Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia

D3_AB_DEF_NORMHYPERIG

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D80.6 Cause of death: ICD-10 — D80.6 2 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints None	43
6. Filter based on genotype QC (FinnGen only)	43

Control definitions (FinnGen only)

Control exclude: D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D80
Name in latin: Deficientia immunalis cum quantitate immunoglobulini prope normali sive cum hyperimmunoglobulinaemia

NAME	D3_AB_DEF_NORMHYPERIG
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D806
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D806
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	159	110	48
Only index persons	151	105	46
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	42.06	42.96	39.86
Only index persons	41.98	42.90	39.86

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	43	31	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	43.73	46.07	37.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4062490)

+∞

16.73

1.8

0.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

11.48

14.35

3.4

1.4

—

(3042936) Bacteria identified in Isolate by Culture

10.45

13.28

4.3

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

9.96

11.82

2.4

1.7

—

(42870588) Differential panel, method unspecified - Blood

116

11.77

11.54

24.1

7.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

9.60

11.46

2.4

1.7

—

(3000494) Fungus identified in Specimen by Culture

7.87

9.30

3.9

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

6.92

8.90

2.5

2.0

—

(3023368) Bacteria identified in Blood by Culture

6.61

8.85

10.0

4.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

8.88

8.61

4.2

2.1

—

(40758558) Short blood count panel - Blood

6.20

8.13

38.2

7.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

10.56

7.91

2.3

1.8

—

(3030467) Casts [#/volume] in Urine by Automated count

5.48

7.14

13.0

3.2

0.4

0.5

e6/l

0.14

(36304419) Bacteria [Presence] in Urine

5.48

7.14

13.0

3.0

—

(3000991) Gas panel - Venous blood

7.18

6.72

33.3

4.5

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

120

5.35

6.58

24.3

6.7

1.2

mmol/l

1.45

108

(3018095) Leukocytes [#/volume] in Urine

114

5.17

6.45

14.6

3.7

39.1

12.8

e6/l

0.40

(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum

+∞

6.39

2.3

0.0

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

+∞

6.39

3.2

0.0

—

(3000492) Spirometry study

5.99

5.98

2.7

1.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

4.80

5.90

4.8

2.2

3.0

2.9

mg/l

0.06

(3002582) Erythrocytes [#/volume] in Urine

4.64

5.82

13.0

3.0

18.1

13.2

e6/l

0.20

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

4.91

5.82

3.4

2.8

4028.5

131.7

ng/l

0.46

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

115

4.62

5.68

2.8

1.8

94.1

103.3

pmol/l

0.73

(21494814) CD8 cells/100 lymphocytes in Specimen

+∞

5.30

2.4

0.0

—

(3016228) CD19 cells/100 cells in Blood

+∞

5.30

2.4

0.0

10.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

106

4.25

5.17

13.6

3.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

4.36

5.01

10.2

2.5

0.5

0.7

e6/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

13.64

5.01

1.6

2.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

4.28

4.77

10.5

2.6

3.1

3.0

e6/l

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

127

4.03

4.70

9.7

4.5

35.3

35.9

g/l

0.22

121

(46235355) HIV 1 and 2 tests - Meaningful Use set

4.00

4.58

2.2

1.8

—

(4010399)

5.13

4.47

1.7

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

116

3.76

4.36

10.1

3.5

33.6

26.7

u/l

1.03

105

(3014007) Fractional oxyhemoglobin in Arterial blood

9.50

4.27

8.4

3.8

95.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

8.63

4.06

8.4

3.5

0.9

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

8.63

4.06

8.4

3.5

0.6

0.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

8.63

4.06

7.3

10.7

24.6

25.0

mmol/l

—

(3020630) Protein [Mass/volume] in Serum or Plasma

4.91

3.95

7.5

1.4

66.6

67.0

g/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

7.89

3.87

7.4

2.3

24.0

25.7

mmol/l

—

(40768443) Skin Pathology biopsy report

7.27

3.69

1.3

1.2

—

(40768797) Stomach Pathology biopsy report

3.90

3.61

1.1

1.2

—

(3032080) INR in Blood by Coagulation assay

106

3.20

3.42

12.2

4.5

1.4

1.1

inr

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

7.35

3.33

1.7

1.8

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

7.35

3.33

1.7

1.8

—

(3036489) Thrombin time

8.47

3.16

6.3

8.0

22.3

21.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

8.47

3.16

2.3

1.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

5.52

3.09

39.6

9.4

4.8

4.9

kpa

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.88

3.09

7.7

1.3

—

(3024928) Oxygen saturation in Venous blood

11.06

3.05

57.8

13.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

3.06

3.01

6.7

3.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

6.19

3.00

1.3

1.2

—

(3044889) 12 lead EKG panel

227

3.37

2.96

4.4

3.2

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

40.7

37.3

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

0.0

g/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

5.74

2.86

2.0

1.1

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

7.2

8.2

g/l

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

9.4

10.7

g/l

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

3.1

0.7

g/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.74

2.86

7.0

5.5

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

0.0

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

3.0

3.3

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

3.3

4.1

g/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

5.74

2.86

44.0

8.6

25.9

25.3

mmol/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

5.74

2.86

9.3

1.0

0.0

g/l

—

(40768804) Tissue Pathology biopsy report

151

2.83

2.73

3.3

1.7

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

364

+∞

2.71

58.6

13.4

139.3

139.7

mmol/l

0.63

352

(3023103) Potassium [Moles/volume] in Serum or Plasma

365

+∞

2.71

59.3

13.4

3.9

4.0

mmol/l

0.15

351

(3014051) Protein [Presence] in Urine by Test strip

6.13

2.64

2.7

1.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

190

2.91

2.64

12.2

7.2

10.9

10.4

umol/l

0.13

182

(3034770) Mitochondria Ab [Titer] in Serum

7.88

2.62

1.0

1.1

—

(3012544) pH of Venous blood

3.93

2.57

37.6

6.8

—

(3002032) Base excess in Venous blood by calculation

3.93

2.57

36.4

6.6

2.1

3.3

mmol/l

—

(3020779) Urea [Moles/volume] in Serum or Plasma

4.22

2.51

7.1

9.5

9.6

8.2

mmol/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

6.89

2.44

1.2

1.4

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

6.89

2.44

1.0

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.76

2.41

3.9

2.2

1.1

0.7

mg/l

—

(3044640) Blood type and Crossmatch panel - Blood

108

2.59

2.33

3.0

2.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

243

2.90

2.28

10.4

4.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.49

2.13

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.49

2.13

1.2

1.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.49

2.13

2.4

1.0

—

(3026008) Bacteria identified in Urine by Culture

2.54

2.13

15.2

2.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

259

2.88

2.12

4.1

3.2

—

(3022621) pH of Urine by Test strip

3.40

2.06

2.4

2.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.51

2.03

2.5

2.4

—

(3000330) Specific gravity of Urine by Test strip

4.18

2.01

2.7

2.6

—

(3045414) Leukocytes [Presence] in Urine

4.18

2.01

2.7

1.6

—

(3025941) Bacteria identified in Stool by Culture

4.18

2.01

1.2

1.3

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

4.98

2.00

1.2

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

170

2.34

1.90

9.7

4.8

0.0

estimate

—

(42529406) Shigella sp [Presence] in Stool by Culture

4.56

1.88

1.2

1.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

4.56

1.88

6.4

2.2

15.1

12.5

nmol/l

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

4.56

1.88

1.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

4.56

1.88

1.2

1.4

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.56

1.88

1.2

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

171

2.32

1.86

6.2

3.3

0.0

estimate

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.80

1.83

9.3

3.0

35.2

27.9

—

(3022145) Colonoscopy Study observation

3.04

1.83

1.8

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

172

2.29

1.82

6.3

3.3

0.0

estimate

—

(3003327) Ova and parasites identified in Stool by Light microscopy

4.20

1.76

1.4

1.5

—

(1002224) Polysomnography panel

3.49

1.73

1.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.01

1.66

2.6

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.00

1.49

1.2

1.6

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

119

2.07

1.44

4.4

3.3

2.3

2.4

mmol/l

0.46

100

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

2.01

1.26

1.5

1.8

1.7

1.4

mmol/l

0.49

(3009343) pH of Capillary blood

2.84

1.25

2.4

5.9

—

(3019060) Gas panel - Arterial blood

2.69

1.18

2.2

4.0

—

(1761868) Lipid panel - Serum or Plasma

126

0.47

1.12

1.6

2.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.15

1.11

2.3

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.00

1.01

2.2

1.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.24

0.93

3.7

3.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.73

0.77

5.6

4.3

36.0

7.2

mg/mmol

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

113

1.66

0.76

3.6

2.7

18.9

19.3

ng/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.71

0.74

1.3

1.4

—

0.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.73

0.66

2.0

1.8

—

(3007461) Platelets [#/volume] in Blood

411

+∞

0.62

70.4

18.2

265.0

260.0

e9/l

0.12

404

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.59

0.61

2.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.57

0.57

1.5

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.57

0.57

3.1

3.0

—

(3015736) pH of Urine

139

1.51

0.56

6.8

2.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.60

0.55

12.0

5.7

—

(3002256) Pathology report gross observation

1.48

0.48

1.6

1.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.8

—

(3035941) MCH [Entitic mass]

412

+∞

0.41

69.6

18.1

30.3

0.02

406

(3024731) MCV [Entitic volume]

412

+∞

0.41

69.6

18.1

90.8

90.7

0.03

406

(3000963) Hemoglobin [Mass/volume] in Blood

412

+∞

0.41

70.3

18.2

131.5

136.0

g/l

1.11

406

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.41

0.33

1.4

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

170

1.33

0.33

3.7

3.9

—

(36660697) Celiac disease serology panel - Serum

1.36

0.24

1.4

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.5

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

292.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.08

0.08

1.3

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

128

1.14

0.08

4.4

3.1

—

(3003694) ABO and Rh group [Type] in Blood

108

0.90

0.03

1.5

1.4

—

(4094501)

0.00

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.9

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

0.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.7

—

(4034850)

0.00

0.0

34.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_AB_DEF_NORMHYPERIG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_AB_DEF_NORMHYPERIG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_AB_DEF_NORMHYPERIG – Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints