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Non-seminoma of testis

C3_TESTIS_NONSEMINOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C62.02&, C62.12&, C62.92&
  • Hospital discharge: ICD-9 186B
  • Cause of death: ICD-10 C62.02&, C62.12&, C62.92&
  • Cause of death: ICD-9 186B
  • Cancer registry: Topography ICD-O-3 C62
  • Cancer registry: Morphology ICD-O-3 907[01]|9080|9100
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

225

4. Check minimum number of events

None

225

5. Include endpoints

None

225

6. Filter based on genotype QC (FinnGen only)

225

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Non-seminoma of testis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 225 - 225
Unadjusted period prevalence (%) 0.10 - 0.10
Median age at first event (years) 30.78 - 30.78

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
203
Matched controls
2029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
194.3
154
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
582.0
183.1
158
12
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
291.1
134.8
125
11
130
Kela drug reimbursment
Malignant tumour
40.9
77.6
99
46
9085/3-C62.9
ICD-O-3
Mixed germ cell tumor of testis, NOS
+∞
57.0
52
*
JN4BD
NOMESCO Finland
Extensive body CT
20.9
53.7
84
66
A03FA01
ATC
metoclopramide; systemic, rectal
16.1
53.1
95
105
9070/3-C62.9
ICD-O-3
Embryonal carcinoma, NOS, of testis, NOS
+∞
50.1
46
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
45.5
48.5
59
18
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
+∞
45.5
42
*
C62.10
ICD-10 Finland
Malignant tumor of the descending testicle, no histological verification
536.4
45.1
43
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
18.9
39.2
62
46
C62.92
ICD-10 Finland
Malignant tumor in unspecified location in testis, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
37.7
35
*
L03AA02
ATC
filgrastim; parenteral
36.3
32.2
41
14
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
+∞
32.1
30
*
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
101.6
31.8
34
*
C62.02
ICD-10 Finland
Malignant tumor of the non-descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
31.0
29
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
27.3
118
418
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
+∞
25.5
24
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
56.0
25.0
29
6
C62.90
ICD-10 Finland
Malignant tumor in unspecified location in testis, no histological verification
270.5
24.2
24
*
A04AA02
ATC
granisetron; systemic, transdermal
20.9
23.6
35
20
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
23.4
22
*
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
46.0
23.3
28
7
C62.99
ICD-10 Finland
Malignant tumor in unspecified location in testis,other or undetermined histology
90.3
22.2
24
*
JN4AD
NOMESCO Finland
Body CT examination
11.9
21.3
40
41
H02AB02
ATC
dexamethasone; systemic
11.8
20.8
39
40
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.9
20.5
55
103
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
64.4
20.4
23
*
9085/3-C62.1
ICD-O-3
Mixed germ cell tumor of descended testis
+∞
20.1
19
*
DFF00
NOMESCO Finland
Pure tone audiometry
9.5
18.1
38
48
A04AA01
ATC
ondansetron; systemic, rectal
13.3
17.7
31
27
9080/3-C62.9
ICD-O-3
Teratoma, malignant, NOS, of testis, NOS
+∞
16.9
16
*
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
13.9
16.4
28
23
121
Kela drug reimbursment
Severe hypofunction of sexual glands
21.4
16.0
23
12
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
+∞
14.8
14
*
C62.00
ICD-10 Finland
Malignant tumor of the non-descending testicle, no histological verification
161.0
14.7
15
*
JN3AD
NOMESCO Finland
Abdominal CT examination
8.0
14.4
33
48
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
43.2
13.4
16
*
N02BE01
ATC
paracetamol; systemic, rectal
3.8
13.3
171
1184
D70.82
ICD-10 Finland
Drug-induced neutropenia
53.6
13.0
15
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
53.6
13.0
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
12.3
73
291
B01AB05
ATC
enoxaparin; parenteral
3.9
12.1
56
182
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
9.0
12.0
25
31
9081/3-C62.9
ICD-O-3
Teratocarcinoma of testis, NOS
+∞
11.6
11
*
18699
ICD-8 Finland
Malignant neoplasm of testis
126.8
11.5
12
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
16.7
11.0
17
11
WX302
NOMESCO Finland
Thoracal epidural anesthesy
10.0
10.8
21
23
C62
ICD-10 Finland
Malignant neoplasm of testis
115.7
10.5
11
*
C62.9
ICD-10 Finland
Malignant neoplasm: Testis, unspecified
115.7
10.5
11
*
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
+∞
10.5
10
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
24.9
10.4
14
6
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
5.0
10.3
34
79
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.9
10.3
81
382
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
10.2
40
111
WW500
NOMESCO Finland
Blood transfusion
17.9
10.0
15
9
B01AB10
ATC
tinzaparin; parenteral
9.1
9.8
20
24
N05BA06
ATC
lorazepam; systemic, sublingual
9.4
9.5
19
22
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
23.0
9.5
13
6
9070/3-C62.1
ICD-O-3
Embryonal carcinoma, NOS, of descended testis
+∞
9.4
9
*
ZXE00
NOMESCO Finland
One hour or less
2.7
9.1
82
411
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.7
9.1
31
75
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
11.5
9.0
16
15
WX402
NOMESCO Finland
General anaesthesia
3.5
8.8
44
150
N02AX02
ATC
tramadol; systemic, rectal
2.6
8.7
78
390
C62.01
ICD-10 Finland
Malignant tumor of the non-descending testicle, seminoma
+∞
8.4
8
*
1869B
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROT),CA EMBR/TERATOCA/CHORIOCA]
+∞
8.4
8
*
Y05
ICPC
Scrotum/testis sympt/compl other
9.4
7.7
15
17
ZX120
NOMESCO Finland
Intravenous
4.8
7.4
24
55
A02BC02
ATC
pantoprazole; systemic
2.3
7.4
107
668
Y78
ICPC
Malign neopl male genital other
+∞
7.3
7
*
9071/3-C62.9
ICD-O-3
Yolk sac tumor, NOS, of testis, NOS
+∞
7.3
7
*
WX320
NOMESCO Finland
Spinalanesthesy
3.2
7.3
40
145
WZC30
NOMESCO Finland
Teaching
3.6
7.2
33
105
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
12.7
7.2
12
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
7.1
23
53
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
6.8
70
368
N02AA05
ATC
oxycodone; systemic
3.8
6.8
28
82
M04AA01
ATC
allopurinol; systemic
4.0
6.7
26
72
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
72.0
6.5
7
*
Z85.4
ICD-10 Finland
Personal history of malignant neoplasm of genital organs
72.0
6.5
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.3
70
380
C62.91
ICD-10 Finland
Malignant tumor in unspecified location in testis, seminoma
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
27.6
6.3
8
*
R50.9
ICD-10 Finland
Fever, unspecified
3.0
6.2
36
136
E29.1
ICD-10 Finland
Testicular hypofunction
7.1
6.1
14
21
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
6.1
25
73

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_TESTIS_NONSEMINOMA – Non-seminoma of testis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).