9
12
*
R50.9
ICD-10 Finland
Fever, unspecified
4.9
10.5
30
84
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
10.4
47
186
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
45.6
10.2
12
*
B03XA01
ATC
erythropoietin; parenteral
30.0
10.1
13
5
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
111.4
9.6
10
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
111.4
9.6
10
*
B05DB
ATC
Hypertonic solutions
+∞
9.5
9
*
L01AA01
ATC
cyclophosphamide; systemic
+∞
9.5
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.7
9.3
15
12
L04AA01
ATC
[U] ciclosporin
41.3
9.2
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
8.6
19
28
B05DA
ATC
Isotonic solutions
99.0
8.6
9
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
99.0
8.6
9
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.9
8.5
22
56
N01.3
ICD-10 Finland
Rapidly progressive nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
8.5
8
*
N04.1
ICD-10 Finland
Nephrotic syndrome, focal and segmental glomerular lesions
+∞
8.5
8
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
8.5
8
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
8.5
8
*
N01
ICD-10 Finland
Rapidly progressive nephritic syndrome
+∞
8.5
8
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
8.5
8
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
8.5
8
*
M04AA01
ATC
allopurinol; systemic
4.5
8.4
25
71
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
8.4
30
98
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.5
8.3
18
39
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.9
8.1
17
23
J01MA14
ATC
moxifloxacin; systemic
5.1
7.6
18
42
V03AE02
ATC
sevelamer; oral
87.0
7.5
8
*
Z49.2
ICD-10 Finland
Other dialysis
87.0
7.5
8
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
87.0
7.5
8
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
7.4
7
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
7.4
7
*
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
+∞
7.4
7
*
C08CA02
ATC
felodipine; oral
5.0
7.1
17
40
L04AD02
ATC
tacrolimus; systemic
43.5
6.9
8
*
C08CA01
ATC
amlodipine; oral
3.2
6.8
47
231
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
75.0
6.5
7
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
75.0
6.5
7
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.3
6.5
11
10
B01AA03
ATC
warfarin; systemic
3.5
6.3
27
98
N01.8
ICD-10 Finland
Rapidly progressive nephritic syndrome, other
+∞
6.3
6
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
6.3
6
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
9.7
6.3
12
14
H02AB06
ATC
prednisolone; systemic
3.1
6.2
55
307
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.3
6.1
18
50
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.6
6.0
24
83
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
184
6.51
17.50
11.5
4.0
54.14
7.79
mg/mmol
3.07
48
124
11
0
+∞
11.71
2.8
0.0
—
—
—
0
0
34
103
4.72
10.81
7.2
2.1
23.45
22.74
%
0.09
29
84
14
6
27.25
10.62
1.8
1.2
—
—
—
0
0
64
320
4.56
10.12
36.7
8.2
1.22
1.21
mmol/l
0.34
52
269
53
250
3.77
8.71
16.5
2.9
—
—
—
0
0
15
18
9.77
7.69
1.9
1.7
—
—
—
0
0
19
53
4.29
6.45
2.9
1.6
—
—
—
0
0
9
6
16.46
6.04
1.3
1.2
—
—
—
0
0
59
346
3.09
6.01
14.1
5.6
0.00
0.00
estimate
-0.00
14
71
59
347
3.08
5.96
10.5
4.0
0.00
0.00
estimate
-0.00
14
73
13
20
7.41
5.81
4.4
2.5
—
—
—
0
0
59
353
2.99
5.67
10.4
4.1
0.00
0.00
estimate
-0.00
12
68
16
46
4.02
5.17
4.1
3.3
41.63
65.35
ml/min/173m2
—
8
17
13
25
5.90
5.00
1.8
4.4
53.20
22.96
mg/l
—
8
19
13
25
5.90
5.00
1.8
4.4
72.98
311.62
mg/l
—
8
19
13
25
5.90
5.00
1.8
4.4
—
—
—
0
0
53
314
2.70
4.96
25.8
13.9
1.10
1.21
inr
0.70
20
91
9
10
9.85
4.91
2.2
1.5
—
—
—
0
0
12
22
6.13
4.80
1.9
2.0
—
—
—
0
0
7
5
15.01
4.65
2.0
1.6
—
—
—
0
0
10
15
7.35
4.61
2.1
1.5
—
—
—
0
0
19
69
3.23
4.35
6.3
4.0
—
—
—
0
0
22
88
2.99
4.29
2.0
1.6
—
—
—
0
0
9
13
7.56
4.28
1.6
1.2
—
—
—
0
0
10
17
6.48
4.27
2.1
2.0
—
—
—
0
0
22
89
2.96
4.20
2.0
1.7
—
—
—
0
0
11
22
5.55
4.16
2.0
2.0
—
—
—
0
0
9
14
7.01
4.09
1.2
1.4
—
—
—
0
0
14
44
3.59
3.97
41.4
6.8
24.11
25.08
mmol/l
0.37
14
44
9
15
6.54
3.92
2.2
1.4
—
—
—
0
0
37
202
2.42
3.88
10.5
4.1
0.00
0.00
estimate
—
9
67
28
134
2.59
3.88
2.2
1.9
—
—
—
0
0
6
5
12.72
3.82
1.8
1.6
—
—
—
0
0
12
30
4.46
3.76
21.6
3.5
22.44
24.49
mmol/l
1.95
12
30
55
363
2.35
3.68
8.5
6.3
8.91
12.13
umol/l
2.78
55
346
9
17
5.76
3.61
1.8
1.7
—
—
—
0
0
45
278
2.25
3.46
11.2
4.2
—
—
—
0
0
7
10
7.48
3.43
2.6
1.5
—
—
—
0
0
6
7
9.08
3.31
2.7
5.4
—
—
—
0
0
12
36
3.69
3.16
10.1
4.6
113.08
123.42
g/l
1.05
12
36
11
31
3.90
3.12
7.9
5.1
24.57
24.42
mmol/l
0.03
11
31
5
5
10.48
3.01
4.8
10.2
—
—
—
0
0
14
56
2.78
2.68
3.4
2.4
0.26
0.22
g/l
0.87
14
51
7
15
4.97
2.65
2.0
1.7
—
—
—
0
0
5
7
7.48
2.58
2.4
1.7
—
—
—
0
0
7
16
4.65
2.53
2.0
1.6
—
—
—
0
0
11
39
3.07
2.45
2.1
1.3
—
—
—
0
0
7
17
4.37
2.41
2.0
1.7
—
—
—
0
0
8
23
3.71
2.33
1.6
1.3
—
—
—
0
0
6
13
4.86
2.31
2.2
1.3
—
—
—
0
0
6
13
4.86
2.31
4.0
4.2
59.83
58.46
%
—
6
13
9
29
3.33
2.30
2.0
2.7
—
—
—
0
0
20
104
2.19
2.22
1.3
1.2
53.34
11.03
u/ml
—
5
43
45
320
1.82
2.03
3.5
2.8
—
—
—
0
0
20
108
2.10
2.02
1.4
1.2
86.07
43.53
iu/ml
0.39
12
35
6
16
3.94
1.97
10.7
3.2
3.12
3.34
g/l
—
6
16
39
269
1.80
1.92
4.6
4.2
37.61
38.68
ng/l
0.03
34
178
6
17
3.70
1.87
2.0
1.5
—
—
—
0
0
10
40
2.69
1.73
2.2
1.6
—
—
—
0
0
8
31
2.73
1.70
9.6
2.9
0.90
1.31
%
—
8
31
8
31
2.73
1.70
2.6
2.2
—
—
—
0
0
7
26
2.83
1.61
3.1
2.2
10524.57
409.26
ug/l
—
7
26
7
26
2.83
1.61
1.7
1.3
—
—
—
0
0
15
82
2.00
1.46
29.7
8.1
1.04
1.42
mmol/l
—
9
64
7
29
2.53
1.42
9.1
4.3
44.94
52.24
%
—
7
29
6
23
2.72
1.39
3.2
1.2
—
—
—
0
0
37
271
1.63
1.38
2.4
2.1
100.91
91.88
pmol/l
0.52
22
149
13
70
2.00
1.32
1.6
2.2
32.00
27.18
u/l
0.38
13
60
5
19
2.72
1.23
2.2
3.5
0.00
0.00
g/l
—
5
19
13
72
1.94
1.23
2.4
2.4
5.12
5.67
umol/l
0.15
13
60
5
20
2.59
1.16
1.8
1.8
—
—
—
0
0
68
598
1.58
1.01
51.6
18.4
14.97
15.02
%
0.03
68
589
13
84
1.64
0.77
36.8
8.0
103.77
103.88
mmol/l
0.04
13
84
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
11
75
1.53
0.53
6.9
4.3
3.39
7.01
ug/l
0.76
11
59
21
166
1.35
0.49
4.2
2.6
—
—
—
0
0
75
707
1.39
0.46
48.5
14.9
16.36
23.87
mg/l
2.56
68
570
8
59
1.39
0.42
2.0
2.2
3.58
5.97
ug/l
—
8
49
69
646
1.30
0.42
41.7
14.2
62.00
83.57
ml/min/173m2
5.33
55
516
5
34
1.50
0.41
2.4
2.6
—
—
—
0
0
6
43
1.42
0.36
1.2
1.1
—
—
—
0
0
55
508
1.22
0.34
3.1
3.8
13.98
14.72
pmol/l
1.65
50
453
76
730
1.28
0.29
50.8
17.1
136.64
78.11
umol/l
5.61
76
730
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
17
189
0.88
0.13
4.5
4.4
22.11
22.37
%
—
10
95
18
163
1.13
0.12
1.2
1.3
1.27
1.51
u/ml
—
6
41
77
785
0.86
0.12
61.0
22.0
127.01
134.63
g/l
3.32
77
768
15
134
1.14
0.11
1.7
1.6
—
—
—
0
0
51
490
1.10
0.11
3.7
3.3
—
—
—
0
0
5
47
1.07
0.09
8.0
1.9
270.60
136.95
ng/l
—
5
41
8
74
1.09
0.08
15.1
7.7
—
—
—
0
0
10
112
0.88
0.07
2.2
2.4
—
—
—
0
0
11
104
1.07
0.01
2.1
2.1
—
—
—
0
0
75
744
1.05
0.00
25.5
10.3
23.41
25.32
u/l
0.57
75
713
11
108
1.02
0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
5.00
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
7.32
—
0
6
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
66
0.90
-0.00
1.7
2.2
—
—
—
0
0
5
59
0.84
-0.00
1.6
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
239.20
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
7.14
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_RAPIDPROGNEPHRITIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RAPIDPROGNEPHRITIC | 2.733 [1.89, 3.96] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 252 females with N14_RAPIDPROGNEPHRITIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RAPIDPROGNEPHRITIC | 3.037 [1.91, 4.83] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 231 males with N14_RAPIDPROGNEPHRITIC died.
Mortality risk
Mortality risk for people of age
years, who have N14_RAPIDPROGNEPHRITIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.228% | 0.493% |
| 5 | 1.488% | 3.599% |
| 10 | 3.874% | 8.098% |
| 15 | 7.352% | 15.216% |
| 20 | 12.18% | 24.741% |
Relationships between endpoints
↥Index endpoint: N14_RAPIDPROGNEPHRITIC – Rapidly progressive nephritic syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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