No definition available.
Disseminated intravascular coagulation [defibrination syndrome]
D3_DISSEINTRAVASCCOAG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
110 |
4. Check minimum number of eventsNone |
110 |
5. Include endpointsNone |
110 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D65-D69
- Name in latin
- Coagulatio intravascularis disseminata
Similar endpoints
↥List of similar endpoints to
Disseminated intravascular coagulation [defibrination syndrome]
based on the number of shared cases.
Similar with more cases:
- Coagulation defects, purpura and other haemorrhagic conditions
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1279 | 631 | 631 |
| Only index persons | 817 | 418 | 399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.83 | 59.55 | 58.04 |
| Only index persons | 56.58 | 56.34 | 56.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 59 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 53.41 | 47.09 | 60.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 105
- Matched controls
- 1048
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D65
ICD-10 Finland
Disseminated intravascular coagulation [defibrination syndrome]
+∞
114.5
88
*
A41.9
ICD-10 Finland
Sepsis, unspecified
54.8
35.2
41
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
15.7
31.8
60
82
N17.9
ICD-10 Finland
Acute renal failure, unspecified
45.1
26.5
32
10
TK800
NOMESCO Finland
Hemodialysis
53.7
24.1
28
7
TK810
NOMESCO Finland
Hemofiltration
214.8
18.1
18
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
39.2
17.9
22
7
Z49.1
ICD-10 Finland
Extracorporeal dialysis
53.7
15.6
18
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
38.1
15.4
19
6
WX872
NOMESCO Finland
Intensive care
16.0
15.4
25
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.7
15.1
35
57
B03XA02
ATC
darbepoetin alfa; parenteral
42.9
15.0
18
5
A11CC03
ATC
alfacalcidol; systemic
32.6
14.9
19
7
L04AA06
ATC
mycophenolic acid; systemic
50.2
14.6
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.6
14.5
37
70
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
79.8
12.9
14
*
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
12.8
12
*
N18.0
ICD-10 Finland
End-stage renal disease
43.2
12.6
15
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.4
12.3
23
25
A12AA04
ATC
calcium carbonate; oral
53.3
12.2
14
*
127
Kela drug reimbursment
Transplant complication
34.6
12.0
15
5
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.6
11.8
23
27
A41.8
ICD-10 Finland
Other specified sepsis
39.9
11.6
14
*
V03AE01
ATC
polystyrene sulfonate; oral
28.8
11.5
15
6
J96.0
ICD-10 Finland
Acute respiratory failure
+∞
10.6
10
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
44.6
10.2
12
*
WX730
NOMESCO Finland
Conventional respirator
29.3
10.1
13
5
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
15.5
10.1
16
12
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
10.8
10.0
19
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.1
10.0
35
94
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
33.5
9.6
12
*
Z94.0
ICD-10 Finland
Kidney transplant status
33.5
9.6
12
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.2
9.4
16
14
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
54.7
8.8
10
*
ZX120
NOMESCO Finland
Intravenous
6.0
8.8
25
52
KA1AE
NOMESCO Finland
Kidney ultrasound examination
18.3
8.8
13
8
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
22.3
8.7
12
6
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
30.4
8.7
11
*
WX882
NOMESCO Finland
High dependency care
11.4
8.3
15
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
36.5
8.2
10
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.0
8.2
20
34
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.6
8.1
13
10
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
14.6
8.1
13
10
Z49.0
ICD-10 Finland
Preparatory care for dialysis
48.8
7.8
9
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
+∞
7.4
7
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
21.9
7.3
10
5
L04AD01
ATC
ciclosporin; systemic
21.9
7.3
10
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
32.5
7.3
9
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
32.5
7.3
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
7.2
28
82
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.9
6.9
19
38
NDQ20
NOMESCO Finland
Amputation of finger
42.9
6.9
8
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
42.9
6.9
8
*
V03AE02
ATC
sevelamer; oral
42.9
6.9
8
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
42.9
6.9
8
*
R4110
NOMESCO Finland
Physiotherapy
3.3
6.8
42
178
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.7
6.8
13
15
JN4BD
NOMESCO Finland
Extensive body CT
4.7
6.5
22
56
321
Kela drug reimbursment
Paricalcitol and cinacalcet
74.2
6.5
7
*
H05BX01
ATC
cinacalcet; oral
74.2
6.5
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.6
6.4
22
57
GBB00
NOMESCO Finland
Tracheostomy
28.6
6.3
8
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
28.6
6.3
8
*
M10.0
ICD-10 Finland
Idiopathic gout
28.6
6.3
8
*
J80
ICD-10 Finland
Adult respiratory distress syndrome
+∞
6.3
6
*
C03CA01
ATC
furosemide; systemic
3.2
6.2
39
165
J01MA12
ATC
levofloxacin; systemic
3.5
6.1
32
118
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
6.1
43
195
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
23
11.71
19.45
2.4
1.9
0.2
0.4
u/ml
—
10
13
18
15
14.15
18.26
1.3
1.7
—
—
—
0
0
38
120
4.31
11.18
7.7
2.5
22.7
24.2
%
0.26
33
109
39
146
3.59
8.77
6.7
3.0
0.8
0.8
mmol/l
1.44
39
138
14
22
7.15
8.76
1.4
1.2
—
—
—
0
0
14
24
6.54
8.07
3.1
1.3
—
—
—
0
0
27
83
3.99
8.02
17.6
4.2
-0.1
2.1
mmol/l
1.70
20
63
11
7
17.25
7.40
1.1
1.3
—
—
—
0
0
27
95
3.44
6.51
1.7
1.7
—
—
—
0
0
19
53
4.12
6.36
2.1
1.4
—
—
—
0
0
34
142
3.02
6.16
1.7
1.9
—
—
—
0
0
25
89
3.34
5.88
1.6
1.6
—
—
—
0
0
5
0
+∞
5.24
1.0
0.0
—
—
—
0
0
10
19
5.69
5.14
1.6
2.1
—
—
—
0
0
38
189
2.54
4.81
5.4
2.1
—
—
—
0
0
10
21
5.14
4.63
1.3
1.1
—
—
—
0
0
10
21
5.14
4.63
1.3
1.1
—
—
—
0
0
18
61
3.33
4.53
3.7
2.8
31.4
59.3
ml/min/173m2
—
9
28
22
86
2.95
4.38
5.0
3.4
—
—
—
0
0
36
183
2.44
4.29
3.6
1.7
5.5
1.1
mg/l
1.49
29
143
9
13
7.43
4.25
1.2
1.2
—
—
—
0
0
7
7
10.57
4.07
2.3
2.4
—
—
—
0
0
18
67
3.02
3.88
6.9
4.3
0.0
2.0
mmol/l
—
10
53
13
40
3.55
3.76
8.8
2.5
0.6
0.7
%
0.37
13
40
12
35
3.73
3.74
1.7
1.6
3.5
3.6
g/l
—
6
27
12
35
3.73
3.74
1.7
1.6
—
—
—
0
0
12
35
3.73
3.74
1.7
1.6
7.2
7.8
g/l
—
6
27
13
41
3.46
3.63
8.8
2.5
0.7
1.4
%
1.56
13
41
10
27
3.97
3.44
1.4
1.3
—
—
—
0
0
11
32
3.71
3.43
1.7
1.6
3.2
3.0
g/l
—
6
27
7
11
6.71
3.23
1.4
1.2
—
—
—
0
0
71
517
2.05
3.19
16.1
10.3
5.8
4.0
e9/l
0.75
65
461
7
12
6.14
3.07
1.0
1.2
—
—
—
0
0
8
17
4.98
2.98
1.4
1.5
—
—
—
0
0
13
47
3.00
2.93
1.5
1.3
—
—
—
0
0
6
9
6.97
2.90
2.3
1.1
—
—
—
0
0
13
48
2.94
2.83
30.5
8.6
93.5
94.6
%
0.59
13
48
50
332
1.93
2.83
8.6
3.3
—
—
—
0
0
12
44
2.94
2.64
1.7
1.6
—
—
—
0
0
55
387
1.84
2.53
6.9
3.9
—
—
—
0
0
8
21
4.02
2.51
1.4
1.1
—
—
—
0
0
83
950
0.49
2.49
42.9
15.9
141.1
77.1
umol/l
3.24
83
950
9
27
3.54
2.45
2.3
2.5
—
—
—
0
0
8
22
3.84
2.41
1.4
1.1
—
—
—
0
0
5
8
6.48
2.39
1.4
2.6
—
—
—
0
0
5
8
6.48
2.39
1.4
1.6
—
—
—
0
0
5
10
5.18
2.09
2.6
3.9
—
—
—
0
0
10
38
2.79
2.07
1.3
1.2
—
—
—
0
0
26
152
1.93
2.07
6.6
2.9
11.1
3.1
e6/l
0.85
20
80
27
161
1.90
2.03
5.9
2.6
2.0
1.0
e6/l
0.31
20
87
7
21
3.49
2.00
1.0
1.4
—
—
—
0
0
73
855
0.57
1.99
5.2
4.5
6.1
5.9
mmol/l
0.68
67
779
8
30
2.79
1.76
1.0
1.4
—
254.2
—
0
16
8
32
2.61
1.63
2.3
1.6
—
—
—
0
0
24
148
1.80
1.61
1.7
1.7
853.9
1192.0
nmol/l
1.34
19
119
30
202
1.67
1.49
1.8
1.5
21.3
22.9
nmol/l
0.25
30
170
5
17
3.03
1.37
1.0
1.8
—
—
—
0
0
10
186
0.49
1.33
1.3
1.8
—
—
—
0
0
50
392
1.51
1.28
7.6
2.7
299.9
110.7
ug/l
2.50
50
367
44
336
1.52
1.27
2.3
1.9
87.7
97.2
pmol/l
0.79
24
169
20
298
0.60
1.25
5.0
4.5
1.0
3.1
ug/l
1.19
20
262
8
43
1.93
0.89
5.0
3.1
55.4
54.0
%
—
8
43
6
32
1.92
0.83
2.0
1.7
47.2
40.9
nmol/l
—
6
32
5
24
2.13
0.75
2.6
1.6
—
—
—
0
0
5
26
1.97
0.71
2.2
1.9
—
—
—
0
0
5
29
1.76
0.64
1.0
1.1
—
—
—
0
0
79
850
0.75
0.62
31.0
12.9
65.3
81.7
ml/min/173m2
3.85
71
702
6
36
1.70
0.57
1.5
2.8
—
—
—
0
0
49
426
1.27
0.56
7.0
3.5
0.0
0.0
estimate
—
8
99
49
432
1.24
0.48
7.1
3.6
0.0
0.0
estimate
—
9
92
85
895
0.78
0.44
42.0
13.6
30.5
22.0
mg/l
2.02
74
708
5
35
1.45
0.40
1.6
2.4
—
—
—
0
0
20
241
0.79
0.36
7.4
3.8
0.0
0.0
estimate
—
7
93
47
426
1.18
0.32
10.6
4.7
0.0
0.0
estimate
—
9
99
17
142
1.23
0.26
2.0
1.4
—
—
—
0
0
30
334
0.86
0.24
6.9
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
37
342
1.12
0.18
2.6
4.0
72.8
45.4
ng/l
0.31
30
234
57
590
0.93
0.10
2.8
3.3
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
6
73
0.81
0.08
9.2
3.5
1.2
1.2
mmol/l
—
6
63
20
213
0.93
0.06
1.6
1.3
0.8
0.8
u/ml
—
5
56
10
108
0.92
0.03
2.3
2.0
—
—
—
0
0
10
98
1.02
0.00
9.3
8.9
—
—
—
0
0
27
265
1.03
0.00
2.9
2.0
300.4
204.1
u/l
0.26
27
254
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
12.8
—
0
6
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
0.00
2.2
1.9
33.3
60.0
u/ml
—
6
53
9
98
0.91
0.00
2.2
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
17.6
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
248.2
—
0
5
6
59
1.02
0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_DISSEINTRAVASCCOAG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 3.462 [2.16, 5.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 307 females with D3_DISSEINTRAVASCCOAG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 4.371 [2.68, 7.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 291 males with D3_DISSEINTRAVASCCOAG died.
Mortality risk
Mortality risk for people of age
years, who have D3_DISSEINTRAVASCCOAG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.317% | 0.77% |
| 5 | 2.11% | 4.787% |
| 10 | 4.958% | 11.208% |
| 15 | 8.941% | 20.685% |
| 20 | 14.772% | 33.351% |
Relationships between endpoints
↥Index endpoint: D3_DISSEINTRAVASCCOAG – Disseminated intravascular coagulation [defibrination syndrome]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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