No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
132 |
4. Check minimum number of eventsNone |
132 |
5. Include endpointsNone |
132 |
6. Filter based on genotype QC (FinnGen only) |
130 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80
- Name in latin
- Hypogammaglobulinaemia hereditaria
Similar endpoints
↥List of similar endpoints to
Hereditary hypogammaglobulinemia
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 605 | 359 | 244 |
| Only index persons | 530 | 325 | 205 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.72 | 45.82 | 38.04 |
| Only index persons | 42.31 | 45.45 | 37.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 130 | 80 | 50 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 46.79 | 46.28 | 47.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 132
- Matched controls
- 1320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
170.3
124
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
78.0
67
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
75.4
65
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
72.8
63
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
27.7
60.6
46
25
ZX120
NOMESCO Finland
Intravenous
15.6
54.4
62
71
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
49.1
44
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
12.2
41.0
52
67
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
40.8
37
*
J01MA12
ATC
levofloxacin; systemic
9.7
39.2
70
137
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
18.0
38.9
35
26
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
37.3
34
*
J01MA14
ATC
moxifloxacin; systemic
11.4
37.1
48
63
TPH04
NOMESCO Finland
Cathetrisation of vein
8.8
35.9
76
177
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.4
34.8
34
29
TDM10
NOMESCO Finland
Puncture of maxillary antrum
14.9
34.1
34
30
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
13.2
32.4
35
35
UGC12
NOMESCO Finland
Flexible bronchoscopy
13.4
31.1
33
32
WW200
NOMESCO Finland
Immunization
40.6
29.1
36
12
C01CA24
ATC
epinephrine; parenteral
10.0
28.8
39
53
H02AB07
ATC
prednisone; oral
8.2
28.3
49
89
R50.9
ICD-10 Finland
Fever, unspecified
7.3
26.3
52
108
H02AB06
ATC
prednisolone; systemic
8.4
25.9
106
433
J45.9
ICD-10 Finland
Asthma, unspecified
6.7
25.4
57
134
J45.1
ICD-10 Finland
Nonallergic asthma
9.6
25.0
34
46
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.2
24.2
34
48
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.9
24.0
98
390
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
34.8
23.5
30
11
J47
ICD-10 Finland
Bronchiectasis
43.8
23.2
28
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.0
23.0
37
61
6BA02, ,
NOMESCO Finland
+∞
22.5
21
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
22.5
21
*
R03BB04
ATC
tiotropium bromide; inhalant
8.7
21.9
32
47
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.5
21.7
71
229
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
8.3
21.6
33
51
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.7
21.4
31
45
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.8
21.4
57
154
Z01.8
ICD-10 Finland
Other specified special examinations
5.5
20.5
60
175
H02AB04
ATC
methylprednisolone; systemic
6.2
20.4
45
102
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
19.2
18
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
19.2
42
94
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.9
18.7
70
246
Z3231
NOMESCO Finland
Registered nurse
4.8
18.1
70
251
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
5.2
17.9
51
143
R03AK06
ATC
salmeterol and fluticasone; inhalant
5.6
17.3
41
98
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
5.0
17.2
52
153
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.4
17.0
33
65
J01FA06
ATC
roxithromycin; oral
4.7
17.0
87
382
Z3226
NOMESCO Finland
Physiotherapist
4.8
16.1
49
144
2790A
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[AGAMMAGLOBULINAEMIA (BRUTON)]
+∞
15.9
15
*
M05BA04
ATC
alendronic acid; oral
7.9
15.9
24
36
J01FA15
ATC
telithromycin; oral
5.7
15.6
35
79
R03BA02
ATC
budesonide; inhalant
4.7
15.5
50
153
R03DC03
ATC
montelukast; oral
4.7
15.2
46
134
TGC00
NOMESCO Finland
Bronchial lavation
22.4
14.8
21
11
J01MA02
ATC
ciprofloxacin; systemic
4.1
14.3
74
316
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.8
14.3
25
44
XF400
NOMESCO Finland
ECG with 12 standard connections
4.9
13.8
37
97
Z2446
NOMESCO Finland
Social worker
6.8
13.8
24
42
J01FF01
ATC
clindamycin; systemic
4.0
13.7
62
240
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
13.6
39
108
UJF32
NOMESCO Finland
Coloscopy
4.1
13.4
53
186
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
13.4
72
312
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.6
13.3
29
63
J01FA09
ATC
clarithromycin; systemic
3.8
13.3
71
307
XW000
NOMESCO Finland
Bone marrow biopsy
14.4
13.2
22
18
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
4.3
12.8
42
128
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.1
12.8
25
49
R4110
NOMESCO Finland
Physiotherapy
3.8
12.8
62
250
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
12.7
12
*
UJF30
NOMESCO Finland
Ileoscopy through colon
5.3
12.4
29
67
A01AB09
ATC
miconazole; local oral
5.4
12.4
28
63
R03AC13
ATC
formoterol; inhalant
9.9
11.9
24
29
J01DA08
ATC
[U] cefaclor
5.0
11.9
30
74
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
11.6
11
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
131.0
11.6
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.0
11.6
29
71
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.5
11.5
25
54
R03AK07
ATC
formoterol and budesonide; inhalant
3.8
11.5
48
173
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
22.5
11.4
16
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
11.4
64
279
J01FA10
ATC
azithromycin; systemic
4.5
11.4
108
658
JN4BD
NOMESCO Finland
Extensive body CT
5.0
11.3
28
68
J01DA06
ATC
[U] cefuroxime
4.1
11.3
39
123
H02AB09
ATC
hydrocortisone; systemic
17.5
11.2
17
11
A28
ICPC
Limited function/disability NOS
4.6
11.1
31
83
R03DA04
ATC
theophylline; systemic, rectal
14.7
11.0
18
14
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
31.0
11.0
14
5
J02AC01
ATC
fluconazole; systemic
3.4
10.9
79
401
A46
ICD-10 Finland
Erysipelas
4.2
10.8
34
100
ZXD20
NOMESCO Finland
Day surgery
4.4
10.7
32
90
N02AX02
ATC
tramadol; systemic, rectal
3.4
10.6
79
406
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
10.6
10
*
J32.4
ICD-10 Finland
Chronic pansinusitis
25.8
10.5
14
6
A07AA02
ATC
nystatin; oral
8.9
10.4
22
29
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.7
10.4
43
153
R01AD08
ATC
fluticasone; nasal
3.3
10.3
61
272
N03AX16
ATC
[U] pregabalin
3.5
10.2
49
192
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
10.1
33
99
R03AC02
ATC
salbutamol; inhalant
3.6
10.1
98
584
ZXA00
NOMESCO Finland
Right side
3.4
9.9
51
208
GD1AD
NOMESCO Finland
Thorax CT examination
9.9
9.7
19
22
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.2
9.6
30
87
J31.0
ICD-10 Finland
Chronic rhinitis
4.5
9.5
26
68
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
9.5
9
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
9.5
9
*
J46
ICD-10 Finland
Status asthmaticus
15.2
9.4
15
11
R01AD09
ATC
mometasone; nasal
3.2
9.3
86
488
R03BA08
ATC
ciclesonide; inhalant
4.5
9.2
25
65
N03AX12
ATC
[U] gabapentin; oral
3.5
9.2
39
140
R03AC12
ATC
salmeterol; inhalant
9.7
9.1
18
21
Z2221
NOMESCO Finland
Medical doctor
3.1
9.1
57
259
R01AD05
ATC
budesonide; nasal
5.0
9.0
21
48
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.7
8.8
20
30
ZXE00
NOMESCO Finland
One hour or less
3.0
8.7
70
363
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
8.7
34
115
-44
ICPC
Preventive immunization/medic
5.5
8.6
18
37
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
29.7
8.6
11
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.8
8.6
21
50
ZX112
NOMESCO Finland
Subcutaneous
10.5
8.6
16
17
132
Kela drug reimbursment
Sarcoidosis
+∞
8.4
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.6
8.4
33
112
R06.0
ICD-10 Finland
Dyspnoea
3.1
8.4
47
199
SPAT1262
SPAT
Handing over of treatment supplies
3.6
8.3
33
113
C03CA01
ATC
furosemide; systemic
3.2
8.2
42
168
WX002
NOMESCO Finland
Sedation and analgesia
3.4
8.2
37
137
C03DA01
ATC
spironolactone; oral
4.4
8.2
23
61
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
23.8
8.2
11
5
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.7
8.1
20
34
R06AE07
ATC
cetirizine; oral
2.9
8.1
78
442
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
8.0
39
151
R03BA01
ATC
beclometasone; inhalant
3.6
7.9
31
105
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
7.8
50
227
R03BA05
ATC
fluticasone; inhalant
3.2
7.8
40
160
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
7.8
19
45
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
7.7
30
101
WZC00
NOMESCO Finland
Treatment plan or consultation
2.8
7.6
64
334
J01DA09
ATC
[U] cefadroxil
2.9
7.5
51
238
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
84.6
7.5
8
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.1
7.4
16
22
J01DA01
ATC
[U] cefalexin
3.0
7.4
98
643
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.0
7.4
17
38
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
7.4
7
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.4
7
*
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
7.4
7
*
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
31.9
7.2
9
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
10.9
7.2
13
13
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.8
7.2
53
258
L04AX01
ATC
azathioprine; systemic
8.3
7.1
15
20
SAA04
NOMESCO Finland
Special examination of mouth
6.8
7.0
17
28
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.8
7.0
90
574
R4120
NOMESCO Finland
Occupational therapy
4.4
7.0
19
49
R03AK03
ATC
[U] fenoterol and ipratropium bromide
7.5
6.7
15
22
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
6.3
6.7
17
30
J45.8
ICD-10 Finland
Mixed asthma
10.9
6.7
12
12
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
6.7
32
122
R03BB01
ATC
ipratropium bromide; inhalant
8.1
6.6
14
19
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
6.5
67
380
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
73.2
6.5
7
*
Z50.1
ICD-10 Finland
Other physical therapy
5.6
6.5
18
36
R05
ICD-10 Finland
Cough
2.8
6.5
40
176
J45
ICD-10 Finland
Asthma
4.0
6.5
20
57
A02BC02
ATC
pantoprazole; systemic
2.9
6.4
100
689
WVA20
NOMESCO Finland
Medicine administration
11.9
6.4
11
10
B99
ICD-10 Finland
Other and unspecified infectious diseases
11.9
6.4
11
10
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.9
6.4
17
32
TAB00
NOMESCO Finland
Lumbar puncture
4.4
6.4
17
43
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
6.3
22
68
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
6.3
64
359
S01GX01
ATC
cromoglicic acid; ophthalmic
2.8
6.3
41
185
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
+∞
6.3
6
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.5
6.3
16
39
B03BA03
ATC
hydroxocobalamin; parenteral
7.3
6.2
14
21
A07EA06
ATC
budesonide; oral, local oral
6.6
6.2
15
25
R03AK11
ATC
formoterol and fluticasone; inhalant
9.3
6.2
12
14
A06AD11
ATC
lactulose; oral
3.6
6.2
22
69
A02BA02
ATC
ranitidine; systemic
3.0
6.2
31
121
XQ800
NOMESCO Finland
Prick test
3.7
6.2
21
64
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
10.8
6.2
11
11
UJF92
NOMESCO Finland
Capsular endoscopy
10.8
6.2
11
11
J01AA02
ATC
doxycycline; systemic
3.7
6.1
116
877
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.4
6.1
16
40
S01
ICPC
Pain/tenderness of skin
7.9
6.1
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
5
97.80
33.86
2.6
1.4
—
—
—
0
0
34
5
90.51
31.65
2.6
1.4
13.26
11.20
%
—
34
5
38
63
8.07
23.53
2.5
1.8
—
—
—
0
0
29
35
10.34
23.20
2.9
1.5
—
—
—
0
0
53
139
5.70
20.45
3.7
1.8
—
—
—
0
0
42
100
5.69
17.81
2.8
1.5
—
—
—
0
0
41
99
5.56
17.06
2.8
1.5
—
—
—
0
0
95
468
4.67
15.32
14.4
8.0
1.21
1.22
mmol/l
0.95
87
397
59
219
4.06
13.90
3.9
2.2
3.20
3.02
mg/l
0.22
59
193
17
6
32.17
13.33
3.5
1.0
—
—
—
0
0
17
6
32.17
13.33
3.5
1.0
—
—
—
0
0
38
108
4.54
12.72
12.6
8.9
1.08
1.11
mmol/l
0.27
38
101
23
23
11.85
12.61
1.5
1.2
—
—
—
0
0
21
22
11.12
11.25
2.5
2.0
—
—
—
0
0
16
9
19.99
11.04
5.1
3.0
—
—
—
0
0
83
435
3.45
10.82
12.3
9.7
1.14
1.15
inr
0.03
27
126
20
21
11.01
10.71
2.6
2.0
—
—
—
0
0
22
45
5.67
10.70
2.2
1.3
—
—
—
0
0
35
107
4.09
10.49
14.7
7.1
104.63
103.86
mmol/l
0.51
35
107
63
285
3.32
10.39
6.0
3.0
0.20
0.42
e6/l
0.82
53
203
57
245
3.33
10.19
2.6
1.7
0.90
1.39
mg/l
0.58
51
191
99
595
3.66
10.01
12.4
4.7
7.08
6.47
mmol/l
1.46
99
548
16
12
14.97
9.97
1.8
2.1
—
—
—
0
0
16
12
14.97
9.97
1.8
2.1
—
—
—
0
0
41
145
3.65
9.93
3.5
1.9
28.51
29.04
s
0.29
41
140
18
18
11.38
9.88
2.6
1.9
—
—
—
0
0
23
53
5.04
9.78
2.1
1.6
—
—
—
0
0
14
8
19.36
9.63
4.4
2.1
—
—
—
0
0
20
42
5.43
9.41
22.0
6.8
24.61
24.24
mmol/l
0.13
20
42
18
20
10.23
9.38
2.4
2.1
—
—
—
0
0
17
17
11.29
9.35
1.9
1.2
—
—
—
0
0
42
157
3.46
9.29
10.2
4.3
0.79
0.84
mmol/l
2.30
42
151
71
372
2.97
8.69
6.6
3.0
—
—
—
0
0
22
54
4.69
8.65
25.7
7.4
24.91
25.53
mmol/l
0.22
22
54
12
7
18.67
8.24
1.6
2.1
—
—
—
0
0
28
87
3.82
8.08
4.1
3.4
—
—
—
0
0
12
8
16.33
7.88
5.0
2.1
—
—
—
0
0
16
20
8.94
7.86
1.6
1.7
—
—
—
0
0
17
24
7.96
7.77
10.6
4.7
53.94
57.87
%
0.44
17
24
17
24
7.96
7.77
10.0
3.7
3.33
4.90
e9/l
1.10
17
24
17
38
4.99
7.42
2.1
1.1
—
—
—
0
0
7
0
+∞
7.35
1.4
0.0
—
—
—
0
0
12
11
11.86
6.95
2.8
1.8
—
—
—
0
0
14
18
8.56
6.81
1.6
1.0
—
—
—
0
0
14
18
8.56
6.81
1.6
1.0
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
12
13
10.02
6.44
2.9
1.7
—
—
—
0
0
9
5
19.14
6.35
1.3
1.8
—
—
—
0
0
9
5
19.14
6.35
1.3
1.8
—
—
—
0
0
26
91
3.31
6.21
10.0
13.0
1.80
1.34
mmol/l
0.18
21
74
12
15
8.67
5.98
4.1
1.7
—
—
—
0
0
12
16
8.13
5.77
4.1
1.6
—
—
—
0
0
12
16
8.13
5.77
4.1
1.6
—
—
—
0
0
14
24
6.39
5.71
3.6
1.5
—
—
—
0
0
22
73
3.42
5.69
4.2
5.5
75.51
82.65
ng/l
0.23
22
67
78
496
2.40
5.64
4.0
2.8
—
—
—
0
0
36
162
2.68
5.49
5.0
2.8
1.60
2.90
e6/l
0.64
24
85
11
15
7.89
5.26
3.2
1.8
—
—
—
0
0
36
168
2.57
5.07
4.9
2.7
0.83
0.97
e6/l
0.18
24
90
12
20
6.48
5.04
1.7
1.2
389.17
520.30
mg/l
0.66
12
20
19
62
3.41
5.02
10.8
4.7
5.13
5.08
kpa
0.11
19
56
63
379
2.27
5.02
2.5
1.8
95.15
99.60
pmol/l
0.39
35
183
10
13
8.22
4.95
1.1
1.2
—
—
—
0
0
13
25
5.65
4.92
1.2
1.0
—
—
—
0
0
7
5
14.67
4.63
1.1
1.2
120.86
56.20
u/l
—
7
5
10
15
7.11
4.56
3.1
1.8
—
—
—
0
0
14
33
4.62
4.48
3.9
1.8
96.21
91.61
%
0.26
14
33
50
286
2.20
4.39
5.4
3.8
16.59
8.48
mg/mmol
0.33
30
173
10
16
6.66
4.38
2.1
1.3
—
—
—
0
0
7
6
12.22
4.32
4.3
1.8
25.43
29.50
umol/l
—
7
6
14
35
4.35
4.25
6.6
2.0
—
—
—
0
0
19
69
3.05
4.23
2.9
3.4
4.02
4.39
pmol/l
0.87
19
63
13
31
4.53
4.14
2.1
1.1
0.00
0.00
g/l
-0.00
13
31
46
261
2.17
4.08
4.1
2.5
—
—
—
0
0
7
7
10.47
4.06
2.4
2.3
—
—
—
0
0
7
7
10.47
4.06
2.4
2.3
—
—
—
0
0
8
11
7.66
3.92
1.1
1.4
—
—
—
0
0
8
11
7.66
3.92
1.8
1.1
—
—
—
0
0
14
44
3.44
3.90
19.9
2.7
0.61
0.64
%
0.13
14
44
14
44
3.44
3.90
3.1
3.7
53.06
51.57
%
0.06
14
44
11
24
4.90
3.84
1.3
1.3
—
—
—
0
0
33
168
2.29
3.77
4.8
3.1
242.09
45.65
ng/l
0.53
22
112
10
20
5.32
3.77
1.6
1.5
—
—
—
0
0
14
40
3.79
3.74
3.6
3.2
25.66
24.93
mmol/l
0.38
14
40
117
974
2.77
3.59
51.1
14.7
15.00
14.49
%
0.57
117
964
14
47
3.21
3.53
20.0
2.7
2.06
1.19
%
0.70
14
47
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
11
27
4.35
3.48
1.7
2.1
—
—
—
0
0
9
18
5.28
3.43
2.7
1.7
—
—
—
0
0
7
10
7.32
3.41
2.4
2.2
—
—
—
0
0
7
10
7.32
3.41
2.4
2.2
—
—
—
0
0
7
10
7.32
3.41
2.4
2.2
—
—
—
0
0
121
1040
2.96
3.19
34.3
11.4
86.86
86.42
ml/min/173m2
0.07
113
838
12
36
3.56
3.11
5.8
2.4
—
—
—
0
0
6
8
7.79
3.08
2.5
1.3
—
—
—
0
0
6
8
7.79
3.08
1.5
2.6
—
—
—
0
0
6
8
7.79
3.08
1.8
1.3
—
—
—
0
0
43
269
1.89
2.77
1.4
1.3
0.32
1.72
u/ml
—
9
73
10
29
3.64
2.75
2.4
1.1
0.00
0.00
g/l
—
10
29
10
29
3.64
2.75
2.4
1.1
0.00
0.00
g/l
—
10
29
6
10
6.22
2.73
1.0
1.0
—
—
—
0
0
8
20
4.19
2.61
5.1
2.8
24.86
25.10
mmol/l
—
8
20
5
7
7.36
2.57
4.8
2.1
—
—
—
0
0
13
51
2.72
2.53
12.2
10.3
0.93
1.41
%
1.45
13
51
13
51
2.72
2.53
11.8
10.7
0.47
0.63
%
1.58
13
51
12
45
2.83
2.53
13.7
5.2
25.13
24.30
mmol/l
0.38
12
45
5
8
6.44
2.39
4.8
2.0
—
—
—
0
0
5
8
6.44
2.39
4.8
2.0
—
—
—
0
0
6
13
4.78
2.30
4.5
1.7
—
—
—
0
0
6
13
4.78
2.30
1.0
1.0
—
—
—
0
0
5
9
5.72
2.23
1.0
1.0
—
—
—
0
0
6
14
4.43
2.17
1.0
1.1
—
—
—
0
0
69
527
1.65
2.10
6.1
3.3
0.00
0.00
estimate
-0.00
17
96
5
10
5.15
2.09
5.0
1.8
—
—
—
0
0
5
10
5.15
2.09
1.0
1.0
—
—
—
0
0
7
20
3.63
2.08
2.0
1.3
—
—
—
0
0
6
15
4.14
2.06
4.5
1.7
—
—
—
0
0
10
39
2.69
1.99
1.6
3.0
—
—
—
0
0
5
12
4.28
1.84
2.2
1.3
—
—
—
0
0
68
531
1.58
1.81
9.2
4.6
0.00
0.00
estimate
-0.00
17
91
6
148
0.38
1.78
1.5
1.7
—
—
—
0
0
68
533
1.57
1.77
6.1
3.3
0.00
0.00
estimate
-0.00
17
89
6
18
3.44
1.76
2.0
1.2
—
—
—
0
0
52
389
1.56
1.63
4.9
3.1
25.19
24.53
ng/l
0.03
43
239
9
37
2.53
1.51
1.3
1.3
—
—
—
0
0
6
22
2.81
1.45
1.2
1.1
—
—
—
0
0
14
76
1.94
1.36
3.1
3.0
100.33
68.12
ml/min/173m2
—
6
33
7
35
2.05
1.01
1.7
1.5
—
5706.00
—
0
10
28
206
1.46
0.91
1.5
1.4
—
—
—
0
0
35
274
1.38
0.82
5.7
3.5
0.00
0.00
estimate
-0.00
17
89
7
117
0.58
0.72
8.9
6.1
—
—
—
0
0
88
798
1.31
0.71
4.7
3.0
57.50
44.78
u/l
0.78
88
755
7
41
1.75
0.71
1.4
1.2
—
—
—
0
0
50
425
1.28
0.66
6.2
3.3
—
—
—
0
0
31
249
1.32
0.61
1.5
1.6
—
—
—
0
0
9
135
0.64
0.55
6.2
4.1
36.56
31.40
%
—
9
88
8
60
1.35
0.41
1.6
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
6
46
1.32
0.33
1.5
1.8
326.17
282.78
mu/l
—
6
41
18
148
1.25
0.31
1.7
1.7
—
—
—
0
0
85
808
1.15
0.27
4.2
3.3
—
—
—
0
0
9
72
1.27
0.26
1.8
1.6
—
—
—
0
0
17
142
1.23
0.26
1.8
1.9
1.63
1.42
%
0.35
12
128
24
272
0.86
0.23
5.5
4.6
2.39
3.02
ug/l
0.20
24
241
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
16
137
1.19
0.20
1.6
1.5
—
—
—
0
0
5
67
0.74
0.17
1.0
1.0
—
—
—
0
0
9
79
1.15
0.15
2.2
2.4
7.62
4.91
ug/l
—
9
67
19
211
0.88
0.14
1.2
1.2
1.27
8.45
u/ml
—
6
90
20
220
0.89
0.13
4.7
4.2
19.51
22.79
%
0.44
14
94
5
63
0.79
0.08
1.4
1.3
—
—
—
0
0
21
207
1.02
0.00
1.3
1.3
12.34
53.33
iu/ml
—
7
72
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
9.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
17.54
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.01
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
52.07
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDHYPOGAMMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDHYPOGAMMA | 3.534 [2.19, 5.71] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 290 females with D3_HEREDHYPOGAMMA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have D3_HEREDHYPOGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.309% | No data |
| 5 | 1.859% | No data |
| 10 | 4.472% | No data |
| 15 | 8.584% | No data |
| 20 | 14.501% | No data |
Relationships between endpoints
↥Index endpoint: D3_HEREDHYPOGAMMA – Hereditary hypogammaglobulinemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data