No definition available.
Disseminated intravascular coagulation [defibrination syndrome]
D3_DISSEINTRAVASCCOAG
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
116 |
4. Check minimum number of eventsNone |
116 |
5. Include endpointsNone |
116 |
6. Filter based on genotype QC (FinnGen only) |
106 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D65-D69
- Name in latin
- Coagulatio intravascularis disseminata
Similar endpoints
↥List of similar endpoints to
Disseminated intravascular coagulation [defibrination syndrome]
based on the number of shared cases.
Similar with more cases:
- Coagulation defects, purpura and other haemorrhagic conditions
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1279 | 631 | 631 |
| Only index persons | 817 | 418 | 399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.83 | 59.55 | 58.04 |
| Only index persons | 56.58 | 56.34 | 56.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 106 | 60 | 46 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 52.30 | 48.28 | 57.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 116
- Matched controls
- 1160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D65
ICD-10 Finland
Disseminated intravascular coagulation [defibrination syndrome]
+∞
126.2
97
*
A41.9
ICD-10 Finland
Sepsis, unspecified
72.5
87.1
50
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
15.4
51.3
68
98
N17.9
ICD-10 Finland
Acute renal failure, unspecified
39.4
28.9
36
13
TK800
NOMESCO Finland
Hemodialysis
48.3
26.9
32
9
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.4
26.4
28
27
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.8
22.9
40
73
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.0
19.6
25
31
TK810
NOMESCO Finland
Hemofiltration
119.7
19.2
20
*
WX872
NOMESCO Finland
Intensive care
16.4
17.9
29
23
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.4
17.8
37
79
B03XA02
ATC
darbepoetin alfa; parenteral
42.2
17.4
21
6
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
28.2
17.2
23
10
Z49.1
ICD-10 Finland
Extracorporeal dialysis
105.6
17.1
18
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
36.1
16.8
21
7
V03AE01
ATC
polystyrene sulfonate; oral
70.3
16.3
18
*
L04AA06
ATC
mycophenolic acid; systemic
28.1
15.8
21
9
N18.0
ICD-10 Finland
End-stage renal disease
92.1
15.0
16
*
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
14.9
14
*
WX730
NOMESCO Finland
Conventional respirator
170.6
14.8
15
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
21.0
14.5
21
12
A11CC03
ATC
alfacalcidol; systemic
24.9
13.9
19
9
TPH07
NOMESCO Finland
Cathetrisation of artery
6.4
13.7
26
50
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
45.8
13.5
16
*
Z94.0
ICD-10 Finland
Kidney transplant status
36.7
13.0
16
5
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
36.7
13.0
16
5
L04AD02
ATC
tacrolimus; systemic
78.7
12.9
14
*
127
Kela drug reimbursment
Transplant complication
28.1
12.9
17
7
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
12.2
12.7
23
23
ZX120
NOMESCO Finland
Intravenous
5.4
12.5
29
67
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
72.5
11.9
13
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
19.6
11.6
17
10
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
39.4
11.6
14
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
39.4
11.6
14
*
ZXD05
NOMESCO Finland
Urgent procedure
3.8
11.5
58
241
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.4
11.3
21
22
A12AA04
ATC
calcium carbonate; oral
24.3
11.0
15
7
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.2
10.9
37
116
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.5
10.9
33
95
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
66.3
10.8
12
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
44.1
10.2
12
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
28.9
10.1
13
5
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.2
10.0
16
12
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
60.2
9.8
11
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.3
9.8
22
49
A41.8
ICD-10 Finland
Other specified sepsis
19.7
9.7
14
8
J96.0
ICD-10 Finland
Acute respiratory failure
33.1
9.6
12
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
20.7
9.2
13
7
196
Kela drug reimbursment
Paricalcitol and cinacalcet
54.2
8.8
10
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
30.1
8.7
11
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
30.1
8.7
11
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
10.7
8.6
16
17
WX882
NOMESCO Finland
High dependency care
12.1
8.6
15
14
321
Kela drug reimbursment
Paricalcitol and cinacalcet
48.3
7.8
9
*
Z2446
NOMESCO Finland
Social worker
4.6
7.7
20
50
K65.0
ICD-10 Finland
Acute peritonitis
27.1
7.7
10
*
TQW11
NOMESCO Finland
Vacuum treatment of wound
27.1
7.7
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
7.5
39
158
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
85.3
7.5
8
*
NDQ20
NOMESCO Finland
Amputation of finger
85.3
7.5
8
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.9
7.4
18
30
A12AA12
ATC
[U] calcium acetate
+∞
7.4
7
*
H02AB04
ATC
methylprednisolone; systemic
3.7
7.3
27
88
R4110
NOMESCO Finland
Physiotherapy
3.0
7.3
47
216
V03AE02
ATC
sevelamer; oral
32.2
7.3
9
*
JN4BD
NOMESCO Finland
Extensive body CT
4.0
7.1
23
68
WX892
NOMESCO Finland
Monitored bed care
6.9
7.1
17
28
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
7.0
44
198
Z3226
NOMESCO Finland
Physiotherapist
3.2
7.0
35
138
H05BX01
ATC
cinacalcet; oral
42.6
6.8
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
6.8
65
365
137
Kela drug reimbursment
Uraemia requiring dialysis
24.2
6.8
9
*
L04AD01
ATC
ciclosporin; systemic
13.3
6.7
11
9
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
6.5
18
47
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
28.4
6.3
8
*
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
7.4
6.3
14
21
L04AX01
ATC
azathioprine; systemic
9.4
6.2
12
14
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
10.9
6.2
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
23
12.84
13.54
2.3
1.9
0.24
0.44
u/ml
—
10
13
40
123
4.44
12.22
8.0
2.6
23.17
24.08
%
0.15
35
112
19
15
14.87
11.63
1.3
1.7
—
—
—
0
0
42
152
3.76
10.01
6.5
3.1
0.78
0.82
mmol/l
1.87
42
143
29
85
4.22
9.23
17.2
4.2
-0.18
2.03
mmol/l
2.08
24
66
30
97
3.82
8.28
1.7
1.6
—
—
—
0
0
12
7
18.90
8.27
1.1
1.3
—
—
—
0
0
38
145
3.41
8.17
1.7
1.9
—
—
—
0
0
27
84
3.89
7.85
19.8
6.5
-1.34
1.30
mmol/l
1.93
22
69
28
91
3.74
7.63
1.6
1.6
—
—
—
0
0
71
414
2.84
6.93
15.3
12.2
1.16
1.21
inr
0.18
17
127
15
24
7.01
6.41
3.2
1.3
—
—
—
0
0
27
97
3.32
6.26
22.7
6.7
102.00
103.62
mmol/l
0.70
27
97
19
54
4.01
6.18
2.1
1.4
—
—
—
0
0
14
23
6.77
5.90
1.4
1.2
—
—
—
0
0
25
92
3.19
5.54
4.6
3.5
—
—
—
0
0
20
64
3.57
5.50
3.6
2.7
33.18
58.90
ml/min/173m2
3.42
11
29
5
0
+∞
5.24
1.0
0.0
—
—
—
0
0
39
190
2.59
5.14
3.5
1.7
5.03
1.03
mg/l
1.47
32
148
20
68
3.35
5.00
6.9
4.2
0.59
2.01
mmol/l
0.98
12
53
40
201
2.51
4.92
5.3
2.1
—
—
—
0
0
69
449
2.32
4.66
32.0
6.4
1.20
1.22
mmol/l
1.40
64
384
14
41
3.75
4.34
8.4
2.5
0.71
1.38
%
1.43
14
41
9
14
6.87
4.07
1.2
1.1
—
—
—
0
0
7
7
10.54
4.06
2.3
2.4
—
—
—
0
0
12
28
4.66
3.95
1.5
1.4
—
—
—
0
0
8
11
7.71
3.93
1.4
1.2
—
—
—
0
0
10
19
5.65
3.92
1.6
2.1
—
—
—
0
0
14
45
3.40
3.79
1.6
1.6
—
—
—
0
0
14
40
3.84
3.76
8.4
2.6
0.59
0.72
%
0.57
14
40
92
1053
0.39
3.70
60.0
19.5
36.65
40.55
%
7.26
83
1011
54
343
2.07
3.60
8.3
3.3
—
—
—
0
0
14
47
3.25
3.55
28.4
8.3
93.71
94.60
%
0.50
14
47
10
22
4.87
3.52
1.3
1.1
—
—
—
0
0
10
22
4.87
3.52
1.3
1.1
—
—
—
0
0
75
545
2.06
3.39
15.7
10.1
5.74
4.02
e9/l
0.81
69
486
12
37
3.50
3.04
1.7
1.5
—
—
—
0
0
59
408
1.91
2.93
5.1
2.4
—
—
—
0
0
7
13
5.65
2.91
1.0
1.2
—
—
—
0
0
6
9
6.96
2.90
2.3
1.1
—
—
—
0
0
8
18
4.69
2.85
1.4
1.6
—
—
—
0
0
13
49
2.86
2.73
1.5
1.3
—
—
—
0
0
8
20
4.21
2.62
1.0
1.5
—
—
—
0
0
9
26
3.66
2.54
2.3
2.5
—
—
—
0
0
29
165
2.01
2.49
5.9
2.6
1.84
0.94
e6/l
0.30
22
90
28
158
2.02
2.46
6.6
2.8
10.16
3.04
e6/l
0.81
22
85
8
22
3.82
2.41
1.4
1.1
—
—
—
0
0
5
8
6.47
2.39
1.4
1.6
—
—
—
0
0
5
8
6.47
2.39
1.4
2.6
—
—
—
0
0
8
23
3.66
2.31
1.4
1.1
—
—
—
0
0
5
9
5.75
2.23
2.6
4.0
—
—
—
0
0
9
33
2.87
1.98
1.0
1.6
—
293.28
—
0
19
33
211
1.79
1.97
1.8
1.5
20.72
22.79
nmol/l
0.37
33
178
89
998
0.54
1.97
42.1
15.7
138.10
76.71
umol/l
3.38
89
998
9
34
2.78
1.91
2.3
1.6
—
—
—
0
0
78
900
0.59
1.78
5.2
4.5
6.19
5.91
mmol/l
0.88
72
823
25
153
1.81
1.71
1.9
1.7
912.95
1208.83
nmol/l
1.07
20
123
10
40
2.64
1.71
1.3
1.2
—
—
—
0
0
10
44
2.39
1.60
4.6
3.1
46.53
52.86
%
—
10
44
53
410
1.54
1.46
7.9
2.7
289.20
109.81
ug/l
2.51
53
382
46
350
1.52
1.34
2.5
1.9
86.95
97.06
pmol/l
0.91
25
176
6
24
2.58
1.32
2.3
1.6
—
—
—
0
0
5
18
2.85
1.30
1.0
1.7
—
—
—
0
0
74
838
0.68
1.16
54.4
15.7
14.75
14.85
%
0.15
74
827
22
309
0.64
1.04
4.9
4.4
1.23
3.04
ug/l
1.01
22
271
12
195
0.57
1.02
1.3
1.7
—
—
—
0
0
54
450
1.37
0.90
6.5
3.5
0.00
0.00
estimate
-0.00
11
110
80
879
0.71
0.88
7.5
5.4
39.47
39.99
mmol/mol
0.18
75
824
6
32
1.92
0.83
2.0
1.7
47.17
40.91
nmol/l
—
6
32
54
455
1.35
0.82
6.6
3.5
0.00
0.00
estimate
-0.00
11
98
5
28
1.82
0.67
1.6
2.0
—
—
—
0
0
52
449
1.29
0.63
9.8
4.6
0.00
0.01
estimate
—
10
105
5
30
1.70
0.62
1.0
1.1
—
—
—
0
0
6
37
1.65
0.56
1.5
2.8
—
—
—
0
0
19
238
0.76
0.46
3.3
4.1
14.04
21.67
%
—
5
105
85
896
0.81
0.40
30.7
12.8
66.16
81.91
ml/min/173m2
3.93
77
740
5
36
1.41
0.38
1.6
2.3
—
—
—
0
0
7
51
1.40
0.32
1.0
1.4
—
82.07
—
0
14
91
942
0.84
0.26
40.9
13.4
32.22
21.87
mg/l
2.60
80
746
18
152
1.22
0.25
2.0
1.4
—
—
—
0
0
39
357
1.14
0.22
2.7
4.0
73.53
44.50
ng/l
0.36
32
244
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
23
256
0.87
0.18
6.7
3.8
0.00
0.01
estimate
—
9
99
9
79
1.15
0.15
6.7
3.6
1.20
1.23
mmol/l
—
9
68
33
352
0.91
0.12
6.4
3.5
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
18
165
1.11
0.09
1.2
1.2
5.53
5.92
u/ml
—
6
63
61
627
0.94
0.08
3.0
3.3
—
—
—
0
0
21
224
0.92
0.07
1.6
1.3
0.75
0.80
u/ml
—
6
62
11
103
1.08
0.02
8.5
8.6
—
—
—
0
0
28
278
1.01
0.00
2.9
2.0
293.86
199.55
u/l
0.26
28
267
10
102
0.98
0.00
2.1
1.8
—
—
—
0
0
11
112
0.98
0.00
2.2
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
13.29
—
0
7
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
17.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
248.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.6
—
—
—
0
0
6
61
0.98
-0.00
2.2
1.9
33.33
58.31
u/ml
—
6
55
0
5
0.00
-0.00
0.0
1.2
—
8.50
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_DISSEINTRAVASCCOAG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 3.462 [2.16, 5.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 307 females with D3_DISSEINTRAVASCCOAG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 4.371 [2.68, 7.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 291 males with D3_DISSEINTRAVASCCOAG died.
Mortality risk
Mortality risk for people of age
years, who have D3_DISSEINTRAVASCCOAG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.317% | 0.77% |
| 5 | 2.11% | 4.787% |
| 10 | 4.958% | 11.208% |
| 15 | 8.941% | 20.685% |
| 20 | 14.772% | 33.351% |
Relationships between endpoints
↥Index endpoint: D3_DISSEINTRAVASCCOAG – Disseminated intravascular coagulation [defibrination syndrome]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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