Kaposi sarcoma, excluding all cancers (controls excluding all cancers)

C3_KAPOSI_SARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C46
  • Cause of death: ICD-10 C46

2 out of 7 registries used, show all original rules.

61

4. Check minimum number of events

None

61

5. Include endpoints

None

61

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
C45-C49
Name in latin
Sarcoma Kaposi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 61 16 45
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 72.97 66.89 75.13

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
52
Matched controls
519
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C46.0
ICD-10 Finland
Kaposi sarcoma of skin
+∞
39.7
33
*
9140/3-C44.7
ICD-O-3
Kaposi sarcoma of skin of lower limb and hip
+∞
18.8
17
*
C46.9
ICD-10 Finland
Kaposi sarcoma, unspecified
+∞
11.9
11
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
27.1
8.4
11
5
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.1
7.2
14
18
ZZA00
NOMESCO Finland
Split skin graft
46.0
6.9
8
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
15.0
6.4
10
8
C46.7
ICD-10 Finland
Kaposi sarcoma of other sites
+∞
6.4
6
*
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
+∞
6.4
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.4
6
*
C46.3
ICD-10 Finland
Kaposi sarcoma of lymph nodes
+∞
6.4
6
*

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_KAPOSI_SARCOMA_EXALLC – Kaposi sarcoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).